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The FGFR4-388arg Variant Promotes Lung Cancer Progression by N-Cadherin Induction.

Abstract：

:The FGFR4-388Arg variant has been related to poor prognosis in several types of cancer, including lung cancer. The mechanism underlying this association has not been addressed in detail in patients with this pathology. Here, we report that this FGFR4 variant induces MAPK and STAT3 activation and causes pro-oncogenic effects in NSCLC in vitro and in vivo. This variant induces the expression of EMT-related genes, such as N-cadherin, vimentin, Snail1 and Twist1. Indeed, the induction of N-cadherin protein expression by this variant is essential for its pro-tumorigenic role. The presence of the FGFR4-388Arg variant correlates with higher N-cadherin expression levels in clinical NSCLC samples and with poorer outcome in patients with FGFR expression. These results support the prognostic role of this FGFR variant in lung cancer and show that these effects may be mediated by the induction of N-cadherin expression and an EMT phenotype.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Quintanal-Villalonga Á,Ojeda-Márquez L,Marrugal Á,Yagüe P,Ponce-Aix S,Salinas A,Carnero A,Ferrer I,Molina-Pinelo S,Paz-Ares L

doi

10.1038/s41598-018-20570-3

subject

Has Abstract

pub_date

2018-02-05 00:00:00

pages

2394

issue

1

issn

2045-2322

pii

10.1038/s41598-018-20570-3

journal_volume

8

pub_type

杂志文章

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