Abstract：
:Models of biological processes are often subject to different sources of noise. Developing an understanding of the combined effects of different types of uncertainty is an open challenge. In this paper, we study a variant of the susceptible-infective-recovered model of epidemic spread, which combines both agent-to-agent heterogeneity and intrinsic noise. We focus on epidemic cycles, driven by the stochasticity of infection and recovery events, and study in detail how heterogeneity in susceptibilities and propensities to pass on the disease affects these quasi-cycles. While the system can only be described by a large hierarchical set of equations in the transient regime, we derive a reduced closed set of equations for population-level quantities in the stationary regime. We analytically obtain the spectra of quasi-cycles in the linear-noise approximation. We find that the characteristic frequency of these cycles is typically determined by population averages of susceptibilities and infectivities, but that their amplitude depends on higher-order moments of the heterogeneity. We also investigate the synchronisation properties and phase lag between different groups of susceptible and infected individuals.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Herrerías-Azcué F,Galla Tdoi
10.1038/s41598-017-12606-xsubject
Has Abstractpub_date
2017-10-11 00:00:00pages
13008issue
1issn
2045-2322pii
10.1038/s41598-017-12606-xjournal_volume
7pub_type
杂志文章abstract：:We have designed a new type of composite materials which not only has a Young's modulus much larger than the Voigt limit, but also is always nearly isotropic. Moreover, its Poisson's ratio can be designed at a desired value, e.g. positive, or negative, or zero. We have also demonstrated that structural hierarchy can h...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep14103
更新日期：2015-09-11 00:00:00
abstract：:Adenosine-to-Inosine (A-to-I) RNA editing is the most prevalent post-transcriptional modification of RNA molecules. Researchers have attempted to find reliable RNA editing using next generation sequencing (NGS) data. However, most of these attempts suffered from a high rate of false positives, and they did not conside...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-41294-y
更新日期：2019-03-25 00:00:00
abstract：:1-aminoperylene diimide/TiO2/MoS2 composite (NH2-PDI/TiO2/MoS2) with ordered structure was prepared by hydrothermal synthesis method. The composite was characterized by XRD, SEM, FTIR, XPS, BET, DRS, PL, EIS, Raman, photocurrent, and Mott-Schottky plots spectroscopy. The potential positions of the conduction and valen...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-78894-y
更新日期：2020-12-15 00:00:00
abstract：:Life-history theory predicts that current behaviour affects future reproduction, implying that animals should optimise their escape strategies to reflect fitness costs and benefits of premature escape. Both costs and benefits of escape may change temporally with important consequences for the evolution of escape strat...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-32252-1
更新日期：2018-09-18 00:00:00
abstract：:Pore-forming toxins are the most common virulence factor in pathogenic bacteria. They lead to membrane permeabilization and cell death. Herein, we show that respiratory epithelial cells (REC) undergoing bacterial pore-forming toxin (PFT)-induced necroptosis simultaneously experienced caspase activation independently o...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-24210-8
更新日期：2018-04-11 00:00:00
abstract：:Artificially structured coatings are widely employed to minimize materials deterioration and corrosion, the annual direct cost of which is over 3% of the gross domestic product (GDP) for industrial countries. Manufacturing higher performance anticorrosive coatings is one of the most efficient approaches to reduce this...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep01177
更新日期：2013-01-01 00:00:00
abstract：:Efficient mitochondrial Ca2+ uptake takes place at contact points between the ER and mitochondria, and represents a key regulator of many cell functions. In a previous study with HeLa cells, we showed that ER-to-mitochondria Ca2+ transfer increases during the early phase of ER stress induced by tunicamycin as an adapt...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep36394
更新日期：2016-11-03 00:00:00
