Loss of PTEN-assisted G2/M checkpoint impedes homologous recombination repair and enhances radio-curability and PARP inhibitor treatment response in prostate cancer.

abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...

journal_title：Scientific reports

authors： Bruneau N,Toumi R,Wang S

更新日期：2018-04-17 00:00:00

abstract：:A wet-chemical method combined with spark plasma sintering was used to prepare a W-Y2O3 alloy. High-temperature tensile tests and nano-indentation microhardness tests were used to characterize the mechanical properties of the alloy. After He-ion irradiation, fuzz and He bubbles were observed on the irradiated surface....

journal_title：Scientific reports

authors： Tan X,Luo L,Chen H,Zhu X,Zan X,Luo G,Chen J,Li P,Cheng J,Liu D,Wu Y

更新日期：2015-07-31 00:00:00

abstract：:Dietary exposure of insects to a feeding deterrent substance for hours to days can induce habituation and concomitant desensitization of the response of peripheral gustatory neurons to such a substance. In the present study, larvae of the herbivore Helicoverpa armigera were fed on diets containing either a high, mediu...

journal_title：Scientific reports

authors： Ma Y,Li J,Tang Q,Zhang X,Zhao X,Yan F,van Loon JJ

更新日期：2016-12-14 00:00:00

abstract：:The intravenous, intramuscular or intraperitoneal administration of water solubilized graphene nanoparticles for biomedical applications will result in their interaction with the hematological components and vasculature. Herein, we have investigated the effects of dextran functionalized graphene nanoplatelets (GNP-Dex...

journal_title：Scientific reports

authors： Chowdhury SM,Kanakia S,Toussaint JD,Frame MD,Dewar AM,Shroyer KR,Moore W,Sitharaman B

更新日期：2013-01-01 00:00:00

abstract：:We study complex scaling properties of RR and QT intervals of electrocardiograms (ECGs) with their equivalences at the cellular level, that is, inter-beat intervals (IBI) and field potential durations (FPD) of spontaneously beating human-induced pluripotent stem cell-derived cardiomyocyte (hiPSC-CM) aggregates. Our de...

journal_title：Scientific reports

authors： Kim J,Shah D,Potapov I,Latukka J,Aalto-Setälä K,Räsänen E

更新日期：2019-03-06 00:00:00

abstract：:The geographic distribution of species depends on their relationships with climate and on the biotic interactions of the species. Ecological Niche Models (ENMs) mainly consider climatic variables only and may tend to overestimate these distributions, especially for species strongly restricted by biotic interactions. W...

journal_title：Scientific reports

authors： Flores-Tolentino M,García-Valdés R,Saénz-Romero C,Ávila-Díaz I,Paz H,Lopez-Toledo L

更新日期：2020-06-12 00:00:00

abstract：:Nocardia is an opportunistic pathogen that most frequently affects the lungs. Evidence is limited regarding the risk factors for nocardiosis. The current study assessed clinical correlates of nocardiosis. A retrospective study was conducted based on medical records of consecutive adult patients (N = 60) with nocardios...

journal_title：Scientific reports

authors： Margalit I,Goldberg E,Ben Ari Y,Ben-Zvi H,Shostak Y,Krause I,Muhsen K

更新日期：2020-08-31 00:00:00

abstract：:Controlling the nanoscale arrangement in polymer-fullerene organic solar cells is of paramount importance to boost the performance of such promising class of photovoltaic diodes. In this work, we use a pseudo-bilayer system made of poly(2,5-bis(3-hexadecylthiophen-2-yl)thieno[3,2-b]thiophene (PBTTT) and [6,6]-phenyl-C...

journal_title：Scientific reports

authors： Paternò GM,Skoda MW,Dalgliesh R,Cacialli F,Sakai VG

更新日期：2016-10-04 00:00:00

abstract：:Autonomic modulation and cardiorespiratory variables are influenced by numerous factors, including anthropometric variables. We investigated autonomic recovery following aerobic exercise in healthy men with different waist-stature ratio (WSR) values. The study was conducted with 52 healthy men aged 18 to 30 years, div...

journal_title：Scientific reports

authors： Fontes AMGG,de Oliveira LS,Vanderlei FM,Garner DM,Valenti VE

更新日期：2018-10-31 00:00:00

abstract：:We present a new model of ESR1 network regulation based on analysis of Doxorubicin, Estradiol, and TNFα combination treatment in MCF-7. We used Doxorubicin as a therapeutic agent, TNFα as marker and mediator of an inflammatory microenvironment and 17β-Estradiol (E2) as an agonist of Estrogen Receptors, known predispos...

