当前位置： SCI文献检索 > Scientific Reports期刊下所有文献 > Operation of a P300-based brain-computer interface in patients with Duchenne muscular dystrophy.

Operation of a P300-based brain-computer interface in patients with Duchenne muscular dystrophy.

Abstract：

:A brain-computer interface (BCI) or brain-machine interface is a technology that enables the control of a computer and other external devices using signals from the brain. This technology has been tested in paralysed patients, such as those with cervical spinal cord injuries or amyotrophic lateral sclerosis, but it has not been tested systematically in Duchenne muscular dystrophy (DMD), which is a severe type of muscular dystrophy due to the loss of dystrophin and is often accompanied by progressive muscle weakness and wasting. Here, we investigated the efficacy of a P300-based BCI for patients with DMD. Eight bedridden patients with DMD and eight age- and gender-matched able-bodied controls were instructed to input hiragana characters. We used a region-based, two-step P300-based BCI with green/blue flicker stimuli. EEG data were recorded, and a linear discriminant analysis distinguished the target from other non-targets. The mean online accuracy of inputted characters (accuracy for the two-step procedure) was 71.6% for patients with DMD and 80.6% for controls, with no significant difference between the patients and controls. The P300-based BCI was operated successfully by individuals with DMD in an advanced stage and these findings suggest that this technology may be beneficial for patients with this disease.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Utsumi K,Takano K,Okahara Y,Komori T,Onodera O,Kansaku K

doi

10.1038/s41598-018-20125-6

subject

Has Abstract

pub_date

2018-01-29 00:00:00

pages

1753

issue

1

issn

2045-2322

pii

10.1038/s41598-018-20125-6

journal_volume

8

pub_type

杂志文章

相关文献

Scientific Reports文献大全
  • Integrated transcriptomic and metabolomic analyses reveal the effects of callose deposition and multihormone signal transduction pathways on the tea plant-Colletotrichum camelliae interaction.

    abstract：:Colletotrichum infects diverse hosts, including tea plants, and can lead to crop failure. Numerous studies have reported that biological processes are involved in the resistance of tea plants to Colletotrichum spp. However, the molecular and biochemical responses in the host during this interaction are unclear. Cuttin...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-69729-x

    authors： Lu Q,Wang Y,Xiong F,Hao X,Zhang X,Li N,Wang L,Zeng J,Yang Y,Wang X

    更新日期：2020-07-30 00:00:00

  • Clear variation of spin splitting by changing electron distribution at non-magnetic metal/Bi2O3 interfaces.

    abstract：:Large spin splitting at Rashba interface, giving rise to strong spin-momentum locking, is essential for efficient spin-to-charge conversion. Recently, a Cu/Bismuth oxide (Bi2O3) interface has been found to exhibit an efficient spin-to-charge conversion similar to a Ag/Bi interface with large Rashba spin splitting. How...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-23787-4

    authors： Tsai H,Karube S,Kondou K,Yamaguchi N,Ishii F,Otani Y

    更新日期：2018-04-03 00:00:00

  • Clinical features of irreversible rejection after allogeneic uterus transplantation in cynomolgus macaques.

    abstract：:Uterus transplantation (UTx) is a potential option for women with uterine factor infertility to have a child. The clinical features indicating irreversible rejection of the uterus are unknown. In our experimental series of allogeneic UTx in cynomolgus macaques, six female macaques were retrospectively examined, which ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-70914-1

    authors： Kisu I,Emoto K,Masugi Y,Yamada Y,Matsubara K,Obara H,Matoba Y,Banno K,Kato Y,Saiki Y,Itagaki I,Kawamoto I,Iwatani C,Murase M,Nakagawa T,Tsuchiya H,Ishigaki H,Urano H,Ema M,Ogasawara K,Aoki D,Nakagawa K,Shiina

    更新日期：2020-08-17 00:00:00

  • Comparison of Biaxial Biomechanical Properties of Post-menopausal Human Prolapsed and Non-prolapsed Uterosacral Ligament.

