Abstract:
:Nasopharyngeal carcinoma (NPC) is a highly metastatic cancer that is consistently associated with Epstein-Barr virus (EBV) infection. In this study, we identify for the first time a role for monoamine oxidase A (MAOA) in NPC. MAOA is a mitochondrial enzyme that catalyzes oxidative deamination of neurotransmitters and dietary amines. Depending on the cancer type, MAOA can either have a tumour-promoting or tumour-suppressive role. We show that MAOA is down-regulated in primary NPC tissues and its down-regulation enhances the migration of NPC cells. In addition, we found that EBV infection can down-regulate MAOA expression in both pre-malignant and malignant nasopharyngeal epithelial (NPE) cells. We further demonstrate that MAOA is down-regulated as a result of IL-6/IL-6R/STAT3 signalling and epigenetic mechanisms, effects that might be attributed to EBV infection in NPE cells. Taken together, our data point to a central role for EBV in mediating the tumour suppressive effects of MAOA and that loss of MAOA could be an important step in the pathogenesis of NPC.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Lee HM,Sia APE,Li L,Sathasivam HP,Chan MSA,Rajadurai P,Tsang CM,Tsao SW,Murray PG,Tao Q,Paterson IC,Yap LFdoi
10.1038/s41598-020-63150-0subject
Has Abstractpub_date
2020-04-09 00:00:00pages
6115issue
1issn
2045-2322pii
10.1038/s41598-020-63150-0journal_volume
10pub_type
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