Interplay between 3'-UTR polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene and the risk of ischemic stroke.

abstract：:The North Sea is one of the most extensively studied marine regions of the world. Hence, large amounts of molecular data for species identification are available in public repositories, and expectations to find numerous new species in this well-known region are rather low. However, molecular reference data for harpact...

journal_title：Scientific reports

authors： Rossel S,Martínez Arbizu P

更新日期：2019-06-24 00:00:00

abstract：:Sequence-controlled polymers (SCPs) such as DNA and proteins play an important role in biology. Many efforts have been devoted to synthesize SCPs in the past half a century. However, to our knowledge, the artificial sequences containing independently functional groups have never been reported. Here, we present a facil...

journal_title：Scientific reports

authors： Han J,Zheng Y,Zhao B,Li S,Zhang Y,Gao C

更新日期：2014-03-17 00:00:00

abstract：:The lack of bone morphological markers associated with the human control of wild animals has prevented the documentation of incipient animal domestication in archaeology. Here, we assess whether direct environmental changes (i.e. mobility reduction) could immediately affect ontogenetic changes in long bone structure, ...

journal_title：Scientific reports

authors： Harbers H,Zanolli C,Cazenave M,Theil JC,Ortiz K,Blanc B,Locatelli Y,Schafberg R,Lecompte F,Baly I,Laurens F,Callou C,Herrel A,Puymerail L,Cucchi T

更新日期：2020-11-04 00:00:00

abstract：:The effect of AM fungi spatial distribution on individual plant development may determine the dynamics of the whole plant community. We investigated whether clonal plants display, like for other resources, a foraging or a specialization response, to adapt to the distribution of AM fungi. Two separate experiments were ...

journal_title：Scientific reports

authors： Vannier N,Bittebiere AK,Vandenkoornhuyse P,Mony C

更新日期：2016-11-25 00:00:00

abstract：:Retinitis pigmentosa (RP) is one of hereditary retinal diseases characterized by the loss of photoreceptors. Cell transplantation has been clinically applied to treat RP patients. Human retinal progenitor cells (HRPCs) and human bone marrow-derived mesenchymal stem cells (HBMSCs) are the two commonly and practically u...

journal_title：Scientific reports

authors： Qu L,Gao L,Xu H,Duan P,Zeng Y,Liu Y,Yin ZQ

更新日期：2017-03-15 00:00:00

abstract：:In this report, we demonstrate mid-infrared dual-waveband (i.e., ~3 μm and ~2 μm) pulses from a cascaded gain-switched Ho3+-doped ZBLAN fiber laser by the use of hybrid pumping of 1150 nm CW and pulse LDs for the first time. Stable ~3 μm gain-switched pulses with the maximum output power 262.14 mW and shortest pulse d...

journal_title：Scientific reports

authors： Luo H,Li J,Zhu C,Lai X,Hai Y,Liu Y

更新日期：2017-12-04 00:00:00

abstract：:Male moths use species-specific sex pheromones to identify and orientate toward conspecific females. Odorant receptors (ORs) for sex pheromone substances have been identified as sex pheromone receptors in various moth species. However, direct in vivo evidence linking the functional role of these ORs with behavioural r...

journal_title：Scientific reports

authors： Sakurai T,Mitsuno H,Mikami A,Uchino K,Tabuchi M,Zhang F,Sezutsu H,Kanzaki R

更新日期：2015-06-05 00:00:00

abstract：:Inhibitory/repressor-receptors are upregulated significantly on activated T cells, and have been the molecules of attention as targets for inducing immune tolerance. Induction of effective antigen specific tolerance depends on concurrent engagement of the TCR and one or more of these inhibitory receptors. Here, we sho...

journal_title：Scientific reports

authors： Gudi RR,Karumuthil-Melethil S,Perez N,Li G,Vasu C

更新日期：2019-08-19 00:00:00

abstract：:Thermal rectifiers whose forward heat fluxes are greater than reverse counterparts have been extensively studied. Here we have discovered, idealized, and derived the ultimate limit of such rectification ratios, which are partially validated by numerical simulations, experiments, and micro-scale Hamiltonian-oscillator ...

journal_title：Scientific reports

authors： Shih TM,Gao Z,Guo Z,Merlitz H,Pagni PJ,Chen Z

更新日期：2015-08-04 00:00:00

abstract：:Sodium taurocholate cotransporting polypeptide (NTCP) is a recently discovered hepatitis B virus (HBV) receptor. In the present study, we used TK-NOG mice with a humanized liver to examine the impact of endogenous NTCP expression on HBV infection. Upon inoculation with HBV, these mice exhibited clear viremia in 2 week...

journal_title：Scientific reports

authors： Nakabori T,Hikita H,Murai K,Nozaki Y,Kai Y,Makino Y,Saito Y,Tanaka S,Wada H,Eguchi H,Takahashi T,Suemizu H,Sakamori R,Hiramatsu N,Tatsumi T,Takehara T

