Chronic Activation of the Renin-Angiotensin System Induces Lung Fibrosis.

abstract：:The fungus-growing ant-microbe symbiosis is an ideal system to study chemistry-based microbial interactions due to the wealth of microbial interactions described, and the lack of information on the molecules involved therein. In this study, we employed a combination of MALDI imaging mass spectrometry (MALDI-IMS) and M...

journal_title：Scientific reports

authors： Boya P CA,Fernández-Marín H,Mejía LC,Spadafora C,Dorrestein PC,Gutiérrez M

更新日期：2017-07-17 00:00:00

abstract：:Here we describe a unique microbial biotechnology for simultaneous bioremediation and biomining of twelve ionic metals overcoming the obstacles of multimetal toxicity to microbes. After a thorough search of key microorganisms in microbiomes of many sulfidic springs in Bavaria (Germany) over an area of 200 km2, we foun...

journal_title：Scientific reports

authors： Hoque E,Fritscher J

更新日期：2019-07-16 00:00:00

abstract：:Nanocrystals of Ln3+ (Ln = Yb, Tm and Ho) doped β-NaLuF4 with average diameter about 200 nm are dispersed in silica-based microtube (MT) by a simple flame heating method. The fabricated microtube has a diameter range from 2 μm to 30 μm and lengths up to hundreds microns. The fluorescence of upconversion nanocrystals (...

journal_title：Scientific reports

authors： Li H,Wang Y,Li H,Zhang Y,Yang J

更新日期：2016-10-25 00:00:00

abstract：:Photocatalysis is a promising strategy to address the global environmental and energy challenges. However, the studies on the application of the photocatalytically degraded dye-polluted water and the multi-purpose use of one type of catalyst have remained sparse. In this report, we try to demonstrate a concept of mult...

journal_title：Scientific reports

authors： Zhang Q,Zhang Y,Meng Z,Tong W,Yu X,An Q

更新日期：2017-09-25 00:00:00

abstract：:Hepatitis B is one of most etiologies of Liver cirrhosis in China, and clinically lacks the effective strategy for Hepatitis B caused cirrhosis (HBC) therapy. As a complementary and alternative medicine, Chinese Traditional Medicine (TCM) has special therapeutic effects for HBC. Here, we focus on the evolution process...

journal_title：Scientific reports

authors： Liu Y,Wang M,Luo Y,Chen J,Lu Y,Shi Y,Tang C,Zhou Q,Zhang H,Hu Y,Su S,Chen Q

更新日期：2017-09-08 00:00:00

abstract：:Asthma is characterized by airway inflammation, mucus secretion, remodeling and hyperresponsiveness (AHR). Recent research has established the bronchodilatory effect of bitter taste receptor (TAS2R) agonists in various models. Comprehensive pre-clinical studies aimed at establishing effectiveness of TAS2R agonists in ...

journal_title：Scientific reports

authors： Sharma P,Yi R,Nayak AP,Wang N,Tang F,Knight MJ,Pan S,Oliver B,Deshpande DA

更新日期：2017-04-11 00:00:00

abstract：:Controlled ovarian stimulation by exogenous gonadotrophins is a key procedure during the in vitro fertilization cycle to obtain a sufficient number of oocytes in humans. Previous studies demonstrated that repeated superovulation had deleterious effects on the ovaries. However, whether repeated superovulation adversely...

journal_title：Scientific reports

authors： Xie JK,Wang Q,Zhang TT,Yin S,Zhang CL,Ge ZJ

更新日期：2016-10-04 00:00:00

abstract：:Fowl cholera is a serious, highly contagious disease caused by the bacterium Pasteurella multocida (P. multocida) in a range of avian species and is characterized by an acute form of septicaemia. The pathogenic mechanism of chicken lung injury caused by the bacterium is unclear. Therefore, P. multocida Q (a reference ...

journal_title：Scientific reports

authors： Li W,Tang Q,Dai N,Feng W,Xie C,Cheng G,Liu X,Zhang W,Hu X,Gu C

更新日期：2020-04-14 00:00:00

abstract：:The health risks associated with spaceflight-induced ocular structural and functional damage has become a recent concern for NASA. The goal of the present study was to characterize the effects of spaceflight and reentry to 1 g on the structure and integrity of the retina and blood-retinal barrier (BRB) in the eye. To ...

journal_title：Scientific reports

authors： Mao XW,Nishiyama NC,Byrum SD,Stanbouly S,Jones T,Drew A,Sridharan V,Boerma M,Tackett AJ,Zawieja D,Willey JS,Delp M,Pecaut MJ

更新日期：2019-06-03 00:00:00

abstract：:In recent years, the monolithic material has been developed increasingly in the high performance liquid phase field, and it could also be applied in the field of catalyst, as a monolithic catalyst carrier, since it has a large specific surface area, and could be customized based on the mould. The monolithic catalyst i...

