Abstract：
:Schistosomes, unlike malaria parasites, are in their diploid stage when targeted by the human immune system. Diploids can be either homozygous or heterozygous. The difference has profound significance for developing immunity and yet has not previously been addressed. We examined the implications of zygosity on immunity to a diploid pathogen, Schistosoma japonicum and showed that the diploid state, and its associated heterozygous advantage, significantly affects the outcome of attack by the immune system and the accumulation of antigenic diversity in the parasite population. We demonstrate here that diploidy provides a novel means of immune evasion for diploid pathogens.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Xu X,Sun J,Zhang J,Wellems D,Qing X,McCutchan T,Pan Wdoi
10.1038/srep00346subject
Has Abstractpub_date
2012-01-01 00:00:00pages
346issn
2045-2322journal_volume
2pub_type
杂志文章abstract：:The early detection of cognitive impairment or dementia is in the focus of current research as the amount of cognitively impaired individuals will rise intensely in the next decades due to aging population worldwide. Currently available diagnostic tools to detect mild cognitive impairment (MCI) or dementia are time-co...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-40010-0
更新日期：2019-03-05 00:00:00
abstract：:The pine wood nematode, Bursaphelenchus xylophilus, is the causal agent of pine wilt disease that has devastated pine forests in Asia. Parasitic nematodes are known to have evolved antioxidant stress responses that defend against host plant defenses. In this study, the infestation of whitebark pine, Pinus bungean, wit...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep27438
更新日期：2016-06-07 00:00:00
abstract：:Cardiomyocytes differentiated from human pluripotent stem cells provide promising tools for screening of cardiotoxic drugs. For evaluation of human pluripotent stem cell-derived cardiomyocytes for cardiotoxicity test, in the present study, human embryonic stem cells (hESCs) were differentiated to cardiomyocytes, follo...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-14198-y
更新日期：2017-10-23 00:00:00
abstract：:Conventional transistor electronics are reaching their limits in terms of scalability, power dissipation, and the underlying Boolean system architecture. To overcome this obstacle neuromorphic analogue systems are recently highly investigated. Particularly, the use of memristive devices in VLSI analogue concepts provi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-27033-9
更新日期：2018-06-11 00:00:00
abstract：:The mechanisms of pattern formation during embryonic development remain poorly understood. Embryonic stem cells in culture self-organise to form spatial patterns of gene expression upon geometrical confinement indicating that patterning is an emergent phenomenon that results from the many interactions between the cell...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-73228-4
更新日期：2020-10-01 00:00:00
abstract：:The tumour suppressor p53 is mutated in cancer, including over 96% of high-grade serous ovarian cancer (HGSOC). Mutations cause loss of wild-type p53 function due to either gain of abnormal function of mutant p53 (mutp53), or absent to low mutp53. Massively parallel sequencing (MPS) enables increased accuracy of detec...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep26191
更新日期：2016-05-18 00:00:00
abstract：:Brain natriuretic peptide (BNP) is the most effective predictor of outcomes in chronic heart failure (CHF). This study sought to determine the qualitative relationship between the BNP levels at discharge and on the day of cardiovascular events in CHF patients. We devised a mathematical probabilistic model between the ...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章
doi：10.1038/srep37073
更新日期：2016-11-15 00:00:00
abstract：:Cervical sagittal alignment is considered to have a special role in the pathogenesis and evaluation of cervical diseases. Previous studies have demonstrated that cervical sagittal alignment is correlated with thoracolumbar and pelvic alignments. As the direct anatomical structures connect to the cervical region, howev...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-33287-0
更新日期：2018-10-18 00:00:00
abstract：:Sugarcane (Saccharum spp.) is a globally important crop for sugar and bioenergy production. Its highly polyploid, complex genome has hindered progress in understanding its molecular structure. Flow cytometric sorting and analysis has been used in other important crops with large genomes to dissect the genome into comp...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-55652-3
更新日期：2019-12-18 00:00:00
abstract：:Epstein-Barr virus-encoded RNAs (EBER1 and EBER2) are two highly abundant, non-protein coding RNAs consistently expressed in all EBV infected cells, but their function remains poorly understood. Conventional in situ hybridization studies have indicated that these RNAs are present exclusively in the nucleus. We have re...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-33758-4
更新日期：2018-10-18 00:00:00
abstract：:The analysis of the choroid in the eye is crucial for our understanding of a range of ocular diseases and physiological processes. Optical coherence tomography (OCT) imaging provides the ability to capture highly detailed cross-sectional images of the choroid yet only a very limited number of commercial OCT instrument...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-49816-4
更新日期：2019-09-16 00:00:00
abstract：:This paper describes two different electrochemical affinity biosensing approaches for the simple, fast and bisulfite and PCR-free quantification of 5-methylated cytosines (5-mC) in DNA using the anti-5-mC antibody as biorecognition element. One of the biosensing approaches used the anti-5-mC as capture bioreceptor and...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-24902-1
更新日期：2018-04-23 00:00:00
abstract：:The present study aimed to develop a plate-screening method, based on the specific color development of complexes formed between chlorogenic acid, a valuable plant-derived compound, and aluminum (III), to detect chlorogenic acid-producing microbial strains. Modified media with 0.75 mM aluminum chloride were developed ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-32968-0
更新日期：2018-10-03 00:00:00
abstract：:To provide a comprehensive analysis of small molecule genotoxic potential we have developed and validated an automated, high-content, high throughput, image-based in vitro Micronucleus (IVM) assay. This assay simultaneously assesses micronuclei and multiple additional cellular markers associated with genotoxicity. Aco...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-021-82115-5
