Abstract：
:Low socioeconomic status (SES) is associated with earlier onset of age-related chronic conditions and reduced life-expectancy, but the underlying biomolecular mechanisms remain unclear. Evidence of DNA-methylation differences by SES suggests a possible association of SES with epigenetic age acceleration (AA). We investigated the association of SES with AA in more than 5,000 individuals belonging to three independent prospective cohorts from Italy, Australia, and Ireland. Low SES was associated with greater AA (β = 0.99 years; 95% CI 0.39,1.59; p = 0.002; comparing extreme categories). The results were consistent across different SES indicators. The associations were only partially modulated by the unhealthy lifestyle habits of individuals with lower SES. Individuals who experienced life-course SES improvement had intermediate AA compared to extreme SES categories, suggesting reversibility of the effect and supporting the relative importance of the early childhood social environment. Socioeconomic adversity is associated with accelerated epigenetic aging, implicating biomolecular mechanisms that may link SES to age-related diseases and longevity.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Fiorito G,Polidoro S,Dugué PA,Kivimaki M,Ponzi E,Matullo G,Guarrera S,Assumma MB,Georgiadis P,Kyrtopoulos SA,Krogh V,Palli D,Panico S,Sacerdote C,Tumino R,Chadeau-Hyam M,Stringhini S,Severi G,Hodge AM,Giles GG,Mardoi
10.1038/s41598-017-16391-5subject
Has Abstractpub_date
2017-11-24 00:00:00pages
16266issue
1issn
2045-2322pii
10.1038/s41598-017-16391-5journal_volume
7pub_type
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