Unveiling the complex organization of recurrent patterns in spiking dynamical systems.

abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...

journal_title：Scientific reports

authors： Carregari VC,Rosa-Fernandes L,Baldasso P,Bydlowski SP,Marangoni S,Larsen MR,Palmisano G

更新日期：2018-10-23 00:00:00

abstract：:Induction chemotherapy treatment for nasopharyngeal carcinoma (NPC) is controversial. The aim of this study was to evaluate the treatment outcomes and toxicities between two induction chemotherapy regimens, with both followed by concurrent chemoradiotherapy. The first strategy used docetaxel, cisplatin and fluorouraci...

journal_title：Scientific reports

authors： Zeng Z,Yan RN,Tu L,Wang YY,Chen PR,Luo F,Liu L

更新日期：2018-10-22 00:00:00

abstract：:Freshwater reservoirs, in particular tropical ones, are an important source of methane (CH4) to the atmosphere, but current estimates are uncertain. The CH4 emitted from reservoirs is microbially produced in their sediments, but at present, the rate of CH4 formation in reservoir sediments cannot be predicted from sedi...

journal_title：Scientific reports

authors： Isidorova A,Grasset C,Mendonça R,Sobek S

更新日期：2019-07-29 00:00:00

abstract：:Methamphetamine (Meth) is one of the most frequently abused drugs worldwide. Recent studies have indicated that antibodies with high affinity for Meth reduce its pharmacological effects. The purpose of this study was to develop a technique for virus-based passive immunization against Meth effects. We generated a recom...

journal_title：Scientific reports

authors： Chen YH,Wu KJ,Wu KL,Wu KL,Tsai HM,Chen ML,Chen YW,Hsieh W,Lin CM,Wang Y

更新日期：2017-04-07 00:00:00

abstract：:The biological functions of nitric oxide (NO) depend on its concentration, and excessive levels of NO induce various harmful situations known as nitrosative stress. Therefore, organisms possess many kinds of strategies to regulate the intracellular NO concentration and/or to detoxify excess NO. Here, we used genetic s...

journal_title：Scientific reports

authors： Anam K,Nasuno R,Takagi H

更新日期：2020-04-07 00:00:00

abstract：:Myocyte Enhancer Factor 2 (MEF2) mediates cardiac remodelling in heart failure (HF) and is also a target of β-adrenergic signalling, a front-line treatment for HF. We identified global gene transcription networks involved in HF with and without β-blocker treatment. Experimental HF by transverse aortic constriction (TA...

journal_title：Scientific reports

authors： Tobin SW,Hashemi S,Dadson K,Turdi S,Ebrahimian K,Zhao J,Sweeney G,Grigull J,McDermott JC

更新日期：2017-06-30 00:00:00

abstract：:Triple-negative breast cancers (TNBC) are unlikely to respond to hormonal therapies and anti-HER2-targeted therapies. TNBCs overexpress EGFR and exhibit constitutive activation of the PI3K/AKT/mTOR signalling pathway. We hypothesized that simultaneously blocking EGFR and mTOR could be a potential therapeutic strategy ...

journal_title：Scientific reports

authors： El Guerrab A,Bamdad M,Bignon YJ,Penault-Llorca F,Aubel C

更新日期：2020-04-14 00:00:00

abstract：:Recessive mutations in the Mlo gene confer broad spectrum resistance in barley (Hordeum vulgare) to powdery mildew (Blumeria graminis f. sp. hordei), a widespread and damaging disease. However, all alleles discovered to date also display deleterious pleiotropic effects, including the naturally occurring mlo-11 mutant ...

journal_title：Scientific reports

authors： Ge X,Deng W,Lee ZZ,Lopez-Ruiz FJ,Schweizer P,Ellwood SR

更新日期：2016-07-12 00:00:00

abstract：:This study investigated Staphylococcus aureus carriage in patients with microbial keratitis (MK). 215 patients with MK, 60 healthy controls and 35 patients with rheumatoid arthritis (RA) were included. Corneal scrapes were collected from patients with MK. Conjunctival, nasal and throat swabs were collected from the no...

journal_title：Scientific reports

authors： Somerville TF,Shankar J,Aldwinckle S,Sueke H,Neal T,Horsburgh MJ,Kaye SB

更新日期：2020-10-29 00:00:00

abstract：:Non-homologous end-joining (NHEJ), which can promote genomic instability when dysfunctional, is a major DNA double-strand break (DSB) repair pathway. Although ubiquitylation of the core NHEJ factor, Ku (Ku70-Ku80), which senses broken DNA ends, is important for its removal from sites of damage upon completion of NHEJ,...

journal_title：Scientific reports

authors： Nishi R,Wijnhoven PWG,Kimura Y,Matsui M,Konietzny R,Wu Q,Nakamura K,Blundell TL,Kessler BM

