Abstract:
:Embryo implantation requires a hospitable uterine environment. A key metabolic change that occurs during the peri-implantation period, and throughout early pregnancy, is the rise in endometrial glycogen content. Glycogen accumulation requires prior cellular uptake of glucose. Here we show that both human and murine endometrial epithelial cells express the high affinity Na+-coupled glucose carrier SGLT1. Ussing chamber experiments revealed electrogenic glucose transport across the endometrium in wild type (Slc5a1 +/+) but not in SGLT1 deficient (Slc5a1 -/-) mice. Endometrial glycogen content, litter size and weight of offspring at birth were significantly lower in Slc5a1 -/- mice. In humans, SLC5A1 expression was upregulated upon decidualization of primary endometrial stromal cells. Endometrial SLC5A1 expression during the implantation window was attenuated in patients with recurrent pregnancy loss when compared with control subjects. Our findings reveal a novel mechanism establishing adequate endometrial glycogen stores for pregnancy. Disruption of this histiotrophic pathway leads to adverse pregnancy outcome.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Salker MS,Singh Y,Zeng N,Chen H,Zhang S,Umbach AT,Fakhri H,Kohlhofer U,Quintanilla-Martinez L,Durairaj RRP,Barros FSV,Vrljicak P,Ott S,Brucker SY,Wallwiener D,Vrhovac Madunić I,Breljak D,Sabolić I,Koepsell H,Brosensdoi
10.1038/s41598-017-11674-3subject
Has Abstractpub_date
2017-10-03 00:00:00pages
12612issue
1issn
2045-2322pii
10.1038/s41598-017-11674-3journal_volume
7pub_type
杂志文章abstract::The incidence of ovarian cancer dramatically increases in early menopause but the factors contributing to cancer onset are unclear. Most ovarian cancers originate in the fallopian tube with subsequent implantation of malignant cells into the ovary. However, the events and conditions that lead to cancer cell implantati...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-30261-8
更新日期:2018-08-17 00:00:00
abstract::Locusts have excellent jumping and kicking abilities to survive in nature, which are achieved through the energy storage and release processes occurring in cuticles, especially in the semi-lunar processes (SLP) at the femorotibial joints. As yet, however, the strain energy-storage mechanisms of the SLP cuticles remain...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep35219
更新日期:2016-10-17 00:00:00
abstract::Graft contracture is a common problem associated with the regeneration processes of tissue-engineered bladders. Currently, most strategies used for incorporating bioactive molecules into biomaterial designs do not work during all phases of tissue regeneration. In this study, we used a growth factor-PLGA nanoparticle t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep20784
更新日期:2016-02-08 00:00:00
abstract::Conduction Electron Paramagnetic Resonance Imaging (CEPRI) is presented as a sensitive technique for mapping metallic lithium species. The method is demonstrated using different samples that are either thick or thin compared to the microwave skin depth. As a thin sample, microstructured metallic lithium deposits in a ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-32112-y
更新日期:2018-09-25 00:00:00
abstract::Solid stress is a biomechanical abnormality of the tumor microenvironment that plays a crucial role in tumor progression. When it is applied to cancer cells, solid stress hinders their proliferation rate and promotes cancer cell invasion and metastatic potential. However, the underlying mechanisms of how it is implica...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-37425-6
更新日期:2019-01-30 00:00:00
abstract::Recently, CuZr-based bulk metallic glass (BMG) composites reinforced by the TRIP (transformation-induced plasticity) effect have been explored in attempt to accomplish an optimal of trade-off between strength and ductility. However, the design of such BMG composites with advanced mechanical properties still remains a ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep42518
更新日期:2017-02-13 00:00:00
abstract::Selective enhancement of GABAergic inhibition is thought to impact many vital brain functions and interferes with the genesis and/or progression of numerous brain disorders. Here, we show that selectively increasing NMDA receptor activity in inhibitory neurons using an NMDAR positive allosteric modulator (PAM) elevate...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-68652-5
更新日期:2020-07-20 00:00:00
abstract::Fitting Ordinary Differential Equation (ODE) models of signal transduction networks (STNs) to experimental data is a challenging problem. Computational parameter fitting algorithms simulate a model many times with different sets of parameter values until the simulated STN behaviour match closely with experimental data...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-30118-0
