Abstract：
:Inositol Requiring Enzyme-1 (IRE1) is the most conserved transducer of the Unfolded Protein Response (UPR), a surveillance mechanism that ensures homeostasis of the endoplasmic reticulum (ER) in eukaryotes. IRE1 activation orchestrates adaptive responses, including lipid anabolism, metabolic reprogramming, increases in protein folding competency, and ER expansion/remodeling. However, we still know surprisingly little regarding the principles by which this ER transducer is deactivated upon ER stress clearance. Here we show that Protein Kinase B-mechanistic Target of Rapamycin (PKB/AKT-mTOR) signaling controls the dynamics of IRE1 deactivation by regulating ER-mitochondria physical contacts and the autophosphorylation state of IRE1. AKT-mTOR-mediated attenuation of IRE1 activity is important for ER remodelling dynamics and cell survival in the face of recursive, transient ER stress. Our observations suggest that IRE1 attenuation is an integral component of anabolic programmes regulated by AKT-mTOR. We suggest that AKT-mTOR activity is part of a 'timing mechanism' to deactivate IRE1 immediately following engagement of the UPR, in order to limit prolonged IRE1 RNAse activity that could lead to damaging inflammation or apoptosis.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Sanchez-Alvarez M,Del Pozo MA,Bakal Cdoi
10.1038/s41598-017-16662-1subject
Has Abstractpub_date
2017-11-28 00:00:00pages
16497issue
1issn
2045-2322pii
10.1038/s41598-017-16662-1journal_volume
7pub_type
杂志文章abstract：:Enrichment of colloidal particles in continuous flow has not only numerous applications but also poses a great challenge in controlling physical forces that are required for achieving particle enrichment. Here, we for the first time experimentally demonstrate the electrokinetically-driven continuous-flow enrichment of...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-11473-w
更新日期：2017-09-07 00:00:00
abstract：:This study proposed a novel method to heal microcrack within Mg alloy tubes using high density eddy current pulse treatment (ECPT). Through electromagnetic induction inside a copper coil connected with a high density pulse power source supply, the high density (greater than 5 × 109 A/m2) and short duration eddy curren...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-24354-7
更新日期：2018-04-16 00:00:00
abstract：:Irreversible electroporation (IRE) is a non-thermal ablation modality that has been shown to be safe and effective in its application to tumors that are close to risky areas. This study aims to assess the safety and efficacy of IRE for unresectable hilar cholangiocarcinoma. Nine patients from two medical centers in As...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-67772-2
更新日期：2020-07-02 00:00:00
abstract：:The use of anti-cancer adjuvant therapy is rationalized by potentiating the efficacy, and/or protecting from major side effects of chemotherapeutics. Thymoquinone (TQ) is a naturally occurring compound with cumulative evidence of anti-cancer properties. In this study, we assessed the chemomodulatory potential of TQ to...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-30046-z
更新日期：2018-08-03 00:00:00
abstract：:Neuroscience findings have recently received critique on the lack of replications. To examine the reproducibility of brain indices of speech sound discrimination and their role in dyslexia, a specific reading difficulty, brain event-related potentials using EEG were measured using the same cross-linguistic passive odd...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-41992-7
更新日期：2019-06-11 00:00:00
abstract：:Hybridization between heterospecific individuals has been documented as playing a direct role in promoting paternal leakage and mitochondrial heteroplasmy in both natural populations and laboratory conditions, by relaxing the egg-sperm recognition mechanisms. Here, we tested the hypothesis that hybridization can lead ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-55764-w
更新日期：2019-12-16 00:00:00
abstract：:GLP-1 receptor agonists (GLP-1RA) and SGLT2 inhibitors (SGLT2i) have been associated with improved glycemic control, body weight loss and favorable changes in cardiovascular risk factors and outcomes. We conducted a systematic review and meta-analysis to evaluate the effects of the addition of GLP-1RA to SGLT2i in pat...
