Characterization of a New Protein Family Associated With the Silica Deposition Vesicle Membrane Enables Genetic Manipulation of Diatom Silica.

abstract：:Hominin dietary specialization is crucial to understanding the evolutionary changes of craniofacial biomechanics and the interaction of food processing methods' effects on teeth. However, the diet-related dental wear processes of the earliest European hominins remain unknown because most of the academic attention has ...

journal_title：Scientific reports

authors： Pérez-Pérez A,Lozano M,Romero A,Martínez LM,Galbany J,Pinilla B,Estebaranz-Sánchez F,Bermúdez de Castro JM,Carbonell E,Arsuaga JL

更新日期：2017-02-27 00:00:00

abstract：:Heme catabolism exerts physiological functions that impact health through depressing inflammation. Upon reactive pathway progression, as in Gilbert's Syndrome (GS; UGT1A1*28 polymorphism), aggravated health effects have been determined. Based on lower inflammation and improved metabolic health reported for GS, inter-g...

journal_title：Scientific reports

authors： Mölzer C,Wallner M,Kern C,Tosevska A,Zadnikar R,Doberer D,Marculescu R,Wagner KH

更新日期：2017-04-07 00:00:00

abstract：:The association between gene polymorphisms and plasma virus load at the set point (SP-PVL) was investigated in Mauritian macaques inoculated with SIV. Among 44 macaques inoculated with 50 AID50, six individuals were selected: three with SP-PVL among the highest and three with SP-PVL among the lowest. The exons of 390 ...

journal_title：Scientific reports

authors： Shiina T,Suzuki S,Congy-Jolivet N,Aarnink A,Garchon HJ,Dereuddre-Bosquet N,Vaslin B,Tchitchek N,Desjardins D,Autran B,Lambotte O,Theodorou I,Le Grand R,Blancher A

更新日期：2019-05-28 00:00:00

abstract：:Nanoscale wavelength-converted optical components are promising components for communication and optical information processing in integrated photonic system. In this work, we report a facile strategy for realizing continuously tunable wavelength-converted wave-guiding in dye-doped nanofibers. The nanofibers with diam...

journal_title：Scientific reports

authors： Yu H,Li B

更新日期：2013-01-01 00:00:00

abstract：:A cDNA library from a pool of all the seven silk glands from a tropical spider species was constructed. More than 1000 expressed sequence tag (EST) clones were created. Almost 65% of the EST clones were identified and around 50% were annotated. The cellular and functional distribution of the EST clones indicated high ...

journal_title：Scientific reports

authors： Huang W,Zhang Y,Chen Y,Wang Y,Yuan W,Zhang N,Lam TJ,Gong Z,Yang D,Lin Z

更新日期：2017-10-17 00:00:00

abstract：:In bacteria, selective promoter recognition by RNA polymerase is achieved by its association with σ factors, accessory subunits able to direct RNA polymerase "core enzyme" (E) to different promoter sequences. Using Chromatin Immunoprecipitation-sequencing (ChIP-seq), we searched for promoters bound by the σ(S)-associa...

journal_title：Scientific reports

authors： Peano C,Wolf J,Demol J,Rossi E,Petiti L,De Bellis G,Geiselmann J,Egli T,Lacour S,Landini P

更新日期：2015-05-28 00:00:00

abstract：:Gut dysbiosis contributes to the development of a dysfunctional gut barrier, facilitating the translocation of bacteria and inflammagens, and is implicated in colorectal cancer (CRC) pathogenesis. Such 'leaky gut' conditions result in systemic inflammation, of which a hallmark is increased hypercoagulability. Fluoresc...

journal_title：Scientific reports

authors： de Waal GM,de Villiers WJS,Forgan T,Roberts T,Pretorius E

更新日期：2020-05-29 00:00:00

abstract：:Single-nucleotide polymorphisms (SNPs) in cytokine genes can affect gene expression and thereby modulate inflammation and carcinogenesis. However, the data on the association between SNPs in the interleukin 1 beta gene (IL1B) and colorectal cancer (CRC) are conflicting. We found an association between a 4-SNP haplotyp...

journal_title：Scientific reports

authors： Sanabria-Salas MC,Hernández-Suárez G,Umaña-Pérez A,Rawlik K,Tenesa A,Serrano-López ML,Sánchez de Gómez M,Rojas MP,Bravo LE,Albis R,Plata JL,Green H,Borgovan T,Li L,Majumdar S,Garai J,Lee E,Ashktorab H,Brim H,Li L,

更新日期：2017-02-03 00:00:00

abstract：:Malaria-associated acute lung injury (ALI) is a frequent complication of severe malaria that is often caused by "excessive" immune responses. To better understand the mechanism of ALI in malaria infection, here we investigated the roles of galectin (Gal)-1, 3, 8, 9 and the receptors of Gal-9 (Tim-3, CD44, CD137, and P...

