Abstract：
:Skeletal complications are common features of neonatal-onset multisystem inflammatory disease (NOMID), a disorder caused by NLRP3-activating mutations. NOMID mice in which NLRP3 is activated globally exhibit several characteristics of the human disease, including systemic inflammation and cartilage dysplasia, but the mechanisms of skeletal manifestations remain unknown. In this study, we find that activation of NLRP3 in myeloid cells, but not mesenchymal cells triggers chronic inflammation, which ultimately, causes growth plate and epiphyseal dysplasia in mice. These responses are IL-1 signaling-dependent, but independent of PARP1, which also functions downstream of NLRP3 and regulates skeletal homeostasis. Mechanistically, inflammation causes severe anemia and hypoxia in the bone environment, yet down-regulates the HIF-1α pathway in chondrocytes, thereby promoting the demise of these cells. Thus, activation of NLRP3 in hematopoietic cells initiates IL-1β-driven paracrine cascades, which promote abnormal growth plate development in NOMID mice.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Wang C,Xu CX,Alippe Y,Qu C,Xiao J,Schipani E,Civitelli R,Abu-Amer Y,Mbalaviele Gdoi
10.1038/s41598-017-05033-5subject
Has Abstractpub_date
2017-07-07 00:00:00pages
4880issue
1issn
2045-2322pii
10.1038/s41598-017-05033-5journal_volume
7pub_type
杂志文章abstract：:Hearing loss is often due to the absence or the degeneration of hair cells in the cochlea. Understanding the mechanisms regulating the generation of hair cells may therefore lead to better treatments for hearing disorders. To elucidate the transcriptional control mechanisms specifying the progenitor cells (i.e. prosen...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-45515-2
更新日期：2019-06-21 00:00:00
abstract：:Empowering an indirect band-gap material like Si with optical functionalities, firstly light emission, represents a huge advancement constantly pursued in the realization of any integrated photonic device. We report the demonstration of giant photoluminescence (PL) emission by a newly synthesized material consisting o...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep02674
更新日期：2013-01-01 00:00:00
abstract：:The metal-air battery is a form of renewable energy generation technology that produces energy electrochemically and can address energy concerns in the near future. However, state-of-the-art Pt electrocatalysts often suffer from agglomeration or detachment from carbon supports under prolonged operation, eventually lim...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-49194-x
更新日期：2019-09-03 00:00:00
abstract：:Optimal mental workload plays a key role in driving performance. Thus, driver-assisting systems that automatically adapt to a drivers current mental workload via brain-computer interfacing might greatly contribute to traffic safety. To design economic brain computer interfaces that do not compromise driver comfort, it...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-80477-w
更新日期：2021-01-12 00:00:00
abstract：:Inflammatory and metabolic diseases can originate during early-life and have been correlated with shifts in intestinal microbial ecology. Here we demonstrate that minor environmental fluctuations during the early neonatal period had sustained effects on the developing porcine microbiota and host-microbe interface. The...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-05689-z
更新日期：2017-07-13 00:00:00
abstract：:The medicinal leech has established a long-term mutualistic association with Aeromonas veronii, a versatile bacterium which can also display free-living waterborne and fish- or human-pathogenic lifestyles. Here, we investigated the role of antibiotics in the dynamics of interaction between the leech and its gut symbio...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep17498
更新日期：2015-12-04 00:00:00
abstract：:Cnidarians, in general, are long-lived organisms and hence may repeatedly encounter common pathogens during their lifespans. It remains unknown whether these early diverging animals possess some type of immunological reaction that strengthens the defense response upon repeated infections, such as that described in mor...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep17425
更新日期：2015-12-02 00:00:00
abstract：:Mitochondria-generated reactive oxygen species (mROS) are frequently associated with DNA damage and cell cycle arrest, but physiological increases in mROS serve to regulate specific cell functions. T3 is a major regulator of mROS, including hydrogen peroxide (H2O2). Here we show that exogenous thyroid hormone (T3) adm...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-53705-1
