Breast cancer associated germline structural variants harboring small noncoding RNAs impact post-transcriptional gene regulation.

abstract：:Therapies targeting somatic bystander genetic events represent a new avenue for cancer treatment. We recently identified a subset of colorectal cancer (CRC) patients who are heterozygous for a wild-type and a low activity allele (NAT2*6) but lack the wild-type allele in their tumors due to loss of heterozygosity (LOH)...

journal_title：Scientific reports

authors： Rendo V,Kundu S,Rameika N,Ljungström V,Svensson R,Palin K,Aaltonen L,Stoimenov I,Sjöblom T

更新日期：2020-12-31 00:00:00

abstract：:Schistosomes, unlike malaria parasites, are in their diploid stage when targeted by the human immune system. Diploids can be either homozygous or heterozygous. The difference has profound significance for developing immunity and yet has not previously been addressed. We examined the implications of zygosity on immunit...

journal_title：Scientific reports

authors： Xu X,Sun J,Zhang J,Wellems D,Qing X,McCutchan T,Pan W

更新日期：2012-01-01 00:00:00

abstract：:Perpendicularly magnetized tunnel junctions (p-MTJs) that contain synthetic antiferromagnetic (SAF) frames show promise as reliable building blocks to meet the demands of perpendicular magnetic anisotropy (PMA)-based spintronic devices. In particular, Co/Pd multilayer-based SAFs have been widely employed due to their ...

journal_title：Scientific reports

authors： Lee JB,An GG,Yang SM,Park HS,Chung WS,Hong JP

更新日期：2016-02-18 00:00:00

abstract：:NanoRNAs are RNA fragments 2 to 5 nucleotides in length that are generated as byproducts of RNA degradation and abortive transcription initiation. Cells have specialized enzymes to degrade nanoRNAs, such as the DHH phosphoesterase family member NanoRNase A (NrnA). This enzyme was originally identified as a 3' → 5' exo...

journal_title：Scientific reports

authors： Schmier BJ,Nelersa CM,Malhotra A

更新日期：2017-09-11 00:00:00

abstract：:Stability and integration are the goals for developing photonic devices. Spirooxazines have the property of photoinduced merocyanine-aggregation in polymer matrix, which can be applied to fluorescence emission and stable information storage. Although visible light coherent radiation with UV-assist has been used to ach...

journal_title：Scientific reports

authors： Ji R,Fu S,Zhang X,Han X,Liu S,Wang X,Liu Y

更新日期：2018-02-28 00:00:00

abstract：:A major issue in human olfaction research is to characterize the main dimensions that organize the space of odors. The present study examines this question and shows that, beside pleasantness, trigeminal sensations, and particularly irritation, play an important role. These results were consistent along two different ...

journal_title：Scientific reports

authors： Licon CC,Manesse C,Dantec M,Fournel A,Bensafi M

更新日期：2018-05-31 00:00:00

abstract：:Various neurophysiological and cognitive functions are based on transferring information between spiking neurons via a complex system of synaptic connections. In particular, the capacity of presynaptic inputs to influence the postsynaptic outputs-the efficacy of the synapses-plays a principal role in all aspects of hi...

journal_title：Scientific reports

authors： Dabaghian Y

更新日期：2019-01-24 00:00:00

abstract：:We investigated the metabolic outcome of different coping strategies in 129S6/SvEvTac (129Sv) and C57BL/6Ntac (Bl6) strains. Two different batches of male 129Sv and Bl6 mice were used. One batch was not subjected to any behavioral manipulations (home cage control; HCC), whereas the other batch was treated with saline ...

journal_title：Scientific reports

authors： Narvik J,Vanaveski T,Innos J,Philips MA,Ottas A,Haring L,Zilmer M,Vasar E

更新日期：2018-02-21 00:00:00

abstract：:Next generation sequencing (NGS) data analysis is highly compute intensive. In-memory computing, vectorization, bulk data transfer, CPU frequency scaling are some of the hardware features in the modern computing architectures. To get the best execution time and utilize these hardware features, it is necessary to tune ...

journal_title：Scientific reports

authors： Kathiresan N,Temanni R,Almabrazi H,Syed N,Jithesh PV,Al-Ali R

更新日期：2017-08-22 00:00:00

abstract：:Extreme differences between the sexes are usually explained by intense sexual selection on male weapons or ornaments. Sexually antagonistic genes, with a positive effect on male traits but a negative effect on female fitness, create a negative inter-sexual correlation for fitness (sexual conflict). However, such antag...

journal_title：Scientific reports

authors： Buzatto BA,Clark HL

更新日期：2020-02-11 00:00:00

abstract：:Dynamic optical imaging (e.g. time delay integration imaging) is troubled by the motion blur fundamentally arising from mismatching between photo-induced charge transfer and optical image movements. Motion aberrations from the forward dynamic imaging link impede the acquiring of high-quality images. Here, we propose a...

