Development of a comprehensive set of tools for genome engineering in a cold- and thermo-tolerant Kluyveromyces marxianus yeast strain.

abstract：:Serotonin 5-HT2C receptor is a G-protein coupled excitatory receptor that regulates several biochemical pathways and has been implicated in obesity, mental state, sleep cycles, autism, neuropsychiatric disorders and neurodegenerative diseases. The activity of 5-HT2CR is regulated via alternative splicing and A to I ed...

journal_title：Scientific reports

authors： Raabe CA,Voss R,Kummerfeld DM,Brosius J,Galiveti CR,Wolters A,Seggewiss J,Huge A,Skryabin BV,Rozhdestvensky TS

更新日期：2019-03-12 00:00:00

abstract：:The objective of this study was to examine whether shorter leukocyte telomere length (LTL) is associated with more rapid pulmonary function decline in a longitudinal study of World Trade Center (WTC) responders. WTC responders (N = 284) participating in a monitoring study underwent blood sampling and were followed pro...

journal_title：Scientific reports

authors： Clouston SAP,Edelman NH,Aviv A,Stewart C,Luft BJ

更新日期：2019-05-31 00:00:00

abstract：:Several microbes, including Staphylococcus epidermidis (S. epidermidis), a Gram-positive bacterium, live inside the human nasal cavity as commensals. The role of these nasal commensals in host innate immunity is largely unknown, although bacterial interference in the nasal microbiome may promote ecological competition...

journal_title：Scientific reports

authors： Chen HW,Liu PF,Liu YT,Kuo S,Zhang XQ,Schooley RT,Rohde H,Gallo RL,Huang CM

更新日期：2016-06-16 00:00:00

abstract：:Acquisition of nutrients during intra-vacuolar growth of L. pneumophila within macrophages or amoebae is poorly understood. Since many genes of L. pneumophila are acquired by inter-kingdom horizontal gene transfer from eukaryotic hosts, we examined the presence of human solute carrier (SLC)-like transporters in the L....

journal_title：Scientific reports

authors： Best A,Jones S,Abu Kwaik Y

更新日期：2018-05-29 00:00:00

abstract：:Wound dressings with silver have been shown to be cytotoxic in vitro. However, the extrapolation of this cytotoxicity to clinical settings is unclear. We applied dressings with various forms of silver on porcine skin ex vivo and investigated silver penetration and DNA damage. We assessed antimicrobial efficacy, cytoto...

journal_title：Scientific reports

authors： Nešporová K,Pavlík V,Šafránková B,Vágnerová H,Odráška P,Žídek O,Císařová N,Skoroplyas S,Kubala L,Velebný V

更新日期：2020-09-16 00:00:00

abstract：:Programmed death-1 (PD-1) is an immunosuppressive receptor functionally bound with programmed death-ligand 1 (PD-L1), which has been reported in various malignancies. However, only a few studies are available for the clinical significance of PD-1/PD-L1 in nasopharyngeal carcinoma (NPC). In this study, we aim to invest...

journal_title：Scientific reports

authors： Zhou Y,Shi D,Miao J,Wu H,Chen J,Zhou X,Hu D,Zhao C,Deng W,Xie C

更新日期：2017-03-03 00:00:00

abstract：:Divalent metal-ion transporter 1 (DMT1) has been found to play an important role in the iron metabolism and hemogenesis. However, little is known about the potential role of DMT1 in the pathogenesis of anemia from patients with inflammatory bowel disease (IBD). Herein, we investigated expression of DMT1 in the intesti...

journal_title：Scientific reports

authors： Wu W,Song Y,He C,Liu C,Wu R,Fang L,Cong Y,Miao Y,Liu Z

更新日期：2015-11-17 00:00:00

abstract：:Ge-monopnictides (GeAs) plays critical role in high-tech industry, especially in the field of advanced optical devices and infrared. As a secondary material, coal fly ash could be further recycled to retrieve germanium and prepare GeAs material with high added values. Hence, the aim of this paper is to propose a one-p...

journal_title：Scientific reports

authors： Zhang L,Xu Z

更新日期：2017-06-16 00:00:00

abstract：:The intercellular spreading of protein assemblies is a major factor in the progression of neurodegenerative disorders. The quantitative study and visualization of cell-to-cell propagation using tagged-proteins is challenging due to the steric effect of relatively large fluorescence tags and the risk of 'false positive...

journal_title：Scientific reports

authors： Peled S,Sade D,Bram Y,Porat Z,Kreiser T,Mimouni M,Lichtenstein A,Segal D,Gazit E

更新日期：2017-03-28 00:00:00

abstract：:The epigenetic status of the genome changes dynamically from fertilization to implantation. In addition, the physiological environment during the process of gametogenesis, including parental age, may affect the epigenome of the embryo after fertilization. It is important to clarify the influence of parental age on gen...

