Identification of Genes Associated with Smad3-dependent Renal Injury by RNA-seq-based Transcriptome Analysis.

abstract：:In 2018, the World Health Organization identified the Zika virus (ZIKV) as a pathogen that should be prioritized for public health research due to its epidemic potential. In this study, whole-genome sequencing (WGS) of travel-acquired ZIKV infections was used to examine the limitations of phylogenetic analysis. WGS an...

journal_title：Scientific reports

authors： Kamelian K,Montoya V,Olmstead A,Dong W,Harrigan R,Morshed M,Joy JB

更新日期：2019-11-11 00:00:00

abstract：:Successful tissue repair requires the activities of myeloid cells such as monocytes and macrophages that guide the progression of inflammation and healing outcome. Immunoregenerative materials leverage the function of endogenous immune cells to orchestrate complex mechanisms of repair; however, a deeper understanding ...

journal_title：Scientific reports

authors： Olingy CE,San Emeterio CL,Ogle ME,Krieger JR,Bruce AC,Pfau DD,Jordan BT,Peirce SM,Botchwey EA

更新日期：2017-03-27 00:00:00

abstract：:Fibrin polymerization is a necessary part of hemostasis but clots can obstruct blood vessels and cause heart attacks and strokes. The polymerization reactions are specific and controlled, involving strong knob-into-hole interactions to convert soluble fibrinogen into insoluble fibrin. It has long been assumed that clo...

journal_title：Scientific reports

authors： Chernysh IN,Nagaswami C,Purohit PK,Weisel JW

更新日期：2012-01-01 00:00:00

abstract：:Theoretical and experimental work has demonstrated that excitatory (E) and inhibitory (I) currents within cortical circuits stabilize to a balanced state. This E/I balance, observed from single neuron to network levels, has a fundamental role in proper brain function and its impairment has been linked to numerous brai...

journal_title：Scientific reports

authors： Shen K,Zeppillo T,Limon A

更新日期：2020-07-09 00:00:00

abstract：:The jerantinine family of Aspidosperma indole alkaloids from Tabernaemontana corymbosa are potent microtubule-targeting agents with broad spectrum anticancer activity. The natural supply of these precious metabolites has been significantly disrupted due to the inclusion of T. corymbosa on the endangered list of threat...

journal_title：Scientific reports

authors： Smedley CJ,Stanley PA,Qazzaz ME,Prota AE,Olieric N,Collins H,Eastman H,Barrow AS,Lim KH,Kam TS,Smith BJ,Duivenvoorden HM,Parker BS,Bradshaw TD,Steinmetz MO,Moses JE

更新日期：2018-07-13 00:00:00

abstract：:We utilized several computational approaches to evaluate the binding energies of tyrosine (Tyr) and several unnatural Tyr analogs, to several orthogonal aaRSes derived from Methanocaldococcus jannaschii and Escherichia coli tyrosyl-tRNA synthetases. The present study reveals the following: (1) AutoDock Vina and ROSETT...

journal_title：Scientific reports

authors： Ren W,Truong TM,Ai HW

更新日期：2015-07-29 00:00:00

abstract：:GabR from Bacillus subtilis is a transcriptional regulator of the MocR subfamily of GntR regulators. The MocR architecture is characterized by the presence of an N-terminal winged-Helix-Turn-Helix domain and a C-terminal domain folded as the pyridoxal 5'-phosphate (PLP) dependent aspartate aminotransferase (AAT). The ...

journal_title：Scientific reports

authors： Frezzini M,Guidoni L,Pascarella S

更新日期：2019-12-17 00:00:00

abstract：:Photoreceptor function is impaired in many retinal diseases like age-related macular degeneration. Currently, assessment of the photoreceptor function for the early diagnosis and monitoring of these diseases is either subjective, as in visual field testing, requires contact with the eye, like in electroretinography, o...

journal_title：Scientific reports

authors： Messner A,Werkmeister RM,Seidel G,Stegmann H,Schmetterer L,Aranha Dos Santos V

更新日期：2019-09-20 00:00:00

abstract：:We aimed to model longitudinal data to create predictive growth charts for weight in preterm infants from birth till discharge, that took into account the differing growth rates post-birth when compared to in-utero growth and therefore was more representative of the data than the UK1990 reference charts. Data from bir...

journal_title：Scientific reports

authors： Watkins WJ,Farewell D,Banerjee S,Nasef H,James A,Chakraborty M

更新日期：2020-03-04 00:00:00

abstract：:The critical role of the regulatory elements at the 5' end of the HIV-1 genome in controlling the life cycle of HIV-1 indicates that this region significantly influences virus fitness and its biological properties. In this study, we performed a detailed characterization of strain-specific variability of sequences from...