journal_title：Scientific reports

authors： Li J,Liu Z

更新日期：2019-08-05 00:00:00

abstract：:Beneficial and deleterious mutations change an organism's fitness but the distribution of these mutational effects on fitness are unknown. Several experimental, theoretical, and computational studies have explored this question but are limited because of experimental restrictions, or disconnect with physiology. Here w...

journal_title：Scientific reports

authors： Brajesh RG,Dutta D,Saini S

更新日期：2019-07-08 00:00:00

abstract：:As continental rifts evolve towards mid-ocean ridges, strain is accommodated by repeated episodes of faulting and magmatism. Discrete rifting episodes have been observed along two subaerial divergent plate boundaries, the Krafla segment of the Northern Volcanic Rift Zone in Iceland and the Manda-Hararo segment of the ...

journal_title：Scientific reports

authors： Passarelli L,Rivalta E,Shuler A

更新日期：2014-01-28 00:00:00

abstract：:Nature disasters and terrorist attacks have occurred globally in recent years. Posttraumatic stress disorder (PTSD) has gained increasing attention, but its incidence and comorbidities in the general population are different from those inside the disaster areas. The present study estimated incident PTSD and comorbid d...

journal_title：Scientific reports

authors： Chang JC,Yen AM,Chen HH,Chen SL,Chiu SY,Fann JC,Lee CS

更新日期：2017-01-27 00:00:00

abstract：:Red mud as a waste material is produced in large quantities by the aluminum industry. Heat activation has been used to enhance sorption capacity of red mud for its beneficial reuse as an effective sorbent. In this study, heat-activated red mud (HARM) was investigated for its Cd(II) sorption capacity under various proc...

journal_title：Scientific reports

authors： Yang T,Sheng L,Wang Y,Wyckoff KN,He C,He Q

更新日期：2018-09-10 00:00:00

abstract：:We developed a spongy-like porous polymer (spongy monolith) consisting of poly(ethylene-co-glycidyl methacrylate) with continuous macropores that allowed efficient in situ reaction between the epoxy groups and proteins of interest. Immobilization of protein A on the spongy monolith enabled high-yield collection of imm...

journal_title：Scientific reports

authors： Kubota K,Kubo T,Tanigawa T,Naito T,Otsuka K

更新日期：2017-03-14 00:00:00

abstract：:MicroRNAs are potent regulators of gene expression that have been widely implicated in reproduction and embryo development. Recent studies have demonstrated that miR-21, a microRNA extensively studied in the context of disease, is important in multiple facets of reproductive biology including folliculogenesis, ovulati...

journal_title：Scientific reports

authors： Tscherner A,Brown AC,Stalker L,Kao J,Dufort I,Sirard MA,LaMarre J

更新日期：2018-08-01 00:00:00

abstract：:Ring-opening graft polymerization (ROGP) of L-Lactide (L-LA) is a practical method of altering the physical and chemical properties of lignocellulose. Previous studies have mainly investigated cellulose and tin-based catalysts, particularly of tin(II) 2-ethylhexanoate (Sn(oct)2), at high temperatures and reported low ...

journal_title：Scientific reports

authors： Zhang X,Wang H,Liu C,Zhang A,Ren J

更新日期：2017-04-03 00:00:00

abstract：:Unimolecular dual agonists for the glucagon-like peptide 1 receptor (GLP1R) and glucagon receptor (GCGR) are emerging as a potential new class of important therapeutics in type 2 diabetes (T2D). Reliable and quantitative assessments of in vivo occupancy on each receptor would improve the understanding of the efficacy ...

journal_title：Scientific reports

authors： Eriksson O,Haack T,Hijazi Y,Teichert L,Tavernier V,Laitinen I,Berglund JE,Antoni G,Velikyan I,Johansson L,Pierrou S,Wagner M,Tillner J

更新日期：2020-10-07 00:00:00

abstract：:Little is known on the causes and pathogenesis of the adipose tissue disorder (familial) Multiple Symmetric Lipomatosis (MSL). In a four-generation MSL-family, we performed whole exome sequencing (WES) in 3 affected individuals and 1 obligate carrier and identified Calcyphosine-like (CAPSL) as the most promising candi...

journal_title：Scientific reports

authors： Lindner A,Marbach F,Tschernitz S,Ortner C,Berneburg M,Felthaus O,Prantl L,Kye MJ,Rappl G,Altmüller J,Thiele H,Schreml S,Schreml J