journal_title：Scientific reports

authors： Nassiri I,Inga A,Meškytė EM,Alessandrini F,Ciribilli Y,Priami C

更新日期：2019-10-23 00:00:00

abstract：:Recent studies on next-generation permanent magnets have focused on filling in the gap between rare-earth magnets and rare-earth-free magnets, taking into account both the cost-effectiveness and magnetic performance of the magnetic materials. As an improved rare-earth-free magnet candidate, here, Ca-substituted M-type...

journal_title：Scientific reports

authors： Lee J,Lee EJ,Hwang TY,Kim J,Choa YH

更新日期：2020-09-28 00:00:00

abstract：:Nitrogen-Vacancy (NV) centers in diamond are promising solid-state quantum emitters that can be utilized for photonic quantum applications. Various diamond nanophotonic devices have been fabricated for efficient extraction of single photons emitted from NV centers to a single guided mode. However, for constructing sca...

journal_title：Scientific reports

authors： Yonezu Y,Wakui K,Furusawa K,Takeoka M,Semba K,Aoki T

更新日期：2017-10-11 00:00:00

abstract：:We herein report that supported copper nanoparticles (CuNPs) on commercially available controlled pore glass (CPG), which exhibit high mechanical, thermal and chemical stability as compared to other silica-based materials, serve as a useful heterogeneous catalyst system for 1,3-dipolar cycloadditions ("click" reaction...

journal_title：Scientific reports

authors： Rafi AA,Ibrahem I,Córdova A

更新日期：2020-11-25 00:00:00

abstract：:An increase of nucleolar number and size has made nucleoli essential markers for cytology and tumour development. However, the underlying basis for their structural integrity and abundance remains unclear. Protein phosphatase PPM1D was found to be up-regulated in different carcinomas including breast cancers. Here, we...

journal_title：Scientific reports

authors： Kozakai Y,Kamada R,Furuta J,Kiyota Y,Chuman Y,Sakaguchi K

更新日期：2016-09-13 00:00:00

abstract：:We introduce QuEST, the Quantum Exact Simulation Toolkit, and compare it to ProjectQ, qHipster and a recent distributed implementation of Quantum++. QuEST is the first open source, hybrid multithreaded and distributed, GPU accelerated simulator of universal quantum circuits. Embodied as a C library, it is designed so ...

journal_title：Scientific reports

authors： Jones T,Brown A,Bush I,Benjamin SC

更新日期：2019-07-24 00:00:00

abstract：:Previous studies have investigated the use of mesenchymal stem cells (MSCs) to treat damaged kidneys. However, the effect of adipose-derived MSCs (ASCs) on vascular calcification in chronic kidney disease (CKD) is still poorly understood. In the present study, we explored the potential of ASCs for the treatment of CKD...

journal_title：Scientific reports

authors： Yokote S,Katsuoka Y,Yamada A,Ohkido I,Yokoo T

更新日期：2017-10-25 00:00:00

abstract：:miRNAs play an indispensable role in human carcinogenesis. Dysregulated miR-1180-3p has been observed in several types of cancer, including hepatocellular carcinoma (HCC). This study intends to correlate the expression level of miR-1180-3p with clinical features and overall survival in HCC patients. The expression and...

journal_title：Scientific reports

authors： Zhou Z,Zhou X,Jiang Y,Qiu M,Liang X,Lin Q,Guo Q,Nong C,Huo R,Chen Q,Liu H,Liu Y,Zhu S,Wang M,Yu H

更新日期：2020-07-14 00:00:00

abstract：:Conventional concentrators with inhomogeneous coating materials that fully enclose the destined region pose great challenges for fabrication. In this paper, we propose to design an EM concentrator with homogeneous materials. Distinguished from conventional ones, the elaborately designed EM concentrator features a conc...

journal_title：Scientific reports

authors： Madni HA,Hussain K,Jiang WX,Liu S,Aziz A,Iqbal S,Mahboob A,Cui TJ

更新日期：2018-06-25 00:00:00

abstract：:Age-related macular degeneration (AMD) is a chronic degenerative disease of the retina. Recent reports have highlighted the potential role of mucosal surface microbes in the pathogenesis of AMD. In this case-control study, the composition of the nasal and oral microbiota in newly diagnosed neovascular age-related macu...

journal_title：Scientific reports

authors： Rullo J,Far PM,Quinn M,Sharma N,Bae S,Irrcher I,Sharma S

更新日期：2020-03-02 00:00:00

abstract：:HIV subtypes or clades differentially induce HIV-associated neurocognitive disorders (HAND) and substance abuse is known to accelerate HIV disease progression. The HIV-1 envelope protein gp120 plays a major role in binding and budding in the central nervous system (CNS) and impacts dopaminergic functions. However, the...

