Improved antitumor activity of TRAIL fusion protein via formation of self-assembling nanoparticle.

abstract：:In typical numerical simulations, the space-charge force is calculated by slicing a beam into many longitudinal segments and by solving the two-dimensional Poisson equation in each segment. This method neglects longitudinal leakage of the space-charge force to nearby segments owing to its longitudinal spread over 1/γ....

journal_title：Scientific reports

authors： Shobuda Y,Chin YH

更新日期：2018-08-24 00:00:00

abstract：:Orientation controllable DNA biosensors hold great application potentials in recognizing small molecules and detecting DNA hybridization. Though electric field is usually used to control the orientation of DNA molecules, it is also of great importance and significance to seek for other triggered methods to control the...

journal_title：Scientific reports

authors： Feng C,Ding HM,Ren CL,Ma YQ

更新日期：2015-09-24 00:00:00

abstract：:A patient's pain during mandibular third molar extraction often creates problems for a dental surgeon and can also cause immense patient discomfort, such as decreased quality of life, serious complications, or even danger to the patients' lives. Effective pain management is therefore of great importance. Conventional ...

journal_title：Scientific reports

authors： Yu F,Xiao Y,Liu H,Wu F,Lou F,Chen D,Bai M,Huang D,Wang C,Ye L

更新日期：2017-01-20 00:00:00

abstract：:Evidence showed preventive impacts of the highly active antiretroviral therapy (HAART) on the Human Immunodeficiency Virus (HIV) transmission amomg heterosexual population, however, that is of deficit among men who have sex with men (MSM). The aim was to systematically examine the efficacy of HAART on HIV transmission...

journal_title：Scientific reports

authors： Jiang Y,Su S,Borné Y

更新日期：2020-01-23 00:00:00

abstract：:We aimed to evaluate the etiologies of constipation in patients with anorectal malformations having a good prognosis for bowel control but a high risk of constipation. We included twenty-five patients from the Odense university hospital in Denmark. Patients were subjected to colon transit time examination and high res...

journal_title：Scientific reports

authors： Bjørsum-Meyer T,Christensen P,Baatrup G,Jakobsen MS,Asmussen J,Qvist N

更新日期：2020-11-12 00:00:00

abstract：:The use of anti-cancer adjuvant therapy is rationalized by potentiating the efficacy, and/or protecting from major side effects of chemotherapeutics. Thymoquinone (TQ) is a naturally occurring compound with cumulative evidence of anti-cancer properties. In this study, we assessed the chemomodulatory potential of TQ to...

journal_title：Scientific reports

authors： Bashmail HA,Alamoudi AA,Noorwali A,Hegazy GA,AJabnoor G,Choudhry H,Al-Abd AM

更新日期：2018-08-03 00:00:00

abstract：:α-Dystroglycanopathy (α-DGP) is a group of muscular dystrophy characterized by abnormal glycosylation of α-dystroglycan (α-DG), including Fukuyama congenital muscular dystrophy (FCMD), muscle-eye-brain disease, Walker-Warburg syndrome, and congenital muscular dystrophy type 1D (MDC1D), etc. LARGE, the causative gene f...

journal_title：Scientific reports

authors： Ohtsuka Y,Kanagawa M,Yu CC,Ito C,Chiyo T,Kobayashi K,Okada T,Takeda S,Toda T

更新日期：2015-02-09 00:00:00

abstract：:The limits of mammography have led to an increasing interest on possible alternatives such as the breast Computed Tomography (bCT). The common goal of all X-ray imaging techniques is to achieve the optimal contrast resolution, measured through the Contrast to Noise Ratio (CNR), while minimizing the radiological risks,...

journal_title：Scientific reports

authors： Delogu P,Di Trapani V,Brombal L,Mettivier G,Taibi A,Oliva P

更新日期：2019-09-11 00:00:00

abstract：:We study stochastic particle systems made up of heterogeneous units. We introduce a general framework suitable to analytically study this kind of systems and apply it to two particular models of interest in economy and epidemiology. We show that particle heterogeneity can enhance or decrease the size of the collective...

journal_title：Scientific reports

authors： Lafuerza LF,Toral R

更新日期：2013-01-01 00:00:00

abstract：:A conductive, uniform, and ultra-smooth flexible transparent composite film is produced by embedding silver nanowires (AgNWs) into poly(vinyl-butyral) (PVB) without pressure or high-temperature annealing. The adhesion of AgNWs was greatly improved by embedding them in PVB, and surface roughness and sheet resistance (R...

journal_title：Scientific reports

authors： Lee DJ,Oh Y,Hong JM,Park YW,Ju BK

更新日期：2018-09-21 00:00:00

abstract：:Concerns related to pulmonary toxicity and non-specificity of nanoparticles have limited their clinical applications for aerosol delivery of chemotherapeutics in lung cancer. We hypothesized that pulmonary surfactant mimetic nanoparticles that offer pH responsive release specifically in tumor may be a possible solutio...