更新日期：2018-12-17 00:00:00

abstract：:Developing therapeutics that target multiple receptor signaling pathways in tumors is critical as therapies targeting single specific biomarker/pathway have shown limited efficacy in patients with cancer. In this study, we extensively characterized a bi-functional molecule comprising of epidermal growth factor recepto...

journal_title：Scientific reports

authors： Zhu Y,Bassoff N,Reinshagen C,Bhere D,Nowicki MO,Lawler SE,Roux J,Shah K

更新日期：2017-06-01 00:00:00

abstract：:In crystalline metals at small scales, the dislocation density will be increased by stochastic events of dislocation network, leading to a universal power law for various material structures. In this work, we develop a model obeyed by a probability distribution of dislocation density to describe the dislocation format...

journal_title：Scientific reports

authors： Huang GR,Huang JC,Tsai WY

更新日期：2016-12-15 00:00:00

abstract：:African black-footed cats (Felis nigripes) are endangered wild felids. One male and full-sibling female African black-footed cat developed vision deficits and mydriasis as early as 3 months of age. The diagnosis of early-onset progressive retinal atrophy (PRA) was supported by reduced direct and consensual pupillary l...

journal_title：Scientific reports

authors： Oh A,Pearce JW,Gandolfi B,Creighton EK,Suedmeyer WK,Selig M,Bosiack AP,Castaner LJ,Whiting RE,Belknap EB,Lyons LA,99 Lives Consortium.

更新日期：2017-03-21 00:00:00

abstract：:Oxidative stress due to hypobaric hypoxia at extreme altitudes causes severe neuronal damage and irreversible cognitive loss. Owing to contraindications of current drug therapies, the aim of the study was to investigate memory enhancing potential of aqueous extract of Ganoderma lucidum (GLAQ) and underlying neuroprote...

journal_title：Scientific reports

authors： Sharma P,Tulsawani R

更新日期：2020-06-02 00:00:00

abstract：:Phytoene desaturases catalyse from two to six desaturation reactions on phytoene, generating a large diversity of molecules that can then be cyclised and produce, depending on the organism, many different carotenoids. We constructed a phylogenetic tree of a subset of phytoene desaturases from the CrtI family for which...

journal_title：Scientific reports

authors： Fournié M,Truan G

更新日期：2020-12-03 00:00:00

abstract：:Up to now, most of stimulated-emission-depletion (STED) systems were lens-based bulky systems. Exchanging some spatial light paths with optical fiber components will make the systems more flexible and will benefit various fields. A big problem to achieve this goal is that the STED beam generated by the traditional met...

journal_title：Scientific reports

authors： Luo H,Wang G,Yuan L

更新日期：2019-06-11 00:00:00

abstract：:The endoplasmic reticulum (ER) is a multi functional organelle and plays a crucial role in protein folding and lipid biosynthesis. The SEC59 gene encodes dolichol kinase, required for protein glycosylation in the ER. The mutation of sec59-1 caused a protein N-glycosylation defect mediated ER stress resulting in increa...

journal_title：Scientific reports

authors： William James A,Ravi C,Srinivasan M,Nachiappan V

更新日期：2019-10-09 00:00:00

abstract：:Clinical and experimental studies indicate that muscarinic acetylcholine receptors are potential pharmacological targets for the treatment of neurological diseases. Although these receptors have been described in human, bovine and rat cerebral microvascular tissue, a subtype functional characterization in mouse brain ...

journal_title：Scientific reports

authors： Radu BM,Osculati AMM,Suku E,Banciu A,Tsenov G,Merigo F,Di Chio M,Banciu DD,Tognoli C,Kacer P,Giorgetti A,Radu M,Bertini G,Fabene PF

更新日期：2017-07-11 00:00:00

abstract：:Although Hepatitis B virus (HBV) X gene mutations are frequently detected in HBV-related human hepatocellular carcinoma (HCC) patients, causative HBx mutations in the development of HCC have not yet been determined. We herein identified C1485T and C1653T mutations in the HBx gene as independent risk of HCC for HBV thr...

journal_title：Scientific reports

authors： Hagiwara S,Nishida N,Park AM,Komeda Y,Sakurai T,Watanabe T,Kudo M

更新日期：2017-09-05 00:00:00

abstract：:Prognosis of patients with advanced sarcoma after progression from FDA approved therapies remains grim. In this study, clinical outcomes of 100 patients with advanced sarcoma who received treatment on novel targeted therapy trials were evaluated. Outcomes of interest included best response, clinical benefit rate, prog...

journal_title：Scientific reports

authors： Subbiah V,Hess KR,Khawaja MR,Wagner MJ,Tang C,Naing A,Fu S,Janku F,Piha-Paul S,Tsimberidou AM,Herzog CE,Ludwig JA,Patel S,Ravi V,Benjamin RS,Meric-Bernstam F,Hong DS