更新日期：2016-06-09 00:00:00

abstract：:The ability to rapidly assess the efficacy of therapeutic strategies for incurable bone metastatic prostate cancer is an urgent need. Pre-clinical in vivo models are limited in their ability to define the temporal effects of therapies on simultaneous multicellular interactions in the cancer-bone microenvironment. Inte...

journal_title：Scientific reports

authors： Cook LM,Araujo A,Pow-Sang JM,Budzevich MM,Basanta D,Lynch CC

更新日期：2016-07-14 00:00:00

abstract：:Selective norepinephrine reuptake inhibitors (sNRIs) provide an effective class of approved antipsychotics, whose inhibitory mechanism could facilitate the discovery of privileged scaffolds with enhanced drug efficacy. However, the crystal structure of human norepinephrine transporter (hNET) has not been determined ye...

journal_title：Scientific reports

authors： Zheng G,Xue W,Wang P,Yang F,Li B,Li X,Li Y,Yao X,Zhu F

更新日期：2016-05-27 00:00:00

abstract：:Assembly of metagenomic samples is a very complex process, with algorithms designed to address sequencing platform-specific issues, (read length, data volume, and/or community complexity), while also faced with genomes that differ greatly in nucleotide compositional biases and in abundance. To address these issues, we...

journal_title：Scientific reports

authors： Scholz M,Lo CC,Chain PS

更新日期：2014-10-01 00:00:00

abstract：:Amyloid-β (Aβ) deposition is known to starts decades before the onset of clinical symptoms of Alzheimer's disease (AD), however, the detailed pathophysiological processes underlying this preclinical period are not well understood. This study aimed to investigate functional network alterations in cognitively intact eld...

journal_title：Scientific reports

authors： Nakamura A,Cuesta P,Kato T,Arahata Y,Iwata K,Yamagishi M,Kuratsubo I,Kato K,Bundo M,Diers K,Fernández A,Maestú F,Ito K

更新日期：2017-07-26 00:00:00

abstract：:The outstanding optoelectronics and photovoltaic properties of metal halide perovskites, including high carrier motilities, low carrier recombination rates, and the tunable spectral absorption range are attributed to the unique electronic properties of these materials. While DFT provides reliable structures and stabil...

journal_title：Scientific reports

authors： Tao SX,Cao X,Bobbert PA

更新日期：2017-10-30 00:00:00

abstract：:Boron carbide (B4C) coating on diamond particle is synthesized by heating diamond particles in a powder mix of H3BO3 and B in Ar atmosphere. The composition, bond state and coverage fraction of boron carbide coating on diamond particles are investigated. The boron carbide coating favors to grow on diamond (100) surfac...

journal_title：Scientific reports

authors： Sun Y,He L,Zhang C,Meng Q,Liu B,Gao K,Wen M,Zheng W

更新日期：2017-09-06 00:00:00

abstract：:Accidental transmission of prions during neurosurgery has been reported as a consequence of re-using contaminated surgical instruments. Several decontamination methods have been studied using the 263K-hamster prion; however, no studies have directly evaluated human prions. A newly developed in vitro amplification syst...

journal_title：Scientific reports

authors： Mori T,Atarashi R,Furukawa K,Takatsuki H,Satoh K,Sano K,Nakagaki T,Ishibashi D,Ichimiya K,Hamada M,Nakayama T,Nishida N

更新日期：2016-04-26 00:00:00

abstract：:(R-)miniCHOP therapy, which delivers approximately half-doses of the (R-)CHOP regimen, has shown efficacy and safety in patients who are more than 80 years old. This study aimed to compare the area under the plasma concentration-time curves (AUCs) of vincristine (VCR), doxorubicin (DXR), and cyclophosphamide (CPA) bet...

journal_title：Scientific reports

authors： Nakagawa J,Takahata T,Hyodo R,Chen Y,Hasui K,Sasaki K,Saito K,Ueno K,Hosoi K,Terui K,Sato A,Niioka T

更新日期：2021-01-12 00:00:00

abstract：:As a source of genetic variation, almond germplasm resources are of great significance in breeding. To better reveal the mutation characteristics and evolution patterns of the almond chloroplast (cp) genome, the complete cp genomes from six almond species were analyzed. The lengths of the chloroplast genome of the six...

journal_title：Scientific reports

authors： Wang W,Yang T,Wang HL,Li ZJ,Ni JW,Su S,Xu XQ

更新日期：2020-06-23 00:00:00

abstract：:State of charge (SOC) is a crucial index used in the assessment of electric vehicle (EV) battery storage systems. Thus, SOC estimation of lithium-ion batteries has been widely investigated because of their fast charging, long-life cycle, and high energy density characteristics. However, precise SOC assessment of lithi...

