Abstract:
:Non-alcoholic fatty liver disease (NAFLD) is closely associated with obesity, metabolic syndrome, and type II diabetes mellitus. Recently, circulating microRNAs (miRNAs) have been proposed as useful disease biomarkers. We examined whether circulating miRNAs, such as miR-20a, miR-27a, and miR-126, were useful biomarkers for NAFLD. We conducted a cross-sectional analysis of 527 subjects aged 39 years or older who had undergone a health examination in the Yakumo Study. Of the residents, 92 were diagnosed with NAFLD using a registered medical sonographer. Serum miR-20a, miR-27a and miR-126 levels were measured by quantitative real-time PCR. We then calculated the odds ratios for serum miRNA level changes according to the severity of NAFLD using normal liver status as the reference group. Serum levels of miR-20a and 27a, but not miR-126, were significantly lower in NAFLD subjects than normal subjects. Serum miR-20a and miR-27a levels were significantly lower in both male and female severe NAFLD subjects. Logistic regression analysis showed a significant relationship between low circulating miR-20a and 27a levels and severe NAFLD. Down-regulated circulating miR-20a and 27a levels were significantly associated with severe NAFLD in the general population. Circulating miR-20a and miR-27a may be useful biomarkers for severe NAFLD.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Ando Y,Yamazaki M,Yamada H,Munetsuna E,Fujii R,Mizuno G,Ichino N,Osakabe K,Sugimoto K,Ishikawa H,Ohashi K,Teradaira R,Ohta Y,Hamajima N,Hashimoto S,Suzuki Kdoi
10.1038/s41598-019-55076-zsubject
Has Abstractpub_date
2019-12-11 00:00:00pages
18856issue
1issn
2045-2322pii
10.1038/s41598-019-55076-zjournal_volume
9pub_type
杂志文章abstract::To identify a vegetation configuration pattern with a high-efficiency purification ability for total nitrogen (TN), available nitrogen (AN), total phosphorous (TP), available phosphorous (AP), and chemical oxygen demand (COD) based on comprehensive assessment results, a water discharge experiment was performed in the ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-38097-y
更新日期:2019-02-20 00:00:00
abstract::Using time-gated fluorescence lifetime imaging microscopy, significantly more signals from 3,6-bis(1-methyl-2-vinyl-pyridinium) carbazole diiodide (o-BMVC) foci, characterized by the longer fluorescent decay time of o-BMVC, were detected in six types of cancer cells than in three types of normal cells. Accumulating ev...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-34378-8
更新日期:2018-10-31 00:00:00
abstract::Plant height (PH) is a key factor in maize (Zea mays L.) yield, biomass, and plant architecture. We investigated the PH of diverse maize inbred lines (117 temperate lines, 135 tropical lines) at four growth stages using unmanned aerial vehicle high-throughput phenotypic platforms (UAV-HTPPs). We extracted PH data usin...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-39448-z
更新日期:2019-03-05 00:00:00
abstract::Amorphophallus paeoniifolius, is a commercially important vegetable crop because of its high production potential. In this study, we generated a total of 166 Gb of genomic data from 16 wild and 20 cultivated A. paeoniifolius individuals in southwestern China using restriction site associated DNA sequencing (RAD-seq). ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-14738-6
更新日期:2017-10-27 00:00:00
abstract::Influence of polyethylene glycol (PEG) mediated osmotic stress on reactive oxygen species (ROS) scavenging machinery of Chinese potato (Solenostemon rotundifolius (Poir.) J. K. Morton) was investigated. Five genotypes of Chinese potato were raised in Murashige and Skoog (MS) basal medium containing 6-benzylaminopurine...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-62317-z
更新日期:2020-03-25 00:00:00
abstract::A tetrameric N-acetyl galactosaminyl (GalNAc) peptidomimetic was constructed by N-acetylation of repeating proline-based hydroxamic acid units, followed by a convergent 'click chemistry' coupling. This novel glycopeptidomimetic was determined to effectively antagonize the interaction between a transmembrane hepatic le...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep05513
更新日期:2014-07-01 00:00:00
abstract::The Vavilov Institute of Plant Genetic Resources (VIR), in St. Petersburg, Russia, houses a unique genebank, with historical collections of landraces. When they were collected, the geographical distribution and genetic diversity of most crops closely reflected their historical patterns of cultivation established over ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-05087-5
更新日期:2017-07-06 00:00:00
