A Novel Mechanism for Nitrosative Stress Tolerance Dependent on GTP Cyclohydrolase II Activity Involved in Riboflavin Synthesis of Yeast.

abstract：:Multiple sequence alignment (MSA) is an integral part of molecular biology. But handling massive number of large sequences is still a bottleneck for most of the state-of-the-art software tools. Knowledge driven algorithms utilizing features of input sequences, such as high similarity in case of DNA sequences, can help...

journal_title：Scientific reports

authors： Vineetha V,Biji CL,Nair AS

更新日期：2019-04-29 00:00:00

abstract：:The effects of ocean acidification (OA) on the early recruitment of pteropods in the Scotia Sea, was investigated considering the process of spawning, quality of the spawned eggs and their capacity to develop. Maternal OA stress was induced on female pteropods (Limacina helicina antarctica) through exposure to present...

journal_title：Scientific reports

authors： Manno C,Peck VL,Tarling GA

更新日期：2016-05-16 00:00:00

abstract：:We demonstrate synthesis of Ni/CuOx/Ni nanowires (NWs) by electrochemical deposition on anodized aluminum oxide (AAO) membranes. AAO with pore diameter of ~70 nm and pore length of ~50 μm was used as the template for synthesis of NWs. After deposition of Au as the seed layer, NWs with a structure of Ni/CuOx/Ni were gr...

journal_title：Scientific reports

authors： Park K,Lee JS

更新日期：2016-03-15 00:00:00

abstract：:Diabetes mellitus (DM) during pregnancy can result in fetal overgrowth, likely due to placental dysfunction, which has health consequences for the infant. Here we test our prediction from previous work using a placental cell line that high glucose concentrations affect placental lipid metabolism. Placentas from women ...

journal_title：Scientific reports

authors： Hulme CH,Nicolaou A,Murphy SA,Heazell AEP,Myers JE,Westwood M

更新日期：2019-10-01 00:00:00

abstract：:The global left ventricular (LV) contractility index, dσ*/dtmax measures the maximal rate of change in pressure-normalized LV wall stress. We aim to describe the trend of dσ*/dtmax in differing severity of aortic stenosis (AS) with preserved left ventricular ejection fraction (LVEF) and the association of dσ*/dtmax wi...

journal_title：Scientific reports

authors： Sim HW,Ngiam NJ,Zhong L,Tan BY,Low LY,Djohan AH,Boey E,Kong WKF,Tan RS,Poh KK

更新日期：2020-04-30 00:00:00

abstract：:Abiotic emergence of ordered information stored in the form of RNA is an important unresolved problem concerning the origin of life. A polymer longer than 40-100 nucleotides is necessary to expect a self-replicating activity, but the formation of such a long polymer having a correct nucleotide sequence by random react...

journal_title：Scientific reports

authors： Totani T

更新日期：2020-02-03 00:00:00

abstract：:Conditional gene expression systems that enable inducible and reversible transcriptional control are essential research tools and have broad applications in biomedicine and biotechnology. The reverse tetracycline transcriptional activator is a canonical system for engineered gene expression control that enables graded...

journal_title：Scientific reports

authors： Roney IJ,Rudner AD,Couture JF,Kærn M

更新日期：2016-06-21 00:00:00

abstract：:The structure of bonds in biomolecules, such as base pairs in RNA chains or native interactions in proteins, can be presented in the form of a chord diagram. A given biomolecule is then characterized by the genus of an auxiliary two-dimensional surface associated to such a diagram. In this work we introduce the notion...

journal_title：Scientific reports

authors： Zając S,Geary C,Andersen ES,Dabrowski-Tumanski P,Sulkowska JI,Sułkowski P

更新日期：2018-12-03 00:00:00

abstract：:The original motivation of the article is to give a systematic investigation on the protocol of combining computer simulation and accurate synthesis of serial peptide protected gold clusters for potent tumor targeting therapy. Glutathione peroxidase-1 (GPx-1) is a crucial antioxidant selenoenzyme that regulates cellul...

journal_title：Scientific reports

authors： Liu M,Gao L,Zhao L,He J,Yuan Q,Zhang P,Zhao Y,Gao X

更新日期：2017-03-09 00:00:00

abstract：:Aminoacyl-tRNA synthetases are the key enzymes for protein synthesis. Glycine, alanine, serine and tyrosine are the major amino acids composing fibroin of silkworm. Among them, the genes of alanyl-tRNA synthetase (AlaRS) and glycyl-tRNA synthetase (GlyRS) have been cloned. In this study, the seryl-tRNA synthetase (Ser...

