当前位置： SCI文献检索 > Scientific Reports期刊下所有文献 > Hepatocellular carcinoma: thyroid hormone promotes tumorigenicity through inducing cancer stem-like cell self-renewal.

Hepatocellular carcinoma: thyroid hormone promotes tumorigenicity through inducing cancer stem-like cell self-renewal.

Abstract：

:Cancer stem-like cells (CSCs) play a key role in maintaining the aggressiveness of hepatocellular carcinoma (HCC), but the cell-biological regulation of CSCs is unclear. In the study, we report that thyroid hormone (TH) promotes cell self-renewal in HCC cells. TH also increases the percentage of CD90 + HCC cells and promotes drug resistance of HCC cells. By analyzing primary human HCC samples, we found that TRα transcript level is significantly elevated in primary liver cancer and portal vein metastatic tumor, compared to that of adjacent normal liver tissue. Knocking down TRα not only inhibits HCC self-renewal in vitro but also suppresses HCC tumor growth in vivo. Interestingly, treatment of TH leads to activation of NF-κB, which is required for the function of TH on inducing HCC cell self-renewal. We also found TRα and p65 cooperatively drive the expression of BMI1 by co-binding to the promoter region of BMI1 gene. In summary, our study uncovers a novel function of TH signaling in regulating the CSCs of HCC, and these findings might be useful for developing novel therapies by targeting TH function in HCC cells.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Wang T,Xia L,Ma S,Qi X,Li Q,Xia Y,Tang X,Cui D,Wang Z,Chi J,Li P,Feng YX,Xia Q,Zhai B

doi

10.1038/srep25183

subject

Has Abstract

pub_date

2016-05-12 00:00:00

pages

25183

issn

2045-2322

pii

srep25183

journal_volume

6

pub_type

杂志文章

相关文献

Scientific Reports文献大全
  • A small-angle X-ray scattering study of alpha-synuclein from human red blood cells.

    abstract：:α-synuclein (α-syn) is the main component of Lewy bodies, which are neuropathological hallmarks of patients with Parkinson's disease. As it has been controversial whether human α-syn from erythrocytes exists as a tetramer under physiological conditions, we tried solving this issue by the small-angle X-ray solution sca...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep30473

    authors： Araki K,Yagi N,Nakatani R,Sekiguchi H,So M,Yagi H,Ohta N,Nagai Y,Goto Y,Mochizuki H

    更新日期：2016-07-29 00:00:00

  • 3-D radar imaging unlocks the untapped behavioral and biomechanical archive of Pleistocene ghost tracks.

    abstract：:Footprint evidence of human-megafauna interactions remains extremely rare in the archaeological and palaeontological records. Recent work suggests ancient playa environments may hold such evidence, though the prints may not be visible. These so-called "ghost tracks" comprise a rich archive of biomechanical and behavio...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-52996-8

    authors： Urban TM,Bennett MR,Bustos D,Manning SW,Reynolds SC,Belvedere M,Odess D,Santucci VL

    更新日期：2019-11-11 00:00:00

  • Publisher Correction: Increase in Interfacial Adhesion and Electrochemical Charge Storage Capacity of Polypyrrole on Au Electrodes Using Polyethyleneimine.

    abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...

    journal_title：Scientific reports

    pub_type： 已发布勘误

    doi：10.1038/s41598-019-42219-5

    authors： Kim KG,Kim SY

    更新日期：2019-04-16 00:00:00

  • Human cooperation in groups: variation begets variation.

    abstract：:Many experiments on human cooperation have revealed that individuals differ systematically in their tendency to cooperate with others. It has also been shown that individuals condition their behaviour on the overall cooperation level of their peers. Yet, little is known about how individuals respond to heterogeneity i...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep16144

    authors： van den Berg P,Molleman L,Junikka J,Puurtinen M,Weissing FJ

    更新日期：2015-11-04 00:00:00

  • Manipulation of Auxin Response Factor 19 affects seed size in the woody perennial Jatropha curcas.

