Development of an embedded multimodality imaging platform for onco-pharmacology using a smart anticancer prodrug as an example.

Abstract:

:Increasingly, in vivo imaging holds a strategic position in bio-pharmaceutical innovation. We will present the implementation of an integrated multimodal imaging setup enabling the assessment of multiple, complementary parameters. The system allows the fusion of information provided by: Near infrared fluorescent biomarkers, bioluminescence (for tumor proliferation status), Photoacoustic and Ultrasound imaging. We will study representative applications to the development of a smart prodrug, delivering a highly cytotoxic chemotherapeutic agent to cancer tumors. The results realized the ability of this embedded, multimodality imaging platform to firstly detect bioluminescent and fluorescent signals, and secondly, record ultrasound and photoacoustic data from the same animal. This study demonstrated that the prodrug was effective in three different models of hypoxia in human cancers compared to the parental cytotoxic agent and the vehicle groups. Monitoring by photoacoustic imaging during the treatments revealed that the prodrug exhibits an intrinsic capability to prevent the progression of tumor hypoxia. It is essential for onco-pharmacology studies to precisely document the hypoxic status of tumors both before and during the time course of treatments. This approach opens new perspectives for exploitation of preclinical mouse models of cancer, especially when considering associations between hypoxia, neoangiogenesis and antitumor activity.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Raes F,Badiane SM,Renoux B,Papot S,Lerondel S,Le Pape A

doi

10.1038/s41598-020-59561-8

subject

Has Abstract

pub_date

2020-02-14 00:00:00

pages

2661

issue

1

issn

2045-2322

pii

10.1038/s41598-020-59561-8

journal_volume

10

pub_type

杂志文章
  • Angiotensin II synergizes with BAFF to promote atheroprotective regulatory B cells.

    abstract::Angiotensin II (AngII) promotes hypertension, atherogenesis, vascular aneurysm and impairs post-ischemic cardiac remodeling through concerted roles on vascular cells, monocytes and T lymphocytes. However, the role of AngII in B lymphocyte responses is largely unexplored. Here, we show that chronic B cell depletion (Ba...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-04438-6

    authors: Ponnuswamy P,Joffre J,Herbin O,Esposito B,Laurans L,Binder CJ,Tedder TF,Zeboudj L,Loyer X,Giraud A,Zhang Y,Tedgui A,Mallat Z,Ait-Oufella H

    更新日期:2017-06-23 00:00:00

  • SDE5, a putative RNA export protein, participates in plant innate immunity through a flagellin-dependent signaling pathway in Arabidopsis.

    abstract::In eukaryotes, RNA silencing, mediated by small interfering RNAs, is an evolutionarily widespread and versatile silencing mechanism that plays an important role in various biological processes. Increasing evidences suggest that various components of RNA silencing pathway are involved in plant defense machinery against...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-07918-x

    authors: Uddin MN,Akhter S,Chakraborty R,Baek JH,Cha JY,Park SJ,Kang H,Kim WY,Lee SY,Mackey D,Kim MG

    更新日期:2017-08-29 00:00:00

  • Controlled Deposition of Particles in Porous Media for Effective Aquifer Nanoremediation.

    abstract::In this study, a model assisted strategy is developed to control the distribution of colloids in porous media in the framework of nanoremediation, an innovative environmental nanotechnology aimed at reclaiming contaminated aquifers. This approach is exemplified by the delivery of humic acid-stabilized iron oxide nanop...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-13423-y

    authors: Bianco C,Patiño Higuita JE,Tosco T,Tiraferri A,Sethi R

    更新日期:2017-10-11 00:00:00

  • Early Preferential Responses to Fear Stimuli in Human Right Dorsal Visual Stream--A Meg Study.

    abstract::Emotional expressions of others are salient biological stimuli that automatically capture attention and prepare us for action. We investigated the early cortical dynamics of automatic visual discrimination of fearful body expressions by monitoring cortical activity using magnetoencephalography. We show that right pari...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep24831

    authors: Meeren HK,Hadjikhani N,Ahlfors SP,Hämäläinen MS,de Gelder B

    更新日期:2016-04-20 00:00:00

  • Remote sensing of zooplankton swarms.

    abstract::Zooplankton provide the key link between primary production and higher levels of the marine food web and they play an important role in mediating carbon sequestration in the ocean. All commercially harvested fish species depend on zooplankton populations. However, spatio-temporal distributions of zooplankton are notor...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-37129-x

    authors: Basedow SL,McKee D,Lefering I,Gislason A,Daase M,Trudnowska E,Egeland ES,Choquet M,Falk-Petersen S

    更新日期:2019-01-24 00:00:00

  • Novel instrumented frame for standing exercising of users with complete spinal cord injuries.