    abstract：:Uterosacral ligaments (USLs) provide structural support to the female pelvic floor, and a loss of USL structural integrity or biomechanical function may induce pelvic organ prolapse (POP). Alterations in extracellular matrix composition and organization dictate USL mechanical function. Changes in USL microstructure an...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-64192-0

    authors： Danso EK,Schuster JD,Johnson I,Harville EW,Buckner LR,Desrosiers L,Knoepp LR,Miller KS

    更新日期：2020-04-30 00:00:00

  • Multi-Domain Negative Capacitance Effects in Metal-Ferroelectric-Insulator-Semiconductor/Metal Stacks: A Phase-field Simulation Based Study.

    abstract：:We analyze the ferroelectric domain-wall induced negative capacitance (NC) effect in Metal-FE-Insulator-Metal (MFIM) and Metal-FE-Insulator-Semiconductor (MFIS) stacks through phase-field simulations by self-consistently solving time-dependent Ginzburg Landau equation, Poisson's equation and semiconductor charge equat...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-66313-1

    authors： Saha AK,Gupta SK

    更新日期：2020-06-23 00:00:00

  • Variable impact of the hemagglutinin polybasic cleavage site on virulence and pathogenesis of avian influenza H7N7 virus in chickens, turkeys and ducks.

    abstract：:Avian influenza viruses (AIV) are classified into 16 hemagglutinin (HA; H1-H16) and 9 neuraminidase (NA; N1-N9) subtypes. All AIV are low pathogenic (LP) in birds, but subtypes H5 and H7 AIV can evolve into highly pathogenic (HP) forms. In the last two decades evolution of HPAIV H7 from LPAIV has been frequently repor...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-47938-3

    authors： Scheibner D,Ulrich R,Fatola OI,Graaf A,Gischke M,Salaheldin AH,Harder TC,Veits J,Mettenleiter TC,Abdelwhab EM

    更新日期：2019-08-09 00:00:00

  • Mild synthesis of isoxazoline derivatives via an efficient [4 + 1] annulation reaction of transient nitrosoalkenes and sulfur ylides.

    abstract：:An efficient [4 + 1] annulation between α-bromooximes and sulfur ylides via in situ generation of nitrosoalkenes under mild basic reaction conditions has been developed, providing an expeditious and scalable approach to synthesize biologically interesting isoxazoline derivatives with good to excellent yields. ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-021-81370-w

    authors： Hua TB,Liu CX,Hu WM,Wang L,Yang QQ

    更新日期：2021-01-22 00:00:00

  • Interferon-alpha therapy for refractory kaposiform hemangioendothelioma: a single-center experience.

    abstract：:Kaposiform hemangioendothelioma (KHE) is a relatively rare vascular tumor with an aggressive and infiltrating nature. Previous studies have revealed an exclusive relationship between KHE and Kasabach-Merritt Phenomenon (KMP), which is associated with high morbidity and mortality. No universally accepted treatment moda...

    journal_title：Scientific reports

    pub_type： 临床试验,杂志文章

    doi：10.1038/srep36261

    authors： Wu HW,Wang X,Zhang L,Zhao HG,Wang YA,Su LX,Fan XD,Zheng JW

    更新日期：2016-10-31 00:00:00

  • Programmable hydraulic resistor for microfluidic chips using electrogate arrays.

    abstract：:Flow rates play an important role in microfluidic devices because they affect the transport of chemicals and determine where and when (bio)chemical reactions occur in these devices. Flow rates can conveniently be determined using external peripherals in active microfluidics. However, setting specific flow rates in pas...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-53885-w

    authors： Salva ML,Temiz Y,Rocca M,Arango YC,Niemeyer CM,Delamarche E

    更新日期：2019-11-21 00:00:00

  • Elimination of Antibiotic Resistant Surgical Implant Biofilms Using an Engineered Cationic Amphipathic Peptide WLBU2.

