Abstract：
:We propose an approach for characterizing structural heterogeneity of lung cancer nodules using Computed Tomography Texture Analysis (CTTA). Measures of heterogeneity were used to test the hypothesis that heterogeneity can be used as predictor of nodule malignancy and patient survival. To do this, we use the National Lung Screening Trial (NLST) dataset to determine if heterogeneity can represent differences between nodules in lung cancer and nodules in non-lung cancer patients. 253 participants are in the training set and 207 participants in the test set. To discriminate cancerous from non-cancerous nodules at the time of diagnosis, a combination of heterogeneity and radiomic features were evaluated to produce the best area under receiver operating characteristic curve (AUROC) of 0.85 and accuracy 81.64%. Second, we tested the hypothesis that heterogeneity can predict patient survival. We analyzed 40 patients diagnosed with lung adenocarcinoma (20 short-term and 20 long-term survival patients) using a leave-one-out cross validation approach for performance evaluation. A combination of heterogeneity features and radiomic features produce an AUROC of 0.9 and an accuracy of 85% to discriminate long- and short-term survivors.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Cherezov D,Goldgof D,Hall L,Gillies R,Schabath M,Müller H,Depeursinge Adoi
10.1038/s41598-019-38831-0subject
Has Abstractpub_date
2019-03-14 00:00:00pages
4500issue
1issn
2045-2322pii
10.1038/s41598-019-38831-0journal_volume
9pub_type
杂志文章,随机对照试验abstract：:Dengue fever is one of the most important mosquito-borne viral infections in large parts of tropical and subtropical countries and is a significant public health concern and socioeconomic burden. There is an urgent need to develop antivirals that can effectively reduce dengue virus (DENV) replication and decrease vira...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-45095-1
更新日期：2019-06-18 00:00:00
abstract：:The Na(3p) + H2(X1Σg+) → NaH(X1Σ+) + H(2S) reaction plays an important role in the field of diabatic reaction dynamics. A set of new diabatic potential energy surfaces (PESs) of the NaH2 system are structured, which include the diabatic coupling between the lowest two adiabatic states. The electronic structure calcula...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-35987-z
更新日期：2018-12-19 00:00:00
abstract：:Fusarium head blight (FHB) is a devastating disease of wheat worldwide. Fhb1 is the most consistently reported quantitative trait locus (QTL) for FHB resistance breeding. A pore-forming toxin-like (PFT) gene at Fhb1 was first cloned by map-based cloning and found to confer FHB resistance in wheat. Proteins often inter...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-52030-x
更新日期：2019-10-29 00:00:00
abstract：:We identify a new instability in electrostatic actuators dubbed quasi-static pull-in. We report experimental evidence of the instability and study its characteristics in two types of micro actuators operating in ambient air. We found that the underlying mechanism is a fast-slow dynamic interaction between slowly-varyi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-61534-w
更新日期：2020-03-19 00:00:00
abstract：:This paper proposes new ways to assess handwriting, a critical skill in any child's school journey. Traditionally, a pen and paper test called the BHK test (Concise Evaluation Scale for Children's Handwriting) is used to assess children's handwriting in French-speaking countries. Any child with a BHK score above a cer...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-60011-8
更新日期：2020-02-21 00:00:00
abstract：:The L-iduronic acid (IdoA) residue is a critically important structural component in heparan sulphate polysaccharide for the biological functions. The pyranose ring of IdoA is present in (1)C4-chair, (2)SO-skew boat, and less frequently, in (4)C1-chair conformations. Here, we analyzed the conformation of IdoA residue ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep29602
更新日期：2016-07-14 00:00:00
abstract：:Research on Giardia lamblia has accumulated large information about its molecular cell biology and infection biology. However, giardiasis is still one of the commonest parasitic diarrheal diseases affecting humans. Additionally, an alarming increase in cases refractory to conventional treatment has been reported in lo...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-45529-w
更新日期：2019-06-20 00:00:00
abstract：:Biological control mechanisms of plant diseases have been intensively studied. However, how plant pathogens respond to and resist or alleviate biocontrol agents remains largely unknown. In this study, a comparative transcriptome analysis was performed to elucidate how the pathogen of sclerotinia stem rot, Sclerotinia ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-69434-9
