Relationship between Diabetic Retinopathy and Subclinical Hypothyroidism: a meta-analysis.

abstract：:Lattice dynamics and elasticity for the high-temperature ε phase (body-centered cubic; bcc) of plutonium is predicted utilizing first-principles electronic structure coupled with a self-consistent phonon method that takes phonon-phonon interaction and strong anharmonicity into account. These predictions establish the ...

journal_title：Scientific reports

authors： Söderlind P

更新日期：2017-04-25 00:00:00

abstract：:Diminished microRNA-29b levels have recently been revealed to provoke increased expression and accumulation of extracellular matrix molecules, such as collagens in fibrotic remodeling. Subsequently, the aim of this study was to find out whether microRNA-29b might also regulate human xylosyltransferase (XT)-I expressio...

journal_title：Scientific reports

authors： Riedel L,Fischer B,Ly TD,Hendig D,Kuhn J,Knabbe C,Faust I

更新日期：2018-12-12 00:00:00

abstract：:Although attempts have been made to reveal the relationships between bacteria and human health, little is known about the species and function of the microbial community associated with oral diseases. In this study, we report the sequencing of 16 metagenomic samples collected from dental swabs and plaques representing...

journal_title：Scientific reports

authors： Wang J,Qi J,Zhao H,He S,Zhang Y,Wei S,Zhao F

更新日期：2013-01-01 00:00:00

abstract：:Alterations in the composition of commensal bacterial populations, a phenomenon known as dysbiosis, are linked to multiple gastrointestinal disorders, such as inflammatory bowel disease and irritable bowel syndrome, or to infections by diverse enteric pathogens. Blastocystis is one of the most common single-celled euk...

journal_title：Scientific reports

authors： Audebert C,Even G,Cian A,Blastocystis Investigation Group.,Loywick A,Merlin S,Viscogliosi E,Chabé M

更新日期：2016-05-05 00:00:00

abstract：:Some styrene/maleic acid (SMA) copolymers solubilise membrane lipids and proteins to form polymer-bounded nanodiscs termed SMA/lipid particles (SMALPs). Although SMALPs preserve a lipid-bilayer core, they appear to be more dynamic than other membrane mimics. We used time-resolved Förster resonance energy transfer and ...

journal_title：Scientific reports

authors： Cuevas Arenas R,Danielczak B,Martel A,Porcar L,Breyton C,Ebel C,Keller S

更新日期：2017-04-05 00:00:00

abstract：:Present study focuses on rainfall over Western Ghats (WG), a complex topographic region (elevation > 500 m) of India to evaluate and to better understand the satellite behavior in contrast with a flat region (FR) (elevation < 500 m) of central India from 1998 to 2016 using the combinatory data sets of TMPA and IMERG (...

journal_title：Scientific reports

authors： Thakur MK,Kumar TVL,Koteswara Rao K,Barbosa H,Rao VB

更新日期：2019-10-30 00:00:00

abstract：:While there is a rich literature on transcription dynamics during the development of many organisms, protein data is limited. We used iTRAQ isotopic labeling and mass spectrometry to generate the largest developmental proteomic dataset for any animal. Expression dynamics of nearly 4,000 proteins of Xenopus laevis was ...

journal_title：Scientific reports

authors： Sun L,Bertke MM,Champion MM,Zhu G,Huber PW,Dovichi NJ

更新日期：2014-03-14 00:00:00

abstract：:Functionalization of monoclonal antibodies (mAbs) requires chemical derivatization and/or genetic manipulation. Inherent in these methods are challenges with protein heterogeneity, stability and solubility. Such perturbations could potentially be avoided by using a high affinity, non-covalent intermediate to bridge th...

journal_title：Scientific reports

authors： Avery KN,Zer C,Bzymek KP,Williams JC

更新日期：2015-01-15 00:00:00

abstract：:Congenital glaucoma (CG) is a heterogeneous, inherited and severe optical neuropathy that originates from maldevelopment of the anterior segment of the eye. To identify new disease genes, we performed whole-exome sequencing of 26 unrelated CG patients. In one patient we identified two rare, recessive and hypermorphic ...

journal_title：Scientific reports

authors： Ferre-Fernández JJ,Aroca-Aguilar JD,Medina-Trillo C,Bonet-Fernández JM,Méndez-Hernández CD,Morales-Fernández L,Corton M,Cabañero-Valera MJ,Gut M,Tonda R,Ayuso C,Coca-Prados M,García-Feijoo J,Escribano J

更新日期：2017-04-11 00:00:00

abstract：:Cytolytic score (CYT), calculated from mRNA expression levels of granzyme and perforin, positively correlates with CD8+ T cell infiltration/activity in a variety of cancers. Unlike other cancers, higher CYT has been associated with worse prognosis in glioblastoma (GBM). To address this discrepancy, we sought to invest...

