Abstract：
:Owing to the growing infectious diseases caused by eukaryotic and prokaryotic pathogens, it is urgent to develop novel antimicrobial agents against clinical pathogenic infections. Biofilm formation and invasion into the host cells are vital processes during pathogenic colonization and infection. In this study, we tested the inhibitory effect of Au nanoparticles (AuNPs) on pathogenic growth, biofilm formation and invasion. Interestingly, although the synthesized AuNPs had no significant toxicity to the tested pathogens, Candida albicans and Pseudomonas aeruginosa, the nanoparticles strongly inhibited pathogenic biofilm formation and invasion to dental pulp stem cells (DPSCs). Further investigations revealed that AuNPs abundantly bound to the pathogen cells, which likely contributed to their inhibitory effect on biofilm formation and invasion. Moreover, treatment of AuNPs led to activation of immune response-related genes in DPSCs, which may enhance the activity of host immune system against the pathogens. Zeta potential analysis and polyethylene glycol (PEG)/polyethyleneimine (PEI) coating tests further showed that the interaction between pathogen cells and AuNPs is associated with electrostatic attractions. Our findings shed novel light on the application of nanomaterials in fighting against clinical pathogens, and imply that the traditional growth inhibition test is not the only way to evaluate the drug effect during the screening of antimicrobial agents.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Yu Q,Li J,Zhang Y,Wang Y,Liu L,Li Mdoi
10.1038/srep26667subject
Has Abstractpub_date
2016-05-25 00:00:00pages
26667issn
2045-2322pii
srep26667journal_volume
6pub_type
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pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2017-12-12 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2019-07-08 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2016-07-14 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2021-01-12 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep41070
更新日期：2017-01-24 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章,meta分析
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pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2015-06-08 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2016-07-01 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2017-02-24 00:00:00
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pub_type： 杂志文章
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2017-11-24 00:00:00