journal_title：Scientific reports

authors： Hu J,Tian J,Li F,Xue B,Hu J,Cheng X,Li J,Shen W,Li B

更新日期：2017-01-30 00:00:00

abstract：:Although the initial formulation of modern concepts of adaptive radiation arose from consideration of the fossil data, rigorous attempts to identify this phenomenon in the fossil record are largely uncommon. Here I focus on direct evidence of the diet (through tooth-wear patterns) and ecologically-relevant traits of o...

journal_title：Scientific reports

authors： DeMiguel D

更新日期：2016-07-13 00:00:00

abstract：:We aimed to discover novel associations between leptin and circulating proteins which could link leptin to the development of cardiovascular disease in patients with type 2 diabetes (T2DM). In a discovery phase, we investigated associations between 88 plasma proteins, assessed with a proximity extension assay, and pla...

journal_title：Scientific reports

authors： Vavruch C,Nowak C,Feldreich T,Östgren CJ,Sundström J,Söderberg S,Lind L,Nyström F,Ärnlöv J

更新日期：2020-08-04 00:00:00

abstract：:Hepatic steatosis (HS) can exacerbate acute pancreatitis (AP). This study aimed to investigate the relation between α1-antitrypsin (AAT) and acute pancreatitis when patients have HS. Using proteomic profiling, we identified 18 differently expressed proteins pots in the serum of rats with or without HS after surgical e...

journal_title：Scientific reports

authors： Wang Q,Du J,Yu P,Bai B,Zhao Z,Wang S,Zhu J,Feng Q,Gao Y,Zhao Q,Liu C

更新日期：2015-12-04 00:00:00

abstract：:High Resolution Melt (HRM) is a versatile and rapid post-PCR DNA analysis technique primarily used to differentiate sequence variants among only a few short amplicons. We recently developed a one-vs-one support vector machine algorithm (OVO SVM) that enables the use of HRM for identifying numerous short amplicon seque...

journal_title：Scientific reports

authors： Fraley SI,Athamanolap P,Masek BJ,Hardick J,Carroll KC,Hsieh YH,Rothman RE,Gaydos CA,Wang TH,Yang S

更新日期：2016-01-18 00:00:00

abstract：:Interference of two combined white light beams produces Newton colors if one of the beams is retarded relative to the other by from 400 nm to 2000 nm. In this case the corresponding interfering spectral components are added as two scalars at the beam combination. If the retardance is below 400 nm the two-beam interfer...

journal_title：Scientific reports

authors： Shribak M

更新日期：2015-11-27 00:00:00

abstract：:Spin-polarized triangular graphene nanoflakes (t-GNFs) serve as ideal building blocks for the long-desired ferromagnetic graphene superlattices, but they are always assembled to planar structures which reduce its mechanical properties. Here, by joining t-GNFs in a spiral way, we propose one-dimensional graphene spiral...

journal_title：Scientific reports

authors： Zhang X,Zhao M

更新日期：2014-07-16 00:00:00

abstract：:Gaucher disease (GD) is a rare inherited metabolic disease caused by pathogenic variants in the GBA1 gene. So far, the pathomechanism of GD was investigated mainly in animal models. In order to delineate the molecular changes in GD cells we analysed gene expression profile in cultured skin fibroblasts from GD patients...

journal_title：Scientific reports

authors： Ługowska A,Hetmańczyk-Sawicka K,Iwanicka-Nowicka R,Fogtman A,Cieśla J,Purzycka-Olewiecka JK,Sitarska D,Płoski R,Filocamo M,Lualdi S,Bednarska-Makaruk M,Koblowska M

更新日期：2019-04-15 00:00:00

abstract：:Caspase-3-related DEVDase activity is initiated upon apoptosis in unfertilized starfish eggs. In this study, we cloned a starfish procaspase-3 corresponding to mammalian effector caspase containing a CARD that is similar to the amino terminal CARD of mammalian capsase-9, and we named it procaspase-3/9. Recombinant pro...

journal_title：Scientific reports

authors： Tamura R,Takada M,Sakaue M,Yoshida A,Ohi S,Hirano K,Hayakawa T,Hirohashi N,Yura K,Chiba K

更新日期：2018-01-25 00:00:00

abstract：:Defects of vitamin B6 metabolism are responsible for severe neurological disorders, such as pyridoxamine 5'-phosphate oxidase deficiency (PNPOD; OMIM: 610090), an autosomal recessive inborn error of metabolism that usually manifests with neonatal-onset severe seizures and subsequent encephalopathy. At present, 27 path...

