Abstract:
:The association of seasonal trivalent influenza vaccine (TIV) with increased infection by 2009 pandemic H1N1 (A(H1N1)pdm09) virus, initially observed in Canada, has elicited numerous investigations on the possibility of vaccine-associated enhanced disease, but the potential mechanisms remain largely unresolved. Here, we investigated if prior immunization with TIV enhanced disease upon A(H1N1)pdm09 infection in mice. We found that A(H1N1)pdm09 infection in TIV-immunized mice did not enhance the disease, as measured by morbidity and mortality. Instead, TIV-immunized mice cleared A(H1N1)pdm09 virus and recovered at an accelerated rate compared to control mice. Prior TIV immunization was associated with potent inflammatory mediators and virus-specific CD8 T cell activation, but efficient immune regulation, partially mediated by IL-10R-signaling, prevented enhanced disease. Furthermore, in contrast to suggested pathological roles, pre-existing non-neutralizing antibodies (NNAbs) were not associated with enhanced virus replication, but rather with promoted antigen presentation through FcR-bearing cells that led to potent activation of virus-specific CD8 T cells. These findings provide new insights into interactions between pre-existing immunity and pandemic viruses.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Kim JH,Reber AJ,Kumar A,Ramos P,Sica G,Music N,Guo Z,Mishina M,Stevens J,York IA,Jacob J,Sambhara Sdoi
10.1038/srep37341subject
Has Abstractpub_date
2016-11-16 00:00:00pages
37341issn
2045-2322pii
srep37341journal_volume
6pub_type
杂志文章abstract::Panax ginseng (GS) and Veratrum nigrum (VN) are representative of incompatible pairs in "eighteen antagonistic medicaments" that have been recorded in the Chinese medicinal literature for over 2,000 years. However, evidence linking interference effects with combination use is scare. Based on the estrogen-like effect o...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep26924
更新日期:2016-05-27 00:00:00
abstract::Field electron emission (FEE) properties of vertically aligned hexagonal boron nitride nanowalls (hBNNWs) grown on Si have been markedly enhanced through the use of nitrogen doped nanocrystalline diamond (nNCD) films as an interlayer. The FEE properties of hBNNWs-nNCD heterostructures show a low turn-on field of 15.2 ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep29444
更新日期:2016-07-11 00:00:00
abstract::We analyze work extraction from an autonomous (self-contained) heat-powered optomechanical setup. The initial state of the quantized mechanical oscillator plays a key role. As the initial mean amplitude of the oscillator decreases, the resulting efficiency increases. In contrast to laser-powered self-induced oscillati...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep07809
更新日期:2015-01-15 00:00:00
abstract::Non-invasive investigation of physiological changes and metabolic events associated with brain activity in mice constitutes a major challenge. Conventionally, fMRI assesses neuronal activity by evaluating activity-evoked local changes in blood oxygenation levels (BOLD). In isoflurane-anaethetized mice, however, we fou...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-46477-1
更新日期:2019-07-22 00:00:00
abstract::We aimed to determine if prematurity and lower birth weight are associated with poorer lung function in a non-western developed setting with less marked confounding by socioeconomic position. Using multivariable linear regression in Hong Kong's "Children of 1997" birth cohort, adjusted associations of prematurity and ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-56086-7
更新日期:2020-01-15 00:00:00
abstract::Metallic glass (MG) generally fails in a brittle manner under uniaxial tension loading at room temperature. The lack of plastic strain of MG is due to the severe plastic instability via the easily formed one dominate shear band. There have been several approaches to improve the ductility in MG, but achieving uniform t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep03319
更新日期:2013-11-25 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-020-58618-y
更新日期:2020-01-28 00:00:00
abstract::New small molecules that regulate the step-wise differentiation of human pluripotent stem cells into dopaminergic neurons have been identified. The steroid, guggulsterone, was found to be the most effective inducer of neural stem cells into dopaminergic neurons. These neurons are extensively characterized and shown to...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep01463
更新日期:2013-01-01 00:00:00
abstract::Clinical trials have recently demonstrated the effectiveness of Pre-Exposure Prophylaxis (PrEP) in preventing HIV infection. Consequently, PrEP may soon be used for epidemic control. We model the dynamic interactions that will occur between treatment programs and potential PrEP interventions in resource-constrained co...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep00185
更新日期:2011-01-01 00:00:00
abstract::Recent studies have demonstrated that immune cells play an important role in the pathogenesis of many neurological conditions. Immune cells constantly survey the brain microvasculature for irregularities in levels of factors that signal homeostasis. Immune responses are initiated when necessary, resulting in mobilisat...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep06997
更新日期:2014-11-11 00:00:00
abstract::Subcortical ischemic vascular dementia (SIVD) caused by chronic cerebral hypoperfusion develops with progressive white matter and cognitive impairments, yet no effective therapy is available. We investigated the temporal effects of minocycline on an experimental SIVD exerted by right unilateral common carotid arteries...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep12079
更新日期:2015-07-15 00:00:00
abstract::The spirochete Leptospira spp. can move in liquid and on a solid surface using two periplasmic flagella (PFs), and its motility is an essential virulence factor for the pathogenic species. Mammals are infected with the spirochete through the wounded dermis, which implies the importance of behaviors on the boundary wit...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-70897-z
更新日期:2020-08-18 00:00:00
abstract::The SLRP opticin (OPTC) has been demonstrated to be produced and degraded in osteoarthritic (OA) human cartilage. Here, we investigated the in vivo effect of OPTC deficiency in OA cartilage. OA was induced in 10-week-old Optc -/- and Optc +/+ mice. Ten weeks post-surgery, cartilage was processed for histology and immu...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-18047-w
更新日期:2018-01-11 00:00:00
abstract::In this study, an anatase/rutile mixed-phase titanium dioxide (TiO2) hierarchical network deposited with Au nanoparticles (Au/TiO2 ARHN) was synthesized using a facile hydrothermal method followed by a simple calcination step. Such a unique structure was designed for improving the light harvest, charge transportation/...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep42524