    abstract::This paper describes a Functional Electrical Stimulation (FES) standing system for rehabilitation of bone mineral density (BMD) in people with Spinal Cord Injury (SCI). BMD recovery offers an increased quality of life for people with SCI by reducing their risk of fractures. The standing system developed comprises an i...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-49237-3

    authors: Zoulias ID,Armengol M,Poulton A,Andrews B,Gibbons R,Harwin WS,Holderbaum W

    更新日期:2019-09-10 00:00:00

  • Integrative Network Analysis of Differentially Methylated and Expressed Genes for Biomarker Identification in Leukemia.

    abstract::Genome-wide DNA methylation and gene expression are commonly altered in pediatric acute lymphoblastic leukemia (PALL). Integrated network analysis of cytosine methylation and expression datasets has the potential to provide deeper insights into the complex disease states and their causes than individual disconnected a...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-58123-2

    authors: Sanchez R,Mackenzie SA

    更新日期:2020-02-07 00:00:00

  • Structure of Mycobacterium thermoresistibile GlgE defines novel conformational states that contribute to the catalytic mechanism.

    abstract::GlgE, an enzyme of the pathway that converts trehalose to α-glucans, is essential for Mycobacterium tuberculosis. Inhibition of GlgE, which transfers maltose from a maltose-1-phosphate donor to α-glucan/maltooligosaccharide chain acceptor, leads to a toxic accumulation of maltose-1-phosphate that culminates in cellula...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep17144

    authors: Mendes V,Blaszczyk M,Maranha A,Empadinhas N,Blundell TL

    更新日期:2015-11-30 00:00:00

  • Cosolvent Analysis Toolkit (CAT): a robust hotspot identification platform for cosolvent simulations of proteins to expand the druggable proteome.

    abstract::Cosolvent Molecular Dynamics (MD) simulations are increasingly popular techniques developed for prediction and characterization of allosteric and cryptic binding sites, which can be rendered "druggable" by small molecule ligands. Despite their conceptual simplicity and effectiveness, the analysis of cosolvent MD traje...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-55394-2

    authors: Sabanés Zariquiey F,de Souza JV,Bronowska AK

    更新日期:2019-12-13 00:00:00

  • Transient unidirectional energy flow and diode-like phenomenon induced by non-Markovian environments.

    abstract::Relying on an exact time evolution scheme, we identify a novel transient energy transfer phenomenon in an exactly-solvable quantum microscopic model consisting of a three-level system coupled to two non-Markovian zero-temperature bosonic baths through two separable quantum channels. The dynamics of this model can be s...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep15332

    authors: Jing J,Segal D,Li B,Wu LA

    更新日期:2015-10-19 00:00:00

  • Risk of malignancy in ankylosing spondylitis: a systematic review and meta-analysis.

    abstract::Current knowledge about the overall and site-specific risk of malignancy associated with ankylosing spondylitis (AS) is inconsistent. We conducted a systematic review and meta-analysis to address this knowledge gap. Five databases (PubMed, EMBASE, Web of Science, the Cochrane library and the virtual health library) we...

    journal_title:Scientific reports

    pub_type: 杂志文章,meta分析,评审

    doi:10.1038/srep32063

    authors: Deng C,Li W,Fei Y,Li Y,Zhang F

    更新日期:2016-08-18 00:00:00

  • Cynomolgus macaque IL37 polymorphism and control of SIV infection.

    abstract::The association between gene polymorphisms and plasma virus load at the set point (SP-PVL) was investigated in Mauritian macaques inoculated with SIV. Among 44 macaques inoculated with 50 AID50, six individuals were selected: three with SP-PVL among the highest and three with SP-PVL among the lowest. The exons of 390 ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-44235-x

    authors: Shiina T,Suzuki S,Congy-Jolivet N,Aarnink A,Garchon HJ,Dereuddre-Bosquet N,Vaslin B,Tchitchek N,Desjardins D,Autran B,Lambotte O,Theodorou I,Le Grand R,Blancher A

    更新日期:2019-05-28 00:00:00

  • Genomic Regions Associated With Interspecies Communication in Dogs Contain Genes Related to Human Social Disorders.

    abstract::Unlike their wolf ancestors, dogs have unique social skills for communicating and cooperating with humans. Previously, significant heritabilities for human-directed social behaviors have been found in laboratory beagles. Here, a Genome-Wide Association Study identified two genomic regions associated with dog's human-d...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep33439

    authors: Persson ME,Wright D,Roth LS,Batakis P,Jensen P

    更新日期:2016-09-29 00:00:00

  • Establish pre-clinical diagnostic efficacy for parathyroid hormone as a point-of-surgery-testing-device (POST).