    abstract：:Antibiotics are unable to remove biofilms from surgical implants. This high antibiotic tolerance is related to bacterial persisters, a sub-population of bacteria phenotypically tolerant to antibiotics secondary to a reduced metabolic state. WLBU2 is an engineered cationic amphipathic peptide designed to maximize antim...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-17780-6

    authors： Mandell JB,Deslouches B,Montelaro RC,Shanks RMQ,Doi Y,Urish KL

    更新日期：2017-12-22 00:00:00

  • Individual versus team heart rate variability responsiveness analyses in a national soccer team during training camps.

    abstract：:Heart rate variability (HRV) analyses can be performed using group or individual changes. Individual changes could be of potential interest during training camps for national soccer teams. The purpose of this study was to compare whether analysis of individual daily HRV could detect changes in cardiac autonomic respon...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-68698-5

    authors： Muñoz-López A,Naranjo-Orellana J

    更新日期：2020-07-16 00:00:00

  • Tunable Polarons in Bose-Einstein Condensates.

    abstract：:A toolbox for the quantum simulation of polarons in ultracold atoms is presented. Motivated by the impressive experimental advances in the area of ultracold atomic mixtures, we theoretically study the problem of ultracold atomic impurities immersed in a Bose-Einstein condensate mixture (BEC). The coupling between impu...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-02398-5

    authors： Compagno E,De Chiara G,Angelakis DG,Palma GM

    更新日期：2017-05-24 00:00:00

  • Enhanced avidity from a multivalent fluorescent antimicrobial peptide enables pathogen detection in a human lung model.

    abstract：:Rapid in situ detection of pathogens coupled with high resolution imaging in the distal human lung has the potential to provide new insights and diagnostic utility in patients in whom pneumonia is suspected. We have previously described an antimicrobial peptide (AMP) Ubiquicidin (fragment UBI29-41) labelled with an en...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-44804-0

    authors： Akram AR,Avlonitis N,Scholefield E,Vendrell M,McDonald N,Aslam T,Craven TH,Gray C,Collie DS,Fisher AJ,Corris PA,Walsh T,Haslett C,Bradley M,Dhaliwal K

    更新日期：2019-06-10 00:00:00

  • Comparison of proteomic profiles in the zebrafish retina during experimental degeneration and regeneration.

    abstract：:Zebrafish spontaneously regenerate the retina after injury. Although the gene expression profile has been extensively studied in this species during regeneration, this does not reflect protein function. To further understand the regenerative process in the zebrafish, we compared the proteomic profile of the retina dur...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep44601

    authors： Eastlake K,Heywood WE,Tracey-White D,Aquino E,Bliss E,Vasta GR,Mills K,Khaw PT,Moosajee M,Limb GA

    更新日期：2017-03-16 00:00:00

  • MicroRNA Profiling Reveals Distinct Profiles for Tissue-Derived and Cultured Endothelial Cells.

    abstract：:Endothelial plasticity enables the cells to switch their phenotype according to the surrounding vascular microenvironment. MicroRNAs (miRNAs) are small noncoding RNAs that control endothelial plasticity. The objective of this study was to investigate the differences in miRNA profiles of tissue-derived cells and cultur...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-11487-4

    authors： Kuosmanen SM,Kansanen E,Sihvola V,Levonen AL

    更新日期：2017-09-08 00:00:00

  • Mirror-backed Dark Alumina: A Nearly Perfect Absorber for Thermoelectronics and Thermophotovotaics.

    abstract：:We present here a broadband, wide-angle, and polarization-independent nearly perfect absorber consisting of mirror-backed nanoporous alumina. By electrochemically anodizing the disordered multicomponent aluminum and properly tailoring the thickness and air-filling fraction of nanoporous alumina, according to the Maxwe...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep19984

    authors： Farhat M,Cheng TC,Le KQ,Cheng MM,Bağcı H,Chen PY

    更新日期：2016-01-28 00:00:00

  • Fewer clouds in the Mediterranean: consistency of observations and climate simulations.