journal_title：Scientific reports

authors： Joshi N,Shirsath N,Singh A,Joshi KS,Banerjee R

更新日期：2014-11-18 00:00:00

abstract：:Controlling thickness and tightness of surface passivation shells is crucial for many applications of core-shell nanoparticles (NP). Usually, to determine shell thickness, core and core/shell particle are measured individually requiring the availability of both nanoobjects. This is often not fulfilled for functional n...

journal_title：Scientific reports

authors： Weigert F,Müller A,Häusler I,Geißler D,Skroblin D,Krumrey M,Unger W,Radnik J,Resch-Genger U

更新日期：2020-11-26 00:00:00

abstract：:Surface and soil core samples from northeast China were analyzed for Pu isotopes. The measured (240)Pu/(239)Pu atomic ratios and (239 + 240)Pu/(137)Cs activity ratios revealed that the global fallout is the dominant source of Pu and (137)Cs at these sites. Migration behavior of Pu varying with land type and human acti...

journal_title：Scientific reports

authors： Xu Y,Qiao J,Hou X,Pan S

更新日期：2013-12-16 00:00:00

abstract：:Electrostatic gates are of paramount importance for the physics of devices based on high-mobility two-dimensional electron gas (2DEG) since they allow depletion of electrons in selected areas. This field-effect gating enables the fabrication of a wide range of devices such as, for example, quantum point contacts (QPC)...

journal_title：Scientific reports

authors： Bennaceur K,Schmidt BA,Gaucher S,Laroche D,Lilly MP,Reno JL,West KW,Pfeiffer LN,Gervais G

更新日期：2015-09-22 00:00:00

abstract：:Duchenne muscular dystrophy (DMD) is a disease marked by the development of skeletal muscle weakness and wasting. DMD results from mutations in the gene for the cytoskeletal protein dystrophin. The loss of dystrophin expression is not limited to muscle weakness but has multiple systemic consequences. Managing the nutr...

journal_title：Scientific reports

authors： Strakova J,Kamdar F,Kulhanek D,Razzoli M,Garry DJ,Ervasti JM,Bartolomucci A,Townsend D

更新日期：2018-09-11 00:00:00

abstract：:Due to the globalization and computerization of financial and economic activities, numerous repetitive leveraged investments have become possible in stock markets and currency exchanges. In reality, repeated leveraged investments up to 100 times/day are possible via online access. With computer-aided programs, this re...

journal_title：Scientific reports

authors： Nii M,Okabe T,Ito H,Morita S,Yasuda Y,Yoshimura J

更新日期：2019-09-24 00:00:00

abstract：:Freezing colloidal suspensions widely exists in nature and industry. Interface instability has attracted much attention for the understandings of the pattern formation in freezing colloidal suspensions. However, the interface instability modes, the origin of the ice banding or ice lamellae, are still unclear. In-situ ...

journal_title：Scientific reports

authors： Wang L,You J,Wang Z,Wang J,Lin X

更新日期：2016-03-21 00:00:00

abstract：:Si and Ge nanocrystals in oxides are of a large interest for photo-effect applications due to the fine-tuning of the optical bandgap by quantum confinement in nanocrystals. In this work, dense Ge nanocrystals suitable for enhanced photoconduction were fabricated from 60% Ge in TiO2 amorphous layers by low temperature ...

journal_title：Scientific reports

authors： Lepadatu AM,Slav A,Palade C,Dascalescu I,Enculescu M,Iftimie S,Lazanu S,Teodorescu VS,Ciurea ML,Stoica T

更新日期：2018-03-20 00:00:00

abstract：:In the present study, channelrhodopsin 2 (ChR2) was specifically introduced into murine cells expressing the Phenylethanolamine n-methyltransferase (Pnmt) gene, which encodes for the enzyme responsible for conversion of noradrenaline to adrenaline. The new murine model enabled the identification of a distinctive class...

journal_title：Scientific reports

authors： Wang Y,Lin WK,Crawford W,Ni H,Bolton EL,Khan H,Shanks J,Bub G,Wang X,Paterson DJ,Zhang H,Galione A,Ebert SN,Terrar DA,Lei M

更新日期：2017-01-13 00:00:00

abstract：:The Na+/H+ exchanger-1 (NHE1) supports tumour growth, making NHE1 inhibitors of interest in anticancer therapy, yet their molecular effects are incompletely characterized. Here, we demonstrate that widely used pyrazinoylguanidine-type NHE1 inhibitors potently inhibit growth and survival of cancer cell spheroids, in a ...