    abstract：:Seed size is a major determinant of seed yield but few is known about the genetics controlling of seed size in plants. Phytohormones cytokinin and brassinosteroid were known to be involved in the regulation of herbaceous plant seed development. Here we identified a homolog of Auxin Response Factor 19 (JcARF19) from a ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep40844

    authors： Sun Y,Wang C,Wang N,Jiang X,Mao H,Zhu C,Wen F,Wang X,Lu Z,Yue G,Xu Z,Ye J

    更新日期：2017-01-19 00:00:00

  • A high-fat diet impairs reproduction by decreasing the IL1β level in mice treated at immature stage.

    abstract：:Obesity causes low-grade inflammation that is involved in male infertility. Interleukin 1 beta (IL1β) plays an important role in this process. A high-fat diet (HFD) is the most common cause of obesity. However, the effect of a HFD on IL1β and its consequence in reproduction remain unclear. We established a HFD model i...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-00505-0

    authors： Zhang J,Li K,Yuan M,Zhang J,Huang G,Ao J,Tan H,Li Y,Gong D,Li J,Kang L,An N,Li F,Lin P,Huang L

    更新日期：2017-04-03 00:00:00

  • Sensitivity of Anatase and Rutile Phases of TiO2 to ion irradiation: Examination of the applicability of Coulomb Explosion and Thermal Spike Models.

    abstract：:Sensitivity of the anatase and rutile phases of titanium dioxide to Swift Heavy Ion (SHI) irradiation was experimentally probed and compared with the predictions of the Coulomb explosion, analytical and inelastic thermal spike models of ion-matter interaction. Conforming to the predictions of all these models, our stu...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-30281-4

    authors： Rath H,Dash BN,Benyagoub A,Mishra NC

    更新日期：2018-08-06 00:00:00

  • A nomogram model for screening the risk of diabetes in a large-scale Chinese population: an observational study from 345,718 participants.

    abstract：:Our study is major to establish and validate a simple type||diabetes mellitus (T2DM) screening model for identifying high-risk individuals among Chinese adults. A total of 643,439 subjects who participated in the national health examination had been enrolled in this cross-sectional study. After excluding subjects with...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-68383-7

    authors： Xue M,Su Y,Feng Z,Wang S,Zhang M,Wang K,Yao H

    更新日期：2020-07-14 00:00:00

  • Association of plasma free amino acids with hyperuricemia in relation to diabetes mellitus, dyslipidemia, hypertension and metabolic syndrome.

    abstract：:Previous studies demonstrated independent contributions of plasma free amino acids (PFAAs) and high uric acid (UA) concentrations to increased risks of lifestyle-related diseases (LSRDs), but the important associations between these factors and LSRDs remain unknown. We quantified PFAAs and UA amongst Japanese subjects...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-17710-6

    authors： Mahbub MH,Yamaguchi N,Takahashi H,Hase R,Ishimaru Y,Sunagawa H,Amano H,Kobayashi-Miura M,Kanda H,Fujita Y,Yamamoto H,Yamamoto M,Kikuchi S,Ikeda A,Kageyama N,Nakamura M,Tanabe T

    更新日期：2017-12-15 00:00:00

  • Chemopreventive effects of Ku-jin tea against AOM-induced precancerous colorectal lesions in rats and metabolomic analysis.

    abstract：:Ku-jin tea (KJT) is a health beverage prepared from the leaves of the plant Acer tataricum subsp. ginnala that has been consumed in some regions of China for thousands of years. KJT contains high levels of anti-inflammatory and antioxidative compounds such as ginnalins, but little is known about the chemopreventive ef...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-16237-0

    authors： Bi W,Liu H,Shen J,Zhang LH,Li P,Peng B,Cao L,Zhang P,He C,Xiao P

    更新日期：2017-11-21 00:00:00

  • Mechanistic insight into the substrate specificity of 1,2-β-oligoglucan phosphorylase from Lachnoclostridium phytofermentans.

