Overdrive pacing of spiral waves in a model of human ventricular tissue.

abstract：:Understanding the processes that shaped contemporary pathogen populations in agricultural landscapes is quite important to define appropriate management strategies and to support crop improvement efforts. Here, we took advantage of an historical record to examine the adaptation pathway of the rice pathogen Xanthomonas...

journal_title：Scientific reports

authors： Quibod IL,Perez-Quintero A,Booher NJ,Dossa GS,Grande G,Szurek B,Vera Cruz C,Bogdanove AJ,Oliva R

更新日期：2016-09-26 00:00:00

abstract：:Sesquiterpene lactones (STL) are a subclass of isoprenoids with many known bioactivities frequently found in the Asteraceae family. In recent years, remarkable progress has been made regarding the biochemistry of STL, and today the biosynthetic pathway of the core backbones of many STLs has been elucidated. Consequent...

journal_title：Scientific reports

authors： Frey M,Klaiber I,Conrad J,Bersch A,Pateraki I,Ro DK,Spring O

更新日期：2019-10-04 00:00:00

abstract：:Entamoeba possesses a highly divergent mitochondrion-related organelle known as the mitosome. Here, we report the discovery of a novel protein in Entamoeba, which we name Mitosomal β-barrel Outer Membrane Protein of 30 kDa (MBOMP30). Initially identified through in silico analysis, we experimentally confirmed that MBO...

journal_title：Scientific reports

authors： Santos HJ,Imai K,Makiuchi T,Tomii K,Horton P,Nozawa A,Ibrahim M,Tozawa Y,Nozaki T

更新日期：2015-02-25 00:00:00

abstract：:The Gram-negative bacterium Pseudomonas aeruginosa represents a prototype of multi-drug resistant opportunistic pathogens for which novel therapeutic options are urgently required. In order to identify new candidates as potential drug targets, we combined large-scale transposon mutagenesis data analysis and bioinforma...

journal_title：Scientific reports

authors： Fernández-Piñar R,Lo Sciuto A,Rossi A,Ranucci S,Bragonzi A,Imperi F

更新日期：2015-12-01 00:00:00

abstract：:G-proteins are implicated in plant productivity, but their genome-wide roles in regulating agronomically important traits remain uncharacterized. Transcriptomic analyses of rice G-protein alpha subunit mutant (rga1) revealed 2270 differentially expressed genes (DEGs) including those involved in C/N and lipid metabolis...

journal_title：Scientific reports

authors： Pathak RR,Mandal VK,Jangam AP,Sharma N,Madan B,Jaiswal DK,Raghuram N

更新日期：2021-01-27 00:00:00

abstract：:Computational determination of peptide conformations is challenging as it is a problem of finding minima in a high-dimensional space. The "divide and conquer" approach is promising for reliably reducing the search space size. A random forest learning model is proposed here to expand the scope of applicability of the "...

journal_title：Scientific reports

authors： Chen X,Yang B,Lin Z

更新日期：2018-06-11 00:00:00

abstract：:Type 2 diabetes mellitus (T2DM) is a low-grade chronic inflammatory diseases, which have been implicated in the pathogenesis of cognitive decline. We aim to evaluate associations between inflammatory markers and the risk of mild cognitive impairment (MCI) in T2DM. This study of 140 diabetic patients involved 71 with M...

journal_title：Scientific reports

authors： Cai R,Huang R,Han J,Sun H,Sun J,Xia W,Tian S,Dong X,Shen Y,Wang S

更新日期：2017-09-26 00:00:00

abstract：:Perovskite LaFeO3/montmorillonite nanocomposites (LaFeO3/MMT) have been successfully prepared via assembling LaFeO3 nanoparticles on the surface of montmorillonite with citric acid assisted sol-gel method. The results indicated that the uniform LaFeO3 nanoparticles were densely deposited onto the surface of montmorill...

journal_title：Scientific reports

authors： Peng K,Fu L,Yang H,Ouyang J

更新日期：2016-01-18 00:00:00

abstract：:The determinants of Xpert MTB/RIF sensitivity, a widely used PCR test for the diagnosis of tuberculosis (TB) are poorly understood. We compared culture time-to-positivity (TTP; a surrogate of bacterial load), MTB/RIF TB-specific and internal positive control (IPC)-specific C(T) values, and clinical characteristics in ...

journal_title：Scientific reports

authors： Theron G,Peter J,Calligaro G,Meldau R,Hanrahan C,Khalfey H,Matinyenya B,Muchinga T,Smith L,Pandie S,Lenders L,Patel V,Mayosi BM,Dheda K

更新日期：2014-07-11 00:00:00

abstract：:HIV-1 Tat plays an important role in HIV-associated neurocognitive disorders (HAND) by disrupting neurotransmission including dopamine uptake by human dopamine transporter (hDAT). Previous studies have demonstrated that HIV-1 Tat directly binds to hDAT and some amino-acid mutations that attenuate the hDAT-Tat binding ...

