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Metabolism and Disposition of Aditoprim in Swine, Broilers, Carp and Rats.

Abstract：

:Aditoprim (ADP) is a newly developed antibacterial agent in veterinary medicine. The metabolism and disposition of ADP in swine, broilers, carp and rats were investigated by using a radio tracer method combined with a radioactivity detector and a liquid chromatography/ion trap/time-of-flight mass spectrometry. After a single oral administration, more than 94% of the dose was recovered within 14 d in the four species. The urine excretion was dominant in swine and rats, making up 78% of the dose. N-monodesmethyl-ADP, N-didesmethyl-ADP, and 10 new metabolites were characterized. These metabolites were biotransformed from the process of demethylation, α-hydroxylation, N-oxidation, and NH2-glucuronidation. After an oral dose for 7 d, ADP-derived radioactivity was widely distributed in tissues, and high concentrations were especially observed in bile, liver, kidney, lung, and spleen. The radioactivity in the liver was eliminated much more slowly than in other tissues, with a half-life of 4.26, 3.38, 6.69, and 5.21 d in swine, broilers, carp, and rats, respectively. ADP, N-monodesmethyl-ADP, and N-didesmethyl-ADP were the major metabolites in edible tissues. Notably, ADP was detected with the highest concentration and the longest duration in these tissues. These findings indicated that ADP is the marker residue and the liver is the residue target tissue.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Wang L,Huang L,Pan Y,Kuča K,Klímová B,Wu Q,Xie S,Ahmad I,Chen D,Tao Y,Wan D,Liu Z,Yuan Z

doi

10.1038/srep20370

subject

Has Abstract

pub_date

2016-02-03 00:00:00

pages

20370

issn

2045-2322

pii

srep20370

journal_volume

6

pub_type

杂志文章

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