High-Throughput Cancer Cell Sphere Formation for Characterizing the Efficacy of Photo Dynamic Therapy in 3D Cell Cultures.

abstract：:Delta-9-tetrahydrocannabinol (THC) is the primary psychoactive compound in Cannabis, which is studied extensively for its medicinal value. A central gap in the science is the underlying mechanisms surrounding THC's therapeutic effects and the role of gut metabolite profiles. Using a mass-spectrometry based metabolomic...

journal_title：Scientific reports

authors： Oza M,Becker W,Gummadidala PM,Dias T,Omebeyinje MH,Chen L,Mitra C,Jesmin R,Chakraborty P,Sajish M,Hofseth LJ,Banerjee K,Wang Q,Moeller PDR,Nagarkatti M,Nagarkatti P,Chanda A

更新日期：2019-07-19 00:00:00

abstract：:Deconvolution is widely used to improve the contrast and clarity of a 3D focal stack collected using a fluorescence microscope. But despite being extensively studied, deconvolution algorithms can introduce reconstruction artifacts when their underlying noise models or priors are violated, such as when imaging biologic...

journal_title：Scientific reports

authors： Ikoma H,Broxton M,Kudo T,Wetzstein G

更新日期：2018-07-31 00:00:00

abstract：:Abscisic acid (ABA) is an ancient stress hormone and is detectable in a wide variety of organisms where it regulates innate immunity and inflammation. Previously, we showed that oral supplementation with ABA decreased parasitemia in a mouse model of malaria, decreased liver and spleen pathology and reduced parasite tr...

journal_title：Scientific reports

authors： Glennon EKK,Megawati D,Torrevillas BK,Ssewanyana I,Huang L,Aweeka F,Greenhouse B,Adams LG,Luckhart S

更新日期：2018-06-11 00:00:00

abstract：:Climate-driven environmental change and land-use change often interact in their impact on biodiversity, but these interactions have received little scientific attention. Here we study the effects of climate-driven environmental variation (i.e. vegetation greenness) and land-use (protected versus unprotected areas) on ...

journal_title：Scientific reports

authors： Santangeli A,Spiegel O,Bridgeford P,Girardello M

更新日期：2018-08-29 00:00:00

abstract：:Based on an inverted bulk band order, antimony thin films presumably could become topological insulators if quantum confinement effect opens up a gap in the bulk bands. Coupling between topological surface states (TSS) from opposite surfaces, however, tends to degrade or even destroy their novel characters. Here the e...

journal_title：Scientific reports

authors： Yao G,Luo Z,Pan F,Xu W,Feng YP,Wang XS

更新日期：2013-01-01 00:00:00

abstract：:As an important online information retaining and processing function, working memory plays critical roles in many other cognitive functions. Several long-term factors, such as age, addiction and diseases, have been affirmed to impair working memory, but whether or how the short-term factors, like painful stimuli or em...

journal_title：Scientific reports

authors： Chen M,Wang YZ,Ma CC,Li QZ,Zhou H,Fu J,Yang QQ,Zhang YM,Liu Y,Cao JL

更新日期：2017-07-03 00:00:00

abstract：:Positions of leaves along a stem usually adhere to a genetically determined, species-specific pattern known as a leaf phyllotaxis. We investigated whether the arrangement of lateral secondary veins along primary midveins adhered to a species-specific pattern that resembled an alternate or opposite phyllotaxis. We anal...

journal_title：Scientific reports

authors： Koyama K,Masuda T

更新日期：2018-11-06 00:00:00

abstract：:The influence of meteorological determinants on tuberculosis (TB) incidence remains severely under-discussed, especially through the perspective of time series analysis. In the current study, we used a distributed lag nonlinear model (DLNM) to analyze a 10-year series of consecutive surveillance data. We found that, a...

journal_title：Scientific reports

authors： Xiao Y,He L,Chen Y,Wang Q,Meng Q,Chang W,Xiong L,Yu Z

更新日期：2018-07-03 00:00:00

abstract：:In this study, the improved Aesop's fable paradigm-a series of experiments originally used to test whether some animals understand the causality associated with water replacement-was used to explore the cognitive ability of Azure-winged magpies (Cyanopica cyanus). Experimental results on causal cue tasks showed that t...

journal_title：Scientific reports

authors： Zhang Y,Yu C,Chen L,Li Z

更新日期：2021-01-12 00:00:00

abstract：:The ability to measure biomolecular dynamics within cells and tissues is very important to understand fundamental physiological processes including cell adhesion, signalling, movement, division or metabolism. Usually, such information is obtained using particle tracking methods or single point fluctuation spectroscopy...

journal_title：Scientific reports

authors： Hedde PN,Stakic M,Gratton E

更新日期：2014-11-14 00:00:00

abstract：:We investigated body mass index (BMI) trajectories in the first 2 years of life in 1170 children from an Asian mother-offspring cohort in Singapore, and examined their predictors and associations with childhood cardio-metabolic risk measures at 5 years. Latent class growth mixture modelling analyses were performed to ...