journal_title：Scientific reports
pub_type： 杂志文章,meta分析
doi：10.1038/s41598-019-55524-w
更新日期：2019-12-18 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-019-55966-2
更新日期：2020-01-14 00:00:00
abstract：:Repetitive traumatic brain injury (TBI) has been linked to late life development of chronic traumatic encephalopathy (CTE), a neurodegenerative disorder histopathologically characterized by perivascular tangles of hyperphosphorylated tau at the depth of sulci to later widespread neurofibrillary pathology. Although tau...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-40678-4
更新日期：2019-03-07 00:00:00
abstract：:The progression of pulmonary fibrosis (PF) entails a complex network of interactions between multiple classes of molecules and cells, which are closely related to the vagus nerve. Stimulation of the vagus nerve increases fibrogenic cytokines in humans, therefore, activation of the nerve may promote PF. The hypothesis ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep13419
更新日期：2015-08-20 00:00:00
abstract：:Multidrug-resistant enterococcal pathogens, especially vancomycin-resistant enterococci (VRE), are among the pathogens that require new antibiotic innovation. The colonization of the gut represents a major pathway by which VRE can cause infection and spread to other patients. In the current study, auranofin (FDA-appro...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-26674-0
更新日期：2018-05-29 00:00:00
abstract：:We present here a combined theoretical and experimental investigation on effective excitation of microcantilever by using photoacoustic waves. The photoacoustic waves arose from a vibrating Al foil induced by an intensity-modulated laser. We demonstrate that, superior to photothermal excitation, this new configuration...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep19935
更新日期：2016-01-27 00:00:00
abstract：:This study aimed to investigate the prevalence, antibiogram of Pseudomonas aeruginosa (P. aeruginosa), and the distribution of virulence genes (oprL, exoS, phzM, and toxA) and the antibiotic-resistance genes (blaTEM, tetA, and blaCTX-M). A total of 285 fish (165 Oreochromis niloticus and 120 Clarias gariepinus) were c...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-72264-4
更新日期：2020-09-29 00:00:00
abstract：:Bacterial vaginosis (BV) is associated with HIV acquisition and adverse pregnancy outcomes. Recurrence after metronidazole treatment is high. HIV-negative, non-pregnant Rwandan BV patients were randomized to four groups (n = 17/group) after seven-day oral metronidazole treatment: behavioral counseling only (control), ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-60671-6
更新日期：2020-03-03 00:00:00
abstract：:We examined the physical and mechanical properties of wood in Siberian larch (Larix sibirica) trees that grow naturally in five Mongolian provenances (Khentii, Arkhangai, Zavkhan, Khuvsgul, and Selenge) and the geographic variations between them. Five trees with stem diameters of 20 to 30 cm at 1.3 m above ground were...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-69781-7
更新日期：2020-07-31 00:00:00
abstract：:Mobile phone microscopes are a natural platform for point-of-care imaging, but current solutions require an externally powered illumination source, thereby adding bulk and cost. We present a mobile phone microscope that uses the internal flash or sunlight as the illumination source, thereby reducing complexity whilst ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-21543-2
更新日期：2018-02-19 00:00:00
abstract：:Associated with global warming, drought has destructive influences on agriculture and ecosystems, especially in the fragile Qinghai-Tibet Plateau (QTP). This study investigated spatial-temporal patterns of meteorological drought in the QTP and its surrounding areas and made an attempt to explore the relationship betwe...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-71295-1
更新日期：2020-08-31 00:00:00
abstract：:The therapeutic potential of nonthermal plasma for cancer treatment has been reported recently. The heterogeneity of cancer cells need to be addressed to design effective anticancer treatments. Here, we show that treatment with nonthermal atmospheric-pressure plasma dissolved in a liquid (liquid plasma) induces oxidat...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep29020
更新日期：2016-07-01 00:00:00
abstract：:Boehmeria tricuspis includes sexually reproducing diploid and apomictic triploid individuals. Previously, we established that triploid B. tricuspis reproduces through obligate diplospory. To understand the molecular basis of apomictic development in B. tricuspis, we sequenced and compared transcriptomic profiles of th...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep46043