    abstract::Measuring the Parathyroid hormone (PTH) levels assists in the investigation and management of patients with parathyroid disorders. Rapid PTH monitoring is a valid tool for accurate assessment intraoperatively. Rapid Electro-Analytical Device (READ) is a point-of-care device that uses impedance change between target an...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-75856-2

    authors: Tanak AS,Muthukumar S,Hashim IA,Prasad S

    更新日期:2020-11-02 00:00:00

  • A versatile strategy for rapid conditional genome engineering using loxP sites in a small synthetic intron in Plasmodium falciparum.

    abstract::Conditional genome engineering in the human malaria pathogen Plasmodium falciparum remains highly challenging. Here we describe a strategy for facile and rapid functional analysis of genes using an approach based on the Cre/lox system and tailored for organisms with short and few introns. Our method allows the conditi...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep21800

    authors: Jones ML,Das S,Belda H,Collins CR,Blackman MJ,Treeck M

    更新日期:2016-02-19 00:00:00

  • Fluorescence spectroscopy as an efficient tool for staging the degree of liver fibrosis: an in vivo comparison with MRI.

    abstract::The study utilizes autofluorescence spectroscopy (AFS) along with multivariate spectral analysis for differentiating various stages of hepatic fibrosis. AFS has recently emerged as an efficient tool for evaluating the variations in different endogenous flurophores. In this study, the potential of AFS for differentiati...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-29370-1

    authors: Nazeer SS,Saraswathy A,Shenoy SJ,Jayasree RS

    更新日期:2018-07-20 00:00:00

  • Impact of the severity of restrictive spirometric pattern on nutrition, physical activity, and quality of life: results from a nationally representative database.

    abstract::The general disease burden associated with the restrictive spirometric pattern (RSP) is substantial. However, the impact of RSP by its severity on general health problems and quality of life has not been well elucidated. This study aimed to analyse nutrition, physical activity, and quality of life in subjects who part...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-76777-w

    authors: Chung SJ,Kim HI,Yang B,Kim T,Sim YS,Kang HK,Kim SH,Yoon HJ,Choi H,Lee H

    更新日期:2020-11-12 00:00:00

  • Simvastatin may induce insulin resistance through a novel fatty acid mediated cholesterol independent mechanism.

    abstract::Statins are a class of oral drugs that are widely used for treatment of hypercholesterolemia. Recent clinical data suggest that chronic use of these drugs increases the frequency of new onset diabetes. Studies to define the risks of statin-induced diabetes and its underlying mechanisms are clearly necessary. We explor...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep13823

    authors: Kain V,Kapadia B,Misra P,Saxena U

    更新日期:2015-09-08 00:00:00

  • In situ structural characterization of early amyloid aggregates in Alzheimer's disease transgenic mice and Octodon degus.

    abstract::Amyloid plaques composed of Aβ amyloid peptides and neurofibrillary tangles are a pathological hallmark of Alzheimer's disease. In situ identification of early-stage amyloid aggregates in Alzheimer's disease is relevant for their importance as potential targets for effective drugs. Synchrotron-based infrared imaging i...

    journal_title:Scientific reports

    pub_type: 杂志文章,收录出版

    doi:10.1038/s41598-020-62708-2

    authors: Benseny-Cases N,Álvarez-Marimon E,Aso E,Carmona M,Klementieva O,Appelhans D,Ferrer I,Cladera J

    更新日期:2020-04-03 00:00:00

  • Human spatial memory implicitly prioritizes high-calorie foods.

    abstract::All species face the important adaptive problem of efficiently locating high-quality nutritional resources. We explored whether human spatial cognition is enhanced for high-calorie foods, in a large multisensory experiment that covertly tested the location memory of people who navigated a maze-like food setting. We fo...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-72570-x

    authors: de Vries R,Morquecho-Campos P,de Vet E,de Rijk M,Postma E,de Graaf K,Engel B,Boesveldt S

    更新日期:2020-10-08 00:00:00

  • Bleaching of leaf litter accelerates the decomposition of recalcitrant components and mobilization of nitrogen in a subtropical forest.

    abstract::Selective removal of lignin and other recalcitrant compounds, collectively registered as acid-unhyrolyzable residue (AUR), results in bleaching of leaf litter, but the importance of bleaching in decomposition processes on forest soil has not been fully evaluated. The aims of this study were to elucidate the occurrence...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-021-81206-7

    authors: Osono T,Hiradate S,Hobara S

    更新日期:2021-01-19 00:00:00

  • Hybrid Modelling of Transarterial Chemoembolisation Therapies (TACE) for Hepatocellular Carcinoma (HCC).

    abstract::We extend an agent-based multiscale model of vascular tumour growth and angiogenesis to describe transarterial chemoembolisation (TACE) therapies. The model accounts for tumour and normal cells that are both nested in a vascular system that changes its structure according to tumour-related growth factors. Oxygen promo...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-65012-1

    authors: Perfahl H,Jain HV,Joshi T,Horger M,Malek N,Bitzer M,Reuss M

    更新日期:2020-06-29 00:00:00

  • Bile-duct proliferation as an unexpected side-effect after AAV2-LDLR gene transfer to rabbit liver.

