Abstract:
:In the current report, we describe the identification of three genetically distinct groups of prophages integrated into three different chromosomal sites of human gut-associated Bifidobacterium breve and Bifidobacterium longum strains. These bifidobacterial prophages are distantly related to temperate actinobacteriophages of several hosts. Some prophages, integrated within the dnaJ2 gene, are competent for induction, excision, replication, assembly and lysis, suggesting that they are fully functional and can generate infectious particles, even though permissive hosts have not yet been identified. Interestingly, several of these phages harbor a putative phase variation shufflon (the Rin system) that generates variation of the tail-associated receptor binding protein (RBP). Unlike the analogous coliphage-associated shufflon Min, or simpler Cin and Gin inversion systems, Rin is predicted to use a tyrosine recombinase to promote inversion, the first reported phage-encoded tyrosine-family DNA invertase. The identification of bifidobacterial prophages with RBP diversification systems that are competent for assembly and lysis, yet fail to propagate lytically under laboratory conditions, suggests dynamic evolution of bifidobacteria and their phages in the human gut.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Mavrich TN,Casey E,Oliveira J,Bottacini F,James K,Franz CMAP,Lugli GA,Neve H,Ventura M,Hatfull GF,Mahony J,van Sinderen Ddoi
10.1038/s41598-018-31181-3subject
Has Abstractpub_date
2018-08-24 00:00:00pages
12772issue
1issn
2045-2322pii
10.1038/s41598-018-31181-3journal_volume
8pub_type
杂志文章abstract::In the present work, the mechanisms involved in the recently reported antiviral activity of zebrafish C-reactive protein-like protein (CRP1-7) against the spring viraemia of carp rhabdovirus (SVCV) in fish are explored. The results neither indicate blocking of the attachment or the binding step of the viral replicatio...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-57501-0
更新日期:2020-01-17 00:00:00
abstract::Considering environmental concerns regarding air pollution which is induced by burning fossil fuels to generate electrical power, utilizing solar energy as a green and sustainable energy source is of great interest. This study proposes a novel framework to determine the optimal location for constructing solar photovol...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-65165-z
更新日期:2020-05-18 00:00:00
abstract::Extracellular data analysis has become a quintessential method for understanding the neurophysiological responses to stimuli. This demands stringent techniques owing to the complicated nature of the recording environment. In this paper, we highlight the challenges in extracellular multi-electrode recording and data an...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep28533
更新日期:2016-06-24 00:00:00
abstract::Photonic crystal materials are based on a periodic modulation of the dielectric constant on length scales comparable to the wavelength of light. These materials can exhibit photonic band gaps; frequency regions for which the propagation of electromagnetic radiation is forbidden due to the depletion of the density of s...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep21818
更新日期:2016-02-25 00:00:00
abstract::Highly selective hydrogenative carbon-carbon bond scission of biomass-derived platform oxygenates was achieved with a cerium oxide-supported ruthenium nanoparticle catalyst in water. The present catalyst enabled the selective cleavage of carbon-carbon σ bonds adjacent to carboxyl, ester, and hydroxymethyl groups, open...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-14373-1
更新日期:2017-10-25 00:00:00
abstract::The present study aimed to explore a new source of montmorillonite and to develop an extraction and purification protocol for its isolation from raw clay samples acquired from the Koh-e-Suleiman mountain range in Pakistan. The process involved the collection of raw clay from the source, identification and quantificati...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-57511-y
更新日期:2020-01-17 00:00:00
abstract::Rabies is still a public health threat in China. Evaluating the exposure history, clinical characteristics, and post-exposure prophylaxis (PEP) of the cases could help in identifying approaches to reducing the number of these preventable deaths. We analysed data collected from 10,971 case-investigations conducted in C...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-35158-0
更新日期:2018-11-21 00:00:00
