Abstract：
:Cartilage engineering that combines competent seeding cells and a compatible scaffold is increasingly gaining popularity and is potentially useful for the treatment of various bone and cartilage diseases. Intensive efforts have been made by researchers to improve the viability and functionality of seeding cells of engineered constructs that are implanted into damaged cartilage. Here, we designed an integrative system combining gene engineering and the controlled-release concept to solve the problems of both seeding cell viability and functionality through precisely regulating the anti-apoptotic gene bcl-2 in the short-term and the chondrogenic master regulator Sox9 in the long-term. Both in vitro and in vivo experiments demonstrated that our system enhances the cell viability and chondrogenic effects of the engineered scaffold after introduction of the system while restricting anti-apoptotic gene expression to only the early stage, thereby preventing potential oncogenic and overdose effects. Our system was designed to be modular and can also be readily adapted to other tissue engineering applications with minor modification.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Ma Y,Li J,Yao Y,Wei D,Wang R,Wu Qdoi
10.1038/srep26617subject
Has Abstractpub_date
2016-05-25 00:00:00pages
26617issn
2045-2322pii
srep26617journal_volume
6pub_type
杂志文章abstract：:Thermoelectric properties of Graphene nano-ribbons (GNRs) with nanopores (NPs) are explored for a range of pore dimensions in order to achieve a high performance two-dimensional nano-scale thermoelectric device. We reduce thermal conductivity of GNRs by introducing pores in them in order to enhance their thermoelectri...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep11297
更新日期：2015-06-17 00:00:00
abstract：:The microbial community during fermented vegetable production has a large impact on the quality of the final products. Lactic acid bacteria have been well-studied in such processes, but knowledge about the roles of non-lactic acid bacteria is limited. This study aimed to provide useful knowledge about the relationship...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-021-81105-x
更新日期：2021-01-19 00:00:00
abstract：:Our purpose was to examine the effect of model, puffing topography (voltage, air-flow, puff interval), and method of collection on 19 elements/metals in aerosols from six tank-style electronic cigarettes (EC). Aerosols were collected from six brands using a cold trap or impinger and various puffing topographies. 19 el...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-50441-4
更新日期：2019-09-27 00:00:00
abstract：:The introduced oriental shrimp Palaemon macrodactylus has recently become widespread in temperate estuaries worldwide. However, this recent worldwide spread outside of its native range arises after a previous introduction to the US Pacific coast, where it was restricted for more than 30 years. Using a phylogeographic ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep05808
更新日期：2014-07-24 00:00:00
abstract：:A wet-chemical method combined with spark plasma sintering was used to prepare a W-Y2O3 alloy. High-temperature tensile tests and nano-indentation microhardness tests were used to characterize the mechanical properties of the alloy. After He-ion irradiation, fuzz and He bubbles were observed on the irradiated surface....
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep12755
更新日期：2015-07-31 00:00:00
abstract：:Molecular crystals demonstrate drastically different behavior in solid and liquid state, mainly due to their difference in structural frameworks. Therefore, designing of unique structured molecular compound which can work at both these interfaces has been a challenge. Here, we present remarkable 'molecular' property b...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep14460
更新日期：2015-09-28 00:00:00
abstract：:Previously reported associations between second-to-fourth digit length ratio (2D:4D), a proxy for prenatal androgen load, and transgender identity have been inconsistent. The objectives of the present study were to provide additional original data and an updated meta-analysis concerning this association. In a study of...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-72486-6
更新日期：2020-11-09 00:00:00
abstract：:In social interactions, including cooperation and conflict, individuals can adjust their behaviour over the shorter term through learning within a generation, and natural selection can change behaviour over the longer term of many generations. Here we investigate the evolution of cognitive bias by individuals investin...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-52781-7
更新日期：2019-11-08 00:00:00
abstract：:Latent class modeling can be used to combine the results of multiple tests to compare the sensitivity and specificity of those tests in the absence of a gold standard. Seroepidemiology for chlamydia infection may be useful for determining the cumulative risk of infection within a population. Initial studies using the ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-22708-9
更新日期：2018-03-09 00:00:00
abstract：:Identification of AD (Alzheimer's disease)-related genes obtained from blood samples is crucial for early AD diagnosis. We used three public datasets, ADNI, AddNeuroMed1 (ANM1), and ANM2, for this study. Five feature selection methods and five classifiers were used to curate AD-related genes and discriminate AD patien...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-60595-1
更新日期：2020-02-26 00:00:00
abstract：:Dendritic spines are small, bulbous protrusions along dendrites in neurons and play a critical role in synaptic transmission. Dendritic spines come in a variety of shapes that depend on their developmental state. Additionally, roughly 14-19% of mature spines have a specialized endoplasmic reticulum called the spine ap...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-48028-0
