Abstract:
:Isolating actively proliferating cardioblasts is the first crucial step for cardiac regeneration through cell implantation. However, the origin and identity of putative cardioblasts are still unclear. Here, we uncover a novel class of cardiac lineage cells, PDGFRα+Flk1- cardioblasts (PCBs), from mouse and human pluripotent stem cells induced using CsAYTE, a combination of the small molecules Cyclosporin A, the rho-associated coiled-coil kinase inhibitor Y27632, the antioxidant Trolox, and the ALK5 inhibitor EW7197. This novel population of actively proliferating cells is cardiac lineage-committed but in a morphologically and functionally immature state compared to mature cardiomyocytes. Most important, most of CsAYTE-induced PCBs spontaneously differentiated into functional αMHC+ cardiomyocytes (M+CMs) and could be a potential cellular resource for cardiac regeneration.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Hong SP,Song S,Cho SW,Lee S,Koh BI,Bae H,Kim KH,Park JS,Do HS,Im I,Heo HJ,Ko TH,Park JH,Youm JB,Kim SJ,Kim I,Han J,Han YM,Koh GYdoi
10.1038/srep41840subject
Has Abstractpub_date
2017-02-06 00:00:00pages
41840issn
2045-2322pii
srep41840journal_volume
7pub_type
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