COVID-Net: a tailored deep convolutional neural network design for detection of COVID-19 cases from chest X-ray images.

Abstract:

:The Coronavirus Disease 2019 (COVID-19) pandemic continues to have a devastating effect on the health and well-being of the global population. A critical step in the fight against COVID-19 is effective screening of infected patients, with one of the key screening approaches being radiology examination using chest radiography. It was found in early studies that patients present abnormalities in chest radiography images that are characteristic of those infected with COVID-19. Motivated by this and inspired by the open source efforts of the research community, in this study we introduce COVID-Net, a deep convolutional neural network design tailored for the detection of COVID-19 cases from chest X-ray (CXR) images that is open source and available to the general public. To the best of the authors' knowledge, COVID-Net is one of the first open source network designs for COVID-19 detection from CXR images at the time of initial release. We also introduce COVIDx, an open access benchmark dataset that we generated comprising of 13,975 CXR images across 13,870 patient patient cases, with the largest number of publicly available COVID-19 positive cases to the best of the authors' knowledge. Furthermore, we investigate how COVID-Net makes predictions using an explainability method in an attempt to not only gain deeper insights into critical factors associated with COVID cases, which can aid clinicians in improved screening, but also audit COVID-Net in a responsible and transparent manner to validate that it is making decisions based on relevant information from the CXR images. By no means a production-ready solution, the hope is that the open access COVID-Net, along with the description on constructing the open source COVIDx dataset, will be leveraged and build upon by both researchers and citizen data scientists alike to accelerate the development of highly accurate yet practical deep learning solutions for detecting COVID-19 cases and accelerate treatment of those who need it the most.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Wang L,Lin ZQ,Wong A

doi

10.1038/s41598-020-76550-z

subject

Has Abstract

pub_date

2020-11-11 00:00:00

pages

19549

issue

1

issn

2045-2322

pii

10.1038/s41598-020-76550-z

journal_volume

10

pub_type

杂志文章
  • Kremen1 regulates mechanosensory hair cell development in the mammalian cochlea and the zebrafish lateral line.

    abstract::Here we present spatio-temporal localization of Kremen1, a transmembrane receptor, in the mammalian cochlea, and investigate its role in the formation of sensory organs in mammal and fish model organisms. We show that Kremen1 is expressed in prosensory cells during cochlear development and in supporting cells of the a...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep31668

    authors: Mulvaney JF,Thompkins C,Noda T,Nishimura K,Sun WW,Lin SY,Coffin A,Dabdoub A

    更新日期:2016-08-23 00:00:00

  • IκBζ facilitates protective immunity against Salmonella infection via Th1 differentiation and IgG production.

    abstract::Inhibitor of kappa B (IκB)-ζ transcription is rapidly induced by stimulation with TLR ligands and IL-1. Despite high IκBζ expression in inflammation sites, the association of IκBζ with host defence via systemic immune responses against bacterial infection remains unclear. Oral immunisation with a recombinant attenuate...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-44019-3

    authors: Ahn JH,Cho J,Kwon BE,Lee GS,Yoon SI,Kang SG,Kim PH,Kweon MN,Yang H,Vallance BA,Kim YI,Chang SY,Ko HJ

    更新日期:2019-06-10 00:00:00

  • Pharmacological therapies for infantile hemangiomas: A clinical study in 853 consecutive patients using a standard treatment algorithm.

    abstract::Infantile hemangiomas are the most common infantile benign vascular tumor. While most infantile hemangiomas proliferate then involute, some may persist and require treatment for reasons including risk of disfigurement or functional impairment. Treatments currently include observation, pharmacological therapy, laser, c...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep21670

    authors: Zhang L,Yuan WE,Zheng JW

    更新日期:2016-02-15 00:00:00

  • Efficient Volumetric Absorption Solar Thermal Platforms Employing Thermally Stable - Solar Selective Nanofluids Engineered from Used Engine Oil.

    abstract::We report a low cost and scalable method to synthesize solar selective nanofluids from 'used engine oil'. The as-prepared nanofluids exhibit excellent long-term stability (presently tested up to 6 months under undisturbed stagnant conditions at room temperature) and photo-thermal conversion efficiency. Moreover, these...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-47126-3

    authors: Singh N,Khullar V

    更新日期:2019-07-22 00:00:00

  • Annexin B12 Trimer Formation is Governed by a Network of Protein-Protein and Protein-Lipid Interactions.