    abstract：:Glycoside phosphorylases catalyze the phosphorolysis of oligosaccharides into sugar phosphates. Recently, we found a novel phosphorylase acting on β-1,2-glucooligosaccharides with degrees of polymerization of 3 or more (1,2-β-oligoglucan phosphorylase, SOGP) in glycoside hydrolase family (GH) 94. Here, we characterize...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep42671

    authors： Nakajima M,Tanaka N,Furukawa N,Nihira T,Kodutsumi Y,Takahashi Y,Sugimoto N,Miyanaga A,Fushinobu S,Taguchi H,Nakai H

    更新日期：2017-02-15 00:00:00

  • Whole-genome assembly of the coral reef Pearlscale Pygmy Angelfish (Centropyge vrolikii).

    abstract：:The diversity of DNA sequencing methods and algorithms for genome assemblies presents scientists with a bewildering array of choices. Here, we construct and compare eight candidate assemblies combining overlapping shotgun read data, mate-pair and Chicago libraries and four different genome assemblers to produce a high...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-19430-x

    authors： Fernandez-Silva I,Henderson JB,Rocha LA,Simison WB

    更新日期：2018-01-24 00:00:00

  • Fluoxetine does not enhance the effect of perceptual learning on visual function in adults with amblyopia.

    abstract：:Amblyopia is a common visual disorder that is treatable in childhood. However, therapies have limited efficacy in adult patients with amblyopia. Fluoxetine can reinstate early-life critical period-like neuronal plasticity and has been used to recover functional vision in adult rats with amblyopia. We conducted a Phase...

    journal_title：Scientific reports

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1038/s41598-018-31169-z

    authors： Huttunen HJ,Palva JM,Lindberg L,Palva S,Saarela V,Karvonen E,Latvala ML,Liinamaa J,Booms S,Castrén E,Uusitalo H

    更新日期：2018-08-27 00:00:00

  • Role of oxidants in enhancing dewaterability of anaerobically digested sludge through Fe (II) activated oxidation processes: hydrogen peroxide versus persulfate.

    abstract：:Improving dewaterability of sludge is important for the disposal of sludge in wastewater treatment plants (WWTPs). This study, for the first time, investigated the Fe(II) activated oxidization processes in improving anaerobically digested sludge (ADS) dewaterability. The combination of Fe(II) (0-100 mg/g total solids ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep24800

    authors： Song K,Zhou X,Liu Y,Gong Y,Zhou B,Wang D,Wang Q

    更新日期：2016-04-25 00:00:00

  • Benchmarking of Whole Exome Sequencing and Ad Hoc Designed Panels for Genetic Testing of Hereditary Cancer.

    abstract：:Next generation sequencing panels have been developed for hereditary cancer, although there is some debate about their cost-effectiveness compared to exome sequencing. The performance of two panels is compared to exome sequencing. Twenty-four patients were selected: ten with identified mutations (control set) and four...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep37984

    authors： Feliubadaló L,Tonda R,Gausachs M,Trotta JR,Castellanos E,López-Doriga A,Teulé À,Tornero E,Del Valle J,Gel B,Gut M,Pineda M,González S,Menéndez M,Navarro M,Capellá G,Gut I,Serra E,Brunet J,Beltran S,Lázaro C

    更新日期：2017-01-04 00:00:00

  • A meta-analysis of the efficacy of HAART on HIV transmission and its impact on sexual risk behaviours among men who have sex with men.

    abstract：:Evidence showed preventive impacts of the highly active antiretroviral therapy (HAART) on the Human Immunodeficiency Virus (HIV) transmission amomg heterosexual population, however, that is of deficit among men who have sex with men (MSM). The aim was to systematically examine the efficacy of HAART on HIV transmission...

    journal_title：Scientific reports

    pub_type： 杂志文章,meta分析

    doi：10.1038/s41598-019-56530-8

    authors： Jiang Y,Su S,Borné Y

    更新日期：2020-01-23 00:00:00

  • Four-pole galvanic vestibular stimulation causes body sway about three axes.