journal_title：Scientific reports

authors： Aris IM,Chen LW,Tint MT,Pang WW,Soh SE,Saw SM,Shek LP,Tan KH,Gluckman PD,Chong YS,Yap F,Godfrey KM,Kramer MS,Lee YS

更新日期：2017-08-21 00:00:00

abstract：:The uncertainty relation is a fundamental limit in quantum mechanics and is of great importance to quantum information processing as it relates to quantum precision measurement. Due to interactions with the surrounding environment, a quantum system will unavoidably suffer from decoherence. Here, we investigate the dyn...

journal_title：Scientific reports

authors： Wang D,Huang AJ,Hoehn RD,Ming F,Sun WY,Shi JD,Ye L,Kais S

更新日期：2017-04-21 00:00:00

abstract：:Plant litter is an important component in wetland ecosystems, and the role of plant litter decomposition is considered to be important for wetland ecosystem functions and services. However, the consequences of litter inputs have seldom been experimentally tested in real ecosystems such as constructed wetlands (CWs). T...

journal_title：Scientific reports

authors： Ping Y,Pan X,Li W,Wang J,Cui L

更新日期：2019-09-25 00:00:00

abstract：:Present study is designed for the synthesis, characterization and corrosion inhibition behavior of two diamine aromatic epoxy pre-polymers (DAEPs) namely, N1,N1,N2,N2-tetrakis (oxiran-2-ylmethyl) benzene-1,2-diamine (DAEP1) and 4-methyl-N1,N1,N2,N2-tetrakis (oxiran-2-ylmethyl) benzene-1,2-diamine (DAEP2) for carbon st...

journal_title：Scientific reports

authors： Dagdag O,Safi Z,Hsissou R,Erramli H,El Bouchti M,Wazzan N,Guo L,Verma C,Ebenso EE,El Harfi A

更新日期：2019-08-12 00:00:00

abstract：:Hepatic encephalopathy is a neuropsychiatric syndrome evolving from cerebral osmotic disturbances and oxidative/nitrosative stress. Ammonia, the main toxin of hepatic encephalopathy, triggers astrocyte senescence in an oxidative stress-dependent way. As miRNAs are critically involved in cell cycle regulation and their...

journal_title：Scientific reports

authors： Oenarto J,Karababa A,Castoldi M,Bidmon HJ,Görg B,Häussinger D

更新日期：2016-01-12 00:00:00

abstract：:To assess the response of lichen elemental compositions to road traffic and species difference in the context of high dust input and anthropogenic emissions, two foliose epiphytic lichens (Phaeophyscia hirtuosa, PHh; Candelaria fibrosa, CAf) were sampled near a road adjacent to Dolon Nor Town (Duolun County, Inner Mon...

journal_title：Scientific reports

authors： Liu HJ,Wang JG,Xia Y,Yang MJ,Liu SW,Zhao LC,Guo XP,Jiang YJ,Li X,Wu QF,Fang SB

更新日期：2017-07-17 00:00:00

abstract：:Protein aggregation is a process by which misfolded proteins polymerizes into aggregates and forms fibrous structures with a β-sheet conformation, known as amyloids. It is an undesired outcome, as it not only causes numerous neurodegenerative diseases, but is also a major deterrent in the development of protein biopha...

journal_title：Scientific reports

authors： Rajan R,Matsumura K

更新日期：2017-04-04 00:00:00

abstract：:High-throughput technology can now provide rich information on a person's biological makeup and environmental surroundings. Important discoveries have been made by relating these data to various health outcomes in fields such as genomics, proteomics, and medical imaging. However, cross-investigations between several h...

journal_title：Scientific reports

authors： Roshchupkin GV,Adams HH,Vernooij MW,Hofman A,Van Duijn CM,Ikram MA,Niessen WJ

更新日期：2016-10-26 00:00:00

abstract：:Thioflavin T (ThT) is standardly used as a fluorescent marker to detect aggregation of amyloid fibrils by conventional fluorescence microscopy, including polarization resolved imaging that brings information on the orientational order of the fibrils. These techniques are however diffraction limited and cannot provide ...

journal_title：Scientific reports

authors： Shaban HA,Valades-Cruz CA,Savatier J,Brasselet S

更新日期：2017-10-02 00:00:00

abstract：:Aggregates of corundum crystals with skeletal to hopper morphology occur in pyroclastic rocks erupted from Cretaceous basaltic volcanoes on Mt Carmel, N. Israel. The rapid growth of the crystals trapped volumes of the parental Al2O3-supersaturated melt; phenocrysts of tistarite (Ti2O3) in the trapped melts indicate cr...

journal_title：Scientific reports

authors： Oliveira B,Griffin WL,Gain SEM,Saunders M,Shaw J,Toledo V,Afonso JC,O'Reilly SY

