Abstract:
:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Carregari VC,Rosa-Fernandes L,Baldasso P,Bydlowski SP,Marangoni S,Larsen MR,Palmisano Gdoi
10.1038/s41598-018-33284-3subject
Has Abstractpub_date
2018-10-23 00:00:00pages
15908issue
1issn
2045-2322pii
10.1038/s41598-018-33284-3journal_volume
8pub_type
已发布勘误abstract::Induced pluripotent stem cells (iPSCs) are promising candidate cells for cardiomyogenesis in the failing heart. However, teratoma/tumour formation originating from undifferentiated iPSCs contaminating the graft is a critical concern for clinical application. Here, we hypothesized that brentuximab vedotin, which target...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-21923-8
更新日期:2018-02-27 00:00:00
abstract::Least component-based delivery of drug-tagged-nanocarriers across blood-brain-barriers (BBB) will allow site-specific and on-demand release of therapeutics to prevent CNS diseases. We developed a non-invasive magnetically guided delivery of magneto-electric nanocarriers (MENCs), ~20 nm, 10 mg/kg, across BBB in C57Bl/J...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep25309
更新日期:2016-05-04 00:00:00
abstract::Sheepgrass (Leymus chinensis) is one of the dominant grass species present on typical steppes of the Inner Mongolia Plateau. However, L. chinensis has developed a dwarfing phenotype in response to the stressful habitat in grasslands that are severely degraded due to heavy grazing. The lack of transcriptomic and genomi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-35605-y
更新日期:2018-12-17 00:00:00
abstract::Most glioblastoma patients have a dismal prognosis, although some survive several years. However, only few biomarkers are available to predict the disease course. EGR1 and EGR3 have been linked to glioblastoma stemness and tumour progression, and this study aimed to investigate their spatial expression and prognostic ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-66236-x
更新日期:2020-06-09 00:00:00
abstract::Three dimensional (3D) microvascular imaging of cubic millimeter to centimeter size volumes often requires much time and expensive instruments. By combining optical clearing with a novel scatter-based optical coherence tomography (OCT) contrast agent, we have greatly extended OCT imaging depth in excised tissues while...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-37313-z
更新日期:2019-01-29 00:00:00
abstract::Retinitis pigmentosa (RP) is one of hereditary retinal diseases characterized by the loss of photoreceptors. Cell transplantation has been clinically applied to treat RP patients. Human retinal progenitor cells (HRPCs) and human bone marrow-derived mesenchymal stem cells (HBMSCs) are the two commonly and practically u...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-00241-5
更新日期:2017-03-15 00:00:00
abstract::Metagenomics brings in new discoveries and insights into the uncultured microbial world. One fundamental task in metagenomics analysis is to determine the taxonomy of raw sequence fragments. Modern sequencing technologies produce relatively short fragments and greatly increase the number of fragments, and thus make th...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-09947-y
更新日期:2017-08-25 00:00:00
abstract::Fragmentation of thin layers of materials is mediated by a network of cracks on its surface. It is commonly seen in dehydrated paintings or asphalt pavements and even in graphene or other two-dimensional materials, but is also observed in the characteristic polygonal pattern on a crocodile's head. Here, we build a sim...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep04966
更新日期:2014-05-27 00:00:00
abstract::Expression of the mismatch repair gene MutL homolog 1 (MLH1) is silenced in a clinically important subgroup of sporadic colorectal cancers. These cancers exhibit hypermutability with microsatellite instability (MSI) and differ from microsatellite-stable (MSS) colorectal cancers in both prognosis and response to therap...
journal_title:Scientific reports
pub_type: 杂志文章,meta分析
doi:10.1038/s41598-019-49952-x
更新日期:2019-09-17 00:00:00
abstract::The availability and spatial distribution of food resources affect animal behavior and survival. Black howler monkeys (Alouatta pigra) have a foraging strategy to balance their nutrient intake that involves mixing their consumption of leaves and fruits. The spatial aggregation of food items should impact this strategy...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-55932-y
更新日期:2019-12-19 00:00:00
abstract::CD74 is expressed on the cell surface of pulmonary macrophages and contributes to macrophage migration inhibitory factor (MIF)-induced inflammatory response in acute lung injury (ALI). A circulating form of CD74 (soluble CD74, sCD74) was recently discovered in autoimmune liver disease. Using two murine ALI models and ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep30067
更新日期:2016-07-22 00:00:00
abstract::Diabetes is an independent risk factor for development of heart failure and has been associated with poor outcomes in these patients. The prevalence of diabetes continues to rise. Using routine HbA1c measurements on inpatients at a tertiary hospital, we aimed to investigate the prevalence of diabetes amongst patients ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-31473-8
更新日期:2018-09-10 00:00:00
abstract::Sustainable wastewater treatment has been attracting increasing attentions over the past decades. However, the production of nitrous oxide (N2O), a potent GHG, from the energy-efficient granule-based autotrophic nitrogen removal is largely unknown. This study applied a previously established N2O model, which incorpora...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep45609
更新日期:2017-04-03 00:00:00
abstract::The association of cabbage white butterflies (Pieris spec., Lepidoptera: Pieridae) with their glucosinolate-containing host plants represents a well-investigated example of the sequential evolution of plant defenses and insect herbivore counteradaptations. The defensive potential of glucosinolates, a group of amino ac...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-29148-5
