Uncovering the Relationship between Sulphation Patterns and Conformation of Iduronic Acid in Heparan Sulphate.

abstract：:Roquins are a family of highly conserved RNA-binding proteins that also contain a RING-type E3 ubiquitin ligase domain. They repress constitutive decay elements containing mRNAs and play a critical role in RNA homeostasis and immunological self-tolerance. Here we present the crystal structures of the RNA-binding regio...

journal_title：Scientific reports

authors： Zhang Q,Fan L,Hou F,Dong A,Wang YX,Tong Y

更新日期：2015-10-22 00:00:00

abstract：:As an AAA-ATPase, Vps4 is important for function of multivesicular bodies (MVB) sorting pathway, which involves in cellular phenomena ranging from receptor down-regulation to viral budding to cytokinesis. The activity of Vps4 is stimulated by the interactions between Vta1 N-terminus (named as Vta1NTD) and Did2 fragmen...

journal_title：Scientific reports

authors： Shen J,Yang Z,Wang J,Zhao B,Lan W,Wang C,Zhang X,Wild CJ,Liu M,Xu Z,Cao C

更新日期：2016-12-07 00:00:00

abstract：:We recently showed that spinal cord injury (SCI) leads to a decrease in mRNA editing of serotonin receptor 2C (5-HT2CR) contributing to post-SCI spasticity. Here we study post-SCI mRNA editing and global gene expression using massively parallel sequencing. Evidence is presented that the decrease in 5-HT2CR editing is ...

journal_title：Scientific reports

authors： Di Narzo AF,Kozlenkov A,Ge Y,Zhang B,Sanelli L,May Z,Li Y,Fouad K,Cardozo C,Koonin EV,Bennett DJ,Dracheva S

更新日期：2015-07-30 00:00:00

abstract：:Campylobacteriosis typically manifests as a short-lived, self-limiting gastrointestinal infection in humans, however prolonged infection can be seen in cases with underlying immunodeficiency. Public Health England received 25 isolates of Campylobacter jejuni from an individual with combined variable immunodeficiency o...

journal_title：Scientific reports

authors： Barker CR,Painset A,Swift C,Jenkins C,Godbole G,Maiden MCJ,Dallman TJ

更新日期：2020-06-22 00:00:00

abstract：:Triple-negative breast cancer (TNBC) is sometimes mistaken for fibroadenoma due to its tendency to show benign morphology on breast ultrasound (US) albeit its aggressive nature. This study aims to develop a radiomics score based on US texture analysis for differential diagnosis between TNBC and fibroadenoma, and to ev...

journal_title：Scientific reports

authors： Lee SE,Han K,Kwak JY,Lee E,Kim EK

更新日期：2018-09-10 00:00:00

abstract：:Hesperiidae is one of the largest families of butterflies. Our knowledge of the higher systematics on hesperiids from China is still very limited. We infer the phylogenetic relationships of the subfamilies of Chinese skippers based on three mitochondrial genes (cytochrome b (Cytb), the NADH dehydrogenase subunit 1 (ND...

journal_title：Scientific reports

authors： Yuan X,Gao K,Yuan F,Wang P,Zhang Y

更新日期：2015-06-10 00:00:00

abstract：:It has been known that some traumatic macular holes can close spontaneously. However, knowledge about the types of macular hole that can close spontaneously is limited. In this retrospective study, we investigated patients with traumatic macular hole who were followed-up for at least 6 months without any surgical inte...

journal_title：Scientific reports

authors： Chen H,Chen W,Zheng K,Peng K,Xia H,Zhu L

更新日期：2015-07-21 00:00:00

abstract：:The physical mechanism of the anthropogenic triggering of large earthquakes on active faults is studied on the basis of experimental phenomenology, i.e., that earthquakes occur on active tectonic faults, that crustal stress values are those measured in situ and, on active faults, comply to the values of the stress dro...

journal_title：Scientific reports

authors： Mulargia F,Bizzarri A

更新日期：2014-08-26 00:00:00

abstract：:Glaucoma is a leading cause of blindness worldwide. Purpose of this study was to identify molecular markers that were significantly correlated with presence of glaucoma and outcome of glaucoma surgery. To accomplish this, we determined the profiles of pro-inflammatory cytokines in the aqueous humor of 101 glaucoma pat...

journal_title：Scientific reports

authors： Chono I,Miyazaki D,Miyake H,Komatsu N,Ehara F,Nagase D,Kawamoto Y,Shimizu Y,Ideta R,Inoue Y

更新日期：2018-09-28 00:00:00

abstract：:Cytochrome P450 (CYP) 3A accounts for nearly 30% of the total CYP enzymes in the human liver and participates in the metabolism of over 50% of clinical drugs. Moreover, CYP3A plays an important role in chemical metabolism, toxicity, and carcinogenicity. New animal models are needed to investigate CYP3A functions, espe...