    abstract：:Galvanic vestibular stimulation (GVS) can be applied to induce the feeling of directional virtual head motion by stimulating the vestibular organs electrically. Conventional studies used a two-pole GVS, in which electrodes are placed behind each ear, or a three-pole GVS, in which an additional electrode is placed on t...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep10168

    authors： Aoyama K,Iizuka H,Ando H,Maeda T

    更新日期：2015-05-11 00:00:00

  • Maternal body mass index moderates antenatal depression effects on infant birthweight.

    abstract：:Obesity and depression are two common medical problems that pregnant women present with in antenatal care. Overweight and obesity at the beginning of the pregnancy, and excessive weight gain during pregnancy, are independent explanatory variables for fetal birthweight and independent risk factors for giving birth to a...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-42360-1

    authors： Petursdottir Maack H,Skalkidou A,Sjöholm A,Eurenius-Orre K,Mulic-Lutvica A,Wikström AK,Sundström Poromaa I

    更新日期：2019-04-17 00:00:00

  • Host Directed Therapy for Chronic Tuberculosis via Intrapulmonary Delivery of Aerosolized Peptide Inhibitors Targeting the IL-10-STAT3 Pathway.

    abstract：:Here we demonstrate that aerosols of host directed therapies [HDT] administered during a chronic Mycobacterium tuberculosis (Mtb) infection have bactericidal effect. The pulmonary bacterial load of C57BL/6 mice chronically infected with Mtb was reduced by 1.7 and 0.6 log10CFU after two weeks of treatment via aerosol d...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-35023-0

    authors： Upadhyay R,Sanchez-Hidalgo A,Wilusz CJ,Lenaerts AJ,Arab J,Yeh J,Stefanisko K,Tarasova NI,Gonzalez-Juarrero M

    更新日期：2018-11-09 00:00:00

  • Effect of proton-conduction in electrolyte on electric efficiency of multi-stage solid oxide fuel cells.

    abstract：:Solid oxide fuel cells (SOFCs) are promising electrochemical devices that enable the highest fuel-to-electricity conversion efficiencies under high operating temperatures. The concept of multi-stage electrochemical oxidation using SOFCs has been proposed and studied over the past several decades for further improving ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep12640

    authors： Matsuzaki Y,Tachikawa Y,Somekawa T,Hatae T,Matsumoto H,Taniguchi S,Sasaki K

    更新日期：2015-07-28 00:00:00

  • Author Correction: Diversity of gut microflora is required for the generation of B cell with regulatory properties in a skin graft model.

    abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title：Scientific reports

    pub_type： 已发布勘误

    doi：10.1038/s41598-020-62381-5

    authors： Alhabbab R,Blair P,Elgueta R,Stolarczyk E,Marks E,Becker PD,Ratnasothy K,Smyth L,Safinia N,Sharif-Paghaleh E,O'Connell S,Noelle RJ,Lord GM,Howard JK,Spencer J,Lechler RI,Lombardi G

    更新日期：2020-04-06 00:00:00

  • Enduring rules of care within pairs - how blue tit parents resume provisioning behaviour after experimental disturbance.

    abstract：:Sexual conflict over parental investment can result in suboptimal reproductive output. A recent hypothesis suggests that equality in investment, and hence conflict resolution, may be reached via coordination of parental activities like alternating nest visits. However, how robust patterns of care within couples are ag...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-39139-9

    authors： Iserbyt A,Griffioen M,Eens M,Müller W

    更新日期：2019-02-26 00:00:00

  • An investigation into non-covalent functionalization of a single-walled carbon nanotube and a graphene sheet with protein G:A combined experimental and molecular dynamics study.

    abstract：:Investigation of non-covalent interaction of hydrophobic surfaces with the protein G (PrG) is necessary due to their frequent utilization in immunosensors and ELISA. It has been confirmed that surfaces, including carbonous-nanostructures (CNS) could orient proteins for a better activation. Herein, PrG interaction with...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-37311-1

    authors： Ebrahim-Habibi MB,Ghobeh M,Mahyari FA,Rafii-Tabar H,Sasanpour P

    更新日期：2019-02-04 00:00:00

  • Proposed mechanism for the length dependence of the force developed in maximally activated muscles.