journal_title：Scientific reports

authors： Kawai K,Harada T,Ishikawa T,Sugiyama R,Kawamura T,Yoshida A,Tsutsumi O,Ishino F,Kubota T,Kohda T

更新日期：2018-02-05 00:00:00

abstract：:A new species of fossil conifer wood, Podocarpoxylon donghuaiense sp. nov., is described from the late Eocene of Nadu Formation in Baise Basin of the Guangxi Province, South China. This fossil wood is characterized by distinct growth rings, circular to oval tracheids in cross section, 1-2-seriate opposite pits on radi...

journal_title：Scientific reports

authors： Li L,Jin JH,Quan C,Oskolski AA

更新日期：2016-08-30 00:00:00

abstract：:Many neurological disorders of gluten-related diseases (GRD), not directly referable to the gastrointestinal tract, have been reported in association with celiac disease (CD), including ataxia, neuropathy and epilepsy. In particular, people with epilepsy diagnosed with CD seems to be characterized by intractable seizu...

journal_title：Scientific reports

authors： Gerace E,Resta F,Landucci E,Renzi D,Masi A,Pellegrini-Giampietro DE,Calabrò A,Mannaioni G

更新日期：2017-11-09 00:00:00

abstract：:In the cochlea, mammals maintain a uniquely high endolymphatic potential (EP), which is not observed in other vertebrate groups. However, a high [K+] is always present in the inner ear endolymph. Here, we show that Kir4.1, which is required in the mammalian stria vascularis to generate the highly positive EP, is absen...

journal_title：Scientific reports

authors： Wilms V,Köppl C,Söffgen C,Hartmann AM,Nothwang HG

更新日期：2016-09-29 00:00:00

abstract：:Aditoprim (ADP) is a newly developed antibacterial agent in veterinary medicine. The metabolism and disposition of ADP in swine, broilers, carp and rats were investigated by using a radio tracer method combined with a radioactivity detector and a liquid chromatography/ion trap/time-of-flight mass spectrometry. After a...

journal_title：Scientific reports

authors： Wang L,Huang L,Pan Y,Kuča K,Klímová B,Wu Q,Xie S,Ahmad I,Chen D,Tao Y,Wan D,Liu Z,Yuan Z

更新日期：2016-02-03 00:00:00

abstract：:Pond-dwelling cyclic parthenogens are often proposed to be highly vagile. However, the Holarctic biogeography of parthenogens has been hampered by very limited sampling in the eastern Palearctic. Here we examine the geographic boundaries, diversity, and connectivity across the Palearctic for the Daphnia curvirostris c...

journal_title：Scientific reports

authors： Kotov AA,Taylor DJ

更新日期：2019-05-02 00:00:00

abstract：:Magnetic small-angle neutron scattering (SANS) is a powerful technique for investigating magnetic nanoparticle assemblies in nonmagnetic matrices. For such microstructures, the standard theory of magnetic SANS assumes uniformly magnetized nanoparticles (macrospin model). However, there exist many experimental and theo...

journal_title：Scientific reports

authors： Vivas LG,Yanes R,Michels A

更新日期：2017-10-12 00:00:00

abstract：:Modeling the dynamic nature of protein-ligand binding with atomistic simulations is one of the main challenges in computational biophysics, with important implications in the drug design process. Although in the past few years hardware and software advances have significantly revamped the use of molecular simulations,...

journal_title：Scientific reports

authors： Lecina D,Gilabert JF,Guallar V

更新日期：2017-08-16 00:00:00

abstract：:Most bacterial cells are stressed, and as a result, some become tolerant to antibiotics by entering a dormant state known as persistence. The key intracellular metabolite that has been linked to this persister state is guanosine tetraphosphate (ppGpp), the alarmone that was first linked to nutrient stress. In Escheric...

journal_title：Scientific reports

authors： Chowdhury N,Kwan BW,Wood TK

更新日期：2016-02-03 00:00:00

abstract：:How diverse adult stem and progenitor populations regenerate tissue following damage to the brain is poorly understood. In highly regenerative vertebrates, such as zebrafish, radial-glia (RG) and neuro-epithelial-like (NE) stem/progenitor cells contribute to neuronal repair after injury. However, not all RG act as neu...

journal_title：Scientific reports

authors： Lindsey BW,Aitken GE,Tang JK,Khabooshan M,Douek AM,Vandestadt C,Kaslin J

更新日期：2019-03-14 00:00:00

abstract：:Orthographic regularity is important for processing Chinese characters. However, the issues how orthographic regularity influences the visual recognition of real Chinese characters and whether common processes related to the potential effect exist between successive (SUCC) and concurrent (CONC) conditions with asynchr...