更新日期：2019-11-27 00:00:00
abstract：:In this paper, for the first time, the switchable two-color quantum dot laser has been realized considering solution process technology, which has both simultaneous and lonely lasing capability exploiting selective energy contacts. Furthermore, both channels can be modulated independently, which is a significant featu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-60859-w
更新日期：2020-03-24 00:00:00
abstract：:Temporal baselines are needed for biodiversity, in order for the change in biodiversity to be measured over time, the targets for biodiversity conservation to be defined and conservation progress to be evaluated. Limited biodiversity information is widely recognized as a major barrier for identifying temporal baseline...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep41591
更新日期：2017-01-30 00:00:00
abstract：:We have studied in-situ cleaved (0001) surfaces of the magnetic Weyl semimetal Mn3Sn by low-temperature scanning tunneling microscopy and spectroscopy (STM/S). It was found that freshly cleaved Mn3Sn surfaces are covered with unknown clusters, and the application of voltage pulses in the tunneling condition was needed...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-45958-7
更新日期：2019-07-04 00:00:00
abstract：:High mortality and dependent living after hip fracture pose a significant public health concern. Retrospective study was conducted with 481 hip fracture patients (≥65 years of age) undergoing surgery from March 2009 to May 2014. The Hip-MFS was calculated by Comprehensive Geriatric Assessment (CGA). The primary outcom...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep42966
更新日期：2017-02-24 00:00:00
abstract：:Microalgae are versatile organisms capable of converting CO2, H2O, and sunlight into fuel and chemicals for domestic and industrial consumption. Thus, genetic modifications of microalgae for enhancing photosynthetic productivity, and biomass and bio-products generation are crucial for both academic and industrial appl...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep30620
更新日期：2016-07-28 00:00:00
abstract：:A subwoofer generates the lowest frequency range in loudspeaker systems. Subwoofers are used in audio systems for live concerts, movie theatres, home theatres, gaming consoles, cars, etc. During the last decades, numerical simulations have emerged as a cost- and time-efficient complement to traditional experiments in ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-80092-9
更新日期：2021-01-08 00:00:00
abstract：:The aim was to analyze the effect of fractional flow reserve (FFR), intravascular ultrasound (IVUS) and optical coherence tomography (OCT) on fluoroscopy time (FT), radiation dose (RD) and contrast volume (CV) in patients undergoing coronary angiography. This case-control study included consecutive patients above the ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-63791-1
更新日期：2020-04-24 00:00:00
abstract：:Single epitaxially-grown semiconductor quantum dots have great potential as single photon sources for photonic quantum technologies, though in practice devices often exhibit nonideal behavior. Here, we demonstrate that amplitude modulation can improve the performance of quantum-dot-based sources. Starting with a brigh...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep01397
更新日期：2013-01-01 00:00:00
abstract：:By growing monolayer FeSe on SrTiO3(001) surface, researchers obtain the highest superconducting transition-temperature for iron-based superconductor. Here, we study the antiferromagnetic (AFM) checkerboard monolayer FeSe adsorbed on SrTiO3(001) surface. We show that the system has a considerable charge transfer from ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep02213
更新日期：2013-01-01 00:00:00
abstract：:This study introduces a new chemical carving technique as an alternative to existing lithography and etching techniques. Chemical carving incorporates the concept of scanning probe lithography and metal-assisted chemical etching (MaCE). A catalyst-coated probe mechanically scans a Si substrate in a solution, and the S...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-70407-1
更新日期：2020-08-07 00:00:00
abstract：:Drug delivery by topical application has higher patient acceptance and lower morbidity than intraocular injection, but many ophthalmic treatments are unable to enter the eye or reach the posterior segment after topical application. The first stage towards posterior segment delivery after topical application is ocular ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-68254-1