journal_title：Scientific reports

authors： Samikkannu T,Rao KVK,Salam AAA,Atluri VSR,Kaftanovskaya EM,Agudelo M,Perez S,Yoo C,Raymond AD,Ding H,Nair MPN

更新日期：2015-06-09 00:00:00

abstract：:The shape of fragments generated by the breakup of solids is central to a wide variety of problems ranging from the geomorphic evolution of boulders to the accumulation of space debris orbiting Earth. Although the statistics of the mass of fragments has been found to show a universal scaling behavior, the comprehensiv...

journal_title：Scientific reports

authors： Domokos G,Kun F,Sipos AÁ,Szabó T

更新日期：2015-03-16 00:00:00

abstract：:Intuitively, deriving meaning from an abstract image is a uniquely human, idiosyncratic experience. Here we show that, despite having no universally recognised lexical association, abstract images spontaneously elicit specific concepts conveyed by words, with a consistency akin to that of concrete images. We presented...

journal_title：Scientific reports

authors： Kuipers JR,Jones MW,Thierry G

更新日期：2018-05-08 00:00:00

abstract：:To evaluate the corneal spherical aberrations in cataract patients with and without high myopia, we conducted a retrospective case series of 502 cataract eyes with high myopia and 1500 age-related cataract eyes and measure their corneal biometric data and axial length using Pentacam and IOLMaster. Both the anterior an...

journal_title：Scientific reports

authors： Zhang M,Qian D,Jing Q,Chen J,Jiang Y

更新日期：2019-02-05 00:00:00

abstract：:Increasing influence of Atlantic water in the Arctic Ocean has the potential to significantly impact regional water temperature and salinity. Here we use a rDNA barcoding approach to reveal how microbial communities are partitioned into distinct assemblages across a gradient of Atlantic-Polar Water influence in the No...

journal_title：Scientific reports

authors： Carter-Gates M,Balestreri C,Thorpe SE,Cottier F,Baylay A,Bibby TS,Moore CM,Schroeder DC

更新日期：2020-11-06 00:00:00

abstract：:Individuals infected with hepatitis C virus (HCV) are at high risk of developing progressive liver disease, including cirrhosis and hepatocellular carcinoma (HCC). How HCV infection causes liver destruction has been of significant interest for many years, and apoptosis has been proposed as one operative mechanism. In ...

journal_title：Scientific reports

authors： Kofahi HM,Taylor NG,Hirasawa K,Grant MD,Russell RS

更新日期：2016-12-15 00:00:00

abstract：:Silicene is an exciting two-dimensional material that shares many of graphene's electronic properties, but differs in its structural buckling. This buckling allows opening a bandgap in silicene through the application of a perpendicular electric field. Here we show that this buckling also enables highly effective modu...

journal_title：Scientific reports

authors： Al-Dirini F,Hossain FM,Mohammed MA,Nirmalathas A,Skafidas E

更新日期：2015-10-06 00:00:00

abstract：:The development of bulk, three-dimensional (3D), macroporous polymers with high permeability, large surface area and large volume is highly desirable for a range of applications in the biomedical, biotechnological and environmental areas. The experimental techniques currently used are limited to the production of smal...

journal_title：Scientific reports

authors： Savina IN,Ingavle GC,Cundy AB,Mikhalovsky SV

更新日期：2016-02-17 00:00:00

abstract：:Angiosperm mitochondrial genomes (mtDNA) exhibit variable quantities of alien sequences. Many of these sequences are acquired by intracellular gene transfer (IGT) from the plastid. In addition, frequent events of horizontal gene transfer (HGT) between mitochondria of different species also contribute to their expanded...

journal_title：Scientific reports

authors： Gandini CL,Sanchez-Puerta MV

更新日期：2017-03-06 00:00:00

abstract：:In this work, we apply homodyne detection to investigate the frequency-resolved photon statistics of a cw light field emitted by a driven-dissipative semiconductor system in real time. We demonstrate that studying the frequency dependence of the photon number noise allows us to distinguish intrinsic noise properties o...

journal_title：Scientific reports

authors： Lüders C,Aßmann M

更新日期：2020-12-29 00:00:00

abstract：:Several studies have shown that the 'poor' sperm DNA quality appears to be an important factor affecting male reproductive ability. In the case of sperm cells from males with the correct somatic karyotype but with deficient spermatogenesis, resulting in a high degree of sperm DNA fragmentation, we observed changes in ...

journal_title：Scientific reports

authors： Wiland E,Fraczek M,Olszewska M,Kurpisz M

更新日期：2016-08-25 00:00:00