Abstract:
:Recent studies have demonstrated that immune cells play an important role in the pathogenesis of many neurological conditions. Immune cells constantly survey the brain microvasculature for irregularities in levels of factors that signal homeostasis. Immune responses are initiated when necessary, resulting in mobilisation of the microglial cells resident in the central nervous system (CNS) and/or of infiltrating peripheral cells. However, little is known about the kinetics of immune cells in healthy and diseased CNS, because it is difficult to perform long-term visualisation of cell motility in live tissue with minimal invasion. Here, we describe highly sensitive in vivo MRI techniques for sequential monitoring of cell migration in the CNS at the single-cell level. We show that MRI combined with intravenous administration of super-paramagnetic particles of iron oxide (SPIO) can be used to monitor the transmigration of peripheral phagocytes into healthy or LPS-treated mouse brains. We also demonstrate dynamic cell migration in live animal brains with time-lapse MRI videos. Time-lapse MRI was used to visualise and track cells with low motility in a control mouse brain. High-sensitivity MRI cell tracking using SPIO offers new insights into immune cell kinetics in the brain and the mechanisms of CNS homeostasis.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Mori Y,Chen T,Fujisawa T,Kobashi S,Ohno K,Yoshida S,Tago Y,Komai Y,Hata Y,Yoshioka Ydoi
10.1038/srep06997subject
Has Abstractpub_date
2014-11-11 00:00:00pages
6997issn
2045-2322pii
srep06997journal_volume
4pub_type
杂志文章abstract::The rapid spread of the SARS-CoV-2 in the COVID-19 pandemic had raised questions on the route of transmission of this disease. Initial understanding was that transmission originated from respiratory droplets from an infected host to a susceptible host. However, indirect contact transmission of viable virus by fomites ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-021-81935-9
更新日期:2021-01-28 00:00:00
abstract::There are only few studies that explore the ecological consequences of forest management on several organism groups. We studied the short-term effects of four forestry treatments including preparation cutting, clear-cutting, retention tree group and gap-cutting in a temperate managed forest on the assemblage structure...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-35159-z
更新日期:2018-11-19 00:00:00
abstract::At the moment it is unknown to what extent the impaired function of T lymphocytes in ESRD patients depends on uremia, and to what extent on hemodialysis (HD) procedure. Therefore, the purpose of the study was to evaluate percentages of T lymphocyte subpopulations ex vivo, plasma concentrations of IL12p70, TNF, IL-10, ...
journal_title:Scientific reports
pub_type: 临床试验,杂志文章
doi:10.1038/s41598-019-41619-x
更新日期:2019-03-25 00:00:00
abstract::Interleukin-6 (IL-6) overproduction has been involved in the pathogenesis of several chronic inflammatory diseases and the administration of an anti-IL-6 receptor monoclonal antibody has been proven clinically efficient to treat them. However, the drawbacks of monoclonal antibodies have led our group to develop an inn...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep19549
更新日期:2016-01-19 00:00:00
abstract::The overlap between pain and reward processing pathways leds researchers to hypothesize that there are interactions between them in the human brain. Two hypotheses have been proposed. The "competition hypothesis" posits that reward can reduce pain-related neural activity and vice versa. The "salience hypothesis" sugge...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep26426
更新日期:2016-05-19 00:00:00
abstract::Smoking aggravates HIV-1 pathogenesis and leads to decreased responses to antiretroviral therapy. In this study, we aim to find a molecular mechanism that would explain smoking-induced HIV-1 replication. Benzo(a)pyrene (BaP), a major carcinogen in cigarette, requires metabolic activation through cytochrome P450s (CYPs...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-28500-z
更新日期:2018-07-10 00:00:00
abstract::Large spin splitting at Rashba interface, giving rise to strong spin-momentum locking, is essential for efficient spin-to-charge conversion. Recently, a Cu/Bismuth oxide (Bi2O3) interface has been found to exhibit an efficient spin-to-charge conversion similar to a Ag/Bi interface with large Rashba spin splitting. How...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-23787-4
更新日期:2018-04-03 00:00:00
