Fewer clouds in the Mediterranean: consistency of observations and climate simulations.

abstract：:Cas13 endonuclease activity depends on the RNA local secondary structure with strong preference for single-stranded (SS) regions. Hence, it becomes indispensable to identify the SS regions for effective Cas13 mediated RNA knockdown. We herein present rational gRNA design by integrating experimental structure-seq data ...

journal_title：Scientific reports

authors： Bandaru S,Tsuji MH,Shimizu Y,Usami K,Lee S,Takei NK,Yoshitome K,Nishimura Y,Otsuki T,Ito T

更新日期：2020-07-14 00:00:00

abstract：:In this study, we report a microfluidic device for the whole-life culture of the nematode Caenorhabditis elegans that allows the scoring of animal survival and health measures. This device referred to as the NemaLife chip features: (1) an optimized micropillar arena in which animals can crawl, (2) sieve channels that ...

journal_title：Scientific reports

authors： Rahman M,Edwards H,Birze N,Gabrilska R,Rumbaugh KP,Blawzdziewicz J,Szewczyk NJ,Driscoll M,Vanapalli SA

更新日期：2020-10-01 00:00:00

abstract：:Single nucleotide polymorphisms (SNPs) and genes associated with susceptibility to hepatitis B virus (HBV) infection that have been identified by genome-wide association studies explain only a limited portion of the known heritability, indicating more genetic variants remain to be discovered. In this study, we adopted...

journal_title：Scientific reports

authors： Jiang X,Zhang B,Zhao J,Xu Y,Han H,Su K,Tao J,Fan R,Zhao X,Li L,Li MD

更新日期：2019-09-17 00:00:00

abstract：:Globally, lung cancer accounts for approximately 20% of all cancer related deaths. Five-year survival is poor and rates have remained unchanged for the past four decades. There is an urgent need to identify markers of lung carcinogenesis and new targets for therapy. Given the recent successes of immune modulators in c...

journal_title：Scientific reports

authors： Baird AM,Gray SG,Richard DJ,O'Byrne KJ

更新日期：2016-01-13 00:00:00

abstract：:Prostate cancer (PCa) is the most common solid neoplasm diagnosed in developed countries. Nerve-sparing radical prostatectomy (NS-RP) has been widely accepted as the best choice treatment for localised PCa. However, erectile dysfunction (ED) and urinary incontinence are commonly observed after NS-RP. Using meta-analys...

journal_title：Scientific reports

authors： Li J,Shi Q,Pu C,Tang Y,Bai Y,Yuan H,Li X,Dong Q,Wei Q,Yuan J,Han P

更新日期：2014-07-23 00:00:00

abstract：:We propose a new method to extend the path length tunability of rotary delay-lines. This method was shown to achieve a duty cycle of >80% and repetition rates of over 40 kHz. The new method relies on a new multi-segmented micro-machined mirror and serial injection of a single reflection onto separate segments of this ...

journal_title：Scientific reports

authors： Fleddermann R,Lee WM,Huang K,Campbell GT,Lam PK,Chow JH

更新日期：2017-08-24 00:00:00

abstract：:MicroRNAs (miRNAs) play an important role in guiding development and maintaining function of the human heart. Dysregulation of miRNAs has been linked to various congenital heart diseases including Tetralogy of Fallot (TOF), which represents the most common cyanotic heart malformation in humans. Several studies have id...

journal_title：Scientific reports

authors： Grunert M,Appelt S,Dunkel I,Berger F,Sperling SR

更新日期：2019-12-13 00:00:00

abstract：:The ability to accurately forecast seizures could significantly improve the quality of life of patients with drug-refractory epilepsy. Prediction capabilities rely on the adequate identification of seizure activity precursors from electroencephalography recordings. Although a long list of features has been proposed, n...

journal_title：Scientific reports

authors： Bou Assi E,Gagliano L,Rihana S,Nguyen DK,Sawan M

更新日期：2018-10-19 00:00:00

abstract：:Neurite growth is controlled by a complex molecular signaling network that regulates filamentous actin (F-actin) dynamics at the growth cone. The evolutionarily conserved ezrin, radixin, and moesin family of proteins tether F-actin to the cell membrane when phosphorylated at a conserved threonine residue and modulate ...

journal_title：Scientific reports

authors： Jin EJ,Ko HR,Hwang I,Kim BS,Choi JY,Park KW,Cho SW,Ahn JY

更新日期：2018-02-07 00:00:00

abstract：:Helicobacter pullorum is an avian bacterium that causes gastroenteritis, intestinal bowel and hepatobiliary diseases in humans. Although H. pullorum has been shown to activate the mammalian innate immunity with release of nitric oxide (NO), the proteins that afford protection against NO and reactive nitrogen species (...