journal_title：Scientific reports

authors： Hannan MA,Lipu MSH,Hussain A,Ker PJ,Mahlia TMI,Mansor M,Ayob A,Saad MH,Dong ZY

更新日期：2020-03-13 00:00:00

abstract：:Trees produce pollen during specific times of the year. Pollen can induce pollinosis, a type of allergic rhinitis, in humans. In Japan, allergenic pollen is mainly dispersed from February to May. Using data collected at 120 observation sites managed by the Japanese Ministry of the Environment, we studied the annual pa...

journal_title：Scientific reports

authors： Ishibashi A,Sakai K

更新日期：2019-08-07 00:00:00

abstract：:The adipogenic process is characterized by the expression of adipocyte differentiation markers that lead to changes in cell metabolism and to the accumulation of lipid droplets. Moreover, during early adipogenesis, cells undergo a strong downregulation of translational activity with a decrease in cell size, proliferat...

journal_title：Scientific reports

authors： Marcon BH,Shigunov P,Spangenberg L,Pereira IT,de Aguiar AM,Amorín R,Rebelatto CK,Correa A,Dallagiovanna B

更新日期：2019-04-04 00:00:00

abstract：:The involvement of the immune system, particularly the role of T-cells, in sarcoidosis is unclear. The existence of higher CD4+ T-cells and increased CD4/CD8 ratio may indicate a pathogenic role of T-cells in the disease. In this study, we quantified the contribution of T-cells associated variants and of CD4/CD8 ratio...

journal_title：Scientific reports

authors： Rivera NV,Hagemann-Jensen M,Ferreira MAR,Kullberg S,Eklund A,Martin NG,Padyukov L,Grunewald J

更新日期：2017-07-17 00:00:00

abstract：:A novel sesquiterpene methylcyclopentenedione, penicilliumin B (1), was obtained from a deep sea-derived fungus Penicillium sp. F00120, together with three known sesquiterpene cyclohexenones (2-4). Penicilliumin B (1), presenting the first example with the sesquiterpene cyclopentenedione skeleton as natural products, ...

journal_title：Scientific reports

authors： Lin X,Wu Q,Yu Y,Liang Z,Liu Y,Zhou L,Tang L,Zhou X

更新日期：2017-09-07 00:00:00

abstract：:Cell motility requires the precise coordination of cell polarization, lamellipodia formation, adhesion, and force generation. LKB1 is a multi-functional serine/threonine kinase that associates with actin at the cellular leading edge of motile cells and suppresses FAK. We sought to understand how LKB1 coordinates these...

journal_title：Scientific reports

authors： Wilkinson S,Hou Y,Zoine JT,Saltz J,Zhang C,Chen Z,Cooper LA,Marcus AI

更新日期：2017-01-19 00:00:00

abstract：:Resistance to epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) has become the main clinical challenge of advanced lung cancer. This research aimed to explore the role of PARP1-mediated autophagy in the progression of TKI therapy. PARP1-mediated autophagy was evaluated in vitro by CCK-8 assay, cl...

journal_title：Scientific reports

authors： Zhang Z,Lian X,Xie W,Quan J,Liao M,Wu Y,Yang ZZ,Wang G

更新日期：2020-12-01 00:00:00

abstract：:Incredible accomplishments have been achieved in agricultural production in China, but many demanding challenges for ensuring food security and environmental sustainability remain. Field experiments were conducted from 2011-2013 at three different sites, including Honghu, Shayang, and Jingzhou in China, to determine t...

journal_title：Scientific reports

authors： Yousaf M,Li J,Lu J,Ren T,Cong R,Fahad S,Li X

更新日期：2017-04-28 00:00:00

abstract：:Here we describe a unique microbial biotechnology for simultaneous bioremediation and biomining of twelve ionic metals overcoming the obstacles of multimetal toxicity to microbes. After a thorough search of key microorganisms in microbiomes of many sulfidic springs in Bavaria (Germany) over an area of 200 km2, we foun...

journal_title：Scientific reports

authors： Hoque E,Fritscher J

更新日期：2019-07-16 00:00:00

abstract：:Measuring toxicity is one of the main steps in drug development. Hence, there is a high demand for computational models to predict the toxicity effects of the potential drugs. In this study, we used a dataset, which consists of four toxicity effects:mutagenic, tumorigenic, irritant and reproductive effects. The propos...

journal_title：Scientific reports

authors： Tharwat A,Moemen YS,Hassanien AE

更新日期：2016-12-09 00:00:00

abstract：:APOBEC3G (A3G) belongs to the family of cytosine deaminases that play an important role in the innate immune response. Similar to other, two-domain members of the APOBEC family, A3G is prone to concentration-dependent oligomerization, which is an integral for its function in the cell. It is shown that oligomerization ...

journal_title：Scientific reports

authors： Pan Y,Zagorski K,Shlyakhtenko LS,Lyubchenko YL

更新日期：2018-12-18 00:00:00