journal_title：Scientific reports

authors： Tsai SB,Ma H

更新日期：2018-11-09 00:00:00

abstract：:Previous studies have consistently reported an association between circulating levels of branched-chain amino acids (BCAAs) or adipokines and insulin resistance; however, the association between BCAA and adipokine levels remains to be clarified. In this cross-sectional study involving 678 participants (435 men) withou...

journal_title：Scientific reports

authors： Katagiri R,Goto A,Budhathoki S,Yamaji T,Yamamoto H,Kato Y,Iwasaki M,Tsugane S

更新日期：2018-01-18 00:00:00

abstract：:Multiple epidermal growth factor-like-domains 10 (MEGF10), a critical member of the apoptotic engulfment pathway, mediates axon pruning and synapse elimination during brain development. Previous studies indicated that synaptic pruning deficit was associated with autism-related phenotypes. However, the relationship bet...

journal_title：Scientific reports

authors： Wu Z,Qin J,You Y,Ma Y,Jia M,Wang L,Lu T,Yue W,Ruan Y,Zhang D,Li J,Wang L

更新日期：2017-05-23 00:00:00

abstract：:Carcinomas constitute over 80% of all human cancer types with no effective therapy for metastatic disease. Here, we demonstrate, for the first time, the efficacy of therapeutic-ultrasound (TUS) to deliver a human tumor suppressor gene, hSef-b, to prostate tumors in vivo. Sef is downregulated in various human carcinoma...

journal_title：Scientific reports

authors： Mishel S,Shneyer B,Korsensky L,Goldshmidt-Tran O,Haber T,Machluf M,Ron D

更新日期：2017-11-08 00:00:00

abstract：:The Malay people are an important ethnic composition in Southeast Asia, but their genetic make-up and population structure remain poorly studied. Here we conducted a genome-wide study of four geographical Malay populations: Peninsular Malaysian Malay (PMM), Singaporean Malay (SGM), Indonesian Malay (IDM) and Sri Lanka...

journal_title：Scientific reports

authors： Deng L,Hoh BP,Lu D,Saw WY,Twee-Hee Ong R,Kasturiratne A,Janaka de Silva H,Zilfalil BA,Kato N,Wickremasinghe AR,Teo YY,Xu S

更新日期：2015-09-23 00:00:00

abstract：:The association between active musical engagement (as leisure activity or professionally) and mental health is still unclear, with earlier studies reporting contrasting findings. Here we tested whether musical engagement predicts (1) a diagnosis of depression, anxiety, schizophrenia, bipolar or stress-related disorder...

journal_title：Scientific reports

authors： Wesseldijk LW,Ullén F,Mosing MA

更新日期：2019-08-30 00:00:00

abstract：:The molecular bases of the Frank-Starling law of the heart and of its cellular counterpart, the length dependent activation (LDA), are largely unknown. However, the recent discovery of the thick filament activation, a second pathway beside the well-known calcium mediated thin filament activation, is promising for eluc...

journal_title：Scientific reports

authors： Marcucci L,Washio T,Yanagida T

更新日期：2019-02-04 00:00:00

abstract：:In this manuscript, we studied the thermal properties of hundred-watt fiber laser oscillator by real-time in-situ distributed temperature measurement. Optical frequency domain reflectometry (OFDR) was introduced to measure the temperature distribution of gain fiber core. The fiber laser oscillator operated at 1080 nm ...

journal_title：Scientific reports

authors： Lou Z,Yang B,Han K,Wang X,Zhang H,Xi X,Liu Z

更新日期：2020-06-02 00:00:00

abstract：:There is an increasing appreciation for the role of the human Y chromosome in phenotypic differences between the sexes in health and disease. Previous studies have shown that genetic variation within the Y chromosome is associated with cholesterol levels, which is an established risk factor for atherosclerosis, the un...

journal_title：Scientific reports

authors： Molina E,Chew GS,Myers SA,Clarence EM,Eales JM,Tomaszewski M,Charchar FJ

更新日期：2017-12-01 00:00:00

abstract：:Obesity affects male fertility and maternal diabetes affects the offspring sperm epigenome. However, the effects of in utero exposure to maternal glucose intolerance in combination with postnatal high fat, high sucrose (HFHS) diet consumption on offspring spermatogenesis is not clear. The present study was designed to...

journal_title：Scientific reports

authors： Mao J,Pennington KA,Talton OO,Schulz LC,Sutovsky M,Lin Y,Sutovsky P

更新日期：2018-05-16 00:00:00

abstract：:Analysis of the developing proteome has been complicated by a lack of tools that can be easily employed to label and identify newly synthesized proteins within complex biological mixtures. Here, we demonstrate that the methionine analogs azidohomoalanine and homopropargylglycine can be globally incorporated into the p...

