Abstract：
:The epigenetic status of the genome changes dynamically from fertilization to implantation. In addition, the physiological environment during the process of gametogenesis, including parental age, may affect the epigenome of the embryo after fertilization. It is important to clarify the influence of parental age on gene expression in the embryo in terms of transgenerational epigenetics to improve the techniques currently used in assisted reproductive medicine. Here, we performed single-embryo RNA-seq analysis on human blastocysts fertilized by intracytoplasmic sperm injection, including from relatively elderly mothers, to elucidate the effects of parental age on the embryonic gene expression profile. We identified a number of genes in which the expression levels were decreased with increasing maternal age. Among these genes, several are considered to be important for meiotic chromosomal segregation, such as PTTG1, AURKC, SMC1B and MEIKIN. Furthermore, the expression levels of certain genes critical for autophagy and embryonic growth, specifically GABARAPL1 and GABARAPL3, were negatively correlated with advanced paternal age. In addition, levels of transcripts derived from major satellite repeats also decreased as the maternal age increased. These results suggest that epigenetic modifications of the oocyte genome may change with parental age and be transmitted to the next generation.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Kawai K,Harada T,Ishikawa T,Sugiyama R,Kawamura T,Yoshida A,Tsutsumi O,Ishino F,Kubota T,Kohda Tdoi
10.1038/s41598-018-20614-8subject
Has Abstractpub_date
2018-02-05 00:00:00pages
2380issue
1issn
2045-2322pii
10.1038/s41598-018-20614-8journal_volume
8pub_type
杂志文章abstract：:There are three sex ratio strategies (SRS) in nature-male-biased sex ratio, female-biased sex ratio and, equal sex ratio. It was R. A. Fisher who first explained why most species in nature display a sex ratio of ½. Consequent SRS theories such as Hamilton's local mate competition (LMC) and Clark's local resource compe...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep39807
更新日期：2016-12-23 00:00:00
abstract：:We compare the prey capture glues produced by orb-weaving spiders (viscid glue) and their evolutionary descendents, the cobweb-weaving spiders (gumfoot glue). These glues are produced in homologous glands but exhibit contrasting structure, properties and response to changing humidity. Individual glue droplet stretchin...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep00041
更新日期：2011-01-01 00:00:00
abstract：:Estimates suggest that at least half of all extant insect genera harbor obligate bacterial mutualists. Whereas an endosymbiotic relationship imparts many benefits upon host and symbiont alike, the intracellular lifestyle has profound effects on the bacterial genome. The obligate endosymbiont genome is a product of opp...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-31796-6
更新日期：2018-09-07 00:00:00
abstract：:Although Heme Oxygenase-1 (HO-1) induction in various forms of kidney injury is protective, its role in age-related renal pathology is unknown. In the ageing kidney there is nephron loss and lesions of focal glomerulosclerosis, interstitial fibrosis, tubular atrophy and arteriolosclerosis. Underlying mechanisms includ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-62016-9
更新日期：2020-03-31 00:00:00
abstract：:We demonstrate synthesis of Ni/CuOx/Ni nanowires (NWs) by electrochemical deposition on anodized aluminum oxide (AAO) membranes. AAO with pore diameter of ~70 nm and pore length of ~50 μm was used as the template for synthesis of NWs. After deposition of Au as the seed layer, NWs with a structure of Ni/CuOx/Ni were gr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep23069
更新日期：2016-03-15 00:00:00
abstract：:Gout/hyperuricemia is a common multifactorial disease having typical environmental risks. Recently, common dysfunctional variants of ABCG2, a urate exporter gene also known as BCRP, are revealed to be a major cause of gout/hyperuricemia. Here, we compared the influence of ABCG2 dysfunction on serum uric acid (SUA) lev...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep05227
更新日期：2014-06-09 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-019-48627-x
更新日期：2019-08-28 00:00:00
abstract：:The domestic dog (Canis familiaris) is a promising animal model. Yet, the canine neuroscience literature is predominantly comprised of studies wherein (semi-)invasive methods and intensive training are used to study awake dog behavior. Given prior findings with humans and/or dogs, our goal was to assess, in 16 family ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-25546-x