    abstract::Membrane protein oligomerization mediates a wide range of biological events including signal transduction, viral infection and membrane curvature induction. However, the relative contributions of protein-protein and protein-membrane interactions to protein oligomerization remain poorly understood. Here, we used the Ca...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-62343-x

    authors: Tao M,Isas JM,Langen R

    更新日期:2020-03-24 00:00:00

  • Peripapillary microvascular changes in patients with systemic hypertension: An optical coherence tomography angiography study.

    abstract::The purpose of this study was to investigate changes in peripapillary microvasculature using optical coherence tomography angiography (OCTA) in systemic hypertension (HTN) patients. This was a cross-sectional study. Based on the duration of HTN, seventy-eight HTN patients were divided into two groups. (HTN group 1: <1...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-63603-6

    authors: Shin YI,Nam KY,Lee WH,Ryu CK,Lim HB,Jo YJ,Kim JY

    更新日期:2020-04-16 00:00:00

  • Reconstruction of noise-driven nonlinear networks from node outputs by using high-order correlations.

    abstract::Many practical systems can be described by dynamic networks, for which modern technique can measure their outputs, and accumulate extremely rich data. Nevertheless, the network structures producing these data are often deeply hidden in the data. The problem of inferring network structures by analyzing the available da...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep44639

    authors: Chen Y,Zhang Z,Chen T,Wang S,Hu G

    更新日期:2017-03-21 00:00:00

  • Evaluation of a preclinical photon-counting CT prototype for pulmonary imaging.

    abstract::The purpose of this study was to investigate a preclinical spectral photon-counting CT (SPCCT) prototype compared to conventional CT for pulmonary imaging. A custom-made lung phantom, including nodules of different sizes and shapes, was scanned with a preclinical SPCCT and a conventional CT in standard and high-resolu...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-35888-1

    authors: Kopp FK,Daerr H,Si-Mohamed S,Sauter AP,Ehn S,Fingerle AA,Brendel B,Pfeiffer F,Roessl E,Rummeny EJ,Pfeiffer D,Proksa R,Douek P,Noël PB

    更新日期:2018-11-26 00:00:00

  • Seasonality and light phase-resetting in the mammalian circadian rhythm.

    abstract::We study the impact of light on the mammalian circadian system using the theory of phase response curves. Using a recently developed ansatz we derive a low-dimensional macroscopic model for the core circadian clock in mammals. Significantly, the variables and parameters in our model have physiological interpretations ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-74002-2

    authors: Hannay KM,Forger DB,Booth V

    更新日期:2020-11-11 00:00:00

  • Principles and development of collagen-mediated tissue fusion induced by laser irradiation.

    abstract::The mechanism underlying tissue fusion mediated by laser irradiation remains unclear. We clarify the mechanisms underlying laser-mediated tissue fusion using a novel model. Microscopic examinations of morphological changes within the adventitia of a bovine carotid artery and a collagen sheet prepared from bovine dermi...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-45486-4

    authors: Sasaki S,Ikeda T,Okihara SI,Nishimura S,Nakadate R,Saeki H,Oki E,Mori M,Hashizume M,Maehara Y

    更新日期:2019-06-28 00:00:00

  • Using remote sensing environmental data to forecast malaria incidence at a rural district hospital in Western Kenya.

    abstract::Malaria surveillance data provide opportunity to develop forecasting models. Seasonal variability in environmental factors correlate with malaria transmission, thus the identification of transmission patterns is useful in developing prediction models. However, with changing seasonal transmission patterns, either due t...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-02560-z

    authors: Sewe MO,Tozan Y,Ahlm C,Rocklöv J

    更新日期:2017-06-01 00:00:00

  • Signature of topological states in antiferromagnetic Sm-substituted Bi2Te3.

    abstract::An antiferromagnetic topological insulator has been predicted to be preserved by breaking both time-reversal symmetry and primitive lattice translational symmetry. However, the topological surface state has often been observed to disappear in an antiferromagnetic phase because the doped magnetic impurity acts as an ex...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-66521-9

    authors: Jun JH,Kim J,Kim SW,Jung MH

    更新日期:2020-06-15 00:00:00

  • A broadband terahertz ultrathin multi-focus lens.

    abstract::Ultrathin transmission metasurface devices are designed on the basis of the Yang-Gu amplitude-phase retrieval algorithm for focusing the terahertz (THz) radiation into four or nine spots with focal spacing of 2 or 3 mm at a frequency of 0.8 THz. The focal properties are experimentally investigated in detail, and the r...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep28800

    authors: He J,Ye J,Wang X,Kan Q,Zhang Y

    更新日期:2016-06-27 00:00:00

  • Connection adaption for control of networked mobile chaotic agents.