更新日期：2021-01-28 00:00:00
abstract：:The elastic modulus of ZnO nanowires was measured using a resonance method based on laser Doppler effect and their fracture strains were determined via two-point bending with the aid of optical nanomanipulation. The elastic moduli of ZnO nanowires with diameters of 78 to 310 nm vary from 123 to 154 GPa, which are clos...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-09843-5
更新日期：2017-08-25 00:00:00
abstract：:Cognition has been found to constrain several aspects of human behaviour, such as the number of friends and the number of favourite places a person keeps stable over time. This limitation has been empirically defined in the physical and social spaces. But do people exhibit similar constraints in the digital space? We ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-47493-x
更新日期：2019-07-29 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-019-50846-1
更新日期：2019-10-18 00:00:00
abstract：:We propose and experimentally demonstrate real-time locating and speed measurement of fibre fuse by analysing the Doppler shift of reflected light using optical frequency-domain reflectometry (OFDR). Our method can detect the start of a fibre fuse within 200 ms which is equivalent to a propagation distance of about 10...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep25585
更新日期：2016-05-05 00:00:00
abstract：:During locomotion, the human ankle-foot system dynamically alters its gearing, or leverage of the ankle joint on the ground. Shifting ankle-foot gearing regulates speed of plantarflexor (i.e., calf muscle) contraction, which influences economy of force production. Here, we tested the hypothesis that manipulating ankle...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-65626-5
更新日期：2020-05-29 00:00:00
abstract：:Steep-slope transistors allow to scale down the supply voltage and the energy per computed bit of information as compared to conventional field-effect transistors (FETs), due to their sub-60 mV/decade subthreshold swing at room temperature. Currently pursued approaches to achieve such a subthermionic subthreshold swin...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-00359-6
更新日期：2017-03-23 00:00:00
abstract：:It has been a key issue for photovoltaic (PV) cells to survive under mechanical impacts by tiny dust. In this paper, the performance degradation and the damage behavior of PV cells subjected to massive dust impact are investigated using laser-shock driven particle impact experiments and mechanical modeling. The result...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-80879-w
更新日期：2021-01-12 00:00:00
abstract：:It is a common belief that reptile eggs should not be turned after oviposition once the embryo has attached itself to the inner membrane of the shell as it might kill developing embryos. Here, we used 338 eggs from 32 clutches of the water snake Natrix maura to (1) thoroughly describe natural clutch arrangement, (2) e...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep13385
更新日期：2015-08-21 00:00:00
abstract：:We tried to establish a reliable detrusor underactivity (DUA) rat model and to investigate pathophysiology of chronic bladder ischemia (CBI) on voiding behavior and bladder function. Adult male rats were divided into five groups. The arterial injury (AI) groups (AI-10, AI-20, AI-30) underwent vascular endothelial dama...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-52811-4
更新日期：2019-11-08 00:00:00
abstract：:Facial emotion perception plays a key role in interpersonal communication and is a precursor for a variety of socio-cognitive abilities. One brain region thought to support emotion perception is the inferior frontal cortex (IFC). The current study aimed to examine whether modulating neural activity in the IFC using hi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-11578-2
更新日期：2017-09-12 00:00:00
abstract：:LiYF4:Eu nanophosphors with a single tetragonal phase are synthesized, and various strategies to enhance the Eu(3+) emission from the nanophosphors are investigated. The optimized Eu(3+) concentration is 35 mol%, and the red emission peaks due to the (5)D0 →(7)FJ (J = 1 and 2) transitions of Eu(3+) ions are further en...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep07866
更新日期：2015-01-19 00:00:00
abstract：:Deformable elastomeric spheres are evaluated experimentally as they skip multiple times over a lake surface. Some spheres are embedded with small inertial measurement units to measure the acceleration experienced during water surface impact. A model for multiple impact events shows good agreement between measured acce...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-42453-x
更新日期：2019-04-15 00:00:00
abstract：:The UCSC Cancer Genomics Browser (https://genome-cancer.ucsc.edu) offers interactive visualization and exploration of TCGA genomic, phenotypic, and clinical data, as produced by the Cancer Genome Atlas Research Network. Researchers can explore the impact of genomic alterations on phenotypes by visualizing gene and pro...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep02652
更新日期：2013-10-02 00:00:00
abstract：:Fluorescence-based western blots are quantitative in principal, but require determining linear range for each antibody. Here, we use microwestern array to rapidly evaluate suitable conditions for quantitative western blotting, with up to 192 antibody/dilution/replicate combinations on a single standard size gel with a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-29436-0
更新日期：2018-07-27 00:00:00
abstract：:During action observation, several visual features of observed actions can modulate the level of sensorimotor reactivity in the onlooker. Among possibly relevant parameters, one of the less investigated in humans is the visual perspective from which actions are observed. In the present EEG study, we assessed the react...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-30912-w
更新日期：2018-08-20 00:00:00
abstract：:Marine plant communities such as kelp forests produce significant amounts of detritus, most of which is exported to areas where it can constitute an important trophic subsidy or potentially be sequestered in marine sediments. Knowing the vertical transport speed of detrital particles is critical to understanding the p...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-34721-z
更新日期：2018-11-21 00:00:00