更新日期:2018-07-17 00:00:00
abstract::A prophage vB_CibM-P1 was induced by mitomycin C from the epipelagic strain Citromicrobium bathyomarinum JL354, a member of the alpha-IV subcluster of marine aerobic anoxygenic phototrophic bacteria (AAPB). The induced bacteriophage vB_CibM-P1 had Myoviridae-like morphology and polyhedral heads (approximately capsid 6...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep07118
更新日期:2014-11-19 00:00:00
abstract::Quantum coherence is one of the primary non-classical features of quantum systems. While protocols such as the Leggett-Garg inequality (LGI) and quantum tomography can be used to test for the existence of quantum coherence and dynamics in a given system, unambiguously detecting inherent "quantumness" still faces serio...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep00885
更新日期:2012-01-01 00:00:00
abstract::Metastasis of head and neck tumors is responsible for a high mortality rate. Understanding its biochemistry may allow insights into tumorigenesis. To that end we carried out RNA-Seq analyses of 5 SCC9 derived oral cancer cell lines displaying increased invasive potential. Differentially expressed genes (DEGs) were ann...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-19010-5
更新日期:2018-01-31 00:00:00
abstract::Electrochemical pre-doping of a silicon electrode was investigated to create a new class of rechargeable battery with higher energy density. The electrochemical reaction during pre-doping formed a high-quality solid electrolyte interface (SEI) on the surface of silicon particles, which improved the charge and discharg...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-59913-4
更新日期:2020-02-21 00:00:00
abstract::G-quadruplexes (G4s) are nucleic acids secondary structures, epigenetic regulators in cells and viruses. In herpes simplex virus 1 (HSV-1)-infected cells, G4s are massively present during viral replication. We here aimed at investigating the possibility to target the HSV-1 G4s by a core extended naphtalene diimide (c-...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-02667-3
更新日期:2017-05-24 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-019-53129-x
更新日期:2019-11-05 00:00:00
abstract::A highly sensitive bismuth/silver nanoparticles/Nafion-modified screen-printed graphene electrode was fabricated and was utilized for the detection of trace lead (Pb) concentrations in river water samples prior to and after remediation using calamansi (Citrofortunella Microcarpa) rinds in different forms viz., ground ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-80672-9
更新日期:2021-01-14 00:00:00
abstract::Genome-wide association studies (GWAS) have uncovered numerous variants associated with body mass index (BMI), waist circumference, and waist-to-hip ratio. Our study aims to investigate how these variants are linked to fat distribution. We genotyped 56 validated variants of BMI, waist circumference, and waist-to-hip r...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep20691
更新日期:2016-02-05 00:00:00
abstract::Autism spectrum disorder involves persistent difficulties in social communication. Although these difficulties affect both verbal and nonverbal communication, there are no quantitative behavioral studies to date investigating the cross-modal coordination of verbal and nonverbal communication in autism. The objective o...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-54587-z
更新日期:2019-12-04 00:00:00
abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-018-23598-7
更新日期:2018-04-11 00:00:00
abstract::Cardiac progenitor cells (CPCs) have been shown to promote cardiac regeneration and improve heart function. However, evidence suggests that their regenerative capacity may be limited in conditions of severe hypoxia. Elucidating the mechanisms involved in CPC protection against hypoxic stress is essential to maximize t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-09813-x
更新日期:2017-08-29 00:00:00
abstract::The usage of gelatin hydrogel is limited due to its instability and poor mechanical properties, especially under physiological conditions. Divalent metal ions present in gelatin such as Ca(2+) and Fe(2+) play important roles in the gelatin molecule interactions. The objective of this study was to determine the impact ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep04706
更新日期:2014-04-16 00:00:00
abstract::Photoreceptor cell death is the ultimate process underlying many retinal diseases, including retinal detachment (RD). Both autophagy and inflammatory factors, such as tumor necrosis factor-alpha (TNF-α), participate in photoreceptor cell death after RD. In this study, we examined whether TNF-α inhibition would impact ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-17400-3
更新日期:2017-12-07 00:00:00
abstract::Evidence suggest that overexpression of hypoxia-inducible factor-1α (HIF-1α) is linked to multidrug resistance of epilepsy. Here we explored whether aberrant expression of HIF-1α is regulated by miRNAs. Genome-wide microRNA expression profiling was performed on temporal cortex resected from mesial temporal lobe epilep...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep32091
更新日期:2016-08-24 00:00:00
abstract::Nanoscale wavelength-converted optical components are promising components for communication and optical information processing in integrated photonic system. In this work, we report a facile strategy for realizing continuously tunable wavelength-converted wave-guiding in dye-doped nanofibers. The nanofibers with diam...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep01674
更新日期:2013-01-01 00:00:00
abstract::The goal of this study was to develop a cheap and simple medium and to optimize fermentation parameters for fibrinolytic enzyme production by Bacillus subtilis WR350. A low-cost medium containing 35 g/L sucrose, 20 g/L corn steep powder and 2 g/L MgSO4·7H2O was developed via single-factor and orthogonal experiments. A...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-43371-8
更新日期:2019-05-02 00:00:00