    abstract::Familial hypercholesterolemia (FH) is an inherited disease of lipoprotein metabolism caused by a defect in the LDL receptor (LDLR) leading to severe hypercholesterolemia, and associated with an increased risk of coronary heart disease and myocardial infarction. We have developed a gene therapy protocol for FH using AA...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-43459-1

    authors: Hytönen E,Laurema A,Kankkonen H,Miyanohara A,Kärjä V,Hujo M,Laham-Karam N,Ylä-Herttuala S

    更新日期:2019-05-06 00:00:00

  • Long-term drug modification to the surface of mesenchymal stem cells by the avidin-biotin complex method.

    abstract::Mesenchymal stem cells (MSCs) have various functions, making a significant contribution to tissue repair. On the other hand, the viability and function of MSCs are not lasting after an in vivo transplant, and the therapeutic effects of MSCs are limited. Although various chemical modification methods have been applied ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-17166-8

    authors: Takayama Y,Kusamori K,Hayashi M,Tanabe N,Matsuura S,Tsujimura M,Katsumi H,Sakane T,Nishikawa M,Yamamoto A

    更新日期:2017-12-05 00:00:00

  • Production of dumbbell probe through hairpin cleavage-ligation and increasing RCA sensitivity and specificity by circle to circle amplification.

    abstract::Dumbbell probe (DP) attracts increasing interests in rolling circle amplification (RCA). A universal DP production method through cleavage-ligation of hairpin was proposed and optimized. The production is characterized by restriction endonuclease (RE)-induced cleavage ends ligation. It has the advantage of phosphoryla...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep29229

    authors: Wei H,Tang S,Hu T,Zhao G,Guan Y

    更新日期:2016-07-07 00:00:00

  • Antifungal synergy of a topical triazole, PC945, with a systemic triazole against respiratory Aspergillus fumigatus infection.

    abstract::Invasive pulmonary Aspergillosis is a leading cause of morbidity and mortality in immunosuppressed patients and treatment outcomes using oral antifungal triazoles remain suboptimal. Here we show that combining topical treatment using PC945, a novel inhaled triazole, with systemic treatment using known triazoles demons...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-45890-w

    authors: Colley T,Sehra G,Daly L,Kimura G,Nakaoki T,Nishimoto Y,Kizawa Y,Strong P,Rapeport G,Ito K

    更新日期:2019-07-01 00:00:00

  • Caveolin-3 differentially orchestrates cholinergic and serotonergic constriction of murine airways.

    abstract::The mechanisms of controlling airway smooth muscle (ASM) tone are of utmost clinical importance as inappropriate constriction is a hallmark in asthma and chronic obstructive pulmonary disease. Receptors for acetylcholine and serotonin, two relevant mediators in this context, appear to be incorporated in specialized, c...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-25445-1

    authors: Keshavarz M,Skill M,Hollenhorst MI,Maxeiner S,Walecki M,Pfeil U,Kummer W,Krasteva-Christ G

    更新日期:2018-05-14 00:00:00

  • Strip rotary tillage with a two-year subsoiling interval enhances root growth and yield in wheat.

    abstract::Excessive tillage and soil compaction threaten the sustainable farmlands in the Huang-Huai-Hai Plains of China. Our study explores tillage practices to improve soil and root ecology and promote productivity in the winter wheat fields. We tested the impact of plowing, rotary, strip rotary tillage and strip rotary tilla...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-48159-4

    authors: He J,Shi Y,Zhao J,Yu Z

    更新日期:2019-08-12 00:00:00

  • Zeb2 is a negative regulator of midbrain dopaminergic axon growth and target innervation.

    abstract::Neural connectivity requires neuronal differentiation, axon growth, and precise target innervation. Midbrain dopaminergic neurons project via the nigrostriatal pathway to the striatum to regulate voluntary movement. While the specification and differentiation of these neurons have been extensively studied, the molecul...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-08900-3

    authors: Hegarty SV,Wyatt SL,Howard L,Stappers E,Huylebroeck D,Sullivan AM,O'Keeffe GW

    更新日期:2017-08-17 00:00:00

  • Mycobacterium tuberculosis virulence inhibitors discovered by Mycobacterium marinum high-throughput screening.

    abstract::High-throughput screening facilities do not generally support biosafety level 3 organisms such as Mycobacterium tuberculosis. To discover not only antibacterials, but also virulence inhibitors with either bacterial or host cell targets, an assay monitoring lung fibroblast survival upon infection was developed and opti...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-37176-4

    authors: Tükenmez H,Edström I,Ummanni R,Fick SB,Sundin C,Elofsson M,Larsson C

    更新日期:2019-01-10 00:00:00