journal_title：Scientific reports

authors： Yuan Y,Quizon PM,Sun WL,Yao J,Zhu J,Zhan CG

更新日期：2016-06-02 00:00:00

abstract：:Although recovery following a stroke is limited, undamaged neurons under the right conditions can establish new connections and take on-board lost functions. Sonic hedgehog (Shh) signaling is integral for developmental axon growth, but its role after injury has not been fully examined. To investigate the effects of Sh...

journal_title：Scientific reports

authors： Berretta A,Gowing EK,Jasoni CL,Clarkson AN

更新日期：2016-02-23 00:00:00

abstract：:The Anfinsen hypothesis, the demonstration of which led to the Nobel prize in Chemistry, posits that all information required to determine a proteins' three dimensional structure is contained within its amino acid sequence. This suggests that it should be possible, in theory, to fold any protein in vitro. In practice,...

journal_title：Scientific reports

authors： Biter AB,de la Peña AH,Thapar R,Lin JZ,Phillips KJ

更新日期：2016-01-19 00:00:00

abstract：:Spatially explicit information on electric power consumption (EPC) is crucial for effective electricity allocation and utilization. Many studies have estimated fine-scale spatial EPC based on remotely sensed nighttime light (NTL). However, the spatial non-stationary relationship between EPC and NTL at prefectural leve...

journal_title：Scientific reports

authors： Chen M,Cai H,Yang X,Jin C

更新日期：2020-10-29 00:00:00

abstract：:Friction stir processing (FSP) was used to achieve grain refinement on Mg-Al-Zn alloys, which also brought in significant texture modification. The different micro-texture characteristics were found to cause irregular micro-hardness distribution in FSPed region. The effects of texture and grain size were investigated ...

journal_title：Scientific reports

authors： Peng J,Zhang Z,Liu Z,Li Y,Guo P,Zhou W,Wu Y

更新日期：2018-03-08 00:00:00

abstract：:Repetitive transcranial magnetic stimulation (rTMS) has been proposed as a tinnitus treatment option. Promising results have been obtained by consecutive stimulation of lateral frontal and auditory brain regions. We investigated a combined stimulation paradigm targeting the anterior cingulate cortex (ACC) with double ...

journal_title：Scientific reports

authors： Kreuzer PM,Lehner A,Schlee W,Vielsmeier V,Schecklmann M,Poeppl TB,Landgrebe M,Rupprecht R,Langguth B

更新日期：2015-12-15 00:00:00

abstract：:Nano-sized hydroxyapatite (n-HA) is considered as a bio-active material, which is often mixed into bone implant material, polyetheretherketone (PEEK). To reveal the global protein expression modulations of osteoblast in response to direct contact with the PEEK composite containing high level (40%) nano-sized hydroxyap...

journal_title：Scientific reports

authors： Zhao M,Li H,Liu X,Wei J,Ji J,Yang S,Hu Z,Wei S

更新日期：2016-03-09 00:00:00

abstract：:Mal11 catalyzes proton-coupled maltose transport across the plasma membrane of Saccharomyces cerevisiae. We used structure-based design of mutants and a kinetic analysis of maltose transport to determine the energy coupling mechanism of transport. We find that wildtype Mal11 is extremely well coupled and allows yeast ...

journal_title：Scientific reports

authors： Henderson R,Poolman B

更新日期：2017-10-30 00:00:00

abstract：:In some fibroblasts, casein kinase 1α (CK1α) is localized to nuclear speckles, which are sub-nuclear compartments supplying splicing factors, whereas it is recruited on keratin filaments in colorectal cancer cells such as DLD1 cells. In order to obtain a deeper understanding of why CK1α is localized to these different...

journal_title：Scientific reports

authors： Kuga T,Kume H,Adachi J,Kawasaki N,Shimizu M,Hoshino I,Matsubara H,Saito Y,Nakayama Y,Tomonaga T

更新日期：2016-09-29 00:00:00

abstract：:Umami taste perception indicates the presence of amino acids, which are essential nutrients. Although the physiology of umami perception has been described in mammals, how insects detect amino acids remains unknown except in Drosophila melanogaster. We functionally characterized a gustatory receptor responding to L-am...

journal_title：Scientific reports

authors： Lim S,Jung J,Yunusbaev U,Ilyasov R,Kwon HW

更新日期：2019-08-12 00:00:00

abstract：:Wurtzite solid solutions between GaN and ZnO highlight an intriguing paradigm for water splitting into hydrogen and oxygen using solar energy. However, large composition discrepancy often occurs inside the compound owing to the volatile nature of Zn, thereby prescribing rigorous terms on synthetic conditions. Here we ...