    abstract：:Clouds play a major role in the climate system, but large uncertainties remain about their decadal variations. Here we report a widespread decrease in cloud cover since the 1970 s over the Mediterranean region, in particular during the 1970 s-1980 s, especially in the central and eastern areas and during springtime. C...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep41475

    authors： Sanchez-Lorenzo A,Enriquez-Alonso A,Calbó J,González JA,Wild M,Folini D,Norris JR,Vicente-Serrano SM

    更新日期：2017-02-02 00:00:00

  • Repeated surveying over 6 years reveals that fine-scale habitat variables are key to tropical mountain ant assemblage composition and functional diversity.

    abstract：:High-altitude-adapted ectotherms can escape competition from dominant species by tolerating low temperatures at cooler elevations, but climate change is eroding such advantages. Studies evaluating broad-scale impacts of global change for high-altitude organisms often overlook the mitigating role of biotic factors. Yet...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-80077-8

    authors： Muluvhahothe MM,Joseph GS,Seymour CL,Munyai TC,Foord SH

    更新日期：2021-01-08 00:00:00

  • The eastern extent of seasonal iron limitation in the high latitude North Atlantic Ocean.

    abstract：:The availability of iron (Fe) can seasonally limit phytoplankton growth in the High Latitude North Atlantic (HLNA), greatly reducing the efficiency of the biological carbon pump. However, the spatial extent of seasonal iron limitation is not yet known. We present autumn nutrient and dissolved Fe measurements, combined...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-37436-3

    authors： Birchill AJ,Hartner NT,Kunde K,Siemering B,Daniels C,González-Santana D,Milne A,Ussher SJ,Worsfold PJ,Leopold K,Painter SC,Lohan MC

    更新日期：2019-02-05 00:00:00

  • The Transmembrane Conformation of the Influenza B Virus M2 Protein in Lipid Bilayers.

    abstract：:Influenza A and B viruses cause seasonal flu epidemics. The M2 protein of influenza B (BM2) is a membrane-embedded tetrameric proton channel that is essential for the viral lifecycle. BM2 is a functional analog of AM2 but shares only 24% sequence identity for the transmembrane (TM) domain. The structure and function o...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-40217-1

    authors： Mandala VS,Liao SY,Gelenter MD,Hong M

    更新日期：2019-03-06 00:00:00

  • CREB3L2-mediated expression of Sec23A/Sec24D is involved in hepatic stellate cell activation through ER-Golgi transport.

    abstract：:Hepatic fibrosis is caused by exaggerated wound healing response to chronic injury, which eventually leads to hepatic cirrhosis. Differentiation of hepatic stellate cells (HSCs) to myofibroblast-like cells by inflammatory cytokines is the critical step in fibrosis. This step is accompanied by enlargement of the endopl...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-08703-6

    authors： Tomoishi S,Fukushima S,Shinohara K,Katada T,Saito K

    更新日期：2017-08-11 00:00:00

  • Graphene oxide as an interface phase between polyetheretherketone and hydroxyapatite for tissue engineering scaffolds.

    abstract：:The poor bonding strength between biopolymer and bioceramic has remained an unsolved issue. In this study, graphene oxide (GO) was introduced as an interface phase to improve the interfacial bonding between polyetheretherketone (PEEK) and hydroxyapatite (HAP) for tissue engineering scaffolds. On the one hand, the conj...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep46604

    authors： Peng S,Feng P,Wu P,Huang W,Yang Y,Guo W,Gao C,Shuai C

    更新日期：2017-04-20 00:00:00

  • Transcription factor ZNF148 is a negative regulator of human muscle differentiation.

    abstract：:Muscle differentiation is a complex process in which muscle progenitor cells undergo determination and eventually cellular fusion. This process is heavily regulated by such master transcription factors as MYOD and members of the MEF2 family. Here, we show that the transcription factor ZNF148 plays a direct role in hum...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-08267-5

    authors： Bakke J,Wright WC,Zamora AE,Ong SS,Wang YM,Hoyer JD,Brewer CT,Thomas PG,Chen T