journal_title：Scientific reports

authors： Haddad AF,Chen JS,Oh T,Pereira MP,Joshi RS,Aghi MK

更新日期：2020-10-16 00:00:00

abstract：:The FGFR4-388Arg variant has been related to poor prognosis in several types of cancer, including lung cancer. The mechanism underlying this association has not been addressed in detail in patients with this pathology. Here, we report that this FGFR4 variant induces MAPK and STAT3 activation and causes pro-oncogenic e...

journal_title：Scientific reports

authors： Quintanal-Villalonga Á,Ojeda-Márquez L,Marrugal Á,Yagüe P,Ponce-Aix S,Salinas A,Carnero A,Ferrer I,Molina-Pinelo S,Paz-Ares L

更新日期：2018-02-05 00:00:00

abstract：:Most gliomas are invasive tumors formed from glial cells and associated with high mortality rates. In this study, we characterized four glioma cell lines of varying degree of aggressiveness (H4, SW1088, A172 and U87-MG) in terms of morphology, cytoskeleton organization and stiffness, and evaluated their invasive poten...

journal_title：Scientific reports

authors： Louca M,Stylianou A,Minia A,Pliaka V,Alexopoulos LG,Gkretsi V,Stylianopoulos T

更新日期：2019-05-23 00:00:00

abstract：:Motility dysfunction is present not only during bowel obstruction (BO), but after obstruction is resolved. Previous studies found that lumen distension associated mechano-transcription of COX-2 and production of PGE2 in gut smooth muscle cells (SMC) account for motility dysfunction during obstruction. We hypothesized ...

journal_title：Scientific reports

authors： Lin YM,Fu Y,Hegde S,Tang Y,Radhakrishnan R,Shi XZ

更新日期：2018-06-11 00:00:00

abstract：:Toward the increasing demands of portable energy storage and electric vehicle applications, the widely used graphite anodes with significant drawbacks become more and more unsuitable. Herein, we report a novel scaffold of hierarchical silicon nanowires-carbon textiles anodes fabricated via a facile method. Further, co...

journal_title：Scientific reports

authors： Liu B,Wang X,Chen H,Wang Z,Chen D,Cheng YB,Zhou C,Shen G

更新日期：2013-01-01 00:00:00

abstract：:The presence of hepatic steatosis (HS) is an important histological feature in a variety of liver disease. It is critical to assess HS accurately, particularly where it plays an integral part in defining the disease. Conventional methods of quantifying HS remain semi-quantitative, with potential limitations in precisi...

journal_title：Scientific reports

authors： Goh GB,Leow WQ,Liang S,Wan WK,Lim TKH,Tan CK,Chang PE

更新日期：2019-02-27 00:00:00

abstract：:The use of impedance-based label free cell analysis is increasingly popular and has many different applications. Here, we report that a real-time cell analyzer (RTCA) can be used to study the stimulation of Natural Killer (NK) cells. Engagement of NK cells via plate-bound antibodies directed against different activati...

journal_title：Scientific reports

authors： Fasbender F,Watzl C

更新日期：2018-03-21 00:00:00

abstract：:Pulmonary fibrosis is a serious lung disorder that can lead to respiratory failure. Here we show that transgenic mice expressing active renin from the liver (RenTgMK) developed progressive pulmonary fibrosis leading to impaired pulmonary function. Histological analyses revealed a marked increase in extracellular matri...

journal_title：Scientific reports

authors： Wang J,Chen L,Chen B,Meliton A,Liu SQ,Shi Y,Liu T,Deb DK,Solway J,Li YC

更新日期：2015-10-23 00:00:00

abstract：:Transforming growth factor-β/Smad3 signaling plays a critical role in the process of chronic kidney disease (CKD), but targeting Smad3 systematically may cause autoimmune disease by impairing immunity. In this study, we used whole-transcriptome RNA-sequencing to identify the differential gene expression profile, gene ...

journal_title：Scientific reports

authors： Zhou Q,Xiong Y,Huang XR,Tang P,Yu X,Lan HY

更新日期：2015-12-09 00:00:00

abstract：:Highly invasive animal based test procedures for risk assessment such as the Draize eye test are under increasing criticism due to poor transferability for the human organism and animal-welfare concerns. However, besides all efforts, the Draize eye test is still not completely replaced by alternative animal-free metho...

journal_title：Scientific reports

authors： Lotz C,Kiesewetter L,Schmid FF,Hansmann J,Walles H,Groeber-Becker F

更新日期：2018-10-09 00:00:00

abstract：:Large consortia efforts and genome-wide association studies (GWASs) have linked a number of genetic variants within the 6p21 chromosomal region to non-Hodgkin lymphoma (NHL). Complementing these efforts, we genotyped previously reported SNPs in the human leukocyte antigen (HLA) class I (rs6457327) and class II (rs9271...

journal_title：Scientific reports

authors： Ten LC,Chin YM,Tai MC,Chin EF,Lim YY,Suthandiram S,Chang KM,Ong TC,Bee PC,Mohamed Z,Gan GG,Ng CC