    abstract::In this paper, we propose a strategy for the control of mobile chaotic oscillators by adaptively rewiring connections between nearby agents with local information. In contrast to the dominant adaptive control schemes where coupling strength is adjusted continuously according to the states of the oscillators, our metho...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-16235-2

    authors: Zhou J,Zou Y,Guan S,Liu Z,Xiao G,Boccaletti S

    更新日期:2017-11-22 00:00:00

  • Colorectal Cancer Screening Programme in Spain: Results of Key Performance Indicators After Five Rounds (2000-2012).

    abstract::Effective quality assurance is essential in any screening programme. This article provides a unique insight into key quality indicators of five rounds of the first population-based colorectal cancer screening programme implemented in Spain (2000-2012), providing the results according to the type of screening (prevalen...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep19532

    authors: Binefa G,Garcia M,Milà N,Fernández E,Rodríguez-Moranta F,Gonzalo N,Benito L,Clopés A,Guardiola J,Moreno V

    更新日期:2016-01-20 00:00:00

  • Nitrogen sufficiency enhances thermal tolerance in habitat-forming kelp: implications for acclimation under thermal stress.

    abstract::Local and global changes associated with anthropogenic activities are impacting marine and terrestrial ecosystems. Macroalgae, especially habitat-forming species like kelp, play critical roles in temperate coastal ecosystems. However, their abundance and distribution patterns have been negatively affected by warming i...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-60104-4

    authors: Fernández PA,Gaitán-Espitia JD,Leal PP,Schmid M,Revill AT,Hurd CL

    更新日期:2020-02-21 00:00:00

  • Analysis of the "centrosome-ome" identifies MCPH1 deletion as a cause of centrosome amplification in human cancer.

    abstract::The centrosome is the microtubule organizing center of human cells and facilitates a myriad of cellular functions including organization of the mitotic spindle to ensure faithful chromosome segregation during mitosis, cell polarization and migration, and primary cilia formation. A numerical increase in centrosomes, or...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-68629-4

    authors: Denu RA,Burkard ME

    更新日期:2020-07-17 00:00:00

  • Increasing Boiling Heat Transfer using Low Conductivity Materials.

    abstract::We report the counterintuitive mechanism of increasing boiling heat transfer by incorporating low-conductivity materials at the interface between the surface and fluid. By embedding an array of non-conductive lines into a high-conductivity substrate, in-plane variations in the local surface temperature are created. Du...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep13145

    authors: Rahman MM,Pollack J,McCarthy M

    更新日期:2015-08-18 00:00:00

  • Metastability in lipid based particles exhibits temporally deterministic and controllable behavior.

    abstract::The metastable-to-stable phase-transition is commonly observed in many fields of science, as an uncontrolled independent process, highly sensitive to microscopic fluctuations. In particular, self-assembled lipid suspensions exhibit phase-transitions, where the underlying driving mechanisms and dynamics are not well un...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep09481

    authors: Jacoby G,Cohen K,Barkan K,Talmon Y,Peer D,Beck R

    更新日期:2015-03-30 00:00:00

  • A bivariate genome-wide association study identifies ADAM12 as a novel susceptibility gene for Kashin-Beck disease.

    abstract::Kashin-Beck disease (KBD) is a chronic osteoarthropathy, which manifests as joint deformities and growth retardation. Only a few genetic studies of growth retardation associated with the KBD have been carried out by now. In this study, we conducted a two-stage bivariate genome-wide association study (BGWAS) of the KBD...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep31792

    authors: Hao J,Wang W,Wen Y,Xiao X,He A,Guo X,Yang T,Liu X,Shen H,Chen X,Tian Q,Deng HW,Zhang F

    更新日期:2016-08-22 00:00:00

  • Manual, In situ, Real-Time Nanofabrication using Cracking through Indentation.

    abstract::Nanofabrication has seen an increasing demand for applications in many fields of science and technology, but its production still requires relatively difficult, time-consuming, and expensive processes. Here we report a simple but very effective one dimensional (1D) nano-patterning technology that suggests a new nanofa...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep18892

    authors: Nam KH,Suh YD,Yeo J,Woo D

    更新日期:2016-01-04 00:00:00

  • Biocompatibility and biodegradation studies of a commercial zinc alloy for temporary mini-implant applications.

    abstract::In this study, the biocompatibility and in vitro degradation behaviour of a commercial zinc-based alloy (Zn-5 Al-4 Mg) were evaluated and compared with that of pure zinc for temporary orthopaedic implant applications. Biocompatibility tests were conducted using human alveolar lung epithelial cells (A549), which showed...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-15873-w

    authors: Kannan MB,Moore C,Saptarshi S,Somasundaram S,Rahuma M,Lopata AL

    更新日期:2017-11-15 00:00:00

  • Association between one-carbon metabolism indices and DNA methylation status in maternal and cord blood.