abstract：:In this study, we prepared, characterized, and performed toxicity analyses of poly(ε-caprolactone) nanocapsules loaded with neem oil. Three formulations were prepared by the emulsion/solvent evaporation method. The nanocapsules showed a mean size distribution around 400 nm, with polydispersity below 0.2 and were stabl...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-06092-4
更新日期：2017-07-19 00:00:00
abstract：:Colorectal cancer (CRC) is one of the most prevalent cancers worldwide and Alpha B-crystallin (CRYAB) protein has been identified as a prognostic biomarker for CRC. We evaluated CRYAB C-802G (rs14133)polymorphism in association with CRC risk and survival in Chinese population. We genotyped for CRYAB C-802G (rs14133), ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-29589-y
更新日期：2018-08-06 00:00:00
abstract：:Aggregates of Pseudomonas aeruginosa form a protective barrier against antibiotics and the immune system. These barriers, known as biofilms, are associated with several infectious diseases. One of the main components of these biofilms is alginate, a homo- and hetero-polysaccharide that consists of β-D-mannuronate (M) ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-66293-2
更新日期：2020-06-10 00:00:00
abstract：:Aspergillus flavus is a pathogenic fungus infecting maize and producing aflatoxins that are health hazards to humans and animals. Characterizing host defense mechanism and prioritizing candidate resistance genes are important to the development of resistant maize germplasm. We investigated methods amenable for the ana...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep04815
更新日期：2014-04-28 00:00:00
abstract：:In this report, a facile and effective one-pot oxidation-assisted dealloying protocol has been developed to massively synthesize monolithic core-shell architectured nanoporous copper@cuprous oxide nanonetworks (C-S NPC@Cu2O NNs) by chemical dealloying of melt-spun Al 37 at.% Cu alloy in an oxygen-rich alkaline solutio...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep36084
更新日期：2016-11-10 00:00:00
abstract：:Directed transport of biological species across the surface of a substrate is essential for realizing lab-on-chip technologies. Approaches that utilize localized magnetic fields to manipulate magnetic particles carrying biological entities are attractive owing to their sensitivity, selectivity, and minimally disruptiv...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-10149-9
更新日期：2017-08-31 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-020-64342-4
更新日期：2020-05-08 00:00:00
abstract：:Microbial induced calcite precipitation (MICP) based on ureolysis has a high potential for many applications, e.g. restoration of construction materials. The gram-positive bacterium Sporosarcina pasteurii is the most commonly used microorganism for MICP due to its high ureolytic activity. However, Sporosarcina pasteur...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-79904-9
更新日期：2020-12-31 00:00:00
abstract：:Seeds of tomato were magnetoprimed at 100 mT for 30 min followed by imbibition for 12 and 24 h, respectively, at 20 °C, to examine the biochemical and molecular changes involved in homeostasis of hydrogen peroxide (H2O2) and its signaling associated with hormone interactions for promoting vigor. The relative transcrip...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-45102-5
更新日期：2019-06-19 00:00:00
abstract：:The major virulence factors of Clostridium difficile are toxins A and B. These toxins are encoded by tcdA and tcdB genes, which form a pathogenicity locus (PaLoc) together with three additional genes that have been implicated in regulation (tcdR and tcdC) and secretion (tcdE). To date, the PaLoc has always been found ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep15023
更新日期：2015-10-08 00:00:00
abstract：:Flexible energy storage devices are highly demanded for various applications. Carbon cloth (CC) woven by carbon fibers (CFs) is typically used as electrode or current collector for flexible devices. The low surface area of CC and the presence of big gaps (ca. micro-size) between individual CFs lead to poor performance...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep11792
更新日期：2015-07-07 00:00:00
abstract：:Polymer electrolyte membranes (PEM) and Pt-based catalysts are two crucial components which determine the properties and price of fuel cells. Even though, PEM faces problem of fuel crossover in liquid fuel cells such as direct methanol fuel cell (DMFC) and direct borohydride fuel cell (DBFC), which lowers power output...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep00567
更新日期：2012-01-01 00:00:00