更新日期:2017-02-10 00:00:00
abstract::Brain hypometabolism is a common epilepsy-related finding in both patients and animal models. Fluorodeoxyglucose positron emission tomography studies have shown that recurrent seizures lead to reduced glucose metabolism in certain brain regions, but no studies have definitively determined whether this induces epilepto...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-05038-0
更新日期:2017-07-19 00:00:00
abstract::Understanding how animals respond to injury and how wounds heal remains a challenge. These questions can be addressed using genetically tractable animals, including the nematode Caenorhabditis elegans. Given its small size, the current methods for inflicting wounds in a controlled manner are demanding. To facilitate a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-60333-7
更新日期:2020-02-27 00:00:00
abstract::MicroRNAs are a class of small noncoding RNAs that regulate gene expression post-transcriptionally either by inhibiting protein translation or by causing the degradation of target mRNAs. Current evidence indicates that miR-33b is involved in the regulation of lipid metabolism, cholesterol homeostasis, glucose metaboli...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep09995
更新日期:2015-04-28 00:00:00
abstract::Apurinic/apyrimidinic endonuclease 1 (APE1) is a multifunctional protein that controls the cellular response to oxidative stress and possesses DNA-repair functions. It has important roles in the progression and outcomes of various diseases; however, its function and therapeutic prospects with respect to kidney injury ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-44241-z
更新日期:2019-05-24 00:00:00
abstract::Chaotic resonance is a phenomenon that can replace the fluctuation source in stochastic resonance from additive noise to chaos. We previously developed a method to control the chaotic state for suitably generating chaotic resonance by external feedback even when the external adjustment of chaos is difficult, establish...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-48950-3
更新日期:2019-09-02 00:00:00
abstract::We have engineered the electronic structure at the interface between Cu2O and ZnO nanorods (NRs) array, through adjusting the carrier concentration of Cu2O. The electrodeposition of Cu2O at pH 11 acquired the highest carrier concentration, resulting in the largest interfacial electric field between Cu2O and ZnO, which...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep07882
更新日期:2015-01-20 00:00:00
abstract::The interaction between two different materials can present novel phenomena that are quite different from the physical properties observed when each material stands alone. Strong electronic correlations, such as magnetism and superconductivity, can be produced as the result of enhanced Coulomb interactions between ele...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep21460
更新日期:2016-02-18 00:00:00
abstract::Autophagy is the major intracellular degradation system by which cytoplasmic materials are delivered to and degraded in the vacuole/lysosome in eukaryotic cells. MoAtg14 in M. oryzae, a hitherto uncharacterized protein, is the highly divergent homolog of the yeast Atg14 and the mammal BARKOR. The MoATG14 deletion muta...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep40018
更新日期:2017-01-09 00:00:00
abstract::Models of biological processes are often subject to different sources of noise. Developing an understanding of the combined effects of different types of uncertainty is an open challenge. In this paper, we study a variant of the susceptible-infective-recovered model of epidemic spread, which combines both agent-to-age...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-12606-x
更新日期:2017-10-11 00:00:00
abstract::The present study aimed to evaluate the accuracy and repeatability of morphological contour interpolation (MCI)-based semiautomatic segmentation method for volumetric measurements of bone grafts around dental implants. Three in vitro (one with a cylinder and two with a geometrically complex form) and four ex vivo mode...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-71651-1
更新日期:2020-09-10 00:00:00
abstract::An optical radon detection method is presented. Radon decay is directly measured by observing the secondary radiolumines cence light that alpha particles excite in air, and the selectivity of coincident photon detection is further enhanced with online pulse-shape analysis. The sensitivity of a demonstration device was...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep21532
更新日期:2016-02-12 00:00:00
abstract::Glutamine (Gln) is converted to excitatory (glutamate, aspartate) and inhibitory (γ-amino butyric acid) amino acid neurotransmitters in brain, and is a source of energy during glucose deprivation. Current research utilized an Analytical Quality by Design approach to optimize levels and combinations of critical gas pre...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-64099-w
更新日期:2020-04-28 00:00:00
abstract::Seabirds are known to concentrate on prey patches or at predators aggregations standing for potential feeding opportunities. They may search for prey using olfaction or by detecting visually feeding con-specifics and sub-surface predators, or even boats. Thus, they might form a foraging network. We hypothesized that c...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-07480-6
更新日期:2017-08-04 00:00:00
abstract::We compare two approaches for deriving corrections to the "linear model" of cavity optomechanics, in order to describe effects that are beyond first order in the radiation pressure coupling. In the regime where the mechanical frequency is much lower than the cavity one, we compare: (I) a widely used phenomenological H...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-26739-0
更新日期:2018-06-14 00:00:00
abstract::Viral infection triggers a series of signaling cascades, which converge to activate the transcription factors nuclear factor-κB (NF-κB) and interferon regulatory factor 3 (IRF3), thereby inducing the transcription of type I interferons (IFNs). Although not fully characterized, these innate antiviral responses are fine...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep11220
更新日期:2015-06-10 00:00:00
abstract::Accurate measurements of autonomic nerve regulation in heart failure (HF) were unresolved. The discriminating performance of deceleration and acceleration capacities of heart rate in HF was evaluated in 130 HF patients and 212 controls. Acceleration capacity and deceleration capacity were independent risk factors for ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep23617
更新日期:2016-03-23 00:00:00