Abstract:
:Flow rates play an important role in microfluidic devices because they affect the transport of chemicals and determine where and when (bio)chemical reactions occur in these devices. Flow rates can conveniently be determined using external peripherals in active microfluidics. However, setting specific flow rates in passive microfluidics is a significant challenge because they are encoded on a design and fabrication level, leaving little freedom to users for adjusting flow rates for specific applications. Here, we present a programmable hydraulic resistor where an array of "electrogates" routes an incoming liquid through a set of resistors to modulate flow rates in microfluidic chips post-fabrication. This approach combines a battery-powered peripheral device with passive capillary-driven microfluidic chips for advanced flow rate control and measurement. We specifically show a programmable hydraulic resistor composed of 7 parallel resistors and 14 electrogates. A peripheral and smartphone application allow a user to activate selected electrogates and resistors, providing 127 (27-1) flow resistance combinations with values spanning on a 500 fold range. The electrogates feature a capillary pinning site (i.e. trench across the flow path) to stop a solution and an electrode, which can be activated in a few ms using a 3 V bias to resume flow based on electrowetting. The hydraulic resistor and microfluidic chip shown here enable flow rates from ~0.09 nL.s-1 up to ~5.66 nL.s-1 with the resistor occupying a footprint of only 15.8 mm2 on a 1 × 2 cm2 microfluidic chip fabricated in silicon. We illustrate how a programmable hydraulic resistor can be used to set flow rate conditions for laminar co-flow of 2 liquids and the enzymatic conversion of a substrate by stationary enzymes (alkaline phosphatase) downstream of the programmable hydraulic resistor.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Salva ML,Temiz Y,Rocca M,Arango YC,Niemeyer CM,Delamarche Edoi
10.1038/s41598-019-53885-wsubject
Has Abstractpub_date
2019-11-21 00:00:00pages
17242issue
1issn
2045-2322pii
10.1038/s41598-019-53885-wjournal_volume
9pub_type
杂志文章abstract::During nervous system development growing axons can interact with each other, for example by adhering together in order to produce bundles (fasciculation). How does such axon-axon interaction affect the resulting axonal trajectories, and what are the possible benefits of this process in terms of network function? In t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-13804-3
更新日期:2017-10-19 00:00:00
abstract::Gamma-glutamyl hydroxymethyl rhodamine green (gGlu-HMRG) is an activatable fluorescent probe that can be activated by γ-glutamyltranspeptidase (GGT). The expression of GGT in the kidney, which is one of the major organs exhibiting enhanced GGT expression, is exclusively localised to the cortex. Here, we aimed to inves...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-69077-w
更新日期:2020-07-21 00:00:00
abstract::The demand for patterning functional materials precisely on surfaces of stimuli-responsive devices has increased in many research fields. In situ polymerization technology is one of the most convenient ways to place the functional materials on a desired location with micron-scale accuracy. To fabricate stimuli-respons...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep15629
更新日期:2015-10-22 00:00:00
abstract::Airports can affect birds by hindering acoustic communication. Here, we investigated the impacts of aircraft events on vocal behavior in wood thrush (Hylocichla mustelina) breeding one mile from an airport in Ithaca, NY, USA. We identified the number of wood thrush songs between 0500 and 0800 h at various distances fr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-80380-4
更新日期:2021-01-13 00:00:00
abstract::In 2010, a new rabbit hemorrhagic disease virus (RHDV) variant, designated RHDV2, was identified for the first time in Italy. Studies have shown that RHDV2 differs from RHDV1 (traditional RHDV) in terms of its antigenic profile and genetic characteristics. The VP60 protein of RHDV is a structural protein that plays im...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep20857
更新日期:2016-02-16 00:00:00
abstract::The microgravity environment during space flight imposes numerous adverse effects on animal and microbial physiology. It is unclear, however, how microgravity impacts those cellular interactions between mutualistic microbes and their hosts. Here, we used the symbiosis between the host squid Euprymna scolopes and its l...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep01340
更新日期:2013-01-01 00:00:00