更新日期：2017-04-06 00:00:00
abstract：:Cesium (Cs) removal from nuclear liquid wastewater has become an emerging issue for safeguarding public health after the accident at the Fukushima Daiichi Nuclear Power Plant. A novel macrocyclic ligand of o-benzo-p-xylyl-22-crown-6-ether (OBPX22C6) was developed and successfully immobilized onto mesoporous silica for...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep19937
更新日期：2016-01-28 00:00:00
abstract：:Onychomycosis (OM) is a common nail disease. Although controversial, vascular diseases are considered independent predictors of OM and vice versa. Sequential pattern mining (SPM) has not been previously used for statistical analysis in dermatology, but it is an efficient method for identifying frequent association rul...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-35909-z
更新日期：2018-12-14 00:00:00
abstract：:Regime shift from grasslands to shrub-dominated landscapes occur worldwide driven by altered land-use and climate change, affecting landscape function, biodiversity, and productivity. Warming winter temperatures are a main driver of expansion of the native, evergreen shrub, Morella cerifera, in coastal landscapes. Shr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-65161-3
更新日期：2020-05-19 00:00:00
abstract：:The pathophysiological actions of fatty acids (FAs) on Alzheimer's disease (AD), which are possibly mediated by genomic effects, are widely known; however, their non-genomic actions remain elusive. The aim of this study was to investigate the non-genomic mechanism of extra-cellular palmitic acid (PA) regulating beta-a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-04175-w
更新日期：2017-06-28 00:00:00
abstract：:Immunoaffinity enrichment of proteotypic peptides, coupled with selected reaction monitoring, enables indirect protein quantification. However the lack of suitable antibodies limits its widespread application. We developed a method in which multi-specific antibodies are used to enrich groups of peptides, thus facilita...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep08759
更新日期：2015-03-04 00:00:00
abstract：:Alpha melanocyte stimulating hormone (α-MSH) and Forkhead box C2 protein (Foxc2) enhance lipolysis in multiple tissues. However, their relationship in adipose fatty acid oxidation (FAO) remains unclear. Here, we demonstrated that α-MSH and Foxc2 increased palmitate oxidation to CO2 in white (WAT) and brown adipose tis...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep36661
更新日期：2016-11-07 00:00:00
abstract：:We have studied photoinduced reduction of absorption and emission in p3ht, a semiconducting polymer, and found that the rate of photodegradation (destruction of the constituent thiophene rings) does not correlate with the luminescence intensity and, correspondingly, does not depend on the excited state concentration. ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep33238
更新日期：2016-09-15 00:00:00
abstract：:Beta oscillations observed in motor cortical local field potentials (LFPs) recorded on separate electrodes of a multi-electrode array have been shown to exhibit non-zero phase shifts that organize into planar waves. Here, we generalize this concept to additional classes of salient patterns that fully describe the spat...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-22990-7
更新日期：2018-03-26 00:00:00
abstract：:There is increasing demand for safe and effective sanitizers for irrigation water disinfection to prevent transmission of foodborne pathogens to fresh produce. Here we compared the efficacy of pH-neutral electrolyzed oxidizing water (EOW), sodium hypochlorite (NaClO) and chlorine dioxide (ClO2) against single and mixe...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-56248-7
更新日期：2019-12-27 00:00:00
abstract：:Single nucleotide variations (SNVs) can result in loss or gain of protein functional sites. We analyzed the effects of SNVs on enzyme active sites, ligand binding sites, and various types of post translational modification (PTM) sites. We found that, for most types of protein functional sites, the SNV pattern differs ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep42169
更新日期：2017-02-08 00:00:00
abstract：:microRNAs regulate the expression of over 60% of protein coding genes by targeting their mRNAs to AGO2-containing complexes in the cytoplasm and promoting their translational inhibition and/or degradation. There is little evidence so far for microRNA-mediated regulation of other classes of non-coding RNAs. Here we rep...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep02535
更新日期：2013-01-01 00:00:00