journal_title：Scientific reports

authors： Lu J,Shao Y,Qin X,Liu D,Chen A,Li D,Liu M,Wang X

更新日期：2017-02-20 00:00:00

abstract：:We presented the unusual result of photobleaching (PB) in Ge-deficient Ge16.8Se83.2 thin films with continuous irradiation with 560 nm laser for 12000 s, which is contradicted with the previous reports that the PB only occurs in GexSe100-x films with x > 30. Observation of the dynamics variations of the photo-induced ...

journal_title：Scientific reports

authors： Zhang S,Chen Y,Wang R,Shen X,Dai S

更新日期：2017-11-06 00:00:00

abstract：:PC4 is an abundant single-strand DNA binding protein that has been implicated in transcription and DNA repair. Here, we show that PC4 is involved in the cellular DNA damage response. To elucidate the role, we used the DT40 chicken B cell model, which produces clustered DNA lesions at Ig loci via the action of activati...

journal_title：Scientific reports

authors： Caldwell RB,Braselmann H,Schoetz U,Heuer S,Scherthan H,Zitzelsberger H

更新日期：2016-07-04 00:00:00

abstract：:Acute kidney injury (AKI) in patients with septic shock is associated with high mortality, but the appropriate timing for initiating continuous renal replacement therapy (CRRT) is controversial. We retrospectively enrolled 158 septic shock patients with AKI in the medical intensive care unit (ICU) from July 2016 to Ap...

journal_title：Scientific reports

authors： Yoon BR,Leem AY,Park MS,Kim YS,Chung KS

更新日期：2019-08-19 00:00:00

abstract：:Biomass waste treatment and detrimental dye adsorption are two of the crucial environmental issues nowadays. In this study, we investigate to simultaneously resolve the aforementioned issues by synthesizing chitosan sponges as adsorbents toward rose bengal (RB) dye adsorption. Through a temperature-controlled freeze-c...

journal_title：Scientific reports

authors： Wang M,Ma Y,Sun Y,Hong SY,Lee SK,Yoon B,Chen L,Ci L,Nam JD,Chen X,Suhr J

更新日期：2017-12-22 00:00:00

abstract：:Targeted protein degradation (TPD) through a proteasome-dependent pathway induced by heterofunctional small molecules is initiated by the formation of a ternary complex with recruited E3 ligases. This complex formation affects the degradation ability of TPD molecules, and thus we tested for visualization of the intrac...

journal_title：Scientific reports

authors： Kaji T,Koga H,Kuroha M,Akimoto T,Hayata K

更新日期：2020-02-20 00:00:00

abstract：:Recent advances in the field of Tissue Engineering allowed to control the three-dimensional organization of engineered constructs. Cell pattern imaging and in vivo follow-up remain a major hurdle in in situ bioprinting onto deep tissues. Magnetic Resonance Imaging (MRI) associated with Micron-sized superParamagnetic I...

journal_title：Scientific reports

authors： Kérourédan O,Ribot EJ,Fricain JC,Devillard R,Miraux S

更新日期：2018-10-25 00:00:00

abstract：:Pochonia chlamydosporia infects eggs and females of economically important plant-parasitic nematodes. The fungal isolates parasitizing different nematodes are genetically distinct. To understand their intraspecific genetic differentiation, parasitic mechanisms, and adaptive evolution, we assembled seven putative chrom...

journal_title：Scientific reports

authors： Lin R,Qin F,Shen B,Shi Q,Liu C,Zhang X,Jiao Y,Lu J,Gao Y,Suarez-Fernandez M,Lopez-Moya F,Lopez-Llorca LV,Wang G,Mao Z,Ling J,Yang Y,Cheng X,Xie B

更新日期：2018-01-18 00:00:00

abstract：:Despite our increasing understanding of zebrafish heart development and regeneration, there is limited information about the distribution of endothelial cells (ECs) in the adult zebrafish heart. Here, we investigate and compare the distribution of cardiac ECs (cECs) in adult mouse and zebrafish ventricles. Surprisingl...

journal_title：Scientific reports

authors： Patra C,Kontarakis Z,Kaur H,Rayrikar A,Mukherjee D,Stainier DYR

更新日期：2017-06-02 00:00:00

abstract：:The morphological and topochemical changes in wood tissues in compression wood of Japanese cedar (Cryptomeria japonica) upon treated with two types of ionic liquids, 1-ethyl-3-methylimidazolium chloride ([C2mim][Cl]) and 1-ethylpyridinium bromide ([EtPy][Br]) were investigated. Compression wood tracheids were swollen ...

journal_title：Scientific reports

authors： Kanbayashi T,Miyafuji H

更新日期：2016-07-18 00:00:00

abstract：:Vapor-phase deposited polymer coatings are applied on thin indomethacin films to modify the drug release. Hydrogel-forming co-polymers of 2-hydroxyethyl methacrylate and ethylene glycol dimethacrylate were prepared directly on top of solution cast indomethacin thin films by initiated Chemical Vapor Deposition (iCVD). ...