更新日期：2020-07-28 00:00:00
abstract：:The distribution of carbon from a branch setting pod in alfalfa was investigated during the seed development of seeds to determine the relative contribution of pod and leaf photoassimilates to the total C balance and to investigate the partitioning of these photoassimilates to other plant organs. A 13Clabeling procedu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep42026
更新日期：2017-02-07 00:00:00
abstract：:Monoclonal antibodies (mAbs) are attractive therapeutics for treating a wide range of human disorders, and bind to the antigen through their complementarity-determining regions (CDRs). Small stable proteins containing structurally retained CDRs are promising alternatives to mAbs. In this report, we present a method to...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-57713-4
更新日期：2020-01-21 00:00:00
abstract：:Microphysiological systems (MPSs) are in vitro models that capture facets of in vivo organ function through use of specialized culture microenvironments, including 3D matrices and microperfusion. Here, we report an approach to co-culture multiple different MPSs linked together physiologically on re-useable, open-syste...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-22749-0
更新日期：2018-03-14 00:00:00
abstract：:Using second-generation sequencing (SGS) RNA-Seq strategies, extensive alterative splicing prediction is impractical and high variability of isoforms expression quantification is inevitable in organisms without true reference dataset. we report the development of a novel analysis method, termed hybrid sequencing and m...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep43793
更新日期：2017-03-08 00:00:00
abstract：:Lymph node (LN) metastasis through the lymphatic network is a major route for cancer dissemination. Tumor cells reach the marginal sinuses of LNs via afferent lymphatic vessels (LVs) and form metastatic lesions that lead to distant metastasis. Thus, targeting of metastatic cells in the marginal sinuses could improve c...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-49386-5
更新日期：2019-09-13 00:00:00
abstract：:Carbon fiber-synthetic foam core sandwich composites are widely used for many structural applications due to their superior mechanical performance and low weight. Unfortunately these structures typically have very poor acoustic performance. There is increasingly growing demand in mitigating this noise issue in sandwic...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep00403
更新日期：2012-01-01 00:00:00
abstract：:The controversial anti-proliferative effects of Echinacea purpurea (L.) Moench (Asteraceae) might be related to different plant metabolites contained in plant samples, extracts and products. The influence of bacterial endophytes on the synthesis of bioactive compounds in the medicinal plants has been previously demons...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-47329-8
更新日期：2019-07-26 00:00:00
abstract：:Neutrophil elastase (NE) suppresses IL-8/CXCL8 in human airway smooth muscle cells (hASM) while stimulating its production in respiratory epithelial cells. This differential effect is mediated by the selective induction of NKRF and dysregulation in chronic inflammatory diseases. We hypothesized that the differential a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep44930
更新日期：2017-03-21 00:00:00
abstract：:Fibril formation implies the conversion of a protein's native secondary structure and is associated with several neurodegenerative diseases. A better understanding of fibrillation inhibition and fibril dissection requires nanoscale molecular characterization of amyloid structures involved. Tip-enhanced Raman scatterin...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep39622
更新日期：2016-12-23 00:00:00
abstract：:This corrects the article DOI: 10.1038/srep41699. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/srep46942
更新日期：2018-02-12 00:00:00
abstract：:Guanine-rich quadruplex (G-QD) are formed by conversion of nucleotides with specific sequences by stabilization of positively charged K+ or Na+. These G-QD structures differentially absorb two-directional (right- and left-handed) circularly polarized light, which can discriminate the parallel or anti-parallel structur...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-77449-5
更新日期：2020-11-24 00:00:00
abstract：:Several epidemiological studies have found a positive association between diabetic retinopathy (DR) and subclinical hypothyroidism (SCH), but the findings are varied or even contradictory. In the work, we performed a meta-analysis to ascertain the relationship between DR and SCH. We searched relevant studies on the re...