更新日期:2018-08-03 00:00:00
abstract::Toll-like receptors (TLRs) recognise microbes that contribute to the severity of bronchiolitis and the subsequent risk of asthma. We evaluated whether post-bronchiolitis asthma was associated with polymorphisms in the TLR3 rs3775291, TLR4 rs4986790, TLR7 rs179008, TLR8 rs2407992, TLR9 rs187084, and TLR10 rs4129009 gen...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-03429-x
更新日期:2017-06-07 00:00:00
abstract::Two of the important traits for wheat yield are tiller and fertile tiller number, both of which have been thought to increase cereal yield in favorable and unfavorable environments. A total of 6,349 single nucleotide polymorphism (SNP) markers from the 15 K wheat Infinium array were employed for genome-wide associatio...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-69442-9
更新日期:2020-08-20 00:00:00
abstract::Relying on an exact time evolution scheme, we identify a novel transient energy transfer phenomenon in an exactly-solvable quantum microscopic model consisting of a three-level system coupled to two non-Markovian zero-temperature bosonic baths through two separable quantum channels. The dynamics of this model can be s...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep15332
更新日期:2015-10-19 00:00:00
abstract::Hydrogen in the Earth's deep interior has been thought to exist as a hydroxyl group in high-pressure minerals. We present Muon Spin Rotation experiments on SiO2 stishovite, which is an archetypal high-pressure mineral. Positive muon (which can be considered as a light isotope of proton) implanted in stishovite was fou...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep08437
更新日期:2015-02-13 00:00:00
abstract::Pulmonary alveolar proteinosis (PAP) is a rare pulmonary disease in which the abnormalities in alveolar surfactant accumulation are caused by impairments of GM-CSF pathway attributing to defects in a variety of genes. However, hereditary PAP is extremely uncommon and a detailed understanding in the genetic inheritance...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep43469
更新日期:2017-02-24 00:00:00
abstract::Silicon Carbide (SiC) is a promising cladding material for accident-tolerant fuel in light water reactors due to its excellent resistance to chemical attacks at high temperatures, which can prevent severe accident-induced environmental disasters. Although it has been known for decades that radiation-induced swelling a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-15037-w
更新日期:2017-11-07 00:00:00
abstract::Respiratory Distress Syndrome (RDS) is the commonest diagnosis after premature birth. We aimed to audit clinical practices before and after introduction of a national guideline in Wales on RDS management. Anonymised, prospective data on all infants born at <34 weeks of gestation and cared for at one of the participati...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-60091-6
更新日期:2020-02-26 00:00:00
abstract::Neuroscience findings have recently received critique on the lack of replications. To examine the reproducibility of brain indices of speech sound discrimination and their role in dyslexia, a specific reading difficulty, brain event-related potentials using EEG were measured using the same cross-linguistic passive odd...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-41992-7
更新日期:2019-06-11 00:00:00
abstract::Dibutyl phthalate (DBP) is recognized as an environmental endocrine disruptor that has been detected in fetal and postnatal samples. Recent evidence found that in utero DBP exposure was associated with an increase of adipose tissue weight and serum lipids in offspring, but the precise mechanism is unknown. Here we aim...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-73477-3
更新日期:2020-10-01 00:00:00
abstract::The controlled preparation of Au nanoparticles (NPs) in the size range of 6 to 22 nm is explored in this study. The Au NPs were prepared by the reduction of tetrachloroauric acid using maltose in the presence of nonionic surfactant Tween 80 at various concentrations to control the size of the resulting Au NPs. With in...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-22976-5
更新日期:2018-03-15 00:00:00
abstract::The cytoskeletal filament vimentin is inherent to the endothelial phenotype and is critical for the proper function of endothelial cells in adult mice. It is unclear, however, if the presence of vimentin is necessary during differentiation to the endothelial phenotype. Here we evaluated gene and protein expression of ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep30814