abstract::The Indian Ocean Dipole (IOD) is an interannual mode of climate variability in the Indian Ocean that has intensified with 20th century global-warming. However, instrumental data shows a global-warming hiatus between the late-1990s and 2015. It is presently not clear how the global-warming hiatus affects modes of clima...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-38429-y
更新日期:2019-02-13 00:00:00
abstract::Although thimerosal, an ethylmercury-based preservative, has been removed from most pediatric vaccines in the United States, some multidose vaccines, such as influenza vaccines, still contain thimerosal. Considering that a growing number of studies indicate involvement of the gut microbiome in infant immune developmen...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-34019-0
更新日期:2018-10-26 00:00:00
abstract::It is our contention that for multiscale modelling of infectious disease systems to evolve and expand in scope, it needs to be founded on a theory. Such a theory would improve our ability to describe infectious disease systems in terms of their scales and levels of organization, and their inter-relationships. In this ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-52820-3
更新日期:2019-11-08 00:00:00
abstract::Tumor cells tend to behave differently in response to immune selective conditions. Contrary to those in therapeutic antitumor conditions, tumor cells in prophylactic antitumor conditions lose antigen expression for antitumor immune escape. Here, using a CT26/HER2 tumor model, we investigate the underlying mechanism(s)...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-39557-9
更新日期:2019-02-27 00:00:00
abstract::The complexity of the frictional dynamics at the microscopic scale makes difficult to identify all of its controlling parameters. Indeed, experiments on sheared elastic bodies have shown that the static friction coefficient depends on loading conditions, the real area of contact along the interfaces and the confining ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep06772
更新日期:2014-10-27 00:00:00
abstract::Monochamus beetles are the dispersing vectors of the nematode Bursaphelenchus xylophilus, the causative agent of pine wilt disease (PWD). PWD inflicts significant damages in Eurasian pine forests. Symbiotic microorganisms have a large influence in insect survival. The aim of this study was to characterize the bacteria...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep23908
更新日期:2016-04-05 00:00:00
abstract::Long-term potentiation (LTP) is the persistent increase in the strength of the synapses. However, the neural networks would become saturated if there is only synaptic strenghthening. Synaptic weakening could be facilitated by active processes like long-term depression (LTD). Molecular mechanisms that facilitate the we...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-15917-1
更新日期:2017-11-14 00:00:00
abstract::The activation energy of the β → α/ω phase transformation increased monotonously with the application of a continuous heating process to a Ti-15Mo-2.7Nb-3Al-0.2Si alloy. Precipitation behaviour of the alloy aged at different temperatures were analysed with scanning electron microscopy, electron backscattered diffracti...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-54114-0
更新日期:2019-11-26 00:00:00
abstract::In surface science and model catalysis, cerium oxide (ceria) is mostly grown as an ultra-thin film on a metal substrate in the ultra-high vacuum to understand fundamental mechanisms involved in diverse surface chemistry processes. However, such ultra-thin films do not have the contribution of a bulk ceria underneath, ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep21165
更新日期:2016-02-16 00:00:00
abstract::Waves of any kinds, including sound waves and light waves, can interfere constructively or destructively when they are overlapped, allowing for myriad applications. However, unlike continuous waves of a single frequency, interference of photoacoustic pulses is often overlooked because of their broadband characteristic...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep21511
更新日期:2016-02-12 00:00:00
abstract::Uterosacral ligaments (USLs) provide structural support to the female pelvic floor, and a loss of USL structural integrity or biomechanical function may induce pelvic organ prolapse (POP). Alterations in extracellular matrix composition and organization dictate USL mechanical function. Changes in USL microstructure an...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-64192-0
更新日期:2020-04-30 00:00:00
abstract::Although poaching (illegal killing) is an important cause of death for large carnivores globally, the effect of lethal management policies on poaching is unknown for many populations. Two opposing hypotheses have been proposed: liberalizing killing may decrease poaching incidence ('tolerance hunting') or increase it (...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-70837-x