journal_title：Scientific reports

authors： Parente MR,Forte E,Falabella M,Boneca IG,Teixeira M,Giuffrè A,Saraiva LM

更新日期：2017-08-30 00:00:00

abstract：:The new π-extended redox-active ligand with both TTF and triazole units, 6-(4,5-bis(propylthio)-1,3-dithiol-2-ylidene)-1H-[1,3]dithiolo[4',5':4,5]benzo [1,2-d] [1-3]triazole, has been successfully prepared. Based on the versatile ligand and Cu(tta)2 precursors (tta(-) = 4,4,4-trifluoro-1-(thiophen-2-yl)butane-1,3-dion...

journal_title：Scientific reports

authors： Cui L,Geng YF,Leong CF,Ma Q,D'Alessandro DM,Deng K,Zeng QD,Zuo JL

更新日期：2016-05-06 00:00:00

abstract：:Amyloids are highly organized fibril aggregates arise from inappropriately folded form of the protein or polypeptide precursors under both physiological as well as simulated ambience. Amyloid synthesis is a multistep process that involves formation of several metastable intermediates. Among various intermediate specie...

journal_title：Scientific reports

authors： Kazmi S,Mujeeb AA,Owais M

更新日期：2018-11-23 00:00:00

abstract：:The brain is possibly the most complex system known to mankind, and its complexity has been called upon to explain the emergence of consciousness. However, complexity has been defined in many ways by multiple different fields: here, we investigate measures of algorithmic and process complexity in both the temporal and...

journal_title：Scientific reports

authors： Varley TF,Luppi AI,Pappas I,Naci L,Adapa R,Owen AM,Menon DK,Stamatakis EA

更新日期：2020-01-23 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Mei X,Glueckert R,Schrott-Fischer A,Li H,Ladak HM,Agrawal SK,Rask-Andersen H

更新日期：2020-05-01 00:00:00

abstract：:A body with mechanical sensors may remotely detect particles suspended in the surrounding fluid via controlled agitation. Here we propose a sensory mode that relies on generating unsteady flow and sensing particle-induced distortions in the flow field. We demonstrate the basic physical principle in a simple analytical...

journal_title：Scientific reports

authors： Takagi D,Strickler JR

更新日期：2020-02-14 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Bartz M,Arnold LJ,Spooner NA,Demuro M,Campaña I,Rixhon G,Brückner H,Duval M

更新日期：2020-03-18 00:00:00

abstract：:Intrahepatic cholestasis represents a frequent manifestation of drug-induced liver injury; however, the mechanisms underlying such injuries are poorly understood. In this study of human HepaRG and primary hepatocytes, we found that bile canaliculi (BC) underwent spontaneous contractions, which are essential for bile a...

journal_title：Scientific reports

authors： Sharanek A,Burban A,Burbank M,Le Guevel R,Li R,Guillouzo A,Guguen-Guillouzo C

更新日期：2016-05-12 00:00:00

abstract：:This study aims to prepare, characterize and evaluate the pharmacokinetics of liposomal donepezil HCl (LDH) dispersed into thiolated chitosan hydrogel (TCH) in rabbits. Various hydrogels including TCH were prepared, and after characterization, TCH was selected for subsequent evaluations, due to the promising results. ...

journal_title：Scientific reports

authors： Al Harthi S,Alavi SE,Radwan MA,El Khatib MM,AlSarra IA

更新日期：2019-07-02 00:00:00

abstract：:Fluorescence visualization devices (FVs) are useful for detecting malignant lesions because of their simple and noninvasive application. However, their quantitative application has been challenging. This study aimed to quantitatively and statistically evaluate the change in fluorescence intensity (FI) during the progr...

journal_title：Scientific reports

authors： Kosugi A,Kasahara M,Yang L,Nakamura-Takahashi A,Shibahara T,Mori T

更新日期：2019-05-24 00:00:00

abstract：:Data on post stroke outcomes in developing countries are scarce due to uncoordinated healthcare delivery systems. In Malaysia, the national stroke clinical practice guideline does not address transfer of care and longer term post stroke care beyond tertiary care. Hence, post stroke care delivery may be delivered at ei...

journal_title：Scientific reports

authors： Abdul Aziz AF,Ali MF,Yusof MF,Che' Man Z,Sulong S,Aljunid SM

更新日期：2018-12-19 00:00:00

abstract：:Natural and anthropogenic stressors can cause phase shifts from coral-dominated to algal-dominated states. In the Caribbean, over-fishing of large herbivorous fish and disease among the long-spined urchin, Diadema, have facilitated algal growth on degraded reefs. We found that diminutive species of urchin and parrotfi...