journal_title：Scientific reports

authors： Rolver MG,Elingaard-Larsen LO,Andersen AP,Counillon L,Pedersen SF

更新日期：2020-04-02 00:00:00

abstract：:Geographical variation of diabetic emergencies attended by prehospital emergency medical services (EMS) and the relationship between area-level social and demographic factors and risk of a diabetic emergency were examined. All cases of hypoglycaemia and hyperglycaemia attended by Ambulance Victoria between 1/01/2009 a...

journal_title：Scientific reports

authors： Villani M,Earnest A,Smith K,de Courten B,Zoungas S

更新日期：2018-03-23 00:00:00

abstract：:Cartilage engineering that combines competent seeding cells and a compatible scaffold is increasingly gaining popularity and is potentially useful for the treatment of various bone and cartilage diseases. Intensive efforts have been made by researchers to improve the viability and functionality of seeding cells of eng...

journal_title：Scientific reports

authors： Ma Y,Li J,Yao Y,Wei D,Wang R,Wu Q

更新日期：2016-05-25 00:00:00

abstract：:Carbon dioxide supercritical fluid extraction (CO2 SFE) is a clean and cost-effective method of extracting cannabinoids from cannabis. Using design of experiment methodologies an optimised protocol for extraction of medicinal cannabis bud material (population of mixed plants, combined THC:CBD approximately 1:1.5) was ...

journal_title：Scientific reports

authors： Rochfort S,Isbel A,Ezernieks V,Elkins A,Vincent D,Deseo MA,Spangenberg GC

更新日期：2020-06-04 00:00:00

abstract：:Methylation of DNA CpG sites is a major mechanism of epigenetic gene silencing and plays important roles in cell division, development and carcinogenesis. One of its regulators is the 64-residue C-terminal Transcriptional Repressor Domain (the TRD) of MBD1, which recruits several repressor proteins such as MCAF1, HDAC...

journal_title：Scientific reports

authors： Hameed UF,Lim J,Zhang Q,Wasik MA,Yang D,Swaminathan K

更新日期：2014-05-09 00:00:00

abstract：:FcRn mediates recycling and transcytosis of IgG and albumin in various cell types. The MHC-class-I-like protein of the FcRn heterodimer is encoded by FCGRT. Few determinants of variable FCGRT expression in humans have been identified so far. In this study, we investigated the presence of DNA methylation in regulatory ...

journal_title：Scientific reports

authors： Cejas RB,Ferguson DC,Quiñones-Lombraña A,Bard JE,Blanco JG

更新日期：2019-06-17 00:00:00

abstract：:Aberrant fetal growth is associated with morbidities and mortality during childhood and adult life. Although genetic and environmental factors are known to influence in utero growth, their relative contributions over pregnancy is unknown. We estimated, across gestation, the genetic heritability, contribution of shared...

journal_title：Scientific reports

authors： Workalemahu T,Grantz KL,Grewal J,Zhang C,Louis GMB,Tekola-Ayele F

更新日期：2018-05-08 00:00:00

abstract：:Laminotomy and transforaminal lumbar interbody fusion (TLIF) is usually used to treat unstable spinal stenosis. Minimally invasive surgery (MIS) can cause less muscle injury than conventional open surgery (COS). The purpose of this study was to compare the degree of postoperative fatty degeneration in the paraspinal m...

journal_title：Scientific reports

authors： Fu CJ,Chen WC,Lu ML,Cheng CH,Niu CC

更新日期：2020-09-03 00:00:00

abstract：:This work demonstrates an anisotropic increase in resistivity with decreasing width in single crystal tungsten (W) nanowires having a height of 21 nm. Nanowire-widths were in the range of 15-451 nm, with the anisotropy observed for widths below 50 nm. The longitudinal directions of the nanowires coincided with the <10...

journal_title：Scientific reports

authors： Choi D,Moneck M,Liu X,Oh SJ,Kagan CR,Coffey KR,Barmak K

更新日期：2013-01-01 00:00:00

abstract：:The topotactic phase transition in SrCoO x (x = 2.5-3.0) makes it possible to reversibly transit between the two distinct phases, i.e. the brownmillerite SrCoO2.5 that is a room-temperature antiferromagnetic insulator (AFM-I) and the perovskite SrCoO3 that is a ferromagnetic metal (FM-M), owing to their multiple valen...

journal_title：Scientific reports

authors： Lee JH,Choi WS,Jeen H,Lee HJ,Seo JH,Nam J,Yeom MS,Lee HN

更新日期：2017-11-22 00:00:00

abstract：:The selective arterial calcium injection (SACI) test is useful for patients with functional pancreatic neuroendocrine tumors (F-PNETs). This study evaluated which patients with F-PNETs would benefit from the SACI test. We retrospectively analyzed the preoperative findings of patients on computed tomography (CT), magne...

journal_title：Scientific reports

authors： Nakano Y,Kitago M,Shinoda M,Nakatsuka S,Kurihara I,Yagi H,Abe Y,Oshima G,Hori S,Yokose T,Kitagawa Y

更新日期：2021-01-08 00:00:00