Abstract：
:This retrospective study was undertaken to provide more modern data of real-life management of non-metastatic rectal cancer, to compare therapeutic strategies, and to identify prognostic factors of overall survival (OS) in a large cohort of patients. Data on efficacy and on acute/late toxicity were retrospectively collected. Patients were diagnosed a non-metastatic rectal cancer between 2004 and 2015, and were treated at least with radiotherapy. OS was correlated with patient, tumor and treatment characteristics with univariate and multivariate analyses. Data of 593 consecutive non-metastatic rectal cancer patients were analyzed. Median follow-up was 41 months. Median OS was 9 years. Radiotherapy was delivered in pre-operative (n = 477, 80.5%), post-operative (n = 75, 12.6%) or exclusive (n = 41, 6.9%) setting. In the whole set of patients, age, nutritional condition, tumor stage, tumor differentiation, and surgery independently influenced OS. For patients experiencing surgery, OS was influenced by age, tumor differentiation and nodal status. Surgical resection is the cornerstone treatment for locally-advanced rectal cancer. Poor tumor differentiation and node involvement were identified as major predictive factor of poor OS. The research in treatment intensification and in identification of radioresistance biomarkers should therefore probably be focused on this particular subset of patients.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Langrand-Escure J,Diao P,Garcia MA,Wang G,Guy JB,Espenel S,Guillaume E,Rehailia-Blanchard A,Pigné G,de Laroche G,Kaczmarek D,Muron T,Porcheron J,Phelip JM,Vallard A,Magné Ndoi
10.1038/s41598-018-29040-2subject
Has Abstractpub_date
2018-07-16 00:00:00pages
10708issue
1issn
2045-2322pii
10.1038/s41598-018-29040-2journal_volume
8pub_type
杂志文章abstract：:Several studies have shown that dysmenorrhea increased the risk of depression. However, the association between dysmenorrhea and postpartum depression (PPD) is unclear. The purpose of this study is to evaluate the effects of dysmenorrhea on the development of PPD among Chinese women. A case-control study was performed...
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pub_type： 历史文章,杂志文章
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