journal_title：Scientific reports

authors： Liu J,Huang S,Su XZ,Song J,Lu F

更新日期：2016-08-24 00:00:00

abstract：:The establishment of the infant gut microbiota is a highly dynamic process dependent on extrinsic and intrinsic factors. We characterized the faecal microbiota of 4 breastfed infants and 4 formula-fed infants at 17 consecutive time points during the first 12 weeks of life. Microbiota composition was analysed by a comb...

journal_title：Scientific reports

authors： Timmerman HM,Rutten NBMM,Boekhorst J,Saulnier DM,Kortman GAM,Contractor N,Kullen M,Floris E,Harmsen HJM,Vlieger AM,Kleerebezem M,Rijkers GT

更新日期：2017-08-21 00:00:00

abstract：:People with ataxia-telangiectasia (A-T) display phenotypic variability with regard to progression of immunodeficiency, sino-pulmonary disease, and neurologic decline. To determine the association between differential gene expression, epigenetic state, and phenotypic variation among people with A-T, we performed transc...

journal_title：Scientific reports

authors： McGrath-Morrow SA,Ndeh R,Helmin KA,Khuder B,Rothblum-Oviatt C,Collaco JM,Wright J,Reyfman PA,Lederman HM,Singer BD

更新日期：2020-05-04 00:00:00

abstract：:The ability of Treponema pallidum, the syphilis spirochete to colonize various tissues requires the presence of surface-exposed adhesins that have been difficult to identify due to the inability to culture and genetically manipulate T. pallidum. Using a Borrelia burgdorferi-based heterologous system and gain-in-functi...

journal_title：Scientific reports

authors： Chan K,Nasereddin T,Alter L,Centurion-Lara A,Giacani L,Parveen N

更新日期：2016-05-10 00:00:00

abstract：:Noise-induced hearing loss (NIHL) is a common health concern with significant social, psychological, and cognitive implications. Moderate levels of acoustic overstimulation associated with tinnitus and impaired speech perception cause cochlear synaptopathy, characterized physiologically by reduction in wave I of the s...

journal_title：Scientific reports

authors： Rouse SL,Matthews IR,Li J,Sherr EH,Chan DK

更新日期：2020-10-22 00:00:00

abstract：:Decline in episodic memory performance usually causes the first clinical symptoms of Alzheimer's disease. At present, Alzheimer's disease can only be diagnosed at a very late stage when neurodegeneration and cognitive impairment is already irreversible. New early disease markers are needed for earlier and more efficie...

journal_title：Scientific reports

authors： Konki M,Lindgren N,Kyläniemi M,Venho R,Laajala E,Ghimire B,Lahesmaa R,Kaprio J,Rinne JO,Lund RJ

更新日期：2020-08-25 00:00:00

abstract：:Telomere DNA ends with a single-stranded 3' overhang. Long 3' overhangs may cause aberrant DNA damage responses and accelerate telomere attrition, which is associated with cancer and aging, respectively. Genetic studies have indicated several important players in preventing 5' end hyper-resection, yet detailed knowled...

journal_title：Scientific reports

authors： Runnberg R,Narayanan S,Cohn M

更新日期：2017-08-18 00:00:00

abstract：:The behavior of diatomic molecular solids under pressure have attracted great interest and been extensively studied. Under ambient pressure, the structure of bromine is known to be a molecular phase (phase I). With increasing pressure, it transforms into an incommensurate phase (phase V) before eventually to a monoato...

journal_title：Scientific reports

authors： Wu M,Tse JS,Pan Y

更新日期：2016-05-09 00:00:00

abstract：:Novel pain killers without adverse effects are urgently needed. Opioids induce central and intestinal side effects such as respiratory depression, sedation, addiction, and constipation. We have recently shown that a newly designed agonist with a reduced acid dissociation constant (pKa) abolished pain by selectively ac...

journal_title：Scientific reports

authors： Spahn V,Del Vecchio G,Rodriguez-Gaztelumendi A,Temp J,Labuz D,Kloner M,Reidelbach M,Machelska H,Weber M,Stein C

更新日期：2018-06-12 00:00:00

abstract：:RNA virus-based episomal vector (REVec) is an emerging viral vector system that mediates long-term stable gene expression in variety of cell types in vitro. However, little is known about its tissue tropism and persistence of gene expression in vivo. Here, to evaluate the feasibility of REVec for in vivo gene delivery...

journal_title：Scientific reports

authors： Komatsu Y,Tanaka C,Komorizono R,Tomonaga K

更新日期：2020-04-03 00:00:00

abstract：:Fear is an adaptive emotion that elicits defensive behavioural responses against aversive threats in animals. In mammals, serotonin receptors (5-HTRs) have been shown to modulate fear-related neural circuits in the basolateral amygdala complex (BLA). To understand the phylogenetic continuity of the neural basis for fe...

journal_title：Scientific reports

authors： Fujita T,Aoki N,Mori C,Fujita E,Matsushima T,Homma KJ,Yamaguchi S

更新日期：2020-12-03 00:00:00

abstract：:We propose a reflection type metal-insulator-metal (MIM) metasurface composed of hybrid nano-antennas for comprehensive spatial engineering of the properties of optical fields. The capability of such structure is illustrated in the design of a device that can be used to produce a radially polarized vectorial beam for ...

