Detection of prion seeding activity in the olfactory mucosa of patients with Fatal Familial Insomnia.

abstract：:CobK catalyzes the essential reduction of the precorrin ring in the cobalamin biosynthetic pathway. The crystal structure of CobK reveals that the enzyme, despite not having the signature sequence, comprises two Rossmann fold domains which bind coenzyme and substrate respectively. The two parallel β-sheets have swappe...

journal_title：Scientific reports

authors： Gu S,Sushko O,Deery E,Warren MJ,Pickersgill RW

更新日期：2015-11-30 00:00:00

abstract：:Ribonucleotide reductases (RNR) catalyze the last step of deoxyribonucleotide synthesis, and are therefore essential to DNA-based life. Three forms of RNR exist: classes I, II, and III. While eukaryotic cells use only class Ia RNR, bacteria can harbor any combination of classes, granting them adaptability. The opportu...

journal_title：Scientific reports

authors： Crespo A,Pedraz L,Van Der Hofstadt M,Gomila G,Torrents E

更新日期：2017-12-20 00:00:00

abstract：:Phosphoinositides play important roles in numerous intracellular membrane pathways. Little is known about the regulation or function of these lipids in rod photoreceptor cells, which have highly active membrane dynamics. Using new assays with femtomole sensitivity, we determined that whereas levels of phosphatidylinos...

journal_title：Scientific reports

authors： He F,Agosto MA,Anastassov IA,Tse DY,Wu SM,Wensel TG

更新日期：2016-06-01 00:00:00

abstract：:The increasing ease and accuracy of protein-protein interaction detection has resulted in the ability to map the interactomes of multiple species. We now have an opportunity to compare species to better understand how interactomes evolve. As DNA and protein sequence alignment algorithms were required for comparative g...

journal_title：Scientific reports

authors： Law B,Bader GD

更新日期：2015-07-13 00:00:00

abstract：:This present paper was focused on the manufacture of activated carbon (AC) and its application in the electrokinetic remediation (EKR) technology on removal of the heavy metals (HMs) from the municipal solid waste incineration fly ash. AC was produced from Neosinocalamus affinis (NF) by chemical activation with H3PO4 ...

journal_title：Scientific reports

authors： Liu K,Huang T,Huang X,Yu L,Muhammad F,Jiao B,Li D

更新日期：2016-12-21 00:00:00

abstract：:Jute fibre is the second most important fibre next to cotton. It is obtained from the bark of plant through microbial retting process. Here we report optimized microbial retting protocol that can lower retting period and produce high fibre quality. A total of 451 bacterial colonies have been isolated from five jute re...

journal_title：Scientific reports

authors： Hasan R,Aktar N,Kabir SMT,Honi U,Halim A,Islam R,Sarker MDH,Haque MS,Alam MM,Islam MS

更新日期：2020-03-20 00:00:00

abstract：:Nucleosome not only directly affects cellular processes, such as DNA replication, recombination, and transcription, but also severs as a fundamentally important target of epigenetic modifications. Our previous study indicated that the bending property of DNA is important in nucleosome formation, particularly in predic...

journal_title：Scientific reports

authors： Liu G,Xing Y,Zhao H,Cai L,Wang J

更新日期：2018-06-11 00:00:00

abstract：:We propose a hybrid plasmonic device consisting of a planar dielectric waveguide covering a gold nanostripe array fabricated on a gold film and investigate its guiding properties at telecom wavelengths. The fundamental modes of a hybrid device and their dependence on the key geometric parameters are studied. A communi...

journal_title：Scientific reports

authors： Thomas PA,Auton GH,Kundys D,Grigorenko AN,Kravets VG

更新日期：2017-03-24 00:00:00

abstract：:Awe, a complex emotion composed by the appraisal components of vastness and need for accommodation, is a profound and often meaningful experience. Despite its importance, psychologists have only recently begun empirical study of awe. At the experimental level, a main issue concerns how to elicit high intensity awe exp...

journal_title：Scientific reports

authors： Chirico A,Cipresso P,Yaden DB,Biassoni F,Riva G,Gaggioli A

更新日期：2017-04-27 00:00:00

abstract：:Confident characterization of the microheterogeneity of protein glycosylation through identification of intact glycopeptides remains one of the toughest analytical challenges for glycoproteomics. Recently proposed mass spectrometry (MS)-based methods still have some defects such as lack of the false discovery rate (FD...

journal_title：Scientific reports

authors： Zeng WF,Liu MQ,Zhang Y,Wu JQ,Fang P,Peng C,Nie A,Yan G,Cao W,Liu C,Chi H,Sun RX,Wong CC,He SM,Yang P