更新日期：2018-05-08 00:00:00
abstract：:Coronary computed tomography angiography is an established technique in clinical practice and a valuable tool in the diagnosis of coronary artery disease in humans. Imaging of coronaries in preclinical research, i.e. in small animals, is very difficult due to the high demands on spatial and temporal resolution. Mice e...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-73735-4
更新日期：2020-10-08 00:00:00
abstract：:Hysteresis, which is the history dependence of physical systems, is one of the most important topics in physics. Interestingly, bi-stability of plasma with a huge hysteresis loop has been observed in inductive plasma discharges. Despite long plasma research, how this plasma hysteresis occurs remains an unresolved ques...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep15254
更新日期：2015-10-20 00:00:00
abstract：:Numerous essential metal elements (EMEs) are necessary to maintain the proper function of human body. In this case-control study, we investigated the associations of 11 EMEs [Calcium (Ca), potassium (K), magnesium (Mg), sodium (Na), manganese (Mn), selenium (Se), cobalt (Co), Molybdenum (Mo), copper (Cu), zinc (Zn), a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-66496-7
更新日期：2020-07-03 00:00:00
abstract：:Male moths efficiently recognize conspecific sex pheromones thanks to their highly accurate and specific olfactory system. The Heliothis/Helicoverpa species are regarded as good models for studying the perception of sex pheromones. In this study, we performed a series of experiments to investigate the peripheral mecha...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep18742
更新日期：2016-01-08 00:00:00
abstract：:Proton irradiation is often used as a proxy for neutron irradiation but the irradiated layer is typically <50 μm deep; this presents a problem when trying to obtain mechanical test data as a function of irradiation level. Two novel methodologies have been developed to record stress-strain curves for thin proton-irradi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-62241-2
更新日期：2020-03-24 00:00:00
abstract：:The capacity of healthy adult listeners to accommodate to altered spectral cues to the source locations of broadband sounds has now been well documented. In recent years we have demonstrated that the degree and speed of accommodation are improved by using an integrated sensory-motor training protocol under anechoic co...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-11981-9
更新日期：2017-09-14 00:00:00
abstract：:Individuals who have prior history of childhood traumatic experiences are at a high risk for a variety of psychological and behavioral problems throughout their lifetime. This study aimed to investigate whether such individuals exhibit altered cortical functional networks during a behavioral inhibition task. One hundr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-28329-6
更新日期：2018-07-04 00:00:00
abstract：:Although microbes influence plant growth, little is known about the impact of microbial diversity on plant fitness trade-offs, intraspecific-interactions, and soil nutrient dynamics in the context of biodiversity-ecosystem functioning (BEF) research. The BEF theory states that higher species richness can enhance ecosy...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-72516-3
更新日期：2020-09-22 00:00:00
abstract：:The Hauraki Gulf, a shallow embayment in north-eastern New Zealand, provides an interesting environment for ecological soundscape research. It is situated on a tectonic plate boundary, contains one of the busiest ports in the southern hemisphere and is home to a diverse range of soniferous animals. The underwater soun...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-06347-0
更新日期：2017-07-18 00:00:00
abstract：:The gene encoding the cytosolic β-glucosidase GBA3 shows pseudogenization due to a truncated allele (rs358231) that is polymorphic in humans. Since this enzyme is involved in the transformation of many plant β-glycosides, this particular case of gene loss may have been influenced by dietary adaptations during evolutio...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-68106-y
更新日期：2020-07-14 00:00:00
abstract：:Tobacco smoking is common in HIV-infected patients, and is prevalent among intravenous opiate abusers. Conversely, intravenous opiate abusers are more likely HIV-infected, and opiate abuse is associated with more severe neuroinflammation. Given the coincident use of tobacco smoking among HIV-infected intravenous drug ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-70374-7
