Abstract：
:Cell therapy using intramuscular injections of autologous bone-marrow mononuclear cells (BM-MNCs) improves clinical symptoms and can prevent limb amputation in atherosclerotic peripheral arterial disease (PAD) patients with critical limb ischemia (CLI). The purpose of this study was to evaluate the effects of the number of implanted BM-MNCs on clinical outcomes in atherosclerotic PAD patients with CLI who underwent cell therapy. This study was a retrospective observational study with median follow-up period of 13.5 years (range, 6.8-15.5 years) from BM-MNC implantation procedure. The mean number of implanted cells was 1.2 ± 0.7 × 109 per limb. There was no significant difference in number of BM-MNCs implanted between the no major amputation group and major amputation group (1.1 ± 0.7 × 109 vs. 1.5 ± 0.8 × 109 per limb, P = 0.138). There was also no significant difference in number of BM-MNCs implanted between the no death group and death group (1.5 ± 0.9 × 109 vs. 1.8 ± 0.8 × 109 per patient, P = 0.404). Differences in the number of BM-MNCs (mean number, 1.2 ± 0.7 × 109 per limb) for cell therapy did not alter the major amputation-free survival rate or mortality rate in atherosclerotic PAD patients with CLI. A large number of BM-MNCs will not improve limb salvage outcome or mortality.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Yusoff FM,Kajikawa M,Takaeko Y,Kishimoto S,Hashimoto H,Maruhashi T,Nakashima A,Wahid SFSA,Higashi Ydoi
10.1038/s41598-020-76886-6subject
Has Abstractpub_date
2020-11-16 00:00:00pages
19891issue
1issn
2045-2322pii
10.1038/s41598-020-76886-6journal_volume
10pub_type
杂志文章abstract：:Notarchirico (Southern Italy) has yielded the earliest evidence of Acheulean settlement in Italy and four older occupation levels have recently been unearthed, including one with bifaces, extending the roots of the Acheulean in Italy even further back in time. New 40Ar/39Ar on tephras and ESR dates on bleached quartz ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-68617-8
更新日期：2020-08-14 00:00:00
abstract：:Several carbon dots doping with diferent elements (Ca, Ag, Au) were fabricated and their catalytic properties had been investigated in this paper. It was found that the Ag-doped carbon dots (CDAg) had played a role of mimic enzyme on the reaction of HAuCl4-H2O2 and generated nanogold particles with surface enhanced Ra...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-46426-y
更新日期：2019-07-10 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-020-75277-1
更新日期：2020-10-20 00:00:00
abstract：:Human aldose reductase (hAR, AKR1B1) has been explored as drug target since the 1980s for its implication in diabetic complications. An activated form of hAR was found in cells from diabetic patients, showing a reduced sensitivity to inhibitors in clinical trials, which may prevent its pharmacological use. Here we rep...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-39722-0
更新日期：2019-02-28 00:00:00
abstract：:Solar conversion to fuels or to electricity in semiconductors using far red-to-near infrared (NIR) light, which accounts for about 40% of solar energy, is highly significant. One main challenge is the development of novel strategies for activity promotion and new basic mechanisms for NIR response. Mother Nature has ev...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep20001
更新日期：2016-01-28 00:00:00
abstract：:The presence of genetically modified organisms (GMO) is commonly assessed using real-time PCR methods targeting the most common transgenic elements found in GMOs. Once the presence of GM material has been established using these screening methods, GMOs are further identified using a battery of real-time PCR methods, e...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-71614-6
更新日期：2020-09-15 00:00:00
abstract：:Receptor trafficking is pivotal for the temporal and spatial control of GPCR signaling and is regulated by multiple cellular proteins. We provide evidence that GPCRs interact with 14-3-3 signal adaptor/scaffold proteins and that this interaction regulates receptor trafficking in two ways. We found GPCR/14-3-3 interact...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-47478-w
更新日期：2019-08-01 00:00:00
abstract：:Neuroscience findings have recently received critique on the lack of replications. To examine the reproducibility of brain indices of speech sound discrimination and their role in dyslexia, a specific reading difficulty, brain event-related potentials using EEG were measured using the same cross-linguistic passive odd...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-41992-7