abstract::Birgus latro (coconut crab) is an edible crustacean that has experienced serious overharvesting throughout its whole habitat range; however, the negative effects of overharvesting on the genetic diversity within B. latro populations have not been elucidated. Here, we report sex ratio, body size, and genetic diversity ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-66712-4
更新日期:2020-06-22 00:00:00
abstract::Bacteria swim in sequences of straight runs that are interrupted by turning events. They drive their swimming locomotion with the help of rotating helical flagella. Depending on the number of flagella and their arrangement across the cell body, different run-and-turn patterns can be observed. Here, we present fluoresc...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-16428-9
更新日期:2017-12-01 00:00:00
abstract::Rising temperatures in the Arctic cause accelerated mass loss from the Greenland Ice Sheet and reduced sea ice cover. Tidewater outlet glaciers represent direct connections between glaciers and the ocean where melt rates at the ice-ocean interface are influenced by ocean temperature and circulation. However, few measu...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-05089-3
更新日期:2017-07-10 00:00:00
abstract::The human brain contains areas that respond selectively to faces, bodies and scenes. Neuroimaging studies have shown that a subset of these areas preferentially respond more to moving than static stimuli, but the reasons for this functional dissociation remain unclear. In the present study, we simultaneously mapped th...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-44663-9
更新日期:2019-06-03 00:00:00
abstract::Communication between vascular plants through volatile organic compounds (VOCs) impacts on ecosystem functioning. However, nothing is known about that between non-vascular plants. To investigate plant-plant VOCs interaction in bryophytes we exposed rare peatland moss Hamatocaulis vernicosus to VOCs of its common compe...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-64108-y
更新日期:2020-05-04 00:00:00
abstract::Inhibition of the androgen receptor (AR) by second-generation anti-androgens is a standard treatment for metastatic castration resistant prostate cancer (mCRPC), but it inevitably leads to the development of resistance. Since the introduction of highly efficient AR signalling inhibitors, approximately 20% of mCRPC pat...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-50220-1
更新日期:2019-09-24 00:00:00
abstract::Predators are an important ecological and evolutionary force shaping prey population dynamics. Ecologists have extensively assessed the lethal effects of invasive predators on prey populations. However, the role of non-lethal effects, such as physiological stress or behavioural responses like dispersal, has been compa...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-20333-0
更新日期:2018-01-31 00:00:00
abstract::MicroRNAs (miRNAs) are important effectors in mediating host-pathogen interaction. In this report, coelomocytes miRNA libraries of three Japanese sea cucumbers Apostichopus japonicus were built by Illumina(®) Hiseq2000 from different time points after lipopolysaccharide challenge (at time 0 h, 6 h and 12 h). The clean...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep17763
更新日期:2015-12-04 00:00:00
abstract::Downstream analysis of genomic and transcriptomic sequence data is often executed by functional annotation that can be performed by various bioinformatics tools and biological databases. However, a full fast integrated tool is not available for such analysis. Besides, the current available software is not able to prod...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-20211-9
更新日期:2018-01-29 00:00:00
abstract::Root damage due to aluminum (Al) toxicity restricts crop production on acidic soils, which are extensive in the tropics. The sorghum root Al-activated citrate transporter, SbMATE, underlies the Al tolerance locus, AltSB, and increases grain yield under Al toxicity. Here, AltSB loci associated with Al tolerance were co...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-27817-z
更新日期:2018-07-04 00:00:00
abstract::Boreal forests play critical roles in global carbon, water and energy cycles. Recent studies suggest drought is causing a decline in boreal spruce growth, leading to predictions of widespread mortality and a shift in dominant vegetation type in interior Alaska. We took advantage of a large set of tree cores collected ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-15644-7
更新日期:2017-11-10 00:00:00
abstract::The effective differentiation between multiple primary lung tumors (MPs) and intrapulmonary metastases (IMs) in patients is imperative to discover the exact disease stage and to select the most appropriate treatment. In this study, the authors was to evaluate the efficacy and validity of large-scale targeted sequencin...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-75935-4