更新日期：2020-08-19 00:00:00
abstract：:Graphene-based materials have been studied in many applications, owing to the excellent electrical, mechanical, and thermal properties of graphene. In the current study, an environmentally friendly approach to the preparation of a reduced graphene oxide-gold nanoparticle (rGO-AuNP) nanocomposite was developed by using...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-15210-1
更新日期：2017-11-03 00:00:00
abstract：:Emerging evidence demonstrates the importance of sufficient vitamin D (1α, 25-dihydroxyvitamin D3) levels during early life stage development with deficiencies associated with long-term effects into adulthood. While vitamin D has traditionally been associated with mineral ion homeostasis, accumulating evidence suggest...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-72622-2
更新日期：2020-09-29 00:00:00
abstract：:Rising temperatures in the Arctic cause accelerated mass loss from the Greenland Ice Sheet and reduced sea ice cover. Tidewater outlet glaciers represent direct connections between glaciers and the ocean where melt rates at the ice-ocean interface are influenced by ocean temperature and circulation. However, few measu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-05089-3
更新日期：2017-07-10 00:00:00
abstract：:Uncertainties over future climatic conditions pose significant challenges when selecting appropriate conservation strategies for heritage sites. Choosing effective strategies is especially important for earthen heritage sites located in dryland regions, as many are experiencing rapid environmentally-driven deteriorati...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-73456-8
更新日期：2020-10-02 00:00:00
abstract：:Coastal protection design heights typically consider the superimposed effects of tides, surges, waves, and relative sea-level rise (SLR), neglecting non-linear feedbacks between these forcing factors. Here, we use hydrodynamic modelling and multivariate statistics to show that shallow coastal areas are extremely sensi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep40171
更新日期：2017-01-06 00:00:00
abstract：:The mechanism by which the Earth's magnetic field is generated is thought to be thermal convection in the metallic liquid iron core. Here we present results of a suite of self-consistent spherical shell computations with ultra-low viscosities that replicate this mechanism, but using diffusivities of momentum and magne...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-30864-1
更新日期：2018-08-22 00:00:00
abstract：:The study of factors influencing animal intake can provide a better understanding of the dynamics of the pasture ecosystem and serve as a basis for managing livestock in a more efficient way. We measured different sward surface heights of tall fescue in the process of short-term intake rate of sheep. There was a signi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-68827-0
更新日期：2020-07-16 00:00:00
abstract：:How exponentially growing cells maintain size homeostasis is an important fundamental problem. Recent single-cell studies in prokaryotes have uncovered the adder principle, where cells add a fixed size (volume) from birth to division, irrespective of their size at birth. To mechanistically explain the adder principle,...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep30229
更新日期：2016-07-26 00:00:00
abstract：:Polygenic risk scores (PRS) from genome-wide association studies (GWAS) are increasingly used to predict disease risks. However some included variants could be false positives and the raw estimates of effect sizes from them may be subject to selection bias. In addition, the standard PRS approach requires testing over ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep41262
更新日期：2017-02-01 00:00:00
abstract：:We present combined in situ X-ray diffraction and high-speed imaging to monitor the phase evolution upon cyclic rapid laser heating and cooling mimicking the direct energy deposition of Ti-6Al-4V in real time. Additive manufacturing of the industrially relevant alloy Ti-6Al-4V is known to create a multitude of phases ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-16760-0
更新日期：2017-11-27 00:00:00
abstract：:Injured adult tendons do not exhibit optimal healing through a regenerative process, whereas fetal tendons can heal in a regenerative fashion without scar formation. Hence, we compared FFs (mouse fetal fibroblasts) and AFs (mouse adult fibroblasts) as seed cells for the fabrication of scaffold-free engineered tendons....
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep05515
更新日期：2014-07-03 00:00:00