更新日期：2016-10-17 00:00:00

abstract：:Decreasing egg quality following oocyte ageing is a major restricting factor for the breeding programs. The mechanisms behind this process has not yet been clarified. To examine the possible involvement of oxidative stress in the oocyte ageing process, the relative mRNA abundance of specific transcripts were determine...

journal_title：Scientific reports

authors： Samarin AM,Samarin AM,Østbye TK,Ruyter B,Sampels S,Burkina V,Blecha M,Policar T

更新日期：2019-07-18 00:00:00

abstract：:Early treatment of single sided deafness in children has been recommended to protect from neurodevelopmental preference for the better hearing ear and from social and educational deficits. A fairly homogeneous group of five young children (≤3.6 years of age) with normal right sided hearing who received a cochlear impl...

journal_title：Scientific reports

authors： Polonenko MJ,Gordon KA,Cushing SL,Papsin BC

更新日期：2017-12-04 00:00:00

abstract：:MicroRNAs (miRNAs) play an important role in guiding development and maintaining function of the human heart. Dysregulation of miRNAs has been linked to various congenital heart diseases including Tetralogy of Fallot (TOF), which represents the most common cyanotic heart malformation in humans. Several studies have id...

journal_title：Scientific reports

authors： Grunert M,Appelt S,Dunkel I,Berger F,Sperling SR

更新日期：2019-12-13 00:00:00

abstract：:Trimethylation on H3K27 mediated by Polycomb Repressive Complex 2 (PRC2) is required to control gene repression programs involved in development, regulation of tissue homeostasis or maintenance and lineage specification of stem cells. In Drosophila, the PRC2 catalytic subunit is the single protein E(z), while in mamma...

journal_title：Scientific reports

authors： Völkel P,Bary A,Raby L,Chapart A,Dupret B,Le Bourhis X,Angrand PO

更新日期：2019-03-13 00:00:00

abstract：:The effects of sea salt aerosols (SSA) on cloud microphysical processes, precipitation, and upper troposphere/lower stratosphere water vapour in tropical cyclones were studied with the Weather Research and Forecasting with Chemistry model. Two numerical experiments were conducted: a control experiment (CTL) and an exp...

journal_title：Scientific reports

authors： Jiang B,Wang D,Shen X,Chen J,Lin W

更新日期：2019-10-22 00:00:00

abstract：:The complete plastome sequences of six species were sequenced to better understand the evolutionary relationships and mutation patterns in the chloroplast genome of the genus Colobanthus. The length of the chloroplast genome sequences of C. acicularis, C. affinis, C. lycopodioides, C. nivicola, C. pulvinatus and C. su...

journal_title：Scientific reports

authors： Androsiuk P,Jastrzębski JP,Paukszto Ł,Makowczenko K,Okorski A,Pszczółkowska A,Chwedorzewska KJ,Górecki R,Giełwanowska I

更新日期：2020-07-13 00:00:00

abstract：:Skin-derived dendritic cells (DCs) play a crucial role in the maintenance of immune homeostasis due to their role in antigen trafficking from the skin to the draining lymph nodes (dLNs). To quantify the spatiotemporal regulation of skin-derived DCs in vivo, we generated knock-in mice expressing the photoconvertible fl...

journal_title：Scientific reports

authors： Tomura M,Hata A,Matsuoka S,Shand FH,Nakanishi Y,Ikebuchi R,Ueha S,Tsutsui H,Inaba K,Matsushima K,Miyawaki A,Kabashima K,Watanabe T,Kanagawa O

更新日期：2014-08-12 00:00:00

abstract：:Reef-building corals depend on an intracellular symbiosis with photosynthetic dinoflagellates for their survival in nutrient-poor oceans. Symbionts are phagocytosed by coral larvae from the environment and transfer essential nutrients to their hosts. Aiptasia, a small tropical marine sea anemone, is emerging as a trac...

journal_title：Scientific reports

authors： Jones VAS,Bucher M,Hambleton EA,Guse A

更新日期：2018-11-06 00:00:00

abstract：:Acanthamoeba can cause visually destructive Acanthamoeba keratitis (AK) in contact lens (CL) users. The purpose of this study was to determine whether Acanthamoeba was present in the CL cases of CL wearers and to develop techniques to prevent the contaminations. To accomplish this, 512 CL case samples were collected f...

journal_title：Scientific reports

authors： Miyazaki D,Eguchi H,Kuwahara T,Nakayama-Imaohji H,Inaba M,Itoi M,Ueda K,Ohashi Y,Sado K,Mizutani S,Miyamoto H,Sasaki SI,Shimizu Y,Inoue Y

更新日期：2020-07-28 00:00:00

abstract：:We consider an optimal quantum key distribution setup based on minimal number of measurement bases with binary yields used by parties against an eavesdropper limited only by the no-signaling principle. We note that in general, the maximal key rate can be achieved by determining the optimal tradeoff between measurement...

journal_title：Scientific reports

authors： Kamaruddin S,Shaari JS

更新日期：2016-08-03 00:00:00