更新日期：2019-06-11 00:00:00
abstract：:Transgenic expression of I-E molecules prevents diabetes in NOD mice. So far, the precise role of these non-classical MHC II molecules remains elusive. Here, we showed that transgenic expression of I-E(k) alpha 16 molecule in NOD mice selectively reduced Th17 cells in the thymus and pancreatic draining lymph nodes. Th...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep12941
更新日期：2015-08-07 00:00:00
abstract：:Tideland reclamation has drastic effects on coastal ecosystem involved in soil microorganisms. However, the knowledge regarding temporal variations of microbial community along reclamation chronosequence and their environmental variable predictor is still poorly known. Using Illumina sequencing, we qualified bacterial...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-10608-3
更新日期：2017-08-30 00:00:00
abstract：:Bioartificial livers (BAL) may offer acute liver failure (ALF) patients an opportunity for cure without liver transplantation. We evaluated the efficacy of a spheroid-based BAL system, containing aggregates of porcine hepatocytes, in a porcine model of ALF. ALF pigs were divided into three groups. The control group co...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-03424-2
更新日期：2017-06-19 00:00:00
abstract：:Sentinel lymph node (SLN) mapping using dye or radioisotopes has been performed in patients with uterine cancer. Superparamagnetic iron oxide (SPIO) can be handled safely and is taken up by lymph nodes (LNs); however, its efficacy in detecting SLNs in uterine cancer remains unknown. This pilot study evaluated the use ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-64926-0
更新日期：2020-05-14 00:00:00
abstract：:There is currently a lack of effective drugs to cure recurrent aphthous stomatitis. This study aimed to evaluate the efficacy of probiotics alone or as an adjunct in recurrent aphthous stomatitis (RAS) patients. Seven randomized controlled trials (RCTs) were included, of which three were included in quantitative analy...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-78281-7
更新日期：2020-12-03 00:00:00
abstract：:Urinary albumin excretion is an early sign of diabetic kidney disease, affecting every third individual with diabetes. Despite substantial estimated heritability, only variants in the GLRA3 gene have been genome-wide significantly associated (p-value < 5 × 10-8) with diabetic albuminuria, in Finnish individuals with t...
journal_title：Scientific reports
pub_type： 杂志文章,meta分析
doi：10.1038/s41598-018-29211-1
更新日期：2018-08-17 00:00:00
abstract：:Crohn's disease (CD) has been associated with an increased consumption of n-6 polyunsaturated fatty acid (PUFA), while greater intake of n-3 PUFA has been associated with a reduced risk. We sought to investigate serum fatty acid composition in CD, and associations of fatty acids with disease activity, cytokines, and a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-39232-z
更新日期：2019-02-27 00:00:00
abstract：:Solution-based methods represent the most widespread approach used to deposit hybrid organic-inorganic perovskite films for low-cost but efficient solar cells. However, solution-process techniques offer limited control over film morphology and crystallinity, and most importantly do not allow sequential film deposition...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-33760-w
更新日期：2018-10-18 00:00:00
abstract：:Local communities are assembled from larger-scale species pools via dispersal, environmental filtering, biotic interactions, and local stochastic demographic processes. The relative importance, scaling and interplay of these assembly processes can be elucidated by comparing local communities to variously circumscribed...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep09337
更新日期：2015-03-23 00:00:00
abstract：:Our understanding of the interaction between the gut microbiota and host health has recently improved dramatically. However, the effects of toxic metal exposure on the gut microbiota remain poorly characterized. As this microbiota creates a critical interface between the external environment and the host's cells, it m...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-24931-w
更新日期：2018-04-26 00:00:00
abstract：:We investigated retinal structure and function in eyes with optic nerve hypoplasia (ONH). Twenty-nine eyes of 18 patients with ONH and 21 eyes of 21 control patients were analyzed. Spectral-domain optical coherence tomography (SD-OCT), full-field electroretinography (FF-ERG), and focal macular ERG (FM-ERG) were perfor...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep42480
