Abstract:
:The prevention and control of peri-implantitis is a challenge in dental implant surgery. Dental implants with sustained antimicrobial coating are an ideal way of preventing peri-implantitis. This study reports development of a non- immunotoxicity multilayered coating on a titanium surface that had sustained antimicrobial activity and limited early biofilm formation. In this study, the broad spectrum AMP, Tet213, was linked to collagen IV through sulfo-SMPB and has been renamed as AMPCol. The multilayer AMPCol coatings were assembled on smooth titanium surfaces using a LBL technique. Using XPS, AFM, contact angle analysis, and QCM, layer-by-layer accumulation of coating thickness was measured and increased surface wetting compared to controls was confirmed. Non-cytotoxicity to HaCaT and low erythrocyte hemolysis by the AMPCol coatings was observed. In vivo immunotoxicity assays showed IP administration of AMPCol did not effect serum immunoglobulin levels. This coating with controlled release of AMP decreased the growth of both a Gram-positive aerobe (Staphylococcus aureus) and a Gram-negative anaerobe (Porphyromonas gingivalis) up to one month. Early S. aureus biofilm formation was inhibited by the coating. The excellent long-term sustained antimicrobial activity of this multilayer coating is a potential method for preventing peri-implantitis through coated on the neck of implants before surgery.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Shi J,Liu Y,Wang Y,Zhang J,Zhao S,Yang Gdoi
10.1038/srep16336subject
Has Abstractpub_date
2015-11-09 00:00:00pages
16336issn
2045-2322pii
srep16336journal_volume
5pub_type
杂志文章abstract::Fire ants are widely studied, invasive and venomous arthropod pests. There is significant biomedical interest in immunotherapy against fire ant stings. However, mainly due to practical reasons, the physiological effects of envenomation has remained poorly characterized. The present study takes advantage of a recently-...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-32327-z
更新日期:2018-09-26 00:00:00
abstract::Selective filtration of gas, water, and liquid or gaseous oil is essential to prevent possible environmental pollution and machine/facility malfunction in oil-based industries. Novel materials and structures able to selectively and efficiently filter liquid and vapor in various types of solutions are therefore in cont...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep14321
更新日期:2015-09-23 00:00:00
abstract::We study the capillary retraction of a Newtonian semi-infinite liquid filament through analytical methods. We derive a long-time asymptotic-state expansion for the filament profile using a one-dimensional free-surface slender cylindrical flow model based on the three-dimensional axisymmetric Navier-Stokes equations. T...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-51824-3
更新日期:2019-10-29 00:00:00
abstract::Circulating tumor cells (CTCs) are important clinical indicators for prognosis and treatment efficacy. However, CTC investigation is hampered by their low number, making the establishment of permanent CTC lines very challenging. We derived and characterized nine CTC lines using blood samples from a patient with metast...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-34365-z
更新日期:2018-10-29 00:00:00
abstract::Isolating actively proliferating cardioblasts is the first crucial step for cardiac regeneration through cell implantation. However, the origin and identity of putative cardioblasts are still unclear. Here, we uncover a novel class of cardiac lineage cells, PDGFRα+Flk1- cardioblasts (PCBs), from mouse and human plurip...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep41840
更新日期:2017-02-06 00:00:00
abstract::A p-i-n junction diode based on the selectively doped single-walled carbon nanotube (SWCNT) had been investigated, in which two opposite ends of individual SWCNT channel were doped into the p- and n-type SWCNT respectively while the middle segment of SWCNT was kept as the intrinsic. The symmetric and asymmetric contac...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep22203
更新日期:2016-02-26 00:00:00
abstract::Copy Number Variants (CNVs) are a class of structural variations of DNA. Germline CNVs are known to confer disease susceptibility, but their role in breast cancer warrants further investigations. We hypothesized that breast cancer associated germline CNVs contribute to disease risk through gene dosage or other post-tr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-25801-1
更新日期:2018-05-14 00:00:00
abstract::Tunable metasurfaces have emerged as an efficient approach to manipulate the wave propagation. Different from previous work concentrating on electrically tunable mechanisms, here we demonstrate a magnetically tunable metasurface composed of ferrite rods and metallic foils. By tuning the thickness of ferrite rods, meta...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-05625-1
更新日期:2017-07-14 00:00:00
abstract::Using starch as the carbon precursor and different-sized ZnO naoparticles as the hard template, a series of porous carbon materials for electrochemical sensing were prepared. Experiments of scanning electron microscopy, transmission electron microscopy and Nitrogen adsorption-desorption isotherms reveal that the parti...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep22309
更新日期:2016-02-29 00:00:00
abstract::The transcriptional responses of yeast cells to diverse stresses typically include gene activation and repression. Specific stress defense, citric acid cycle and oxidative phosphorylation genes are activated, whereas protein synthesis genes are coordinately repressed. This view was achieved from comparative transcript...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-26170-5
更新日期:2018-05-21 00:00:00
abstract::Humans are good at selectively listening to specific target conversations, even in the presence of multiple concurrent speakers. In our research, we study how auditory-visual cues modulate this selective listening. We do so by using immersive Virtual Reality technologies with spatialized audio. Exposing 32 participant...
