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Cell cycle genes are downregulated after adipogenic triggering in human adipose tissue-derived stem cells by regulation of mRNA abundance.

Abstract：

:The adipogenic process is characterized by the expression of adipocyte differentiation markers that lead to changes in cell metabolism and to the accumulation of lipid droplets. Moreover, during early adipogenesis, cells undergo a strong downregulation of translational activity with a decrease in cell size, proliferation and migration. In the present study, we identified that after 24 hours of adipogenic induction, human adipose tissue-derived stem cells (hASCs) undergo a G1-cell cycle arrest consistent with reduced proliferation, and this effect was correlated with a shift in polysome profile with an enrichment of the monosomal fraction and a reduction of the polysomal fraction. Polysome profiling analysis also revealed that this change in the monosomal/polysomal ratio was related to a strong downregulation of cell cycle and proliferation genes, such as cyclins and cyclin-dependent kinases (CDKs). Comparing total and polysome-associated mRNA sequencing, we also observed that this downregulation was mostly due to a reduction of cell cycle and proliferation transcripts via control of total mRNA abundance, rather than by translational control.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Marcon BH,Shigunov P,Spangenberg L,Pereira IT,de Aguiar AM,Amorín R,Rebelatto CK,Correa A,Dallagiovanna B

doi

10.1038/s41598-019-42005-3

subject

Has Abstract

pub_date

2019-04-04 00:00:00

pages

5611

issue

1

issn

2045-2322

pii

10.1038/s41598-019-42005-3

journal_volume

9

pub_type

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