更新日期：2020-07-16 00:00:00
abstract：:Perovskite solar cells based on series of inorganic cesium lead bromide and iodide mixture, CsPbBr3-xI x , where x varies between 0, 0.1, 0.2, and 0.3 molar ratio were synthesized by two step-sequential deposition at ambient condition to design the variations of wide band gap light absorbers. A device with high overal...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-20228-0
更新日期：2018-02-06 00:00:00
abstract：:E. coli of the phylogenetic group B2 harbouring Extra intestinal Pathogenic Escherichia coli (ExPEC) genes are frequently seen as colonizers of the intestine in patients with active ulcerative colitis (UC). In this study, we describe the influence of E. coli Nissle (EcN) B2 as add-on treatment to conventional therapie...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep31152
更新日期：2016-09-30 00:00:00
abstract：:Short-wavelength luminescence is essential for high-performance optoelectronic device applications. There have been efforts to obtain intense ultraviolet (UV) emission by encapsulating ZnO one-dimensional (1D) nanostructures with materials such as ZnS. However, the encapsulation of ZnS 1D nanostructures with ZnO has n...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-13556-0
更新日期：2017-10-12 00:00:00
abstract：:Stromal capillary sheath cells in human spleens strongly express CD271, the low affinity nerve growth factor receptor p75. Serial sections of a representative adult human spleen were double-stained for CD271 versus smooth muscle alpha actin (SMA) plus CD34 to visualise capillary sheaths, the arterial tree and endothel...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-34105-3
更新日期：2018-10-24 00:00:00
abstract：:Fat deposition of beef cattle varies between breeds. However, the regulation mechanism is still not elucidated completely at molecular level. In the present study, we comparatively analyzed transcriptome of subcutaneous adipose tissue between Wagyu and Holstein cattle with a significant difference in fat deposition to...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-05702-5
更新日期：2017-07-13 00:00:00
abstract：:Bacterial infection and sepsis are common complications of chronic kidney disease (CKD). A vicious cycle of increased gut permeability, endotoxemia, inadequate activation of the innate immune system and resulting innate immune dysfunction is hypothesized. We assessed endotoxemia, neutrophil function and its relation t...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章
doi：10.1038/srep34534
更新日期：2016-10-04 00:00:00
abstract：:The incidence of myopia is increasing worldwide, and the investigation on pathophysiology of myopia is becoming more important. This retrospective study aimed to compare the thicknesses of individual retinal layers between high-myopic and control eyes, and to evaluate the effects of age and sex on each retinal layer t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-50306-w
更新日期：2019-09-30 00:00:00
abstract：:It is now well established that invasive plants may induce drifts in the quantity and/or quality of floral resources. They are then often pointed out as a potential driver of bee decline. However, their impact on bee population remains quite unclear and still controversial, as bee responses are highly variable among s...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-16054-5
更新日期：2017-11-24 00:00:00
abstract：:Reversible polymeric networks can show self-healing properties due to their ability to reassemble after application of stress and fracture, but typically the relation between equilibrium molecular dynamics and self-healing kinetics has been difficult to disentangle. Here we present a well-characterized, self-assembled...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep32356
更新日期：2016-09-01 00:00:00
abstract：:The accelerated increase in global methane (CH4) in the atmosphere, accompanied by a decrease in its 13C/12C isotopic ratio (δ13CCH4) from -47.1‰ to -47.3‰ observed since 2008, has been attributed to increased emissions from wetlands and cattle, as well as from shale gas and shale oil developments. To date both explan...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-61035-w
更新日期：2020-03-06 00:00:00
abstract：:Cassava is one of the most important root crops as a reliable source of food and carbohydrates. Carbohydrate metabolism and starch accumulation in cassava storage root is a cascade process that includes large amounts of proteins and cofactors. Here, comparative proteomics were conducted in cassava root at nine develop...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep19643
更新日期：2016-01-21 00:00:00