journal_title：Scientific reports

authors： Mbondji-Wonje C,Dong M,Zhao J,Wang X,Nanfack A,Ragupathy V,Sanchez AM,Denny TN,Hewlett I

更新日期：2020-08-06 00:00:00

abstract：:In this work, we analysed processive sliding and breakage of actin filaments at various heavy meromyosin (HMM) densities and ATP concentrations in IVMA. We observed that with addition of ATP solution, the actin filaments fragmented stochastically; we then determined mean length and velocity of surviving actin filament...

journal_title：Scientific reports

authors： Rastogi K,Puliyakodan MS,Pandey V,Nath S,Elangovan R

更新日期：2016-08-24 00:00:00

abstract：:Infection can dramatically alter behavioural and physiological traits as hosts become sick and subsequently return to health. Such "sickness behaviours" include disrupted circadian rhythms in both locomotor activity and body temperature. Host sickness behaviours vary in pathogen species-specific manners but the influe...

journal_title：Scientific reports

authors： Prior KF,O'Donnell AJ,Rund SSC,Savill NJ,van der Veen DR,Reece SE

更新日期：2019-07-29 00:00:00

abstract：:Disordered proteins are highly prevalent in biological systems, they control myriad signaling and regulatory processes, and their levels and/or cellular localization are often altered in human disease. In contrast to folded proteins, disordered proteins, due to conformational heterogeneity and dynamics, are not consid...

journal_title：Scientific reports

authors： Iconaru LI,Ban D,Bharatham K,Ramanathan A,Zhang W,Shelat AA,Zuo J,Kriwacki RW

更新日期：2015-10-28 00:00:00

abstract：:Bone morphogenetic proteins (BMPs) regulate hard tissue formation, including bone and tooth. Growth differentiation factor 5 (GDF5), a known BMP, is expressed in cartilage and regulates chondrogenesis, and mutations have been shown to cause osteoarthritis. Notably, GDF5 is also expressed in periodontal ligament tissue...

journal_title：Scientific reports

authors： Liu J,Saito K,Maruya Y,Nakamura T,Yamada A,Fukumoto E,Ishikawa M,Iwamoto T,Miyazaki K,Yoshizaki K,Ge L,Fukumoto S

更新日期：2016-03-31 00:00:00

abstract：:Acid-base homeostasis is critical for normal growth, development, and hearing function. The sodium-hydrogen exchanger 6 (NHE6), a protein mainly expressed in early and recycling endosomes, plays an important role in regulating organellar pH. Mutations in NHE6 cause complex, slowly progressive neurodegeneration. Little...

journal_title：Scientific reports

authors： Kucharava K,Brand Y,Albano G,Sekulic-Jablanovic M,Glutz A,Xian X,Herz J,Bodmer D,Fuster DG,Petkovic V

更新日期：2020-02-27 00:00:00

abstract：:All-inorganic visibly-transparent energy-harvesting clear laminated glass windows are the most practical solution to boosting building-integrated photovoltaics (BIPV) energy outputs significantly while reducing cooling- and heating-related energy consumption in buildings. By incorporating luminophore materials into la...

journal_title：Scientific reports

authors： Alghamedi R,Vasiliev M,Nur-E-Alam M,Alameh K

更新日期：2014-10-16 00:00:00

abstract：:Inconsistent findings have reported on the inflammatory potential of diet and cardiovascular disease (CVD) and mortality risk. The aim of this meta-analysis was to investigate the association between the inflammatory potential of diet as estimated by the dietary inflammatory index (DII) score and CVD or mortality risk...

journal_title：Scientific reports

authors： Zhong X,Guo L,Zhang L,Li Y,He R,Cheng G

更新日期：2017-07-25 00:00:00

abstract：:Herein, we propose an advanced energy-storage system: all-graphene-battery. It operates based on fast surface-reactions in both electrodes, thus delivering a remarkably high power density of 6,450 W kg(-1)(total electrode) while also retaining a high energy density of 225 Wh kg(-1)(total electrode), which is comparabl...

journal_title：Scientific reports

authors： Kim H,Park KY,Hong J,Kang K

更新日期：2014-06-13 00:00:00

abstract：:Microalgal harvesting and dewatering are the main bottlenecks that need to be overcome to tap the potential of microalgae for production of valuable compounds. Water surface-floating microalgae form robust biofilms, float on the water surface along with gas bubbles entrapped under the biofilms, and have great potentia...

journal_title：Scientific reports

authors： Maeda Y,Nojima D,Sakurai M,Nomaguchi T,Ichikawa M,Ishizuka Y,Tanaka T

更新日期：2019-08-01 00:00:00

abstract：:Physical activity (PA) is known to influence cognitive function. However, the impact of PA on patients with cerebrovascular disease (CVD) has not yet been elucidated. PA and cognitive function have not been measured simultaneously over time, which makes it difficult to evaluate their relationship. The purpose of this ...