    abstract：:The molecular bases of the Frank-Starling law of the heart and of its cellular counterpart, the length dependent activation (LDA), are largely unknown. However, the recent discovery of the thick filament activation, a second pathway beside the well-known calcium mediated thin filament activation, is promising for eluc...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-36706-4

    authors： Marcucci L,Washio T,Yanagida T

    更新日期：2019-02-04 00:00:00

  • Grammatical category and the neural processing of phrases.

    abstract：:The interlocking roles of lexical, syntactic and semantic processing in language comprehension has been the subject of longstanding debate. Recently, the cortical response to a frequency-tagged linguistic stimulus has been shown to track the rate of phrase and sentence, as well as syllable, presentation. This could be...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-021-81901-5

    authors： Burroughs A,Kazanina N,Houghton C

    更新日期：2021-01-28 00:00:00

  • Cyclophilin A is associated with peripheral artery disease and chronic kidney disease in geriatrics: The Tianliao Old People (TOP) study.

    abstract：:Cyclophilin A (CyPA), secreted by vascular smooth muscle cells in response to oxidative stress, is important in the pathogenesis of progressive peripheral arterial occlusion disease (PAOD), which is common among chronic kidney disease. We explored the prevalence of PAOD in Taiwan's elderly (≥ 65 years old) population ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep09937

    authors： Liu MC,Lee YW,Lee PT,Chang CS,Tai YL,Yu JR,Su XT,Hsu LW,Lin SH,Wu CH,Liu PY

    更新日期：2015-04-24 00:00:00

  • Extinctions, genetic erosion and conservation options for the black rhinoceros (Diceros bicornis).

    abstract：:The black rhinoceros is again on the verge of extinction due to unsustainable poaching in its native range. Despite a wide historic distribution, the black rhinoceros was traditionally thought of as depauperate in genetic variation, and with very little known about its evolutionary history. This knowledge gap has hamp...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep41417

    authors： Moodley Y,Russo IM,Dalton DL,Kotzé A,Muya S,Haubensak P,Bálint B,Munimanda GK,Deimel C,Setzer A,Dicks K,Herzig-Straschil B,Kalthoff DC,Siegismund HR,Robovský J,O'Donoghue P,Bruford MW

    更新日期：2017-02-08 00:00:00

  • Randomly Distributed Fabry-Pérot-type Metal Nanowire Resonators and Their Lasing Action.

    abstract：:Optical feedback mechanisms are often obtained from well-defined resonator structures fabricated by top-down processes. Here, we demonstrate that two-dimensional networks of metallic nanowires dispersed on the semiconductor slab can provide strong in-plane optical feedback and, thus, form randomly-distributed Fabry-Pé...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep24898

    authors： Kwon K,Jung Y,Kim M,Shim J,Yu K

    更新日期：2016-04-22 00:00:00

  • The assessment of liver fibrosis in children with obesity on two methods: transient and two dimensional shear wave elastography.

    abstract：:The aim of this study was to assess the liver stiffness values in children with obesity versus healthy children on 2D-SWE and TE taking into account different laboratory parameters. We performed a case-control study on 287 children aged between 3 to 18 years, admitted in a Romanian Pediatric Tertiary Hospital, which w...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-56358-2

    authors： Mărginean CO,Meliţ LE,Ghiga DV,Săsăran MO

    更新日期：2019-12-24 00:00:00

  • Controlled electromechanical cell stimulation on-a-chip.

    abstract：:Stem cell research has yielded promising advances in regenerative medicine, but standard assays generally lack the ability to combine different cell stimulations with rapid sample processing and precise fluid control. In this work, we describe the design and fabrication of a micro-scale cell stimulator capable of simu...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep11800

    authors： Pavesi A,Adriani G,Rasponi M,Zervantonakis IK,Fiore GB,Kamm RD

    更新日期：2015-07-02 00:00:00