journal_title：Scientific reports

authors： Xie Y,Wu F,Sun X,Chen H,Lv M,Ni S,Liu G,Xu X

更新日期：2016-01-12 00:00:00

abstract：:Alzheimer's disease (AD) is characterized by excessive production and deposition of amyloid-beta (Aβ) proteins as well as synapse dysfunction and loss. While soluble Aβ oligomers (AβOs) have deleterious effects on synapse function and reduce synapse number, the underlying molecular mechanisms are not well understood. ...

journal_title：Scientific reports

authors： Naito Y,Tanabe Y,Lee AK,Hamel E,Takahashi H

更新日期：2017-02-13 00:00:00

abstract：:ZnO/SiC heterojunctions show great potential for various optoelectronic applications (e.g., ultraviolet light emitting diodes, photodetectors, and solar cells). However, the lack of a detailed understanding of the ZnO/SiC interface prevents an efficient and rapid optimization of these devices. Here, intrinsic (but inh...

journal_title：Scientific reports

authors： Zhang Y,Lin N,Li Y,Wang X,Wang H,Kang J,Wilks R,Bär M,Mu R

更新日期：2016-03-15 00:00:00

abstract：:Various techniques are commonly used to produce nano-crystalline NiAl2O4 materials; however, their practical applications in the microwave region remain very limited. In this work, flexible substrates for metamaterials containing two different concentrations of NiAl2O4 (labelled Ni36 and Ni42) have been synthesised us...

journal_title：Scientific reports

authors： Rahman MA,Ahamed E,Faruque MRI,Islam MT

更新日期：2018-10-08 00:00:00

abstract：:Protein aggregation is a common biological phenomenon, observed in different physiological and pathological conditions. Decreased protein solubility and a tendency to aggregate is also observed during physiological aging but the causes are currently unknown. Herein we performed a biophysical separation of aging-relate...

journal_title：Scientific reports

authors： Tanase M,Urbanska AM,Zolla V,Clement CC,Huang L,Morozova K,Follo C,Goldberg M,Roda B,Reschiglian P,Santambrogio L

更新日期：2016-01-18 00:00:00

abstract：:Various neurophysiological and cognitive functions are based on transferring information between spiking neurons via a complex system of synaptic connections. In particular, the capacity of presynaptic inputs to influence the postsynaptic outputs-the efficacy of the synapses-plays a principal role in all aspects of hi...

journal_title：Scientific reports

authors： Dabaghian Y

更新日期：2019-01-24 00:00:00

abstract：:The existing acoustic emission (AE) source location methods assume that acoustic waves propagate along straight lines, and the source location is determined by average wave velocity. Because of the heterogeneity of materials, location results often fail to meet the accuracy requirement. For this reason, an AE source l...

journal_title：Scientific reports

authors： Zhou ZL,Zhou J,Dong LJ,Cai X,Rui YC,Ke CT

更新日期：2017-08-07 00:00:00

abstract：:Dynamical polarization of nuclear spin ensembles is of central importance for magnetic resonance studies, precision sensing and for applications in quantum information theory. Here we propose a scheme to generate long-lived singlet pairs in an unpolarized nuclear spin ensemble which is dipolar coupled to the electron ...

journal_title：Scientific reports

authors： Greiner JN,Dasari DBR,Wrachtrup J

更新日期：2017-04-03 00:00:00

abstract：:Although guidelines recommend BRCA testing for all women with non-mucinous epithelial ovarian cancer, there is significant variability in access to testing across the UK. A germline BRCA mutation (BRCAm) in ovarian cancer patients provides prognostic and predictive information and influences clinical management, such ...

journal_title：Scientific reports

authors： Rumford M,Lythgoe M,McNeish I,Gabra H,Tookman L,Rahman N,George A,Krell J

更新日期：2020-02-25 00:00:00

abstract：:Heterostructures based on two-dimensional (2D) materials have sparked wide interests in both fundamental physics and applied devices. Recently, Dirac/Weyl semimetals are emerging as capable functional materials for optoelectronic devices. However, thus far the interfacial coupling of an all-semimetal 2D heterostructur...

journal_title：Scientific reports

authors： Liu Y,Liu C,Wang X,He L,Wan X,Xu Y,Shi Y,Zhang R,Wang F

更新日期：2018-08-27 00:00:00

abstract：:Schizophrenia is one of the most prevalent psychiatric disorders with complex genetic etiology. Accumulating evidence suggests that energy metabolism and oxidative stress play important roles in the pathophysiology of schizophrenia. Dysfunction of mitochondrial respiratory chain and altered expression of complex I sub...

journal_title：Scientific reports

authors： Li X,Zhang W,Tang J,Tan L,Luo XJ,Chen X,Yao YG

更新日期：2015-06-08 00:00:00