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Comparison of proteomic profiles in the zebrafish retina during experimental degeneration and regeneration.

Abstract：

:Zebrafish spontaneously regenerate the retina after injury. Although the gene expression profile has been extensively studied in this species during regeneration, this does not reflect protein function. To further understand the regenerative process in the zebrafish, we compared the proteomic profile of the retina during injury and upon regeneration. Using two-dimensional difference gel electrophoresis (2D-DIGE) and label-free quantitative proteomics (quadrupole time of flight LC-MS/MS), we analysed the retina of adult longfin wildtype zebrafish at 0, 3 and 18 days after Ouabain injection. Gene ontology analysis indicates reduced metabolic processing, and increase in fibrin clot formation, with significant upregulation of fibrinogen gamma polypeptide, apolipoproteins A-Ib and A-II, galectin-1, and vitellogenin-6 during degeneration when compared to normal retina. In addition, cytoskeleton and membrane transport proteins were considerably altered during regeneration, with the highest fold upregulation observed for tubulin beta 2 A, histone H2B and brain type fatty acid binding protein. Key proteins identified in this study may play an important role in the regeneration of the zebrafish retina and investigations on the potential regulation of these proteins may lead to the design of protocols to promote endogenous regeneration of the mammalian retina following retinal degenerative disease.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Eastlake K,Heywood WE,Tracey-White D,Aquino E,Bliss E,Vasta GR,Mills K,Khaw PT,Moosajee M,Limb GA

doi

10.1038/srep44601

subject

Has Abstract

pub_date

2017-03-16 00:00:00

pages

44601

issn

2045-2322

pii

srep44601

journal_volume

7

pub_type

杂志文章

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