abstract::The influence of three-dimensional facial contour and dynamic evaluation decoding on factors of smile esthetics is essential for facial beauty improvement. However, the kinematic features of the facial smile contour and the contribution from the soft tissue and underlying skeleton are uncharted. Here, the cheekbone-ma...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep22103
更新日期:2016-02-25 00:00:00
abstract::Increasingly, in vivo imaging holds a strategic position in bio-pharmaceutical innovation. We will present the implementation of an integrated multimodal imaging setup enabling the assessment of multiple, complementary parameters. The system allows the fusion of information provided by: Near infrared fluorescent bioma...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-59561-8
更新日期:2020-02-14 00:00:00
abstract::Fuelled by a desire for greater connectivity, networked systems now pervade our society at an unprecedented level that will affect it in ways we do not yet understand. In contrast, nature has already developed efficient networks that can instigate rapid response and consensus when key elements are stimulated. We prese...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-53942-4
更新日期:2019-11-26 00:00:00
abstract::In this study, we had exploited the advancement in computer technology to determine the stability of four apomyoglobin variants namely wild type, E109A, E109G and G65A/G73A by conducting conventional molecular dynamics simulations in explicit urea solution. Variations in RMSD, native contacts and solvent accessible su...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep44651
更新日期:2017-03-16 00:00:00
abstract::We estimated the prevalence of anemia among school children and investigated factors associated with this problem in Kuwait. A cross-sectional study was conducted on 1415 adolescents randomly selected from middle schools in Kuwait. Hemoglobin, iron, ferritin, folate and vitamin B12, in addition to many other laborator...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-60816-7
更新日期:2020-04-03 00:00:00
abstract::Ensuring lumpfish health and welfare in salmon farms is vital to reduce the high mortality rates reported and to guarantee a high delousing efficiency. Recent observations of farmed lumpfish livers have shown colours ranging from pale (colours 1 and 2), through bright orange (colours 3 and 4), to dark reddish-brown (c...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-65535-7
更新日期:2020-06-02 00:00:00
abstract::ABX464 is a first-in-class, clinical-stage, small molecule for oral administration that has shown strong anti-inflammatory effects in the DSS-model for inflammatory bowel disease (IBD) and also prevents replication of the HIV virus. ABX464 which binds to cap binding complex (CBC) has demonstrated safety and efficacy i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-37813-y
更新日期:2019-01-28 00:00:00
abstract::In this study we characterise three tandem promoters (PR1-1, PR1-2 and PR1-3) within the PR1 regulatory region of the Escherichia coli kps capsule gene cluster. Transcription from promoter PR1-2 was dependent on the activity of the upstream promoter PR1-1, which activated PR1-2 via transcription coupled DNA supercoili...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-17891-0
更新日期:2017-12-20 00:00:00
abstract::We aimed to assess the role of computerized tomography attenuation values (Hounsfield unit-HU) for differentiating pyonephrosis from hydronephrosis and for predicting postoperative infectious complications in patients with obstructive uropathy. We analysed data from 122 patients who underwent nephrostomy tube or urete...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-75672-8
更新日期:2020-10-29 00:00:00
abstract::Complex systems displaying recurrent spike patterns are ubiquitous in nature. Understanding the organization of these patterns is a challenging task. Here we study experimentally the spiking output of a semiconductor laser with feedback. By using symbolic analysis we unveil a nontrivial organization of patterns, revea...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep04696
更新日期:2014-04-15 00:00:00
abstract::Phytoplasmas are transmitted by insect vectors in a persistent propagative manner; however, detailed movements and multiplication patterns of phytoplasmas within vectors remain elusive. In this study, spatiotemporal dynamics of onion yellows (OY) phytoplasma in its vector Macrosteles striifrons were investigated by im...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-61042-x
更新日期:2020-03-09 00:00:00
