Abstract:
:Brain natriuretic peptide (BNP) is the most effective predictor of outcomes in chronic heart failure (CHF). This study sought to determine the qualitative relationship between the BNP levels at discharge and on the day of cardiovascular events in CHF patients. We devised a mathematical probabilistic model between the BNP levels at discharge (y) and on the day (t) of cardiovascular events after discharge for 113 CHF patients (Protocol I). We then prospectively evaluated this model on another set of 60 CHF patients who were readmitted (Protocol II). P(t|y) was the probability of cardiovascular events occurring after >t, the probability on t was given as p(t|y) = -dP(t|y)/dt, and p(t|y) = pP(t|y) = αyβP(t|y), along with p = αyβ (α and β were constant); the solution was p(t|y) = αyβ exp(-αyβt). We fitted this equation to the data set of Protocol I using the maximum likelihood principle, and we obtained the model p(t|y) = 0.000485y0.24788 exp(-0.000485y0.24788t). The cardiovascular event-free rate was computed as P(t) = 1/60Σi=1,…,60 exp(-0.000485yi0.24788t), based on this model and the BNP levels yi in a data set of Protocol II. We confirmed no difference between this model-based result and the actual event-free rate. In conclusion, the BNP levels showed a non-linear relationship with the day of occurrence of cardiovascular events in CHF patients.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Fukuda H,Suwa H,Nakano A,Sakamoto M,Imazu M,Hasegawa T,Takahama H,Amaki M,Kanzaki H,Anzai T,Mochizuki N,Ishii A,Asanuma H,Asakura M,Washio T,Kitakaze Mdoi
10.1038/srep37073subject
Has Abstractpub_date
2016-11-15 00:00:00pages
37073issn
2045-2322pii
srep37073journal_volume
6pub_type
临床试验,杂志文章abstract::Several reviews have analyzed the factors that affect the change in soil organic C (SOC) when forest is converted to agricultural land; however, the effects of forest type and cultivation stage on these changes have generally been overlooked. We collated observations from 453 paired or chronosequential sites where for...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep04062
更新日期:2014-02-11 00:00:00
abstract::Asymmetric cell divisions are of fundamental importance for the development of multicellular organisms, e.g. for the generation of founder cells. Prime examples are asymmetric cell divisions in germline precursors during the early embryogenesis of the transparent roundworm Caenorhabditis elegans, one of the major deve...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-09690-4
更新日期:2017-08-24 00:00:00
abstract::The incidence of myopia is increasing worldwide, and the investigation on pathophysiology of myopia is becoming more important. This retrospective study aimed to compare the thicknesses of individual retinal layers between high-myopic and control eyes, and to evaluate the effects of age and sex on each retinal layer t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-50306-w
更新日期:2019-09-30 00:00:00
abstract::Significant technical and optical advances are required for intraoperative optical coherence tomography (OCT) to be utilized during otological surgeries. Integrating OCT with surgical microscopy makes it possible to evaluate soft tissue in real-time and at a high resolution. Herein, we describe an augmented-reality, i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-35563-5
更新日期:2018-11-27 00:00:00
abstract::Sex hormones influence the prevalence and the outcome of heart diseases. The conversion of testosterone to its more active metabolite dihydrotestosterone drives cardiac growth and dysfunction, while inhibition of this step by the anti-androgenic drug finasteride counteracts these pathological processes in preclinical ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-46640-8
更新日期:2019-07-12 00:00:00
abstract::Lysophospholipids (LPLs) are known to have potentially important roles in the initiation and maintenance of neuropathic pain in animal models. This study investigated the association between the clinical severity of lumbar spinal stenosis (LSS) and the cerebrospinal fluid (CSF) levels of LPLs, using human samples. We ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-45742-7
更新日期:2019-06-24 00:00:00
abstract::Inspired by the well-documented tumor protecting ability of paullones, recently, we synthesized novel paullone-like scaffolds, indole-fused benzo-oxazepines (IFBOs), and screened them against hepatocellular carcinoma (HCC) specific Hep-G2 cells. Three of the synthesized compounds significantly attenuated the progressi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-24288-0
更新日期:2018-04-12 00:00:00