更新日期：2019-08-12 00:00:00
abstract：:We investigated the effect of the crude herbal extract from Uncaria tomentosa (UT) on non-alcoholic fatty liver disease (NAFLD) in two models of obesity: high fat diet (HFD) and genetically obese (ob/ob) mice. Both obese mouse models were insulin resistant and exhibited an abundance of lipid droplets in the hepatocyte...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-29044-y
更新日期：2018-07-20 00:00:00
abstract：:The abundance and sinking of particulate black carbon (PBC) were examined for the first time in the western Arctic and Subarctic Oceans. In the central Arctic Ocean, high PBC concentrations with a mean of 0.021 ± 0.016 μmol L(-1) were observed in the marginal ice zone (MIZ). A number of parameters, including temperatu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep29959
更新日期：2016-07-15 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-55984-0
更新日期：2019-12-20 00:00:00
abstract：:Human umbilical cord mesenchymal stem cells (huMSCs) can treat primary ovarian insufficiency (POI) related to ovarian granulosa cell (OGC) apoptosis caused by cisplatin chemotherapy. Exosomes are a class of membranous vesicles with diameters of 30-200 nm that are constitutively released by eukaryotic cells. Exosomes m...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-02786-x
更新日期：2017-05-31 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-62744-y
更新日期：2020-04-02 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-26277-9
更新日期：2018-05-18 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-11373-z
更新日期：2017-09-12 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep03076
更新日期：2013-11-13 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep15540
更新日期：2015-10-21 00:00:00
abstract：:Quartz is a common phase in high-silica igneous rocks and is resistant to post-eruptive alteration, thus offering a reliable record of magmatic processes in silicic magma systems. Here we employ the 75 ka Toba super-eruption as a case study to show that quartz can resolve late-stage temporal changes in magmatic δ18O v...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep40624
更新日期：2017-01-25 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-77299-1
更新日期：2020-11-27 00:00:00
abstract：:Gut dysbiosis contributes to the development of a dysfunctional gut barrier, facilitating the translocation of bacteria and inflammagens, and is implicated in colorectal cancer (CRC) pathogenesis. Such 'leaky gut' conditions result in systemic inflammation, of which a hallmark is increased hypercoagulability. Fluoresc...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-65324-2
更新日期：2020-05-29 00:00:00
abstract：:The aim of this study was to identify genes for which the expression within carotid atherosclerosis was reproducibly associated with the symptoms of cerebral embolization. Two publically available microarray datasets E-MEXP-2257 and GSE21545 were analysed using GeneSpring 11.5. The two datasets utilized a total of 22 ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-04497-9
更新日期：2017-06-28 00:00:00
abstract：:Converging evidence has proved the attentional bias of Internet addicts (IAs) on network information. However, previous studies have neither explained how characteristics of network information are detected by IAs with priority nor proved whether this advantage is in line with the unconscious and automatic process. To...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-25442-4
更新日期：2018-06-12 00:00:00
abstract：:Despite aggressive antimicrobial therapy, many respiratory pathogens persist in the lung, underpinning the chronic inflammation and eventual lung decline that are characteristic of respiratory disease. Recently, bile acid aspiration has emerged as a major comorbidity associated with a range of lung diseases, shaping t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep29768
更新日期：2016-07-19 00:00:00
abstract：:We have studied the formation of Pd42.5Cu30Ni7.5P20 metallic glass droplets and wires in the gas atomization process. We demonstrate that the sizes of droplets and wires can be distinguished by the Ohnesorge number (Oh), which is the proportion of the spinnability to the capillary instability, and the diameter distrib...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep10711
更新日期：2015-06-01 00:00:00
abstract：:Agrobacterium pathogens of octopine- and nopaline-types force host plants to produce either octopine or nopaline compounds, which they use as nutrients. Two Agrobacterium ABC-transporters and their cognate periplasmic binding proteins (PBPs) OccJ and NocT import octopine and nopaline/octopine, respectively. Here, we s...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-18243-8
更新日期：2017-12-21 00:00:00
abstract：:CVB3 is a common human pathogen to be highly lethal to newborns and causes viral myocarditis and pancreatitis in adults. However, there is no vaccine available for clinical use. CVB3 capsid protein VP1 is an immunodominant structural protein, containing several B- and T-cell epitopes. However, immunization of mice wit...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep41485
更新日期：2017-02-02 00:00:00
abstract：:Anthracnose caused by Colletotrichum is one of the most severe diseases of Hevea brasiliensis. However, research on the diversity and geographical distribution of Colletotrichum remains limited in China. In this study, we investigated the phylogenetic diversity of Colletotrichum isolates associated with symptomatic ti...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-28166-7
更新日期：2018-07-11 00:00:00