journal_title：Scientific reports
pub_type： 杂志文章,meta分析
doi：10.1038/srep12212
更新日期：2015-07-20 00:00:00
abstract：:Modes attenuation of the tube lattice fiber (TLF) is characterized by D/λ, where D is the core diameter and λ is the wavelength. Hence, the TLF is structured with a large core to ensure a low attenuation loss. A small core, on the other hand, facilitates the gas-filled TLF applications, but at the expense of the incre...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-01839-5
更新日期：2017-05-09 00:00:00
abstract：:Both Shewanella oneidensis MR-1 wild type and its mutant ΔomcA/mtrC are capable of transforming Au(III) into Au nanoparticles (AuNPs). Cyclic voltammetry reveals a decrease in redox current after the wild type is exposed to Au(III) but an increase in oxidation current for the mutant. The peak current of the wild type ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep03307
更新日期：2013-11-22 00:00:00
abstract：:Land-use intensification on arable land is expanding and posing a threat to biodiversity and ecosystem services worldwide. We develop methods to link funding for avian breeding habitat conservation and management at landscape scales to equilibrium abundance of a migratory species at the continental scale. We apply thi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-61058-3
更新日期：2020-03-18 00:00:00
abstract：:We characterized an anti-cancer fusion protein consisting of anthrax lethal factor (LF) and the catalytic domain of Pseudomonas exotoxin A by (i) mutating the N-terminal amino acids and by (ii) reductive methylation to dimethylate all lysines. Dimethylation of lysines was achieved quantitatively and specifically witho...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep04754
更新日期：2014-04-23 00:00:00
abstract：:Settlement-inducing protein complex (SIPC) is a pheromone that triggers conspecific larval settlement in the barnacle Amphibalanus amphitrite. In the present study, immunostaining and scanning electron microscopy of SIPC revealed signals in the frontal horn pores and the secretions from carapace pores, suggesting that...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep29376
更新日期：2016-07-20 00:00:00
abstract：:The feedback between dyke and sill intrusions and the evolution of stresses within volcanic systems is poorly understood, despite its importance for magma transport and volcano instability. Long-lived ocean island volcanoes are crosscut by thousands of dykes, which must be accommodated through a combination of flank s...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-74361-w
更新日期：2020-10-15 00:00:00
abstract：:Nasopharyngeal carcinoma (NPC) is a highly metastatic cancer that is consistently associated with Epstein-Barr virus (EBV) infection. In this study, we identify for the first time a role for monoamine oxidase A (MAOA) in NPC. MAOA is a mitochondrial enzyme that catalyzes oxidative deamination of neurotransmitters and ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-63150-0
更新日期：2020-04-09 00:00:00
abstract：:Receptivity is a limited time in which uterine endometrium can establish a successful dialogue with blastocyst. This study was to investigate the effect of asynchronous embryo transfer on uterine receptivity in mice. Embryos under different stages were transferred into two oviduct sides of a recipient mouse on day 1 o...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep15897
更新日期：2015-11-04 00:00:00
abstract：:Glacial refugia are centers of high biodiversity. Therefore, knowledge on their locations and reactions of associated populations and landscapes to climatic changes is crucial for conservation management. We here investigated the biogeography of a butterfly species linked to open forest habitats. Using mitochondrial a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-79376-x
更新日期：2021-01-08 00:00:00
abstract：:Zika virus (ZIKV) is an emerging mosquito-borne pathogen representing a global health concern. It has been linked to fetal microcephaly and other birth defects and neurological disorders in adults. Sanofi Pasteur has engaged in the development of an inactivated ZIKV vaccine, as well as a live chimeric vaccine candidat...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-31375-9
更新日期：2018-09-04 00:00:00