abstract::The development of the optical bio-chemical sensing technology is an extremely important scientific and technological issue for diagnosis and monitoring of diseases, control of industrial processes, environmental detection of air and water pollutants. Owing to their distinctive features, chalcogenide amorphous thin fi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-03678-w
更新日期:2017-06-14 00:00:00
abstract::The dorsal striatum is a brain region involved in action control, with dorsomedial striatum (DMS) mediating goal-directed actions and dorsolateral striatum (DLS) mediating habitual actions. Presynaptic long-term synaptic depression (LTD) plasticity at glutamatergic inputs to dorsal striatum mediates many dorsal striat...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-64203-0
更新日期:2020-04-29 00:00:00
abstract::The human foot and ankle system is equipped with structures that can produce mechanical work through elastic (e.g., Achilles tendon, plantar fascia) or viscoelastic (e.g., heel pad) mechanisms, or by active muscle contractions. Yet, quantifying the work distribution among various subsections of the foot and ankle can ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-15218-7
更新日期:2017-11-13 00:00:00
abstract::Foot-and-mouth disease (FMD) is a highly contagious disease of livestock affecting animal production and trade throughout Asia and Africa. Understanding FMD virus (FMDV) global movements and evolution can help to reconstruct the disease spread between endemic regions and predict the risks of incursion into FMD-free co...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-32693-8
更新日期:2018-10-02 00:00:00
abstract::In this work, we report our study of protein expression in rat peri-infarct tissue, 48 h after the induction of permanent focal cerebral ischemia. Two proteomic approaches, gel electrophoresis with mass spectrometry and combined fractional diagonal chromatography (COFRADIC), were performed using tissue samples from th...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep12030
更新日期:2015-07-08 00:00:00
abstract::A comprehensive understanding of the charge/discharge behaviour of high-capacity anode active materials, e.g., Si and Li, is essential for the design and development of next-generation high-performance Li-based batteries. Here, we demonstrate the in situ scanning electron microscopy (in situ SEM) of Si anodes in a con...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep36153
更新日期:2016-10-26 00:00:00
abstract::Shear-waves are the most energetic body-waves radiated from an earthquake, and are responsible for the destruction of engineered structures. In both short-term emergency response and long-term risk forecasting of disaster-resilient built environment, it is critical to predict spatially accurate distribution of shear-w...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-37524-4
更新日期:2019-01-30 00:00:00
abstract::In kidney disease, higher circulating levels of the mineral-regulating hormone fibroblast growth factor (FGF)-23 are predictive of disease progression but direct pathogenic effects on the kidney are unknown. We sought evidence of local renal synthesis in response to unilateral ureteric obstruction in the mouse, and pr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-02709-w
更新日期:2017-06-13 00:00:00
abstract::Somatostatin (SST)-positive interneurons in the anterior cingulate cortex (ACC) play important roles in neuronal diseases, memory and cognitive functions. However, their development in the ACC remains unclear. Using postnatal day 3 (P3) to P45 GIN mice, we found that most of the intrinsic membrane properties of SST in...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep28137
更新日期:2016-06-20 00:00:00
abstract::There is an increasing appreciation for the role of the human Y chromosome in phenotypic differences between the sexes in health and disease. Previous studies have shown that genetic variation within the Y chromosome is associated with cholesterol levels, which is an established risk factor for atherosclerosis, the un...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-17165-9
更新日期:2017-12-01 00:00:00
abstract::Recent studies showed that somatic cancer mutations target genes that are in specific signaling and cellular pathways. However, in each patient only a few of the pathway genes are mutated. Current approaches consider only existing pathways and ignore the topology of the pathways. For this reason, new efforts have been...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-80204-5
更新日期:2021-01-12 00:00:00
