A simple optimization approach for improving target dose homogeneity in intensity-modulated radiotherapy for sinonasal cancer.

abstract：:Mitochondrial activity is central to tissue homeostasis. Mitochondria dysfunction constitutes a hallmark of many genetic diseases and plays a key role in tumor progression. The essential role of mitochondria, added to their recently documented capacity to transfer from cell to cell, obviously contributes to their curr...

journal_title：Scientific reports

authors： Caicedo A,Fritz V,Brondello JM,Ayala M,Dennemont I,Abdellaoui N,de Fraipont F,Moisan A,Prouteau CA,Boukhaddaoui H,Jorgensen C,Vignais ML

更新日期：2015-03-13 00:00:00

abstract：:Muscular dystrophy-dystroglycanopathies comprise a heterogeneous and complex group of disorders caused by loss-of-function mutations in a multitude of genes that disrupt the glycobiology of α-dystroglycan, thereby affecting its ability to function as a receptor for extracellular matrix proteins. Of the various genes i...

journal_title：Scientific reports

authors： Vannoy CH,Leroy V,Broniowska K,Lu QL

更新日期：2019-07-11 00:00:00

abstract：:Spatial tuning properties of retinal ganglion cells (RGCs) are sharpened by lateral inhibition originating at both the outer and inner plexiform layers. Lateral inhibition in the retina contributes to local contrast enhancement and sharpens edges. In this study, we used dynamic clamp recordings to examine the contribu...

journal_title：Scientific reports

authors： Huang JY,Protti DA

更新日期：2016-02-24 00:00:00

abstract：:Sacha inchi (Plukenetia volubilis L.) is a shrub native to Amazon rainforests that's of commercial interest as its seeds contain 35-60% edible oil (dry weight). This oil is one of the healthiest vegetable oils due to its high polyunsaturated fatty acid content and favourable ratio of omega-6 to omega-3 fatty acids. De...

journal_title：Scientific reports

authors： Liu G,Wu Z,Peng Y,Shang X,Xie Y,Arnold RJ

更新日期：2020-11-24 00:00:00

abstract：:In endometriosis, M2 MΦs are dominant in endometriotic lesions, but the actual role of M2 MΦ is unclear. CD206 positive (+) MΦ is classified in one of M2 type MΦs and are known to produce cytokines and chemokines. In the present study, we used CD206 diphtheria toxin receptor mice, which enable to deplete CD206+ cells ...

journal_title：Scientific reports

authors： Ono Y,Yoshino O,Hiraoka T,Sato E,Furue A,Nawaz A,Hatta H,Fukushi Y,Wada S,Tobe K,Hirota Y,Osuga Y,Unno N,Saito S

更新日期：2021-01-13 00:00:00

abstract：:Plastic pollution is a rapidly worsening environmental problem, especially in oceanic habitats. Environmental pollution with microplastic particles is also causing food consumed by humans to be increasingly polluted, including table salts. Therefore, we present the first study which focuses only on table salt products...

journal_title：Scientific reports

authors： Lee H,Kunz A,Shim WJ,Walther BA

更新日期：2019-07-12 00:00:00

abstract：:Viral nervous necrosis (VNN) certainly represents the biggest challenge for the sustainability and the development of aquaculture. A large number of economically relevant fish species have proven to be susceptible to the disease. Conversely, gilthead sea bream has generally been considered resistant to VNN, although i...

journal_title：Scientific reports

authors： Toffan A,Pascoli F,Pretto T,Panzarin V,Abbadi M,Buratin A,Quartesan R,Gijón D,Padrós F

更新日期：2017-05-02 00:00:00

abstract：:In plants, pathogen triggered programmed cell death (PCD) is frequently mediated by polar lipid molecules referred as long chain bases (LCBs) or ceramides. PCD interceded by LCBs is a well-organized process where several cell organelles play important roles. In fact, light-dependent reactions in the chloroplast have b...

journal_title：Scientific reports

authors： Zavafer A,González-Solís A,Palacios-Bahena S,Saucedo-García M,Tapia de Aquino C,Vázquez-Santana S,King-Díaz B,Gavilanes-Ruiz M

更新日期：2020-06-25 00:00:00

abstract：:The innate and adaptive immune systems fail to control HCV infection in the majority of infected individuals. HCV is an ssRNA virus, which suggests a role for Toll-like receptors (TLRs) 7 and 8 in initiating the anti-viral response. Here we demonstrate that HCV genomic RNA harbours specific sequences that initiate an ...

journal_title：Scientific reports

authors： Zhang Y,El-Far M,Dupuy FP,Abdel-Hakeem MS,He Z,Procopio FA,Shi Y,Haddad EK,Ancuta P,Sekaly RP,Said EA

更新日期：2016-07-07 00:00:00

abstract：:Gefitinib, an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, is used as a first-line treatment for advanced non-small cell lung cancer (NSCLC). However, most NSCLC patients inevitably develop gefitinib resistance, and the mechanisms underlying this resistance are not fully understood. In this study...