更新日期：2016-05-03 00:00:00

abstract：:This study aimed to investigate changes in types of dental arch form during adolescence and explore adolescent changes in size and form of dental arch. Hong Kong Chinese were recruited and digital dental arch models were obtained at ages 12, 15, and 18 years. Geometric morphometrics was used to investigate adolescent ...

journal_title：Scientific reports

authors： Wen YF,Wong HM,Pei T,McGrath C

更新日期：2019-12-06 00:00:00

abstract：:Individuals in the state of psychological suboptimal health keep increasing, only scales and questionnaires were used to diagnose in clinic under current conditions, and symptoms of high reliability and accuracy are destitute. Therefore, the noninvasive and precise laboratory diagnostic methods are needed. This study ...

journal_title：Scientific reports

authors： Tian JS,Xia XT,Wu YF,Zhao L,Xiang H,Du GH,Zhang X,Qin XM

更新日期：2016-09-21 00:00:00

abstract：:This study analyzed hourly mass concentration observations of PM2.5 (particulate matters with diameter less than 2.5 μm) at 512 stations in China from December 2013 to May 2015. We found that the mean concentrations of PM2.5 during the winter and spring of 2015 Dec. 2014 to Feb. 2015 and Mar. 2015 to May 2015) decreas...

journal_title：Scientific reports

authors： Wang X,Wang K,Su L

更新日期：2016-11-02 00:00:00

abstract：:In clinical populations, olfactory abilities parallel executive function, implicating shared neuroanatomical substrates within the ventral prefrontal cortex. In healthy individuals, the relationship between olfaction and personality traits or certain cognitive and behavioural characteristics remains unexplored. We the...

journal_title：Scientific reports

authors： Herman AM,Critchley H,Duka T

更新日期：2018-10-22 00:00:00

abstract：:The objective of this study was to investigate the effects of slightly elevated atmospheric temperature in the spring on photosynthetic products in wheat seedlings and on organic compounds and biological activity in rhizosphere soil under cadmium (Cd) stress. Elevated temperature was associated with increased soluble ...

journal_title：Scientific reports

authors： Jia X,Zhao Y,Wang W,He Y

更新日期：2015-09-23 00:00:00

abstract：:Serratia marcescens is one of the important nosocomial pathogens which rely on quorum sensing (QS) to regulate the production of biofilm and several virulence factors. Hence, blocking of QS has become a promising approach to quench the virulence of S. marcescens. For the first time, QS inhibitory (QSI) and antibiofilm...

journal_title：Scientific reports

authors： Sethupathy S,Ananthi S,Selvaraj A,Shanmuganathan B,Vigneshwari L,Balamurugan K,Mahalingam S,Pandian SK

更新日期：2017-11-27 00:00:00

abstract：:In this study, we categorize the microbial community in mangrove sediment samples from four different locations within a vast mangrove system in Kerala, India. We compared this data to other samples taken from the other known mangrove data, a tropical rainforest, and ocean sediment. An examination of the microbial com...

journal_title：Scientific reports

authors： Imchen M,Kumavath R,Barh D,Azevedo V,Ghosh P,Viana M,Wattam AR

更新日期：2017-08-18 00:00:00

abstract：:Personalized medicine is a promising tool not only for prevention, screening and development of more efficient treatment strategies, but also for diminishing the side effects caused by current therapies. Deciphering gene regulation pathways provides a reliable prognostic analysis to elucidate the origin of grave disea...

journal_title：Scientific reports

authors： Huertas CS,Domínguez-Zotes S,Lechuga LM

更新日期：2017-01-25 00:00:00

abstract：:Tetrandrine (Tet) could enhance the antitumor effect of Paclitaxel (Ptx) by increasing intracellular Reactive Oxygen Species (ROS) levels, which leads to the possibility of co-delivery of both drugs for synergistic antitumor effect. In the current study, we reported an efficient, local therapeutic strategy employing e...

journal_title：Scientific reports

authors： Zhang H,Tian Y,Zhu Z,Xu H,Li X,Zheng D,Sun W

更新日期：2016-05-26 00:00:00

abstract：:Cu removal by a novel multi-amines decorated resin (PAMD) from wastewater in the absence or presence of citric acid (CA) was examined. Adsorption capacity of Cu onto PAMD markedly increased by 186% to 5.07 mmol/g in the presence of CA, up to 7 times of that onto four commercial resins under the same conditions. Preloa...