abstract::We have recently demonstrated that the rate-limiting enzymes in human glucose metabolism organize into cytoplasmic clusters to form a multienzyme complex, the glucosome, in at least three different sizes. Quantitative high-content imaging data support a hypothesis that the glucosome clusters regulate the direction of ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-20348-7
更新日期:2018-02-09 00:00:00
abstract::The ability of human metaphase-II arrested eggs to activate following fertilisation declines with advancing maternal age. Egg activation is triggered by repetitive increases in intracellular Ca(2+) concentration ([Ca(2+)]i) in the ooplasm as a result of sperm-egg fusion. We therefore hypothesised that eggs from older ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep19357
更新日期:2016-01-20 00:00:00
abstract::Accumulating evidence supports the polygenic nature of most complex diseases, suggesting the involvement of many susceptibility genes with small effect sizes. Although hundreds of genes may underlie the genetic architecture of complex diseases, those involved in a given disease are probably not randomly distributed, b...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep33460
更新日期:2016-09-14 00:00:00
abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-019-40293-3
更新日期:2019-04-09 00:00:00
abstract::In the phytopathogenic basidiomycete Ustilago maydis, the Num1 protein has a pivotal function in hyphal morphogenesis. Num1 functions as a core component of the spliceosome-associated Prp19/CDC5 complex (NTC). The interaction of Num1 with the kinesin motor Kin1 suggests a connection between a component of the splicing...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-21628-y
更新日期:2018-02-26 00:00:00
abstract::Selective inhibition of function-specific β-GlcNAcase has great potential in terms of drug design and biological research. The symmetrical bis-naphthalimide M-31850 was previously obtained by screening for specificity against human glycoconjugate-lytic β-GlcNAcase. Using protein-ligand co-crystallization and molecular...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep06188
更新日期:2014-08-26 00:00:00
abstract::An intensified and continuous West Nile virus (WNV) spread across northern Italy has been observed since 2008, which caused more than one hundred reported human infections until 2016. Veneto is one of the Italian regions where WNV is considered endemic, and the greatest intensity of circulation was observed during 201...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-32401-6
更新日期:2018-09-18 00:00:00
abstract::Macrophages and resident microglia play an import role in the secondary neuroinflammation response following spinal cord injury. Reprogramming of macrophage/microglia polarization is an import strategy for spinal cord injury restoration. Low-level laser therapy (LLLT) is a noninvasive treatment that has been widely us...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-00553-6
更新日期:2017-04-04 00:00:00
abstract::Linearly polarized microwave radiation is shown to have its plane of polarization converted to the orthogonal state upon reflection from an ultrathin (λ/25) cavity array. The structure benefits from an uncomplicated design consisting of a metallic grating closely separated from a ground plane by a dielectric spacer. A...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep09366
更新日期:2015-03-23 00:00:00
abstract::Malaria-associated acute lung injury (ALI) is a frequent complication of severe malaria that is often caused by "excessive" immune responses. To better understand the mechanism of ALI in malaria infection, here we investigated the roles of galectin (Gal)-1, 3, 8, 9 and the receptors of Gal-9 (Tim-3, CD44, CD137, and P...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep32024
更新日期:2016-08-24 00:00:00
abstract::Anatase TiO2 nanoparticles with exposed {001} facets were synthesized from Ti powder via a sequential hydrothermal reaction process. At the first-step hydrothermal reaction, H-titanate nanowires were obtained in NaOH solution with Ti powder, and at second-step hydrothermal reaction, anatase TiO2 nanoparticles with exp...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep12143
更新日期:2015-07-20 00:00:00
abstract::Bacterial outer membrane lipopolysaccharide (LPS) potently stimulates the mammalian innate immune system, and can lead to sepsis, the primary cause of death from infections. LPS is sensed by Toll-like receptor 4 (TLR4) in complex with its lipid-binding coreceptor MD-2, but subtle structural variations in LPS can profo...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep17997
更新日期:2015-12-09 00:00:00