abstract::Next generation sequencing (NGS) data analysis is highly compute intensive. In-memory computing, vectorization, bulk data transfer, CPU frequency scaling are some of the hardware features in the modern computing architectures. To get the best execution time and utilize these hardware features, it is necessary to tune ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-09089-1
更新日期:2017-08-22 00:00:00
abstract::An available pathway to prepare the ionized covalent organic nanosheets (iCONs) has been proposed by a metal-assisted aqueous-phase exfoliation route from covalent organic frameworks. The soluble and belt-shaped iCONs could immobilize a large quantity of proteins (2.73 mg/mg, BSA/iCONs) and hence serve as transporters...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-23744-1
更新日期:2018-04-03 00:00:00
abstract::We report a non-iterative localization algorithm that utilizes the scaling of a three-dimensional (3D) image in the axial direction and focuses on evaluating the radial symmetry center of the scaled image to achieve the desired single-particle localization. Using this approach, we analyzed simulated 3D particle images...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep02462
更新日期:2013-01-01 00:00:00
abstract::The association of seasonal trivalent influenza vaccine (TIV) with increased infection by 2009 pandemic H1N1 (A(H1N1)pdm09) virus, initially observed in Canada, has elicited numerous investigations on the possibility of vaccine-associated enhanced disease, but the potential mechanisms remain largely unresolved. Here, ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep37341
更新日期:2016-11-16 00:00:00
abstract::Early cow-calf separation prevents much of cows' natural maternal behaviour. Early separation is thought to prevent the development of a cow-calf bond. To assess this bond, we measured motivation of dairy cows to reunite with their calf. To vary the degree of bonding, some cows were allowed continued contact with thei...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-70927-w
更新日期:2020-08-28 00:00:00
abstract::Contemporary improvements in the type II clustered regularly interspaced short palindromic repeats/CRISPR-associated protein 9 (CRISPR/Cas9) system offer a convenient way for genome editing in zebrafish. However, the low efficiencies of genome editing and germline transmission require a time-intensive and laborious sc...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep34555
更新日期:2016-09-29 00:00:00
abstract::A number of studies have reported that the digit ratio 2D:4D (length of the second finger divided by length of the fourth finger) is smaller (longer fourth digit) in autism spectrum disorder (ASD) than in typically developed (TD) controls. Because form and function are closely related in biological systems, we hypothe...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-38421-6
更新日期:2019-02-11 00:00:00
abstract::Age-related hearing loss (ARHI) is the most common sensory disorder in the elderly. Although telomere attrition has been shown as a determinant in the pathobiology of various age-related diseases, it remains unknown whether telomere length is associated with ARHI. We hypothesized that decreased leukocyte telomere leng...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-10680-9
更新日期:2017-08-31 00:00:00
abstract::Inverse Compton scattering between ultra-relativistic electrons and an intense laser field has been proposed as a major route to generate compact high-brightness and high-energy γ-rays. Attributed to the inherent synchronization mechanism, an all-optical Compton scattering γ-ray source, using one laser to both acceler...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep29518
更新日期:2016-07-13 00:00:00
abstract::The ability to induce reversible phase transitions between homogeneous solutions and biphasic liquid-liquid systems, at pre-defined and suitable operating temperatures, is of crucial relevance in the design of separation processes. Ionic-liquid-based aqueous biphasic systems (IL-based ABS) have demonstrated superior p...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep20276
更新日期:2016-02-04 00:00:00
abstract::Beta oscillations observed in motor cortical local field potentials (LFPs) recorded on separate electrodes of a multi-electrode array have been shown to exhibit non-zero phase shifts that organize into planar waves. Here, we generalize this concept to additional classes of salient patterns that fully describe the spat...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-22990-7
更新日期:2018-03-26 00:00:00
abstract::The CoCrMo matrix composites with nano-TiO2 particle (2 wt.%, 4 wt.% and 6 wt.%) were fabricated by using a powder metallurgy technique (P/M), and the nano-TiO2 content was optimized in matrix. The microstructures, mechanical and high-temperature tribological properties of the synthesized composites were systematicall...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-63918-4