journal_title：Scientific reports

authors： Wang S,Zhan Q

更新日期：2016-07-15 00:00:00

abstract：:Laser has been widely used in many aspects, by now it is difficult to get each frequency that we want, and frequency conversion is an effective way to obtain different frequency laser through a nonlinear optical crystal. MgO-doped LiNbO3 (Mg:LN) crystal has usually been used for second harmonic generation (SHG) throug...

journal_title：Scientific reports

authors： Kong T,Liu H,Ge X,Qu D,Liu S,Chen S,Zhang L,Kong Y,Rupp R,Xu J

更新日期：2018-03-01 00:00:00

abstract：:It is generally believed that anthropogenic aerosols cool the atmosphere; therefore, they offset the global warming resulting from greenhouse gases to some extent. Reduction in sulphate, a primary anthropogenic aerosol, is necessary for mitigating air pollution, which causes atmospheric warming. Here, the changes in t...

journal_title：Scientific reports

authors： Takemura T

更新日期：2020-12-10 00:00:00

abstract：:Lithium vanadium phosphate (Li3V2(PO4)3, LVP)/reduced graphene oxide (rGO) composite is prepared with a rheological method followed by heat treatment. The size and interface of LVP particles, two important merits for a cathode material, can be effectively tuned by the rGO in the composite, which plays as surfactant to...

journal_title：Scientific reports

authors： Zhu X,Yan Z,Wu W,Zeng W,Du Y,Zhong Y,Zhai H,Ji H,Zhu Y

更新日期：2014-08-29 00:00:00

abstract：:HIV-1 latency generates reservoirs that prevent viral eradication by the current therapies. To find strategies toward an HIV cure, detailed understandings of the molecular mechanisms underlying establishment and persistence of the reservoirs are needed. The cellular transcription factor KAP1 is known as a potent repre...

journal_title：Scientific reports

authors： Ait-Ammar A,Bellefroid M,Daouad F,Martinelli V,Van Assche J,Wallet C,Rodari A,De Rovere M,Fahrenkrog B,Schwartz C,Van Lint C,Gautier V,Rohr O

更新日期：2021-01-29 00:00:00

abstract：:The centromeric nucleosome is a key epigenetic determinant of centromere identity and function. Consequently, deciphering how CENP-A containing nucleosomes contribute structurally to centromere function is a fundamental question in chromosome biology. Here, we performed microsecond timescale all-atom molecular dynamic...

journal_title：Scientific reports

authors： Winogradoff D,Zhao H,Dalal Y,Papoian GA

更新日期：2015-11-25 00:00:00

abstract：:To investigate changes in the size of the population of patients who are receiving long-term, active treatment for neovascular age-related macular degeneration (AMD). This retrospective, observational study included 18,165 patients who received anti-vascular endothelial growth factor injections (3,974 eyes). The injec...

journal_title：Scientific reports

authors： Baek SK,Kim JH,Kim JW,Kim CG

更新日期：2019-09-13 00:00:00

abstract：:Neurovascular unit (NVU) is a basic unit in the brain, including neurons, glial cells, blood vessels and extracellular matrix. This concept implies the importance of a three-dimensional (3D) culture model including these cell types for investigating brain functions. However, little is known about the construction of a...

journal_title：Scientific reports

authors： Uwamori H,Higuchi T,Arai K,Sudo R

更新日期：2017-12-11 00:00:00

abstract：:Tumor-associated immune response plays a critical role in cancer pathogenesis. This study evaluated clinical implications of T cell cytokines and regulatory T cells (Tregs) in HCC patients treated with TACE. Whole blood was obtained for analysis of T cell cytokines (IL-1β, IL-2, IL-4, IL-5, IL-6, IL-9, IL-10, IL-12p70...

journal_title：Scientific reports

authors： Lee HL,Jang JW,Lee SW,Yoo SH,Kwon JH,Nam SW,Bae SH,Choi JY,Han NI,Yoon SK

更新日期：2019-03-01 00:00:00

abstract：:CDK5 Regulatory Subunit-Associated Protein 1-like 1 (CDKAL1) was identified as a susceptibility gene for type 2 diabetes and body mass index in genome-wide association studies. Although it was reported that CDKAL1 is a methylthiotransferase essential for tRNALys(UUU) and faithful translation of proinsulin generated in...

journal_title：Scientific reports

authors： Take K,Waki H,Sun W,Wada T,Yu J,Nakamura M,Aoyama T,Yamauchi T,Kadowaki T

更新日期：2017-08-04 00:00:00

abstract：:Reef-building corals depend on an intracellular symbiosis with photosynthetic dinoflagellates for their survival in nutrient-poor oceans. Symbionts are phagocytosed by coral larvae from the environment and transfer essential nutrients to their hosts. Aiptasia, a small tropical marine sea anemone, is emerging as a trac...

journal_title：Scientific reports

authors： Jones VAS,Bucher M,Hambleton EA,Guse A

更新日期：2018-11-06 00:00:00