journal_title:Scientific reports
pub_type: 临床试验,杂志文章
doi:10.1038/s41598-017-04201-x
更新日期:2017-06-19 00:00:00
abstract::In this paper, for the first time, the switchable two-color quantum dot laser has been realized considering solution process technology, which has both simultaneous and lonely lasing capability exploiting selective energy contacts. Furthermore, both channels can be modulated independently, which is a significant featu...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-60859-w
更新日期:2020-03-24 00:00:00
abstract::Inositol Requiring Enzyme-1 (IRE1) is the most conserved transducer of the Unfolded Protein Response (UPR), a surveillance mechanism that ensures homeostasis of the endoplasmic reticulum (ER) in eukaryotes. IRE1 activation orchestrates adaptive responses, including lipid anabolism, metabolic reprogramming, increases i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-16662-1
更新日期:2017-11-28 00:00:00
abstract::Lipomas are benign fatty tumors with a high prevalence rate, mostly found in adults but have a good prognosis. Until now, reason for lipoma occurrence not been identified. We performed whole exome sequencing to define the mutational spectrum in ten lipoma patients along with their matching control samples. We presente...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-50805-w
更新日期:2019-10-07 00:00:00
abstract::We report an integrated system for accelerating assays with concentrators in a standard 12-well plate (ISAAC-12) and demonstrate its versatility for rapid detection of matrix metalloproteinase (MMP)-9 expression in the cell culture supernatant of breast cancer cell line MDA-MB-231 by accelerating the enzymatic reactio...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-29065-7
更新日期:2018-07-17 00:00:00
abstract::Electrospun polycaprolactone (PCL) vascular grafts showed good mechanical properties and patency. However, the slow degradation of PCL limited vascular regeneration in the graft. Polydioxanone (PDS) is a biodegradable polymer with high mechanical strength and moderate degradation rate in vivo. In this study, a small-d...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-03851-1
更新日期:2017-06-15 00:00:00
abstract::Mammalian spermatogenesis is a classic adult stems cell-dependent process, supported by the self-renewal and differentiation of spermatogonial stem cells (SSCs). However, the identification of SSCs and elucidation of their behaviors in undisturbed testis has long been a big challenge. Here, we generated a knock-in mou...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep17594
更新日期:2015-12-01 00:00:00
abstract::The amount of Paper Board Mill Effluent Treatment Plant Sludge (PBM-ETPS) dumped from paper mills are huge and its conversion into hydrochar for the purpose of energy has broad prospects. This study investigated the optimum conditions for the production of PBM-ETPS derived hydrochar (PBM-ETPSH) through Reponse Surface...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-57163-7
更新日期:2020-01-21 00:00:00
abstract::The dispersion properties of metamaterials and photonic crystals (PhCs) lead to an intensive research in the development of cavity resonators for the confinement of electromagnetic (e-m) radiation. In this work, we investigate the formation of Fabry-Pérot (FP) modes associated with hyperbolic-like dispersion (HLD) reg...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-67965-9
更新日期:2020-07-06 00:00:00
abstract::L-R (left and right) symmetry breaking during embryogenesis and the establishment of asymmetric body plan are key issues in developmental biology, but the onset including the handedness-determining gene locus still remains unknown. Using pure dextral (DD) and sinistral (dd) strains of the pond snail Lymnaea stagnalis ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep34809
更新日期:2016-10-06 00:00:00
abstract::The use of entomopathogenic fungi for biocontrol of plant pests is recently receiving an increased interest due to the need of reducing the impact of agricultural practices on the environment. Biocontrol efficacy could be improved by co-inoculation of different microorganisms. However, interactions between the fungal ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-12700-0
更新日期:2017-10-12 00:00:00
abstract::Psychological and behavioural interventions may be effective in reducing menopause-related symptoms. This randomized controlled trial aimed to evaluate the effectiveness of Mindfulness-based Stress Reduction (MBSR) in reducing menopause-related symptoms by comparing with an active control group, the menopause educatio...