journal_title：Scientific reports

authors： Calve S,Witten AJ,Ocken AR,Kinzer-Ursem TL

更新日期：2016-08-30 00:00:00

abstract：:We employed an RNA-guided CRISPR/Cas9 DNA editing system to precisely remove the entire HIV-1 genome spanning between 5' and 3' LTRs of integrated HIV-1 proviral DNA copies from latently infected human CD4+ T-cells. Comprehensive assessment of whole-genome sequencing of HIV-1 eradicated cells ruled out any off-target ...

journal_title：Scientific reports

authors： Kaminski R,Chen Y,Fischer T,Tedaldi E,Napoli A,Zhang Y,Karn J,Hu W,Khalili K

更新日期：2016-03-04 00:00:00

abstract：:Complement Receptor Immunoglobulin (CRIg), selectively expressed by macrophages, plays an important role in innate immunity by promoting phagocytosis of bacteria. Thus modulation of CRIg on macrophages by cytokines can be an important mechanism by which cytokines regulate anti-microbial immunity. The effects of the cy...

journal_title：Scientific reports

authors： Munawara U,Small AG,Quach A,Gorgani NN,Abbott CA,Ferrante A

更新日期：2017-06-22 00:00:00

abstract：:We have designed, fabricated and characterized dual-wavelength metasurfaces that function at two assigned terahertz wavelengths with independent phase and amplitude control at each wavelength. Specifically, we have designed a dual-wavelength achromatic metasurface-based deflector deflecting the incident wave to the sa...

journal_title：Scientific reports

authors： Ding J,Xu N,Ren H,Lin Y,Zhang W,Zhang H

更新日期：2016-09-23 00:00:00

abstract：:Stress-induced sensitization represents a process whereby prior exposure to severe stressors leaves animals or humans in a hyper-responsive state to further stressors. Indeed, this phenomenon is assumed to be the basis of certain stress-associated pathologies, including post-traumatic stress disorder and psychosis. On...

journal_title：Scientific reports

authors： Belda X,Nadal R,Armario A

更新日期：2016-08-11 00:00:00

abstract：:When making decisions, humans can maximize the positive outcome of their actions by choosing the option associated with the highest reward. We have recently shown that choices modulate effects of reward via a bias in spatial attention: Locations associated with a lower reward are anticipatorily suppressed, as indicate...

journal_title：Scientific reports

authors： Heuer A,Wolf C,Schütz AC,Schubö A

更新日期：2019-04-08 00:00:00

abstract：:Why lightning sometimes has multiple discharges to ground is an unanswered question. Recently, the observation of small plasma structures on positive leaders re-ignited the search. These small plasma structures were observed as pulsing radio sources along the positive leader length and were named "needles". Needles ma...

journal_title：Scientific reports

authors： Saba MMF,de Paiva AR,Concollato LC,Warner TA,Schumann C

更新日期：2020-10-15 00:00:00

abstract：:Although large populations feel fatigue, the standardized medicinal therapy is currently absent. In this study, we determined whether 5-aminolevulinic acid (5-ALA) supplementation alleviates the feeling of fatigue in healthy subjects who feel chronic physical tiredness. Males and females between ages of 20 and 64 who ...

journal_title：Scientific reports

authors： Higashikawa F,Kanno K,Ogata A,Sugiyama M

更新日期：2020-09-29 00:00:00

abstract：:The ability to form mineral structures under biological control is widespread among animals. In several species, specific proteins have been shown to be involved in biomineralization, but it is uncertain how they influence the shape of the growing biomineral and the resulting skeleton. Calcareous sponges are the only ...

journal_title：Scientific reports

authors： Voigt O,Adamska M,Adamski M,Kittelmann A,Wencker L,Wörheide G

更新日期：2017-04-13 00:00:00

abstract：:DNA double-strand break (DSB) repair is crucial to maintain genomic stability. The fidelity of the repair depends on the complexity of the lesion, with clustered DSBs being more difficult to repair than isolated breaks. Using live cell imaging of heavy ion tracks produced at a high-energy particle accelerator we visua...

journal_title：Scientific reports

authors： Jakob B,Dubiak-Szepietowska M,Janiel E,Schmidt A,Durante M,Taucher-Scholz G

更新日期：2020-01-29 00:00:00

abstract：:Stochastic differential equations (SDEs) are ubiquitous across disciplines, and uncovering SDEs driving observed time series data is a key scientific challenge. Most previous work on this topic has relied on restrictive assumptions, undermining the generality of these approaches. We present a novel technique to uncove...

journal_title：Scientific reports

authors： Olson R,An SI,Kim SK,Fan Y

更新日期：2021-01-29 00:00:00