    更新日期：2017-08-15 00:00:00

  • Simple fluorometric-based assay of antibiotic effectiveness for Acinetobacter baumannii biofilms.

    abstract：:Despite strengthened antimicrobial therapy, biofilm infections of Acinetobacter baumannii are associated with poor prognosis and limited therapeutic options. Assessing antibiotics on planktonic bacteria can result in failure against biofilm infections. Currently, antibiotics to treat biofilm infections are administere...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-42353-0

    authors： Wannigama DL,Hurst C,Pearson L,Saethang T,Singkham-In U,Luk-In S,Storer RJ,Chatsuwan T

    更新日期：2019-04-19 00:00:00

  • Comparison of phosphorylation and assembly of photosystem complexes and redox homeostasis in two wheat cultivars with different drought resistance.

    abstract：:Reversible phosphorylation of proteins and the assembly of thylakoid complexes are the important protective mechanism against environmental stresses in plants. This research was aimed to investigate the different responses of the antioxidant defense system and photosystem II (PSII) to osmotic stress between drought-re...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-13145-1

    authors： Chen YE,Cui JM,Su YQ,Zhang CM,Ma J,Zhang ZW,Yuan M,Liu WJ,Zhang HY,Yuan S

    更新日期：2017-10-05 00:00:00

  • Flower-like superstructures of AIE-active tetraphenylethylene through solvophobic controlled self-assembly.

    abstract：:The development of well-organized structures with high luminescent properties in the solid and aggregated states is of both scientific and technological interest due to their applications in nanotechnology. In this paper we described the synthesis of amphiphilic and dumbbell shaped AIE-active tetraphenylethylene (TPE)...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep42898

    authors： Salimimarand M,La DD,Kobaisi MA,Bhosale SV

    更新日期：2017-02-23 00:00:00

  • Phenotypic and genetic characterisation of an emerging reovirus from Pekin ducks in China.

    abstract：:In June 2016, a disease characterised by intestinal haemorrhage with a mortality rate of approximately 5% was observed in a duck farm in Shandong province, China. Here, we report the isolation and characterisation of a reovirus from duck tissue samples by inoculating duck embryos and duck embryo fibroblasts (DEF). The...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-44178-3

    authors： Cao Y,Sun M,Wang J,Hu X,He W,Su J

    更新日期：2019-05-23 00:00:00

  • Relationship between cell number and clinical outcomes of autologous bone-marrow mononuclear cell implantation in critical limb ischemia.

    abstract：:Cell therapy using intramuscular injections of autologous bone-marrow mononuclear cells (BM-MNCs) improves clinical symptoms and can prevent limb amputation in atherosclerotic peripheral arterial disease (PAD) patients with critical limb ischemia (CLI). The purpose of this study was to evaluate the effects of the numb...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-76886-6

    authors： Yusoff FM,Kajikawa M,Takaeko Y,Kishimoto S,Hashimoto H,Maruhashi T,Nakashima A,Wahid SFSA,Higashi Y

    更新日期：2020-11-16 00:00:00

  • Quantum Secure Group Communication.

    abstract：:We propose a quantum secure group communication protocol for the purpose of sharing the same message among multiple authorized users. Our protocol can remove the need for key management that is needed for the quantum network built on quantum key distribution. Comparing with the secure quantum network based on BB84, we...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-21743-w

    authors： Li ZH,Zubairy MS,Al-Amri M

    更新日期：2018-03-01 00:00:00

  • Atypical developmental trajectory of local spontaneous brain activity in autism spectrum disorder.

    abstract：:Autism spectrum disorder (ASD) is marked by atypical trajectory of brain maturation, yet the developmental abnormalities in brain function remain unclear. The current study examined the effect of age on amplitude of low-frequency fluctuations (ALFF) in ASD and typical controls (TC) using a cross-sectional design. We c...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep39822

    authors： Guo X,Chen H,Long Z,Duan X,Zhang Y,Chen H

    更新日期：2017-01-06 00:00:00