journal_title:Scientific reports
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1038/s41598-018-24945-4
更新日期:2018-04-26 00:00:00
abstract::Changes in climate extremes pose far-reaching consequences to ecological processes and hydrologic cycles in alpine ecosystems of the arid mountain regions. Therefore, regional assessments in various climates and mountain regions are needed for understanding the uncertainties of the change trends for extreme climate ev...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-02345-4
更新日期:2017-05-22 00:00:00
abstract::Skin ageing is an inevitable consequence of life and accelerated by exposure to ultraviolet (UV) rays. Senescence is an irreversible growth arrest and senescent cells accumulate in ageing tissues, at sites of age-related pathologies and in pre-neoplastic lesions. Conventionally, senescent cells have been detected by s...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-15901-9
更新日期:2017-11-15 00:00:00
abstract::Based on the pro-drug principle, aspirin and eugenol were used to synthesize aspirin eugenol ester (AEE) by esterification reaction. In present study, the anti-atherosclerosis effects of AEE were investigated in hamsters with the utilization of metabonomic approach based on UPLC-Q-TOF/MS. Biochemical parameters and hi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-11422-7
更新日期:2017-09-05 00:00:00
abstract::Anaerobic digestion is a common technology to biologically stabilize wasted solids produced in municipal wastewater treatment. Its efficiency is usually evaluated by calculating the reduction in volatile solids, which assumes no biomass growth associated with digestion. To determine whether this assumption is valid an...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep34090
更新日期:2016-09-26 00:00:00
abstract::We consider the electromagnetic response of a topological Weyl semimetal (TWS) with a pair of Weyl nodes in the bulk and corresponding Fermi arcs in the surface Brillouin zone. We compute the frequency-dependent complex conductivities σαβ(ω) and also take into account the modification of Maxwell equations by the topol...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep12683
更新日期:2015-08-03 00:00:00
abstract::In the field of neuroprosthetics, the current state-of-the-art method involves controlling the prosthesis with electromyography (EMG) or electrooculography/electroencephalography (EOG/EEG). However, these systems are both expensive and time consuming to calibrate, susceptible to interference, and require a lengthy lea...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-73250-6
更新日期:2020-10-01 00:00:00
abstract::This retrospective study was undertaken to provide more modern data of real-life management of non-metastatic rectal cancer, to compare therapeutic strategies, and to identify prognostic factors of overall survival (OS) in a large cohort of patients. Data on efficacy and on acute/late toxicity were retrospectively col...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-29040-2
更新日期:2018-07-16 00:00:00
abstract::Developing an effective universal influenza vaccine against influenza virus with highly conserved antigenic epitopes could induce a broad-spectrum immune response to prevent infection. The soluble protein M1 that can induce the M1 specific immune response was first confirmed in our previous study. In this study, we ch...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-60783-z
更新日期:2020-03-05 00:00:00