更新日期：2017-01-31 00:00:00

abstract：:Peripheral blood indices of systemic inflammation such as the neutrophil-lymphocyte ratio (NLR) have been shown to be prognostic in various cancers. We aim to investigate the clinical significance of these indices in patients with soft tissue sarcoma (STS). Seven hundred and twelve patients with available blood counts...

journal_title：Scientific reports

authors： Chan JY,Zhang Z,Chew W,Tan GF,Lim CL,Zhou L,Goh WL,Poon E,Somasundaram N,Selvarajan S,Sittampalam K,Chin F,Teh J,Tan MH,Soo KC,Teo M,Farid M,Quek R

更新日期：2018-08-10 00:00:00

abstract：:The precision and accuracy of quantifying semi-volatile organic compounds (SVOCs) in solution by GC/MS, particularly when volume errors are unpredictable or difficult to control, are improved by utilizing internal standards (IS). Not obvious though is the extent to which timing IS addition affects measurement. To illu...

journal_title：Scientific reports

authors： Otim O,Rocha J Jr

更新日期：2020-10-19 00:00:00

abstract：:Bone homeostasis is maintained by the balance of osteoblasts (OBs) and osteoclasts (OCs). Increased activity of OCs not only contributes to pathological bone resorption, such as osteoporosis and periodontitis, but also is responsible for physiological conditions like orthodontic tooth movement (OTM). However, the deta...

journal_title：Scientific reports

authors： Guo T,Zhang L,Konermann A,Zhou H,Jin F,Liu W

更新日期：2015-01-26 00:00:00

abstract：:Jagged1 activates Notch signaling and subsequently promotes osteogenic differentiation in human periodontal ligament cells (hPDLs). The present study investigated the participation of the Notch receptor, NOTCH2, in the Jagged1-induced osteogenic differentiation in hPDLs. NOTCH2 and NOTCH4 mRNA expression levels increa...

journal_title：Scientific reports

authors： Manokawinchoke J,Sumrejkanchanakij P,Boonprakong L,Pavasant P,Egusa H,Osathanon T

更新日期：2020-08-07 00:00:00

abstract：:Environmental pollutants as non-heritable factors are now recognized as triggers for multiple human inflammatory diseases involving T cells. We postulated that lipid antigen presentation mediated by cluster of differentiation 1 (CD1) proteins for T cell activation is susceptible to lipophilic environmental pollutants....

journal_title：Scientific reports

authors： Sharma M,Zhang X,Zhang S,Niu L,Ho SM,Chen A,Huang S

更新日期：2017-05-18 00:00:00

abstract：:Although the anxiolytic-like effects of Xiaoyaosan, a Chinese herbal formula, have been described in many previous studies, its underlying mechanism remains undefined. The cytokine tumour necrosis factor-α (TNF-α) and its closely associated janus kinase 2 (JAK2)-signal transducer and activator of transcription (STAT3)...

journal_title：Scientific reports

authors： Li XJ,Ma QY,Jiang YM,Bai XH,Yan ZY,Liu Q,Pan QX,Liu YY,Chen JX

更新日期：2017-03-23 00:00:00

abstract：:Drug delivery by micro- and nano-carriers enables controlled transport of pharmaceuticals to targeted sites. Even though carrier fabrication has made much progress recently, the delivery including controlled particle distribution and adhesion within the body remains a great challenge. The adhesion of carriers is stron...

journal_title：Scientific reports

authors： Müller K,Fedosov DA,Gompper G

更新日期：2014-05-02 00:00:00

abstract：:The family Trichomycteridae is one of the most diverse groups of freshwater catfishes in South and Central America with eight subfamilies, 41 genera and more than 300 valid species. Its members are widely distributed throughout South America, reaching Costa Rica in Central America and are recognized by extraordinary a...

journal_title：Scientific reports

authors： Ochoa LE,Datovo A,DoNascimiento C,Roxo FF,Sabaj MH,Chang J,Melo BF,Silva GSC,Foresti F,Alfaro M,Oliveira C

更新日期：2020-02-14 00:00:00

abstract：:The organismic unit of heterocyst-forming cyanobacteria is a filament of communicating cells connected by septal junctions, proteinaceous structures bridging the cytoplasms of contiguous cells. This distinct bacterial organization is preserved during cell division. In Anabaena, deletion of the zipN gene could not be s...

journal_title：Scientific reports

authors： Camargo S,Picossi S,Corrales-Guerrero L,Valladares A,Arévalo S,Herrero A

更新日期：2019-02-26 00:00:00

abstract：:Low phase noise mode-locked fiber laser finds important applications in telecommunication, ultrafast sciences, material science, and biology, etc. In this paper, two types of carbon nano-materials, i.e. single-wall carbon nanotube (SWNT) and graphene oxide (GO), are investigated as efficient saturable absorbers (SAs) ...

journal_title：Scientific reports

authors： Li X,Wu K,Sun Z,Meng B,Wang Y,Wang Y,Yu X,Yu X,Zhang Y,Shum PP,Wang QJ

更新日期：2016-04-29 00:00:00