journal_title：Scientific reports

authors： He W,Fan C,Ren J,Liu T,Zhang M,Luo W

更新日期：2016-03-23 00:00:00

abstract：:Traditional Protein-Protein Interaction (PPI) networks, which use a node and edge representation, lack some valuable information about the mechanistic details of biological processes. Mapping protein structures to these PPI networks not only provides structural details of each interaction but also helps us to find the...

journal_title：Scientific reports

authors： Halakou F,Kilic ES,Cukuroglu E,Keskin O,Gursoy A

更新日期：2017-08-03 00:00:00

abstract：:Jellyfish stingings are currently raising serious public health concerns around the world. Hence, the search for an effective first aid reagent for the envenomation has been the goal of many investigators in the field. There have been a few previous reports of in vivo as well as in vivo studies suggesting the metallop...

journal_title：Scientific reports

authors： Hwang DH,Lee H,Choudhary I,Kang C,Chae J,Kim E

更新日期：2020-10-29 00:00:00

abstract：:Planktonic foraminifera (PF) life cycles are highly sensitive to marine conditions, which are evolving rapidly due to anthropogenic climate change. Even though PF shells in the sedimentary record serve as prominent proxies of past ocean conditions, very little is still known about their life cycles, particularly in ol...

journal_title：Scientific reports

authors： Chernihovsky N,Almogi-Labin A,Kienast SS,Torfstein A

更新日期：2020-10-15 00:00:00

abstract：:Gene expression regulation is a complex and highly organized process involving a variety of genomic factors. It is widely accepted that differences in gene expression can contribute to the phenotypic variability between species, and that their interpretation can aid in the understanding of the physiologic variability....

journal_title：Scientific reports

authors： Dweep H,Kubikova N,Gretz N,Voskarides K,Felekkis K

更新日期：2015-07-16 00:00:00

abstract：:Successful tick feeding is facilitated by an assortment of pharmacologically-active factors in tick saliva that create an immunologically privileged micro-environment in the host's skin. Through a process known as saliva-assisted transmission, bioactive tick salivary factors modulate the host environment, promoting tr...

journal_title：Scientific reports

authors： Hermance ME,Widen SG,Wood TG,Thangamani S

更新日期：2019-09-11 00:00:00

abstract：:Due to their multipotentiality and immunomodulation, human mesenchymal stem cells (hMSCs) are widely studied for the treatment of degenerative and inflammatory diseases. Transplantation of hMSCs to damaged tissue is a promising approach for tissue regeneration. However, the physiological mechanisms and regulatory proc...

journal_title：Scientific reports

authors： Kim SH,Das A,Chai JC,Binas B,Choi MR,Park KS,Lee YS,Jung KH,Chai YG

更新日期：2016-07-22 00:00:00

abstract：:Several prenatal and perinatal factors have been found to be associated with developmental dyslexia (reading disorder) in alphabetic language. Given the absence of relevant studies of Chinese children, the present study tries to investigate these risk factors. A total of 45,850 students were recruited from grades thre...

journal_title：Scientific reports

authors： Liu L,Wang J,Shao S,Luo X,Kong R,Zhang X,Song R

更新日期：2016-11-07 00:00:00

abstract：:Gout/hyperuricemia is a common multifactorial disease having typical environmental risks. Recently, common dysfunctional variants of ABCG2, a urate exporter gene also known as BCRP, are revealed to be a major cause of gout/hyperuricemia. Here, we compared the influence of ABCG2 dysfunction on serum uric acid (SUA) lev...

journal_title：Scientific reports

authors： Nakayama A,Matsuo H,Nakaoka H,Nakamura T,Nakashima H,Takada Y,Oikawa Y,Takada T,Sakiyama M,Shimizu S,Kawamura Y,Chiba T,Abe J,Wakai K,Kawai S,Okada R,Tamura T,Shichijo Y,Akashi A,Suzuki H,Hosoya T,Sakurai Y,Ic

更新日期：2014-06-09 00:00:00

abstract：:The interplay between the quasi 1-dimensional CuO-chains and the 2-dimensional CuO2 planes of YBa(2)Cu(3)O(6+x) (YBCO) has been in focus for a long time. Although the CuO-chains are known to be important as charge reservoirs that enable superconductivity for a range of oxygen doping levels in YBCO, the understanding o...

journal_title：Scientific reports

authors： Magnuson M,Schmitt T,Strocov VN,Schlappa J,Kalabukhov AS,Duda LC

更新日期：2014-11-12 00:00:00

abstract：:P130CAS/BCAR1 belongs to the CAS family of adaptor proteins, with important regulatory roles in cell migration, cell cycle control, and apoptosis. Previously, we and others showed that P130CAS mediates VEGF-A and PDGF signalling in vitro, but its cardiovascular function in vivo remains relatively unexplored. We charac...

journal_title：Scientific reports

authors： Wisniewski L,French V,Lockwood N,Valdivia LE,Frankel P

更新日期：2020-09-24 00:00:00