journal_title：Scientific reports

authors： Cao X,Lai S,Hu F,Li G,Wang G,Luo X,Fu X,Hu J

更新日期：2017-06-07 00:00:00

abstract：:Footprint evidence of human-megafauna interactions remains extremely rare in the archaeological and palaeontological records. Recent work suggests ancient playa environments may hold such evidence, though the prints may not be visible. These so-called "ghost tracks" comprise a rich archive of biomechanical and behavio...

journal_title：Scientific reports

authors： Urban TM,Bennett MR,Bustos D,Manning SW,Reynolds SC,Belvedere M,Odess D,Santucci VL

更新日期：2019-11-11 00:00:00

abstract：:Chronic alcohol feeding causes lipid accumulation and apoptosis in the liver. This study investigated the role of bioactive lipid metabolites in alcohol-induced liver damage and tested the potential of targeting arachidonate 15-lipoxygenase (ALOX15) in treating alcoholic liver disease (ALD). Results showed that chroni...

journal_title：Scientific reports

authors： Zhang W,Zhong W,Sun Q,Sun X,Zhou Z

更新日期：2017-08-21 00:00:00

abstract：:The use of cardiac troponins (cTn) is the gold standard for diagnosing myocardial infarction. Independent of myocardial infarction (MI), however, sex, age and kidney function affect cTn levels. Here we developed a method to adjust cTnI levels for age, sex, and renal function, maintaining a unified cut-off value such a...

journal_title：Scientific reports

authors： Boeckel JN,Palapies L,Klotsche J,Zeller T,von Jeinsen B,Perret MF,Kleinhaus SL,Pieper L,Tzikas S,Leistner D,Bickel C,Stalla GK,Lehnert H,Lindahl B,Wittchen HU,Silber S,Baldus S,Maerz W,Dimmeler S,Blankenberg S,Mün

更新日期：2018-05-24 00:00:00

abstract：:To achieve six degree-of-freedom autonomous navigation of an inboard spacecraft, a novel algorithm called iterative closest imaging point (ICIP) is proposed, which deals with the pose estimation problem of a vision navigation system (VNS). This paper introduces the basics of the ICIP algorithm, including mathematical ...

journal_title：Scientific reports

authors： Shi S,You Z,Zhao K,Wang Z,Ouyang C,Cao Y

更新日期：2017-12-12 00:00:00

abstract：:This corrects the article DOI: 10.1038/srep42627. ...

journal_title：Scientific reports

authors： Li Z,Lan X,Han R,Wang J,Huang Y,Sun J,Guo W,Chen H

更新日期：2018-04-06 00:00:00

abstract：:There is growing interest in the conservation and utilization of crop wild relatives (CWR) in international food security policy and research. Legumes play an important role in human health, sustainable food production, global food security, and the resilience of current agricultural systems. Pea belongs to the ancien...

journal_title：Scientific reports

authors： Smýkal P,Hradilová I,Trněný O,Brus J,Rathore A,Bariotakis M,Das RR,Bhattacharyya D,Richards C,Coyne CJ,Pirintsos S

更新日期：2017-12-12 00:00:00

abstract：:The G protein-coupled pituitary adenylate cyclase-activating polypeptide receptor (PAC1R) is a potential therapeutic target for endocrine, metabolic and stress-related disorders. However, many questions regarding the protein structure and dynamics of PAC1R remain largely unanswered. Using microsecond-long simulations,...

journal_title：Scientific reports

authors： Liao C,Zhao X,Brewer M,May V,Li J

更新日期：2017-07-14 00:00:00

abstract：:Unlike their wolf ancestors, dogs have unique social skills for communicating and cooperating with humans. Previously, significant heritabilities for human-directed social behaviors have been found in laboratory beagles. Here, a Genome-Wide Association Study identified two genomic regions associated with dog's human-d...

journal_title：Scientific reports

authors： Persson ME,Wright D,Roth LS,Batakis P,Jensen P

更新日期：2016-09-29 00:00:00

abstract：:Tumor necrosis factor (TNF) is best known for inducing a rapid but transient NF-κB-mediated inflammatory response. We investigated later phases of TNF signaling, after the initial transient induction of inflammatory genes has subsided, in primary human macrophages. TNF signaling induced expression of late response gen...

journal_title：Scientific reports

authors： Huynh L,Kusnadi A,Park SH,Murata K,Park-Min KH,Ivashkiv LB

更新日期：2016-08-25 00:00:00

abstract：:A strain glass state was found to be located between B2-B19' (cubic to monoclinic) phase transition and B2-R (cubic to rhombohedral) phase transition in Ti49Ni51 alloys after aging process. After a short time aging, strong strain glass transition was observed, because the size of the precipitates is small, which means...