更新日期：2017-02-16 00:00:00
abstract：:The present work aimed to find out the effect of different levels of hydrolysable tannin (HT) on serum hormonal profile, biochemical indices, lipid profile, apparent digestibility of nutrients and body weight gain in healthy female rats. Forty five adult healthy female rats of 8 weeks old were randomly divided into fi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-77672-0
更新日期：2020-11-26 00:00:00
abstract：:This study aimed to determine ANGPTL3 serum levels in healthy young lean and obese non-diabetic men during an oral glucose tolerance test (OGTT) and correlate them with anthropometric, biochemical and hormonal parameters. A case-control study was carried out and 30 young obese non-diabetic (23.90 ± 3.84 years and BMI ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-77961-8
更新日期：2020-12-03 00:00:00
abstract：:Discovered in 1813, the conoscopic interference pattern observed due to light propagating through a crystal, kept between crossed polarizers, shows isochromates and isogyres, respectively containing information about the dynamic and geometric phase acquired by the beam. We propose and demonstrate a closed-fringe Fouri...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep33141
更新日期：2016-09-14 00:00:00
abstract：:Autophagy is an essential cellular mechanism that degrades cytoplasmic proteins and organelles to recycle their components; however, the contribution of autophagy during meiosis has not been studied in porcine oocytes maturing in vitro. In this study, we observed that the autophagy-related gene, LC3, was expressed in ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-29872-y
更新日期：2018-08-22 00:00:00
abstract：:We present experimental evidence for scale invariant behaviour of the excitation spectrum in phase-fluctuating quasi-1d Bose gases after a rapid change of the external trapping potential. Probing density correlations in free expansion, we find that the temperature of an initial thermal state scales with the spatial ex...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep09820
更新日期：2015-04-13 00:00:00
abstract：:This study assessed the efficacy and tolerability of intravenous ibuprofen in the improvement of post-operative pain control and the reduction of opioid usage. Patients were randomly divided into placebo, ibuprofen 400 mg and ibuprofen 800 mg groups. All patients received patient-controlled intravenous morphine analge...
journal_title：Scientific reports
pub_type： 杂志文章,随机对照试验
doi：10.1038/s41598-018-28428-4
更新日期：2018-07-05 00:00:00
abstract：:Limited data is available on phenotypic variations with the same genotype in hypertrophic cardiomyopathy (HCM). The present study aims to explore the relationship between genotype and phenotype characterized by cardiovascular magnetic resonance (CMR) in a large Chinese family. A proband diagnosed with HCM from a multi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-19372-4
更新日期：2018-01-17 00:00:00
abstract：:p97 is a highly abundant, homohexameric AAA+ ATPase that performs a variety of essential cellular functions. Characterized as a ubiquitin-selective chaperone, p97 recognizes proteins conjugated to K48-linked polyubiquitin chains and promotes their removal from chromatin and other molecular complexes. Changes in p97 ex...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-46949-4
更新日期：2019-07-17 00:00:00
abstract：:All-spin logic device (ASLD) has attracted increasing interests as one of the most promising post-CMOS device candidates, thanks to its low power, non-volatility and logic-in-memory structure. Here we investigate the key current-limiting factors and develop a physics-based model of ASLD through nano-magnet switching, ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep14905
更新日期：2015-10-09 00:00:00
abstract：:Hand, foot and mouth disease (HFMD) is a substantial burden throughout Asia, but the effects of temperature pattern on HFMD risk are inconsistent. To quantify the effect of temperature on HFMD incidence, Wuhan was chosen as the study site because of its high temperature variability and high HFMD incidence. Daily serie...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-20318-z
更新日期：2018-01-31 00:00:00
abstract：:Detection of visible blind UV radiation is not only interesting but also of technologically important. Herein, we demonstrate the efficient detection of UV radiation by using cluster like ZnS quantum dot solid nanostructures prepared by simple reflux condensation technique. The short-chain ligand 3-mercaptopropionic a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-55097-8
更新日期：2019-12-10 00:00:00