更新日期:2020-04-22 00:00:00
abstract::Polystyrene sulfonate (PSS), a strong polyelectrolyte, was used to prepare red photoluminescent PSS-penicillamine (PA) copper (Cu) nanoclusters (NC) aggregates, which displayed high selectivity and sensitivity to the detection of hydrogen sulfide (H2S). The size of the PSS-PA-Cu NC aggregates could be readily controll...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep24882
更新日期:2016-04-26 00:00:00
abstract::Attending a location in space facilitates responses to targets at that location when the time between cue and target is short. Certain types of exogenous cues - such as sudden peripheral onsets - have been described as reflexive and automatic. Recent studies however, have been showing many cases where exogenous cues a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-31633-w
更新日期:2018-09-05 00:00:00
abstract::Pyramidal neurons in the rodent hippocampus exhibit spatial tuning during spatial navigation, and they are reactivated in specific temporal order during sharp-wave ripples observed in quiet wakefulness or slow wave sleep. However, analyzing representations of sleep-associated hippocampal ensemble spike activity remain...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep32193
更新日期:2016-08-30 00:00:00
abstract::Kluyveromyces marxianus, a non-conventional thermotolerant yeast, is potentially useful for production of ethanol and other products. This species has a strong tendency to randomly integrate transforming DNA fragments, making necessary the development of more precise methods for gene targeting. In this study, we first...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-08356-5
更新日期:2017-08-21 00:00:00
abstract::Acute lymphoblastic leukaemia (ALL) is the most common childhood cancer and has a high survival rate when properly managed. Prognosis is correlated with many factors such as age, gender, white blood cell (WBC) count, CD10, French-American-British (FAB) classification, and many others. Many of these factors are include...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-63528-0
更新日期:2020-04-21 00:00:00
abstract::The purpose of this study was to analyze spatiotemporal parameters of gait in children using varyingly loaded Backpacks(BP). This cross-sectional study examined 231 schoolchildren (118 boys, 113 girls) aged six to 12 years, carrying a traditional BP to manipulate loading (Crossing Backpack Children Arpenaz 7 Litres, J...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-48675-3
更新日期:2019-08-21 00:00:00
abstract::Macrophages play an important role in the inflammatory process that contributes to the development of abdominal aortic aneurysm (AAA). Studies of human and mouse AAA tissue reveal expanded populations of macrophages producing an abundance of pro-inflammatory cytokines, including TNF-α, IL-12p40 and high level of metal...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-46909-y
更新日期:2019-07-18 00:00:00
abstract::Alzheimer's disease (AD) is a circadian clock-related disease. However, it is not very clear whether pre-symptomatic AD leads to circadian disruption or whether malfunction of circadian rhythms exerts influence on development of AD. Here, we report a functional clock that exists in the hippocampus. This oscillator bot...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep36035
更新日期:2016-10-31 00:00:00
abstract::Some studies have reported that upper limb tightness is a risk factor for shoulder/elbow pain in high school baseball pitchers; but there has been insufficient research on the relationship between lower limb tightness and shoulder and elbow pain in pitchers. This study aimed to clarify the correlation among pre-season...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-76894-6
更新日期:2020-11-17 00:00:00
abstract::Drug discovery efforts against the pathogen Mycobacterium tuberculosis (Mtb) have been advanced through phenotypic screens of extensive compound libraries. Such a screen revealed sulfolane 1 and indoline-5-sulfonamides 2 and 3 as potent inhibitors of mycobacterial growth. Optimization in the sulfolane series led to co...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-09642-y
更新日期:2017-08-25 00:00:00
abstract::Neutron energy is directly correlated with the energy of the incident ions in experiments involving laser-driven nuclear reactions. Using high-energy incident ions reduces the energy concentration of the generated neutrons. A novel "laser-collider" method was used at the Shenguang II laser facility to produce monoener...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep27363
更新日期:2016-06-02 00:00:00