journal_title：Scientific reports

authors： Kuempel CD,Altieri AH

更新日期：2017-01-05 00:00:00

abstract：:Chaperonin and cochaperonin, represented by E. coli GroEL and GroES, are essential molecular chaperones for protein folding. The double-ring assembly of GroEL is required to function with GroES, and a single-ring GroEL variant GroELSR forms a stable complex with GroES, arresting the chaperoning reaction cycle. GroES I...

journal_title：Scientific reports

authors： Illingworth M,Ellis H,Chen L

更新日期：2017-08-29 00:00:00

abstract：:The recently described site of Kalinga in the Philippines adds to our understanding of Early-Middle Pleistocene hominin behaviour. Yet, disentangling the natural from the anthropogenic modifications that have taken place in such an old archaeological site is challenging. In this paper we use a set of taphonomic tools ...

journal_title：Scientific reports

authors： Ingicco T,Reyes MC,de Vos J,Belarmino M,Albers PCH,Lipardo I,Gallet X,Amano N,van den Bergh GD,Cosalan AD,Bautista A

更新日期：2020-07-06 00:00:00

abstract：:Hydrogen sulfide (H2S) is involved in cancer biological processes. However, there are several controversies concerning the role of H2S in cancer development and progression. In this study, we found that the growth and migration of hepatocellular carcinoma (HCC) cells were enhanced by 10-100 μM NaHS and dose-dependentl...

journal_title：Scientific reports

authors： Wu D,Li M,Tian W,Wang S,Cui L,Li H,Wang H,Ji A,Li Y

更新日期：2017-07-11 00:00:00

abstract：:Desertification due to climate change and increasing drought periods is a worldwide problem for both ecology and economy. Our ability to understand how vegetation manages to survive and propagate through arid and semiarid ecosystems may be useful in the development of future strategies to prevent desertification, pres...

journal_title：Scientific reports

authors： Bordeu I,Clerc MG,Couteron P,Lefever R,Tlidi M

更新日期：2016-09-21 00:00:00

abstract：:The efficacy of different modalities of treating breast cancer is inhibited by several limitations such as off-targeted drug distribution, rapid drug clearance, and drug resistance. To overcome these limitations, we developed Lf-Doxo-PMNSs for combined chemo-MF-PTT. The PMNSs were synthesized by hydrothermal method an...

journal_title：Scientific reports

authors： Sharifi M,Hasan A,Nanakali NMQ,Salihi A,Qadir FA,Muhammad HA,Shekha MS,Aziz FM,Amen KM,Najafi F,Yousefi-Manesh H,Falahati M

更新日期：2020-04-03 00:00:00

abstract：:We investigated the dynamics of the interaction between spin-polarized photo-created carriers and Mn ions on InGaAs/GaAs: Mn structures. The carriers are confined in an InGaAs quantum well and the Mn ions come from a Mn delta-layer grown at the GaAs barrier close to the well. Even though the carriers and the Mn ions a...

journal_title：Scientific reports

authors： Balanta MA,Brasil MJ,Iikawa F,Mendes UC,Brum JA,Danilov YA,Dorokhin MV,Vikhrova OV,Zvonkov BN

更新日期：2016-04-15 00:00:00

abstract：:To face the great challenges of ensuring food security and environmental sustainability, agricultural production must be improved by high yield and high resource utilization efficiency (HYHE). We recently addressed this challenge and evaluated yield potential by surveying 735 farmers in 2008-2012 and then conducting 6...

journal_title：Scientific reports

authors： Guo J,Hu X,Gao L,Xie K,Ling N,Shen Q,Hu S,Guo S

更新日期：2017-05-18 00:00:00

abstract：:Tolerance to Dutch elm disease (DED) has been linked to the rapid and/or high induction of disease-responsive genes after infection with the fungus Ophiostoma novo-ulmi. Although the fungal infection by O. novo-ulmi primarily takes places in xylem vessels, it is still unclear how xylem contributes to the defense again...

journal_title：Scientific reports

authors： Sherif SM,Erland LA,Shukla MR,Saxena PK

更新日期：2017-08-02 00:00:00

abstract：:The healthy adult heart primarily relies on fatty acid oxidation (FAO) for energy production but instantaneously adapts its substrate preference in response to physiological or pathological challenges. Accurate FAO measurements are crucial to investigate early metabolic (mal)adaptations. While measurements in intact c...

journal_title：Scientific reports

authors： Rech M,Luiken JJFP,Glatz JFC,van Bilsen M,Schroen B,Nabben M

更新日期：2018-01-24 00:00:00