journal_title：Scientific reports

authors： Ling C,Liu F,Pei Z,Zhang X,Wei M,Zhang Y,Zheng L,Zhang J,Li A,Xing B

更新日期：2015-05-12 00:00:00

abstract：:During nervous system development growing axons can interact with each other, for example by adhering together in order to produce bundles (fasciculation). How does such axon-axon interaction affect the resulting axonal trajectories, and what are the possible benefits of this process in terms of network function? In t...

journal_title：Scientific reports

authors： Davis O,Merrison-Hort R,Soffe SR,Borisyuk R

更新日期：2017-10-19 00:00:00

abstract：:MicroRNAs (MiRNAs) have been found to be dysregulated in lung cancer tissues compared to their matched paracancerous tissues. However, the roles of miRNAs in peripheral blood as potential biomarkers for early diagnosis of lung cancer remain poorly understood. Here we found that miR-33a-5p and miR-128-3p were down-regu...

journal_title：Scientific reports

authors： Pan J,Zhou C,Zhao X,He J,Tian H,Shen W,Han Y,Chen J,Fang S,Meng X,Jin X,Gong Z

更新日期：2018-11-12 00:00:00

abstract：:Efficient presentation of alien antigens triggers activation of T lymphocytes and robust host defense against invading pathogens. This pathophysiological process relies on the expression of major histocompatibility complex (MHC) molecules in antigen presenting cells such as macrophages. Aberrant MHC II transactivation...

journal_title：Scientific reports

authors： Fan Z,Li J,Li P,Ye Q,Xu H,Wu X,Xu Y

更新日期：2017-01-17 00:00:00

abstract：:Potential of microalgal cultivation as an alternative approach to the treatment of anaerobic digestion (AD) effluents was examined using two representative Chlorella species, Chlorella vulgaris (CV) and Chlorella protothecoides (CP). Both species effectively removed NH4+-N from the AD effluents from four digesters tre...

journal_title：Scientific reports

authors： Yu H,Kim J,Lee C

更新日期：2019-04-16 00:00:00

abstract：:Lepisosteoids are known for their evolutionary conservatism, and their body plan can be traced at least as far back as the Early Cretaceous, by which point two families had diverged: Lepisosteidae, known since the Late Cretaceous and including all living species and various fossils from all continents, except Antarcti...

journal_title：Scientific reports

authors： Brito PM,Alvarado-Ortega J,Meunier FJ

更新日期：2017-12-19 00:00:00

abstract：:Dosimetry models using preclinical positron emission tomography (PET) data are commonly employed to predict the clinical radiological safety of novel radiotracers. However, unbiased clinical safety profiling remains difficult during the translational exercise from preclinical research to first-in-human studies for nov...

journal_title：Scientific reports

authors： Garrow AA,Andrews JPM,Gonzalez ZN,Corral CA,Portal C,Morgan TEF,Walton T,Wilson I,Newby DE,Lucatelli C,Tavares AAS

更新日期：2020-09-29 00:00:00

abstract：:Antibodies are widely used for the detection of specific molecules such as peptides, proteins, and chemical compounds. The specificity of an antibody is therefore its most important feature. However, it is very difficult to confirm antibody specificity. Recently, we made a human protein array consisting of 19,712 kind...

journal_title：Scientific reports

authors： Morishita R,Sugiyama S,Denda M,Tokunaga S,Kido K,Shioya R,Ozawa S,Sawasaki T

更新日期：2019-12-18 00:00:00

abstract：:Homologous recombination (HR) events are key drivers of cancer-promoting mutations, and the ability to visualize these events in situ provides important information regarding mutant cell type, location, and clonal expansion. We have previously created the Rosa26 Direct Repeat (RaDR) mouse model wherein HR at an integr...

journal_title：Scientific reports

authors： Wadduwage DN,Kay J,Singh VR,Kiraly O,Sukup-Jackson MR,Rajapakse J,Engelward BP,So PTC

更新日期：2018-08-14 00:00:00

abstract：:YPEL3 that induces cellular senescence in both normal and tumour cells of humans may show altered expression under the influence of incidental mutations. In this study, we proposed the first structure of Native YPEL3 protein and its five possible deleterious mutants-V40M, C61Y, G98R, G108S, and A131T and predicted the...

journal_title：Scientific reports

authors： Singh A,Thakur M,Singh SK,Sharma LK,Chandra K

更新日期：2020-09-17 00:00:00

abstract：:This study aimed to identify and distinguish various factors that may influence the occurrence of mandibular coronoid fractures. From January 2000 to December 2009, a total of 1131 patients with maxillofacial fractures were enrolled in this statistical study to evaluate the association between mandibular coronoid frac...

journal_title：Scientific reports

authors： Zhou HH,Lv K,Yang RT,Li Z,Li ZB

更新日期：2017-05-19 00:00:00