更新日期：2019-06-11 00:00:00

abstract：:The aim was to investigate the ability of self-assembling Peptide P11-4 Matrix (SAPM) to remineralize artificial initial caries lesions compared to the use of fluoride varnish. Volunteers were recruited for this randomised, cross-over in situ trial. Bovine specimens, half including orthodontic brackets, were recessed ...

journal_title：Scientific reports

authors： Jablonski-Momeni A,Korbmacher-Steiner H,Heinzel-Gutenbrunner M,Jablonski B,Jaquet W,Bottenberg P

更新日期：2019-01-22 00:00:00

abstract：:Using classical molecular dynamics with a more reliable reactive LCBOPII potential, we have performed a detailed study on the direct graphite-to-diamond phase transition. Our results reveal a new so-called "wave-like buckling and slipping" mechanism, which controls the transformation from hexagonal graphite to cubic d...

journal_title：Scientific reports

authors： Xie H,Yin F,Yu T,Wang JT,Liang C

更新日期：2014-08-04 00:00:00

abstract：:Diffuse myocardial fibrosis is a key pathophysiologic feature in heart failure and can be quantified by cardiac magnetic resonance (CMR) T1 mapping. However, increases in myocardial free water also prolong native T1 times and may impact fibrosis quantification. Thus far, the impact of systemic patient volume status re...

journal_title：Scientific reports

authors： Antlanger M,Aschauer S,Kammerlander AA,Duca F,Säemann MD,Bonderman D,Mascherbauer J

更新日期：2018-04-03 00:00:00

abstract：:Bats of the Rhinolophidae and Hipposideridae families, and Pteronotus parnellii, compensate for Doppler shifts generated by their own flight movement. They adjust their call frequency such that the frequency of echoes coming from ahead fall in a specialized frequency range of the hearing system, the auditory fovea, to...

journal_title：Scientific reports

authors： Schoeppler D,Schnitzler HU,Denzinger A

更新日期：2018-03-15 00:00:00

abstract：:Flux balance analysis is the only modelling approach that is capable of producing genome-wide predictions of gene essentiality that may aid to unveil metabolic liabilities in cancer. Nevertheless, a systemic validation of gene essentiality predictions by flux balance analysis is currently missing. Here, we critically ...

journal_title：Scientific reports

authors： Gatto F,Miess H,Schulze A,Nielsen J

更新日期：2015-06-04 00:00:00

abstract：:Bats are an important reservoir for zoonotic viruses. To date, only three RVA strains have been reported in bats in Kenya and China. In the current study we investigated the genetic diversity of RVAs in fecal samples from 87 straw-colored fruit bats living in close contact with humans in Cameroon using viral metagenom...

journal_title：Scientific reports

authors： Yinda CK,Zeller M,Conceição-Neto N,Maes P,Deboutte W,Beller L,Heylen E,Ghogomu SM,Van Ranst M,Matthijnssens J

更新日期：2016-09-26 00:00:00

abstract：:Adult Cebpb KO mice incisors present amelogenin-positive epithelium pearls, enamel and dentin allopathic hyperplasia, fewer Sox2-positive cells in labial cervical loop epitheliums, and reduced Sox2 expression in enamel epithelial stem cells. Thus, Cebpb acts upstream of Sox2 to regulate stemness. In this study, Cebpb ...

journal_title：Scientific reports

authors： Saito K,Takahashi K,Huang B,Asahara M,Kiso H,Togo Y,Tsukamoto H,Mishima S,Nagata M,Iida M,Tokita Y,Asai M,Shimizu A,Komori T,Harada H,MacDougall M,Sugai M,Bessho K

更新日期：2018-03-26 00:00:00

abstract：:Coriander foliage is a distinctive spice employed on a daily basis in curry and other Indian traditional food preparations mainly for the unique flavour attributes and health benefits. Radical scavenging activity has been demonstrated previously for coriander foliage. However, specific molecules responsible were not i...

journal_title：Scientific reports

authors： Priyadarshi S,Harohally NV,Roopavathi C,Naidu MM

更新日期：2018-11-27 00:00:00

abstract：:Grain boundaries (GBs) in graphene prepared by chemical vapor deposition (CVD) greatly degrade the electrical and mechanical properties of graphene and thus hinder the applications of graphene in electronic devices. The seamless stitching of graphene flakes can avoid GBs, wherein the identical orientation of graphene ...

journal_title：Scientific reports

authors： Yuan Q,Song G,Sun D,Ding F

更新日期：2014-10-07 00:00:00

abstract：:In the epoch of the Anthropocene change, complexity, and uncertainty create a demand for new systems of water management and governance. One such management model that is rapidly gaining traction amongst both scholars and practitioners is the concept of water resilience. Although increasing attention has been paid to ...

journal_title：Scientific reports

authors： Baird J,Dale G,Farhad S

更新日期：2020-04-06 00:00:00