journal_title：Scientific reports

authors： Kojima M,Nagano A

更新日期：2019-03-07 00:00:00

abstract：:Perturbations in lipid metabolic pathways to meet the bioenergetic and biosynthetic requirements is a principal characteristic of cancer cells. Sphingolipids (SPLs) are the largest class of bioactive lipids associated to various aspects of tumorigenesis and have been extensively studied in cancer cell lines and experi...

journal_title：Scientific reports

authors： Bhadwal P,Dahiya D,Shinde D,Vaiphei K,Math RGH,Randhawa V,Agnihotri N

更新日期：2020-03-13 00:00:00

abstract：:An important step in oxide photochemistry, the loading of electrons into shallow trap states, was studied using infrared (IR) spectroscopy on both, rutile TiO2 powders and single-crystal, r-TiO2(110) oriented samples. After UV-irradiation or n-doping by exposure to H-atoms broad IR absorption lines are observed for th...

journal_title：Scientific reports

authors： Sezen H,Buchholz M,Nefedov A,Natzeck C,Heissler S,Di Valentin C,Wöll C

更新日期：2014-01-22 00:00:00

abstract：:The 2b protein of Cucumber mosaic virus has a role in nearly all steps of the viral cycle including cell-to-cell movement, symptom induction and suppression of antiviral RNA silencing. Previous studies demonstrated the presence of 2b protein in the nucleus and in cytoplasm as well. Phosphorylation site of 2b protein i...

journal_title：Scientific reports

authors： Nemes K,Gellért Á,Almási A,Vági P,Sáray R,Kádár K,Salánki K

更新日期：2017-10-18 00:00:00

abstract：:When one liquid is introduced into another immiscible one, it ultimately fragments due to hydrodynamic instability. In contrast to neck pinch-off without external actuation, the viscous two-fluid system subjected to an oscillatory flow demonstrates higher efficiency in breaking fluid threads. However, the underlying d...

journal_title：Scientific reports

authors： Zhu P,Tang X,Tian Y,Wang L

更新日期：2016-08-11 00:00:00

abstract：:RNA editing is a molecular event that alters specific nucleotides in RNA post-transcriptionally. RNA editing has the potential to impact a variety of cellular processes and is implicated in diseases such as cancer. Yet, the precise mechanisms by which RNA editing controls cellular processes are poorly understood. Here...

journal_title：Scientific reports

authors： Zhang L,Yang CS,Varelas X,Monti S

更新日期：2016-03-16 00:00:00

abstract：:Distillers grains are co-products of the corn ethanol industry widely used in animal feed. We examined the effects of erythromycin, penicillin, and virginiamycin at low concentrations reflective of those detected in distillers grains on bacterial resistance selection. At 0.1 µg/ml erythromycin, macrolide-resistant mut...

journal_title：Scientific reports

authors： Ge B,Domesle KJ,Yang Q,Young SR,Rice-Trujillo CL,Bodeis Jones SM,Gaines SA,Keller MW,Li X,Piñeiro SA,Whitney BM,Harbottle HC,Gilbert JM

更新日期：2017-09-08 00:00:00

abstract：:The endoplasmic reticulum (ER) is the main site of protein synthesis in eukaryotic cells and requires a high concentration of luminal chaperones to function. During protein synthesis, ER luminal chaperones are swept along the secretory pathway and must be retrieved to maintain cell viability. ER protein retrieval is a...

journal_title：Scientific reports

authors： Wu Z,Newstead S,Biggin PC

更新日期：2020-10-09 00:00:00

abstract：:The biogeographic history of lichenized fungi remains unrevealed because those organisms rarely fossilize due to their delicate, often tiny and quickly rotting thalli. Also the ecology and factors limiting occurrence of numerous taxa, especially those restricted in their distribution to tropical areas are poorly recog...

journal_title：Scientific reports

authors： Kukwa M,Kolanowska M

更新日期：2016-12-08 00:00:00

abstract：:Tractography atlas-based analysis (TABS) is a new diffusion tensor image (DTI) statistical analysis method for detecting and understanding voxel-wise white matter properties along a fiber tract. An important requisite for accurate and sensitive TABS is the availability of a deformation field that is able to register D...

journal_title：Scientific reports

authors： Mu J,Xu Q,Tian J,Liu J

更新日期：2017-10-04 00:00:00

abstract：:Formic acid (FA) has been used for decades to control Varroa destructor, one of the most important parasites of the western honey bee, Apis mellifera. The rather unselective molecular mode of action of FA and its possible effects on honeybees have long been a concern of beekeepers, as it has undesirable side effects t...

journal_title：Scientific reports

authors： Genath A,Sharbati S,Buer B,Nauen R,Einspanier R

更新日期：2020-12-14 00:00:00