    abstract::One-carbon metabolism is essential for multiple cellular processes and can be assessed by the concentration of folate metabolites in the blood. One-carbon metabolites serve as methyl donors that are required for epigenetic regulation. Deficiencies in these metabolites are associated with a variety of poor health outco...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-35111-1

    authors: Knight AK,Park HJ,Hausman DB,Fleming JM,Bland VL,Rosa G,Kennedy EM,Caudill MA,Malysheva O,Kauwell GPA,Sokolow A,Fisher S,Smith AK,Bailey LB

    更新日期:2018-11-15 00:00:00

  • The effect of pulsatile motion and cardiac-gating on reconstruction and diffusion tensor properties of the corticospinal tract.

    abstract::Pulsatile motion occurs in the cardiac systolic period and leads to significantly larger displacement of water molecules as it is observed during diffusion weighted image acquisition. Obvious pulsatile motion arises in the brain stem and basal ganglia and might affect the corticospinal tract. So far there is no consen...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-29525-0

    authors: Bopp MHA,Yang J,Nimsky C,Carl B

    更新日期:2018-07-25 00:00:00

  • Detection of smoking status from retinal images; a Convolutional Neural Network study.

    abstract::Cardiovascular diseases are directly linked to smoking habits, which has both physiological and anatomical effects on the systemic and retinal circulations, and these changes can be detected with fundus photographs. Here, we aimed to 1- design a Convolutional Neural Network (CNN), using retinal photographs, to differe...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-43670-0

    authors: Vaghefi E,Yang S,Hill S,Humphrey G,Walker N,Squirrell D

    更新日期:2019-05-09 00:00:00

  • Differential responses of gut microbiota to the same prebiotic formula in oligotrophic and eutrophic batch fermentation systems.

    abstract::The same prebiotics have produced inconsistent effects on microbiota when evaluated in different batch fermentation studies. To understand the reasons behind these discrepancies, we compared impact of one prebiotic formula on the same inoculated fecal microbiota in two frequently used batch systems: phosphate-buffered...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep13469

    authors: Long W,Xue Z,Zhang Q,Feng Z,Bridgewater L,Wang L,Zhao L,Pang X

    更新日期:2015-08-25 00:00:00

  • Improving polygenic risk prediction from summary statistics by an empirical Bayes approach.

    abstract::Polygenic risk scores (PRS) from genome-wide association studies (GWAS) are increasingly used to predict disease risks. However some included variants could be false positives and the raw estimates of effect sizes from them may be subject to selection bias. In addition, the standard PRS approach requires testing over ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep41262

    authors: So HC,Sham PC

    更新日期:2017-02-01 00:00:00

  • Targeted mutations in myostatin by zinc-finger nucleases result in double-muscled phenotype in Meishan pigs.

    abstract::Myostatin (MSTN) is a dominant inhibitor of skeletal muscle development and growth. Mutations in MSTN gene can lead to muscle hypertrophy or double-muscled (DM) phenotype in cattle, sheep, dog and human. However, there has not been reported significant muscle phenotypes in pigs in association with MSTN mutations. Pigs...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep14435

    authors: Qian L,Tang M,Yang J,Wang Q,Cai C,Jiang S,Li H,Jiang K,Gao P,Ma D,Chen Y,An X,Li K,Cui W

    更新日期:2015-09-24 00:00:00

  • Nonerythropoietic Erythropoietin-Derived Peptide Suppresses Adipogenesis, Inflammation, Obesity and Insulin Resistance.

    abstract::Erythropoietin (EPO) has been identified as being crucial for obesity modulation; however, its erythropoietic activity may limit its clinical application. EPO-derived Helix B-surface peptide (pHBSP) is nonerythrogenic but has been reported to retain other functions of EPO. The current study aimed to evaluate the effec...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep15134

    authors: Liu Y,Luo B,Shi R,Wang J,Liu Z,Liu W,Wang S,Zhang Z

    更新日期:2015-10-13 00:00:00

  • The clinical and urodynamic outcomes of single-incision mesh surgery using the Uphold system for the treatment of pelvic organ prolapse.

    abstract::This retrospective cohort study aims to assess the clinical and urodynamic outcomes of single-incision mesh surgery with the Uphold system. The medical records of 140 women with anterior and/or apical compartment prolapse stage 2 or greater who underwent Uphold mesh surgeries were reviewed. The clinical evaluation inc...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-69886-z

    authors: Wu PC,Wu CH,Liu Y,Loo Z,Lin KL,Long CY

    更新日期:2020-08-11 00:00:00