The Replication-Transmission Relativity Theory for Multiscale Modelling of Infectious Disease Systems.

abstract：:Solving the crystal structure of Cbl(TKB) in complex with a pentapeptide, pYTPEP, revealed that the PEP region adopted a poly-L-proline type II (PPII) helix. An unnatural amino acid termed a proline-templated glutamic acid (ptE) that constrained both the backbone and sidechain to the bound conformation was synthesized...

journal_title：Scientific reports

authors： Kumar EA,Chen Q,Kizhake S,Kolar C,Kang M,Chang CE,Borgstahl GE,Natarajan A

更新日期：2013-01-01 00:00:00

abstract：:N-linked glycosylation is one of the predominant post-translational modifications involved in a number of biological functions. Since experimental characterization of glycosites is challenging, glycosite prediction is crucial. Several predictors have been made available and report high performance. Most of them evalua...

journal_title：Scientific reports

authors： Pitti T,Chen CT,Lin HN,Choong WK,Hsu WL,Sung TY

更新日期：2019-11-04 00:00:00

abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...

journal_title：Scientific reports

authors： Shkarina S,Shkarin R,Weinhardt V,Melnik E,Vacun G,Kluger PJ,Loza K,Epple M,Ivlev SI,Baumbach T,Surmeneva MA,Surmenev RA

更新日期：2018-11-29 00:00:00

abstract：:We have prepared and tested a new surface enhanced Raman scattering (SERS) substrate based on self-assembled graphitic sheets to detect bisphenol A (BPA) in plastic consumer goods. Transmission electron microscopy (TEM) and atomic-force microscopy (AFM) were used to characterize the structure of the graphitic sheets a...

journal_title：Scientific reports

authors： Lin PY,Hsieh CW,Hsieh S

更新日期：2017-12-01 00:00:00

abstract：:A brain-computer interface (BCI) or brain-machine interface is a technology that enables the control of a computer and other external devices using signals from the brain. This technology has been tested in paralysed patients, such as those with cervical spinal cord injuries or amyotrophic lateral sclerosis, but it ha...

journal_title：Scientific reports

authors： Utsumi K,Takano K,Okahara Y,Komori T,Onodera O,Kansaku K

更新日期：2018-01-29 00:00:00

abstract：:In a myriad of engineering situations, we often hope to establish a model which can acquire load conditions around structures through flow features detection. A data-driven method is developed to predict the pressure on a cylinder from velocity distributions in its wake flow. The proposed deep learning neural network ...

journal_title：Scientific reports

authors： Ye S,Zhang Z,Song X,Wang Y,Chen Y,Huang C

更新日期：2020-03-10 00:00:00

abstract：:Inhibition of programmed death 1 (PD-1), expressed on activated T cells, can break through immune resistance and elicit durable responses in human melanoma as well as other types of cancers. Canine oral malignant melanoma is one of the most aggressive tumors bearing poor prognosis due to its high metastatic potency. H...

journal_title：Scientific reports

authors： Igase M,Nemoto Y,Itamoto K,Tani K,Nakaichi M,Sakurai M,Sakai Y,Noguchi S,Kato M,Tsukui T,Mizuno T

更新日期：2020-10-27 00:00:00

abstract：:The niacin receptor HCA2 is implicated in controlling inflammatory host responses with yet poorly understood mechanistic basis. We previously reported that HCA2 in A431 epithelial cells transduced Gβγ-protein kinase C- and Gβγ-metalloproteinase/EGFR-dependent MAPK/ERK signaling cascades. Here, we investigated the role...

journal_title：Scientific reports

authors： Shi Y,Lai X,Ye L,Chen K,Cao Z,Gong W,Jin L,Wang C,Liu M,Liao Y,Wang JM,Zhou N

更新日期：2017-02-10 00:00:00

abstract：:We collected data from Kailuan cohort study from 2006 to 2011 to examine whether short-term effects of ambient temperature on heart rate (HR) and blood pressure (BP) are non-linear or linear, and their potential modifying factors. The HR, BP and individual information, including basic characteristics, life style, soci...

journal_title：Scientific reports

authors： Madaniyazi L,Zhou Y,Li S,Williams G,Jaakkola JJ,Liang X,Liu Y,Wu S,Guo Y

更新日期：2016-02-15 00:00:00

abstract：:Drought stress and pathogen infection simultaneously occur in the field. In this study, the interaction of these two stresses with chickpea, their individual and combined effect and the net impact on plant growth and yield traits were systematically assessed under field and confined pot experiments. The field experime...

journal_title：Scientific reports

authors： Sinha R,Irulappan V,Mohan-Raju B,Suganthi A,Senthil-Kumar M

更新日期：2019-04-03 00:00:00

abstract：:cAMP responsive element binding protein 3-like 3 (CREB3L3), a transcription factor expressed in the liver and small intestine, governs fasting-response energy homeostasis. Tissue-specific CREB3L3 knockout mice have not been generated till date. To our knowledge, this is the first study using the one-step CRISPR/Cas9 s...