abstract：:We studied mechanisms of recombination in InGaN quantum wells in polar and semipolar structures. Photoluminescence measurements show that the optical emission linewidths for polar and semipolar structures are almost identical suggesting the same level of indium fluctuations in quanutm wells. Their "peak-energy-versus-...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-58295-x
更新日期：2020-01-27 00:00:00
abstract：:The natural ligand 17β-estradiol (E2) is so far believed to induce a unique agonist-bound active conformation in the ligand binding domain (LBD) of the estrogen receptors (ERs). Both subtypes, ERα and ERβ, are transcriptionally activated in the presence of E2 with ERβ being somewhat less active than ERα under similar ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-03774-x
更新日期：2017-06-14 00:00:00
abstract：:Cardiomyocytes differentiated from human pluripotent stem cells provide promising tools for screening of cardiotoxic drugs. For evaluation of human pluripotent stem cell-derived cardiomyocytes for cardiotoxicity test, in the present study, human embryonic stem cells (hESCs) were differentiated to cardiomyocytes, follo...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-14198-y
更新日期：2017-10-23 00:00:00
abstract：:Sepsis induced cardiac dysfunction (SIC) is a severe complication to sepsis which significantly worsens patient outcomes. It is known that bacteria have the capacity to release outer membrane vesicles (OMVs), which are nano-sized bilayered vesicles composed of lipids and proteins, that can induce a fatal inflammatory ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-16363-9
更新日期：2017-12-12 00:00:00
abstract：:Sixty norovirus outbreaks that occurred in Pudong District, Shanghai in 2017 and affected 959 people were summarised. Of the outbreaks, 29 (48.3%), 27 (45.0%), and 4 (6.7%) occurred in kindergartens, primary schools, and middle schools, respectively. Although the total number of outbreaks peaked in March (13/60, 21.7%...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-33724-0
更新日期：2018-10-15 00:00:00
abstract：:Due to the lack of a proper imaging approach, a veracious pH map of normal and abnormal cell is still rare. In this work, we presented a rhodamine-salicylaldehyde combination (Rh-SA2) as a novel pH probe, which has dual sensitive units for both acidic and basic environment. This dual sensitive probe acts like a chamel...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep15540
更新日期：2015-10-21 00:00:00
abstract：:Systemic lipopolysaccharide (LPS) is implicated in increasing mortality in patients with alcoholic hepatitis but the underlying mechanisms are not well characterised. The objective of this study was to characterise neutrophil function, LPS and cytokine concentrations within the splanchnic circulation of alcoholic cirr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep40157
更新日期：2017-01-04 00:00:00
abstract：:Hepatocellular carcinoma is a common type of malignancy with a poor prognosis. Identification and utilisation of markers for monitoring and diagnosis are urgently needed. Alpha-fetoprotein (AFP) and Protein Induced by Vitamin K Absence or Antagonist-II (PIVKA-II) have been proved to be efficient biomarkers for hepatit...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-70241-5
更新日期：2020-08-11 00:00:00
abstract：:Emergence of drug-resistant strains of the pathogen Mycobacterium tuberculosis (Mtb) and the ineffectiveness of BCG in curtailing Mtb infection makes vaccine development for tuberculosis an important objective. Identifying immunogenic CD8+ T cell peptide epitopes is necessary for peptide-based vaccine strategies. We p...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep04632
更新日期：2014-04-23 00:00:00
abstract：:Pneumocystis jirovecii pneumonia (PJP) is a potentially life-threatening infection that occurs in immunocompromised patients. The aim of this study was to evaluate risk factors for PJP in kidney transplantation recipients. We conducted a retrospective analysis of patient data from 500 consecutive kidney transplants pe...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-01818-w
更新日期：2017-05-08 00:00:00
abstract：:Since it has been demonstrated that spatial cognition can be affected in visually impaired children, training strategies that exploit the plasticity of the human brain should be early adopted. Here we developed and tested a new training protocol based on the reinforcement of audio-motor associations and thus supportin...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章
doi：10.1038/s41598-019-39981-x
更新日期：2019-03-01 00:00:00