abstract::Ambient seismic noise is characterized by randomness incurred by the random position and strength of the noise sources as well as the heterogeneous properties of the medium through which it propagates. Here we use ambient noise data recorded prior to the 1996 Gjálp eruption in Iceland in order to show that a reduction...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep37733
更新日期:2016-11-24 00:00:00
abstract::Laser-driven ultrafast electron emission offers the possibility of manipulation and control of coherent electron motion in ultrashort spatiotemporal scales. Here, an analytical solution is constructed for the highly nonlinear electron emission from a dc biased metal surface illuminated by a single frequency laser, by ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep19894
更新日期:2016-01-28 00:00:00
abstract::Sampling various compartments within the lower airways to examine human bronchial epithelial cells (HBEC) is essential for understanding numerous lung diseases. Conventional methods to identify HBEC in bronchoalveolar lavage (BAL) and wash (BW) have throughput limitations in terms of efficiency and ensuring adequate c...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep42214
更新日期:2017-02-06 00:00:00
abstract::The capacity of graphene oxide nanoparticles (nGOx) to reduce or increase As and metals availability in polluted soils was compared with that of zero valent iron nanoparticles (nZVI). The nanomaterials used in this study were characterized by X-ray techniques, CHNS-O analysis, dynamic light scattering, and microscopy ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-58852-4
更新日期:2020-02-05 00:00:00
abstract::Core-shell Nb2O5/TiO2 composite with hierarchical heterostructure is successfully synthesized In-situ by a facile template-free and acid-free solvothermal method based on the mechanism of liquid phase epitaxy. The chemical circumstance change induced by the alcoholysis of NbCl5 is utilized tactically to trigger core-s...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep25260
更新日期:2016-04-28 00:00:00
abstract::Fatal Familial Insomnia (FFI) is a genetic prion disease caused by a point mutation in the prion protein gene (PRNP) characterized by prominent thalamic atrophy, diffuse astrogliosis and moderate deposition of PrPSc in the brain. Here, for the first time, we demonstrate that the olfactory mucosa (OM) of patients with ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep46269
更新日期:2017-04-07 00:00:00
abstract::Skin burns are a significant source of injury in both military and civilian sectors. They are especially problematic in low resource environments where non-fatal injuries can lead to high morbidity rates, prolonged hospitalization, and disability. These multifaceted wounds can be highly complex and must be quickly dia...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-65747-x
更新日期:2020-06-09 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-020-62514-w
更新日期:2020-03-31 00:00:00
abstract::Fundamental understanding of guest gas replacement in hydrate reservoirs is crucial for the enhanced recovery of natural gas and carbon dioxide (CO2) sequestration. To gain physical insight into this exchange process, this work aims at developing and validating a clathrate hydrate model for gas replacement. Most of th...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-55476-1
更新日期:2019-12-11 00:00:00
abstract::This study proposed a novel method to heal microcrack within Mg alloy tubes using high density eddy current pulse treatment (ECPT). Through electromagnetic induction inside a copper coil connected with a high density pulse power source supply, the high density (greater than 5 × 109 A/m2) and short duration eddy curren...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-24354-7
更新日期:2018-04-16 00:00:00
abstract::Wave propagation is an important characteristic for pattern formation and pattern dynamics. To date, various waves in homogeneous media have been investigated extensively and have been understood to a great extent. However, the wave behaviors in heterogeneous media have been studied and understood much less. In this w...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep25177
更新日期:2016-05-04 00:00:00
abstract::Lipofectamine reagents are widely accepted as "gold-standard" for the safe delivery of exogenous DNA or RNA into cells. Despite this, a satisfactory mechanism-based explanation of their superior efficacy has remained mostly elusive thus far. Here we apply a straightforward combination of live cell imaging, single-part...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep25879
更新日期:2016-05-11 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-020-60629-8
更新日期:2020-02-25 00:00:00