journal_title：Scientific reports

authors： Nakagawa Y,Oikawa F,Mizuno S,Ohno H,Yagishita Y,Satoh A,Osaki Y,Takei K,Kikuchi T,Han SI,Matsuzaka T,Iwasaki H,Kobayashi K,Yatoh S,Yahagi N,Isaka M,Suzuki H,Sone H,Takahashi S,Yamada N,Shimano H

更新日期：2016-06-13 00:00:00

abstract：:In this work, four water-soluble polythiophene derivatives (PT, PT-DDA, PT-ADA, and PT-ADA-PPR) with different pendant moieties were synthesized via oxidative copolymerization by FeCl3. By increasing the hydrophobic ability of side chain moieties, there is a gradually blue shift for the maximum absorption wavelength a...

journal_title：Scientific reports

authors： Wang F,Li M,Wang B,Zhang J,Cheng Y,Liu L,Lv F,Wang S

更新日期：2015-01-05 00:00:00

abstract：:Frequencies of CpG and UpA dinucleotides in most plant RNA virus genomes show degrees of suppression comparable to those of vertebrate RNA viruses. While pathways that target CpG and UpAs in HIV-1 and echovirus 7 genomes and restrict their replication have been partly characterised, whether an analogous process drives...

journal_title：Scientific reports

authors： Ibrahim A,Fros J,Bertran A,Sechan F,Odon V,Torrance L,Kormelink R,Simmonds P

更新日期：2019-12-04 00:00:00

abstract：:Despite important progress, uncertainty persists regarding the ecological forces driving microbial community assembly. Here, we present the first study to use phylogenetic information to interpret the structure and diversity of diatom communities. We examined local phylogenetic divergence and beta- phylogenetic divers...

journal_title：Scientific reports

authors： Keck F,Kahlert M

更新日期：2019-08-12 00:00:00

abstract：:The development of new materials with reduced noise and vibration levels is an active area of research due to concerns in various aspects of environmental noise pollution and its effects on health. Excessive vibrations also reduce the service live of the structures and limit the fields of their utilization. In oscilla...

journal_title：Scientific reports

authors： Unwin AP,Hine PJ,Ward IM,Fujita M,Tanaka E,Gusev AA

更新日期：2018-02-06 00:00:00

abstract：:Rheumatoid Arthritis (RA) causes chronic inflammation of joints. The cytokines TNFα and IFNγ are central players in RA, however their source has not been fully elucidated. Natural Killer (NK) cells are best known for their role in elimination of viral-infected and transformed cells, and they secrete pro-inflammatory c...

journal_title：Scientific reports

authors： Yamin R,Berhani O,Peleg H,Aamar S,Stein N,Gamliel M,Hindi I,Scheiman-Elazary A,Gur C

更新日期：2019-02-04 00:00:00

abstract：:There is an unmet need for treatments to reduce abdominal aortic aneurysm (AAA) progression. Vascular smooth muscle cell (VSMC) apoptosis precipitates AAA formation, whereas VSMC proliferation repairs the vessel wall. We previously demonstrated that over-expression of EC4-Fc (truncated N-cadherin), or deletion of matr...

journal_title：Scientific reports

authors： Lyon CA,Williams H,Bianco R,Simmonds SJ,Brown BA,Wadey KS,Smith FCT,Johnson JL,George SJ

更新日期：2017-12-11 00:00:00

abstract：:Agglomeration-triggered deactivation of supported platinum electrocatalysts markedly hinders their application in methanol oxidation reaction (MOR). In this study, graphene-supported nickel-iron layered double hydroxide (NiFe-LDH/rGO), in which Fe3+ was introduced to replace Ni2+ partially in the Ni(OH)2 lattice to pr...

journal_title：Scientific reports

authors： Han Y,Li P,Liu J,Wu S,Ye Y,Tian Z,Liang C

更新日期：2018-01-22 00:00:00

abstract：:Mammals typically keep their body temperature (Tb) within a narrow limit with changing environmental conditions. There are indications that some wild ungulates can exhibit certain forms of energy saving mechanisms when ambient temperatures are low and/or food is scarce. Therefore, the aim of the study was to determine...

journal_title：Scientific reports

authors： Riek A,Brinkmann L,Gauly M,Perica J,Ruf T,Arnold W,Hambly C,Speakman JR,Gerken M

更新日期：2017-08-08 00:00:00

abstract：:The anisotropic shape of DNA molecules allows them to form lyotropic liquid crystals (LCs) at high concentrations. This liquid crystalline arrangement is also found in vivo (e.g., in bacteriophage capsids, bacteria or human sperm nuclei). However, the role of DNA liquid crystalline organization in living organisms sti...