journal_title：Scientific reports

authors： Zhou Z,Cui J,Ren X

更新日期：2015-08-26 00:00:00

abstract：:Controlling light and heat via metamaterials has presented interesting technological applications using transformation optics (TO) and transformation thermodynamics (TT). However, such devices are commonly mono-physics and mono-purpose, because the used metamaterial is designed to deal with one type of physical mechan...

journal_title：Scientific reports

authors： Barros WKP,Pereira E

更新日期：2018-07-30 00:00:00

abstract：:Diffusion magnetic resonance imaging (dMRI) proved promising in patients with non-myelopathic degenerative cervical cord compression (NMDCCC), i.e., without clinically manifested myelopathy. Aim of the study is to present a fast multi-shell HARDI-ZOOMit dMRI protocol and validate its usability to detect microstructura...

journal_title：Scientific reports

authors： Labounek R,Valošek J,Horák T,Svátková A,Bednařík P,Vojtíšek L,Horáková M,Nestrašil I,Lenglet C,Cohen-Adad J,Bednařík J,Hluštík P

更新日期：2020-10-16 00:00:00

abstract：:Infantile spasms (ISs) is a devastating form of an early infantile epileptic encephalopathy. The patterns of response of multiple regimens, and the difference in response rates for the cases who receive first-line therapies on time versus those who receive them after non-first-line therapies are unknown. We performed ...

journal_title：Scientific reports

authors： Mao L,Kessi M,Peng P,He F,Zhang C,Yang L,Wu L,Yin F,Peng J

更新日期：2020-07-13 00:00:00

abstract：:Amblyopia is a common visual disorder that is treatable in childhood. However, therapies have limited efficacy in adult patients with amblyopia. Fluoxetine can reinstate early-life critical period-like neuronal plasticity and has been used to recover functional vision in adult rats with amblyopia. We conducted a Phase...

journal_title：Scientific reports

authors： Huttunen HJ,Palva JM,Lindberg L,Palva S,Saarela V,Karvonen E,Latvala ML,Liinamaa J,Booms S,Castrén E,Uusitalo H

更新日期：2018-08-27 00:00:00

abstract：:Studies of morphological integration and modularity, and of anatomical complexity in human evolution typically focus on skeletal tissues. Here we provide the first network analysis of the musculoskeletal anatomy of both the fore- and hindlimbs of the two species of chimpanzee and humans. Contra long-accepted ideas, ne...

journal_title：Scientific reports

authors： Diogo R,Molnar JL,Rolian C,Esteve-Altava B

更新日期：2018-05-02 00:00:00

abstract：:We present a model on the simulation of the measurement-device independent quantum key distribution (MDI-QKD) with phase randomized general sources. It can be used to predict experimental observations of a MDI-QKD with linear channel loss, simulating corresponding values for the gains, the error rates in different bas...

journal_title：Scientific reports

authors： Wang Q,Wang XB

更新日期：2014-04-14 00:00:00

abstract：:Increased filaggrin expression was found to be correlated with severity scores in chronic spontaneous urticaria (CSU); however, the role of filaggrin breakdown products (FBPs) in CSU has not been studied. We collected stratum corneum (SC) specimens from the volar forearms of 10 CSU patients, 10 AD patients, and 10 hea...

journal_title：Scientific reports

authors： Pham DL,Lim KM,Joo KM,Park HS,Leung DYM,Ye YM

更新日期：2017-05-02 00:00:00

abstract：:Recent advances in RNA-seq methodologies from limiting amounts of mRNA have facilitated the characterization of rare cell-types in various biological systems. So far, however, technical variations in these methods have not been adequately characterized, vis-à-vis sensitivity, starting with reduced levels of mRNA. Here...

journal_title：Scientific reports

authors： Bhargava V,Head SR,Ordoukhanian P,Mercola M,Subramaniam S

更新日期：2014-01-14 00:00:00

abstract：:Serotype-cross-reactive memory T cells responding to secondary dengue virus (DENV) infection are thought to contribute to disease. However, epitope-specific T cell responses have not been thoroughly compared between subjects with primary versus secondary DENV infection. We studied CD8(+) T cells specific for the HLA-A...

journal_title：Scientific reports

authors： Friberg H,Bashyam H,Toyosaki-Maeda T,Potts JA,Greenough T,Kalayanarooj S,Gibbons RV,Nisalak A,Srikiatkhachorn A,Green S,Stephens HA,Rothman AL,Mathew A

更新日期：2011-01-01 00:00:00

abstract：:Agricultural soil is often subjected to waterlogging after heavy rainfalls, resulting in sharp and explosive increases in the emission of nitrous oxide (N2O), an important greenhouse gas primarily released from agricultural soil ecosystems. Previous studies on waterlogged soil examined the abundance of denitrifiers bu...

journal_title：Scientific reports

authors： Wang Y,Uchida Y,Shimomura Y,Akiyama H,Hayatsu M

更新日期：2017-04-11 00:00:00