更新日期:2020-11-02 00:00:00
abstract::Invasive species populations periodically collapse from high to low abundance, sometimes even to extinction. Pathogens and the burden they place on invader immune systems have been hypothesised as a mechanism for these collapses. We examined the association of the bacterial pathogen (Pseudomonas spp.) and the viral co...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-41843-5
更新日期:2019-04-08 00:00:00
abstract::Dysregulation in cytokine production has been linked to the pathogenesis of various immune-mediated traits, in which genetic variability contributes to the etiopathogenesis. GWA studies have identified many genetic variants in or near cytokine genes, nonetheless, the translation of these findings into knowledge of fun...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-71018-6
更新日期:2020-09-07 00:00:00
abstract::Autografts tend to be unreliable in older patients. Some of these age-related skeletal changes appear to be attributable to a decline in endogenous WNT signaling. We used a functional in vivo transplantation assay to demonstrate that the bone-forming capacity of an autograft can be traced back to a Wnt-responsive cell...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-18375-x
更新日期:2018-01-08 00:00:00
abstract::Diminished microRNA-29b levels have recently been revealed to provoke increased expression and accumulation of extracellular matrix molecules, such as collagens in fibrotic remodeling. Subsequently, the aim of this study was to find out whether microRNA-29b might also regulate human xylosyltransferase (XT)-I expressio...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-36217-2
更新日期:2018-12-12 00:00:00
abstract::Designing a new generation of energy-intensive and sustainable electrode materials for batteries to power a variety of applications is an imperative task. The use of biomaterials as a nanosized structural template for these materials has the potential to produce hitherto unachievable structures. In this report, we hav...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep07736
更新日期:2015-01-13 00:00:00
abstract::Western wheatgrass (Pascopyrum smithii Rydb.) is an important cool-season forage and turfgrass. However, due to seed dormancy and poor seedling vigor, it is difficult to develop high seed yield production systems, and assessing these components in response to seed yield. Based on multifactor orthogonally designed fiel...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-54586-0
更新日期:2019-11-29 00:00:00
abstract::Sealed-bid auction is an important tool in modern economic especially concerned with networks. However, the bidders still lack the privacy protection in previously proposed sealed-bid auction schemes. In this paper, we focus on how to further protect the privacy of the bidders, especially the non-winning bidders. We f...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-44030-8
更新日期:2019-05-20 00:00:00
abstract::It is known that patients with chronic obstructive pulmonary disease experience dyspnea during unsupported arm exercise (UAE). We examined the respiratory variables in during a hair-washing motion for healthy young people requiring the UAE to find the effects across gender, motion, and speed. In this study, 33 healthy...
journal_title:Scientific reports
pub_type: 临床试验,杂志文章
doi:10.1038/s41598-020-69945-5
更新日期:2020-08-04 00:00:00
abstract::Honeybee pupae morphology can be affected by a number of stressor, but in vivo investigation is difficult. A computed tomography (CT) technique was applied to visualize a comb's inner structure without damaging the brood. The CT scan was performed on a brood comb containing pupae developed from eggs laid by the queen ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-46474-4
更新日期:2019-07-23 00:00:00
abstract::Nasoseptal cartilage has been assumed to be isotropic, unlike the well-defined zonal organization of articular cartilage attributed to postnatal biomechanical loading. We know from clinical experience that malrotation of surgical nasoseptal cartilage grafts can lead to increased graft absorption. Other studies have al...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-48578-3
更新日期:2019-08-28 00:00:00
abstract::Here we report that PTEN contributes to DNA double-strand break (DSB) repair via homologous recombination (HR), as evidenced by (i) inhibition of HR in a reporter plasmid assay, (ii) enhanced sensitivity to mitomycin-C or olaparib and (iii) reduced RAD51 loading at IR-induced DSBs upon PTEN knockdown. No association w...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-22289-7
更新日期:2018-03-02 00:00:00