journal_title：Scientific reports

authors： Brach K,Hatakeyama A,Nogues C,Olesiak-Banska J,Buckle M,Matczyszyn K

更新日期：2018-03-14 00:00:00

abstract：:The Holocene drying trend in the northern Altai Mountains and the wetting trend in the southern Altai Mountains inferred from the paleoclimatic studies indicated it is needed to understand the modern climatic characters in this region. However, a detailed analysis of modern climate variations in the northern and south...

journal_title：Scientific reports

authors： Zhang D,Yang Y,Lan B

更新日期：2018-02-19 00:00:00

abstract：:Communication between vascular plants through volatile organic compounds (VOCs) impacts on ecosystem functioning. However, nothing is known about that between non-vascular plants. To investigate plant-plant VOCs interaction in bryophytes we exposed rare peatland moss Hamatocaulis vernicosus to VOCs of its common compe...

journal_title：Scientific reports

authors： Vicherová E,Glinwood R,Hájek T,Šmilauer P,Ninkovic V

更新日期：2020-05-04 00:00:00

abstract：:In order to study the effect of water-rock interactions on shear strength characteristics, we performed shearing tests under varying hydrochemical environments. Moreover, a custom meso-shear test equipment for coal rock was used for the tests. Through 3D scanning of the shear fractures and scanning electron microscope...

journal_title：Scientific reports

authors： Chen C,Peng S,Wu S,Xu J

更新日期：2019-12-27 00:00:00

abstract：:Current robots can manipulate only surface-attached cells seriously limiting the fields of their application for single cell handling. We developed a computer vision-based robot applying a motorized microscope and micropipette to recognize and gently isolate intact individual cells for subsequent analysis, e.g., DNA/R...

journal_title：Scientific reports

authors： Ungai-Salánki R,Gerecsei T,Fürjes P,Orgovan N,Sándor N,Holczer E,Horvath R,Szabó B

更新日期：2016-02-09 00:00:00

abstract：:Despite advances in stem cell research, cell transplantation therapy for liver failure is impeded by a shortage of human primary hepatocytes (HPH), along with current differentiation protocol limitations. Several studies have examined the concept of co-culture of human induced pluripotent cells (hiPSCs) with various t...

journal_title：Scientific reports

authors： Pettinato G,Lehoux S,Ramanathan R,Salem MM,He LX,Muse O,Flaumenhaft R,Thompson MT,Rouse EA,Cummings RD,Wen X,Fisher RA

更新日期：2019-06-20 00:00:00

abstract：:Facial mimicry has been suggested to be a behavioral index for emotional empathy. The present study is the first to investigate the link between facial muscle activity and empathy for pain by facial electromyographic (EMG) recording while observers watched videos depicting real-life painful events. Three types of visu...

journal_title：Scientific reports

authors： Sun YB,Wang YZ,Wang JY,Luo F

更新日期：2015-12-09 00:00:00

abstract：:Previous studies demonstrated distinct neural correlates underpinning impaired self-regulation (dysregulation) between individuals with autism spectrum disorder (ASD) and typically developing controls (TDC). However, the impacts of dysregulation on white matter (WM) microstructural property in ASD and TDC remain uncle...

journal_title：Scientific reports

authors： Ni HC,Lin HY,Tseng WI,Gau SS

更新日期：2020-08-14 00:00:00

abstract：:It well-known that mental training improves skill performance. Here, we evaluated skill acquisition and consolidation after physical or motor imagery practice, by means of an arm pointing task requiring speed-accuracy trade-off. In the main experiment, we showed a significant enhancement of skill after both practices ...

journal_title：Scientific reports

authors： Ruffino C,Truong C,Dupont W,Bouguila F,Michel C,Lebon F,Papaxanthis C

更新日期：2021-01-27 00:00:00

abstract：:Many practical systems can be described by dynamic networks, for which modern technique can measure their outputs, and accumulate extremely rich data. Nevertheless, the network structures producing these data are often deeply hidden in the data. The problem of inferring network structures by analyzing the available da...

journal_title：Scientific reports

authors： Chen Y,Zhang Z,Chen T,Wang S,Hu G

更新日期：2017-03-21 00:00:00

abstract：:Viruses exploit host factors and environment for their efficient replication. The virus-host interaction mechanisms for achieving an optimal hepatitis B virus (HBV) replication have been largely unknown. Here, a single cell cloning revealed that HepAD38 cells, a widely-used HBV-inducible cell line, contain cell clones...

journal_title：Scientific reports

authors： Iwamoto M,Cai D,Sugiyama M,Suzuki R,Aizaki H,Ryo A,Ohtani N,Tanaka Y,Mizokami M,Wakita T,Guo H,Watashi K

更新日期：2017-09-06 00:00:00