更新日期：2021-01-28 00:00:00

abstract：:Identification of different isomer structures of atomic and molecular clusters has long been a challenging task in the field of cluster science. Here we present a three-dimensional (3D) assignment method, combining the energy (1D) and simulated (2D) spectra to assure the assignment of the global minimum structure. Thi...

journal_title：Scientific reports

authors： Liu YR,Huang T,Gai YB,Zhang Y,Feng YJ,Huang W

更新日期：2015-12-03 00:00:00

abstract：:Circuit QED on a chip has become a powerful platform for simulating complex many-body physics. In this report, we realize a Dicke-Ising model with an antiferromagnetic nearest-neighbor spin-spin interaction in circuit QED with a superconducting qubit array. We show that this system exhibits a competition between the c...

journal_title：Scientific reports

authors： Zhang Y,Yu L,Liang JQ,Chen G,Jia S,Nori F

更新日期：2014-02-13 00:00:00

abstract：:Cyclophilin A (CyPA), secreted by vascular smooth muscle cells in response to oxidative stress, is important in the pathogenesis of progressive peripheral arterial occlusion disease (PAOD), which is common among chronic kidney disease. We explored the prevalence of PAOD in Taiwan's elderly (≥ 65 years old) population ...

journal_title：Scientific reports

authors： Liu MC,Lee YW,Lee PT,Chang CS,Tai YL,Yu JR,Su XT,Hsu LW,Lin SH,Wu CH,Liu PY

更新日期：2015-04-24 00:00:00

abstract：:Werner syndrome (WS) is the canonical adult human progeroid ('premature aging') syndrome. Patients with this autosomal recessive Mendelian disorder display constitutional genomic instability and an elevated risk of important age-associated diseases including cancer. Remarkably few analyses of WS patient tissue and tum...

journal_title：Scientific reports

authors： Tokita M,Kennedy SR,Risques RA,Chun SG,Pritchard C,Oshima J,Liu Y,Bryant-Greenwood PK,Welcsh P,Monnat RJ

更新日期：2016-08-25 00:00:00

abstract：:Directional transport of auxin is essential for plant development, with PIN auxin transport proteins representing an integral part of the machinery that controls hormone distribution. However, unlike the rapidly emerging framework of molecular determinants regulating PIN protein abundance and subcellular localization,...

journal_title：Scientific reports

authors： Benjamins R,Barbez E,Ortbauer M,Terpstra I,Lucyshyn D,Moulinier-Anzola J,Khan MA,Leitner J,Malenica N,Butt H,Korbei B,Scheres B,Kleine-Vehn J,Luschnig C

更新日期：2016-08-24 00:00:00

abstract：:Using two different hydrosilylation methods, low temperature thermal and UV initiation, silicon (111) hydrogenated surfaces were functionalized in presence of an OH-terminated alkyne, a CF3-terminated alkyne and a mixed equimolar ratio of the two alkynes. XPS studies revealed that in the absence of premeditated surfac...

journal_title：Scientific reports

authors： Khung YL,Ngalim SH,Scaccabarozi A,Narducci D

更新日期：2015-06-12 00:00:00

abstract：:Fossils of the sponge Angulosuspongia sinensis from calcareous mudstones of the middle and upper part of the Kaili Formation (Cambrian Stage 5) in the Jianhe area of Guizhou province, South China, exhibit an apparently reticulate pattern, characteristic of the Vauxiidae. Energy Dispersive X-Ray Spectrometry (EDS) and ...

journal_title：Scientific reports

authors： Yang XL,Zhao YL,Babcock LE,Peng J

更新日期：2017-02-21 00:00:00

abstract：:Emergent phases in the two-dimensional electron gas (2DEG) formed at the interface between two insulating oxides have attracted great attention in the past decade. We present ab-initio electronic structure calculations for the interface between a Mott insulator GdTiO3 (GTO) and a band insulator SrTiO3 (STO) and compar...

journal_title：Scientific reports

authors： Banerjee H,Banerjee S,Randeria M,Saha-Dasgupta T

更新日期：2015-12-22 00:00:00

abstract：:Recent studies have demonstrated functions of miR-145 in vascular smooth muscle cells (VSMCs) phenotypes and vascular diseases. In this study, we aim to determine whether CD40 is involved in miR-145 mediated switch of VSMC phenotypes. In cultured VSMCs, the effects of miR-145 and CD40 on TNF-α, TGF-β, and Homocysteine...

journal_title：Scientific reports

authors： Guo X,Li D,Chen M,Chen L,Zhang B,Wu T,Guo R

更新日期：2016-10-12 00:00:00

abstract：:The phylogenetic characteristics of microbial communities associated with periodontitis have been well studied, however, little is known about the functional endowments of this ecosystem. The present study examined 73 microbial assemblages from 25 individuals with generalized chronic periodontitis and 25 periodontally...

journal_title：Scientific reports

authors： Dabdoub SM,Ganesan SM,Kumar PS

更新日期：2016-12-19 00:00:00