更新日期:2020-08-17 00:00:00
abstract::We study the coherent and semi-coherent Al/α-Al2O3 interfaces using molecular dynamics simulations with a mixed, metallic-ionic atomistic model. For the coherent interfaces, both Al-terminated and O-terminated nonstoichiometric interfaces have been studied and their relative stability has been established. To understa...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep04485
更新日期:2014-03-27 00:00:00
abstract::RAS genotyping is mandatory to predict anti-EGFR monoclonal antibodies (mAbs) therapy resistance and BRAF genotyping is a relevant prognosis marker in patients with metastatic colorectal cancer. Although the role of hotspot mutations is well defined, the impact of uncommon mutations is still unknown. In this study, we...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-43646-0
更新日期:2019-05-08 00:00:00
abstract::To develop an effective, safe, and convenient vaccine for the prevention of highly pathogenic avian influenza (HPAI) H5N1, we have constructed a recombinant Bacillus subtilis strain (B.S.-HA) expressing the hemagglutinin (HA) protein. Then we evaluated the immune function in chicken bone marrow derived dendritic cells...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep38403
更新日期:2016-12-16 00:00:00
abstract::Proteins are highly dynamic entities attaining a myriad of different conformations. Protein side chains change their states during dynamics, causing clashes that are propagated at distal sites. A convenient formalism to analyze protein dynamics is based on network theory using Protein Structure Networks (PSNs). Despit...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-01498-6
更新日期:2017-06-06 00:00:00
abstract::Non-destructive measurements of deformations are a quite common application of holography but due to the intrinsic limits in the interferometric technique, those are generally confined only to small targets and in controlled environment. Here we present an advanced technique, based on Mid Infrared Digital Holography (...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep23688
更新日期:2016-04-01 00:00:00
abstract::Antimicrobial peptides, produced by innate immune system of hosts in response to invading pathogens, are capable of fighting against a spectrum of bacteria, viruses, fungi, parasites and cancer cells. Here, a recombinant silkworm AMP Bmattacin2 from heterologous expression is studied, indicating a broad spectrum of an...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep31149
更新日期:2016-08-09 00:00:00
abstract::A growing bacterium typically divides into two genetically identical and morphologically similar sister cells and eventually gives rise to a clonal population. Nevertheless, significant phenotypic differentiation among isogenic cells frequently occurs, with the resulting heterogeneity in cellular behavior often ensuri...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-08660-0
更新日期:2017-08-16 00:00:00
abstract::Selective norepinephrine reuptake inhibitors (sNRIs) provide an effective class of approved antipsychotics, whose inhibitory mechanism could facilitate the discovery of privileged scaffolds with enhanced drug efficacy. However, the crystal structure of human norepinephrine transporter (hNET) has not been determined ye...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep26883
更新日期:2016-05-27 00:00:00
abstract::Arabidopsis thaliana contains the putative K+ efflux transporters KEA1-KEA6, similar to KefB and KefC of Escherichia coli. KEA1-KEA3 are involved in the regulation of photosynthetic electron transport and chloroplast development. KEA4-KEA6 mediate pH regulation of the endomembrane network during salinity stress. Howev...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-46463-7
更新日期:2019-07-11 00:00:00
abstract::Efficient inactivation of Escherichia coli (E. coli) under visible (532 nm) pulsed light irradiation was achieved by fusion of a visible light-absorbing dye with E. coli. Inactivation experiments showed that 3-log inactivation of E. coli was obtained within 20 min under a 50 kJ/cm2 dose. This treatment time and dose m...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-74714-5
更新日期:2020-10-20 00:00:00
abstract::The controlled preparation of Au nanoparticles (NPs) in the size range of 6 to 22 nm is explored in this study. The Au NPs were prepared by the reduction of tetrachloroauric acid using maltose in the presence of nonionic surfactant Tween 80 at various concentrations to control the size of the resulting Au NPs. With in...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-22976-5
更新日期:2018-03-15 00:00:00