journal_title：Scientific reports

authors： Christian P,Tumphart S,Ehmann HMA,Riegler H,Coclite AM,Werzer O

更新日期：2018-05-08 00:00:00

abstract：:Dietary niche width and trophic position are key functional traits describing a consumer's trophic ecology and the role it plays in a community. However, our understanding of the environmental and biological drivers of both traits is predominantly derived from theory or geographically restricted studies and lacks a br...

journal_title：Scientific reports

authors： Hayden B,Palomares MLD,Smith BE,Poelen JH

更新日期：2019-08-06 00:00:00

abstract：:Secondary bacterial infections increase morbidity and mortality of influenza A virus (IAV) infections. Bacteria are able to invade due to virus-induced depletion of alveolar macrophages (AMs), but this is not the only contributing factor. By analyzing a kinetic model, we uncovered a nonlinear initial dose threshold th...

journal_title：Scientific reports

authors： Smith AM,Smith AP

更新日期：2016-12-15 00:00:00

abstract：:Correlating data from different microscopy techniques holds the potential to discover new facets of signaling events in cellular biology. Here we report for the first time a hardware set-up capable of achieving simultaneous co-localized imaging of spatially correlated far-field super-resolution fluorescence microscopy...

journal_title：Scientific reports

authors： Gómez-Varela AI,Stamov DR,Miranda A,Alves R,Barata-Antunes C,Dambournet D,Drubin DG,Paiva S,De Beule PAA

更新日期：2020-01-24 00:00:00

abstract：:Papain-like cysteine proteases (PLCPs) are a class of proteolytic enzymes involved in many plant processes. Compared with the extensive research in Arabidopsis thaliana, little is known in castor bean (Ricinus communis) and physic nut (Jatropha curcas), two Euphorbiaceous plants without any recent whole-genome duplica...

journal_title：Scientific reports

authors： Zou Z,Huang Q,Xie G,Yang L

更新日期：2018-01-10 00:00:00

abstract：:Little is known about the composition and clinical implications of lung microbiome in patients with chronic obstructive pulmonary disease (COPD) and community-acquired pneumonia requiring invasive mechanical ventilation and intensive care unit admission. Therefore, this study aimed to explore the longitudinal changes ...

journal_title：Scientific reports

authors： Huang WC,Wu MF,Huang CC,Liu SY,Chen HC,Chen YY,Hsu JY,Huang CC

更新日期：2020-07-06 00:00:00

abstract：:The nanoscale molecular assembly of mammalian viruses during their infectious life cycle remains poorly understood. Their small dimensions, generally bellow the 300nm diffraction limit of light microscopes, has limited most imaging studies to electron microscopy. The recent development of super-resolution (SR) light m...

journal_title：Scientific reports

authors： Gray RD,Beerli C,Pereira PM,Scherer KM,Samolej J,Bleck CK,Mercer J,Henriques R

更新日期：2016-07-04 00:00:00

abstract：:Biosorption is a cost-effective and simple technique for removing heavy metals and rare earth elements from aqueous solution. Here, metals were recovered from aqueous solutions using phosphorylated dry baker's yeast cells. The cells were phosphorylated using cyclo-triphosphate, Na3P3O9. The total P content of the phos...

journal_title：Scientific reports

authors： Ojima Y,Kosako S,Kihara M,Miyoshi N,Igarashi K,Azuma M

更新日期：2019-01-18 00:00:00

abstract：:Radix Astragali is commonly used in traditional Chinese medicine, and its quality is closely related to ecological factors, such as climate and soil, in the production area. To provide high-quality Radix Astragali to Chinese and foreign markets, we used maximum entropy model and statistical analysis method, combined w...

journal_title：Scientific reports

authors： Yang M,Li Z,Liu L,Bo A,Zhang C,Li M

更新日期：2020-07-27 00:00:00

abstract：:Colorectal cancer (CRC) is a common complex disease caused by the combination of genetic variants and environmental factors. Genome-wide association studies (GWAS) have been performed and reported some novel CRC susceptibility variants. However, the potential genetic mechanisms for newly identified CRC susceptibility ...

journal_title：Scientific reports

authors： Lu X,Cao M,Han S,Yang Y,Zhou J

更新日期：2016-05-05 00:00:00

abstract：:Postsynaptic density protein-95 (PSD-95) is a major regulator in the maturation of excitatory synapses by interacting and trafficking N-methyl-D-aspartic acid receptors (NMDAR) and α-amino-3-hydroxy-5-methyl-4-isox-azoleproprionic acid receptors (AMPAR) to the postsynaptic membrane. PSD-95 disruption has recently been...

journal_title：Scientific reports

authors： Coley AA,Gao WJ

更新日期：2019-07-01 00:00:00