更新日期:2016-08-02 00:00:00
abstract::Tuberculosis, a severe infectious disease caused by the Mycobacterium tuberculosis, arouses huge concerns globally. In this study, a total of 331,594 TB cases in Zhejiang Province were notified during the period of 2009-2018 with the gender ratio of male to female 2.16:1. The notified TB incidences demonstrated a cont...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-64387-5
更新日期:2020-05-04 00:00:00
abstract::Dysregulation of dopaminergic system induced by HIV-1 Tat protein-mediated direct inhibition of the dopamine transporter (DAT) has been implicated as a mediating factor of HIV-1 associated neurocognitive disorders. We have reported that single point mutations on human DAT (hDAT) at tyrosine88 (Y88F), lysine92 (K92M), ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-39872-1
更新日期:2019-03-07 00:00:00
abstract::Rare earths, e.g. neodymium (Nd), praseodymium (Pr) and dysprosium (Dy), are abundant in the rare earth sintered magnet scrap (Nd-Fe-B scrap), but their recycling is tedious and costly due to the high content of impurity Fe. Herein, a novel approach was developed to effectively recycle rare earths from the scrap via a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-54896-3
更新日期:2019-12-04 00:00:00
abstract::High temperature stable selective emitters can significantly increase efficiency and radiative power in thermophotovoltaic (TPV) systems. However, optical properties of structured emitters reported so far degrade at temperatures approaching 1200 °C due to various degradation mechanisms. We have realized a 1D structure...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-43640-6
更新日期:2019-05-10 00:00:00
abstract::To ensure the reliability of the planned multi-center clinical trial, we assessed the consistence and comparability of the quantitative parameters of the eight PET/CT units that will be used in this trial. PET/CT images were scanned using a PET NEMA image quality phantom (Biodex) on the eight units of Discovery PET/CT...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-27143-4
更新日期:2018-06-13 00:00:00
abstract::Ocean warming (OW) and acidification (OA) are key features of global change and are predicted to have negative consequences for marine species and ecosystems. At a smaller scale increasing oil and gas activities at northern high latitudes could lead to greater risk of petroleum pollution, potentially exacerbating the ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-35623-w
更新日期:2018-11-26 00:00:00
abstract::Coating of VO2-based thin film has been extensively studied for fabricating energy-saving smart windows. One of the most efficient ways for fabricating high performance films is to create multi-nanolayered structure. However, it has been highly challenge to make such layers in the VO2-based films using conventional me...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-23412-4
更新日期:2018-03-28 00:00:00
abstract::To what extent deep-time dispersal limitation shapes present-day biodiversity at broad spatial scales remains elusive. Here, we compiled a continental dataset on the distributions of African lizard species in the reptile subfamily Agaminae (a relatively young, Neogene radiation of agamid lizards which ancestors coloni...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep34014
更新日期:2016-09-27 00:00:00
abstract::The aim of this study was to investigate whether a novel physiologically relevant marker, InsuTAG (fasting insulin × fasting triglycerides) can predict insulin resistance (IR) and metabolic syndrome (MetS). Data of 618 participants from the Retirement Health and Lifestyle Study (RHLS) were evaluated for the current st...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-15460-z
更新日期:2017-11-09 00:00:00
abstract::Enamel proteins form a scaffold for growing hydroxyapatite crystals during enamel formation. They are then almost completely degraded during enamel maturation, resulting in a protein content of only 1% (w/v) in mature enamel. Nevertheless, this small amount of remaining proteins has important effects on the mechanical...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep15194
更新日期:2015-10-15 00:00:00
abstract::Lung cancer is the foremost cause of cancer related deaths in the U.S. It is a heterogeneous disease composed of genetically and phenotypically distinct tumor cells surrounded by heterotypic cells and extracellular matrix dynamically interacting with the tumor cells. Research in lung cancer is often restricted to pati...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-41301-2
更新日期:2019-03-20 00:00:00