journal_title：Scientific reports

authors： Barile A,Nogués I,di Salvo ML,Bunik V,Contestabile R,Tramonti A

更新日期：2020-08-12 00:00:00

abstract：:Recent research shows that continuous overgrazing not only causes grassland biodiversity to decline, but also causes light fungal disease. Achnatherum inebrians is susceptible to fungal diseases and increases in prevalence during over grazing due its toxicity to livestock. This study aimed to examine the effects of A....

journal_title：Scientific reports

authors： Yao X,Fan Y,Chai Q,Johnson RD,Nan Z,Li C

更新日期：2016-09-16 00:00:00

abstract：:This paper explores the empirical links between achieving the Sustainable Development Goals (SDGs) and subjective well-being. Globally, we find that in terms of well-being, there are increasing marginal returns to sustainable development. Unpacking the SDGs by looking at how each SDG relates to well-being shows, in mo...

journal_title：Scientific reports

authors： De Neve JE,Sachs JD

更新日期：2020-09-15 00:00:00

abstract：:α-synuclein (α-syn) is the main component of Lewy bodies, which are neuropathological hallmarks of patients with Parkinson's disease. As it has been controversial whether human α-syn from erythrocytes exists as a tetramer under physiological conditions, we tried solving this issue by the small-angle X-ray solution sca...

journal_title：Scientific reports

authors： Araki K,Yagi N,Nakatani R,Sekiguchi H,So M,Yagi H,Ohta N,Nagai Y,Goto Y,Mochizuki H

更新日期：2016-07-29 00:00:00

abstract：:In the last 40 years only one new antitubercular drug has been approved, whilst resistance to current drugs, including rifampicin, is spreading. Here, we used the model organism Mycobacterium smegmatis to study mechanisms of phenotypic mycobacterial resistance, employing quantitative mass spectrometry-based proteomics...

journal_title：Scientific reports

authors： Giddey AD,de Kock E,Nakedi KC,Garnett S,Nel AJ,Soares NC,Blackburn JM

更新日期：2017-03-06 00:00:00

abstract：:Cell lytic enzymes represent an alternative to chemical decontamination or use of antibiotics to kill pathogenic bacteria, such as listeria. A number of phage cell lytic enzymes against listeria have been isolated and possess listericidal activity; however, there has been no attempt to incorporate these enzymes onto s...

journal_title：Scientific reports

authors： Solanki K,Grover N,Downs P,Paskaleva EE,Mehta KK,Lee L,Schadler LS,Kane RS,Dordick JS

更新日期：2013-01-01 00:00:00

abstract：:Evaluating and tuning the properties of two-dimensional (2D) materials is a major focus of advancing 2D science and technology. While many claim that the photonic properties of a 2D layer provide evidence that the material is "high quality", this may not be true for electronic performance. In this work, we deconvolute...

journal_title：Scientific reports

authors： Zhang K,Borys NJ,Bersch BM,Bhimanapati GR,Xu K,Wang B,Wang K,Labella M,Williams TA,Haque MA,Barnard ES,Fullerton-Shirey S,Schuck PJ,Robinson JA

更新日期：2017-12-05 00:00:00

abstract：:Emerging evidence suggests substantial health benefits from using meditation. While there are some indications that the popularity of meditation is increasing, little is known about the prevalence, patterns, and predictors of meditation use in the general population. In this secondary analysis of data from the 2012 US...

journal_title：Scientific reports

authors： Cramer H,Hall H,Leach M,Frawley J,Zhang Y,Leung B,Adams J,Lauche R

更新日期：2016-11-10 00:00:00

abstract：:Peach is an economically import fruit crop worldwide, and serves as a model species of the Rosaceae family as well. However, peach functional genomics studies are severely hampered due to its recalcitrance to regeneration and stable transformation. Here, we report a fast and efficient Agrobacterium rhizogenes-mediated...

journal_title：Scientific reports

authors： Xu S,Lai E,Zhao L,Cai Y,Ogutu C,Cherono S,Han Y,Zheng B

更新日期：2020-02-18 00:00:00

abstract：:The growth dynamics of Ga(In)N semiconductors by Plasma-Assisted Molecular Beam Epitaxy (PAMBE) at low temperatures (T = 450 °C) is here investigated. The presence of droplets at the growth surface strongly affects the adatom incorporation dynamics, making the growth rate a decreasing function of the metal flux imping...

journal_title：Scientific reports

authors： Azadmand M,Barabani L,Bietti S,Chrastina D,Bonera E,Acciarri M,Fedorov A,Tsukamoto S,Nötzel R,Sanguinetti S

更新日期：2018-07-26 00:00:00

abstract：:The histological spectrum of nonalcoholic fatty liver diseases (NAFLD) ranges from hepatic steatosis to steatohepatitis and fibrosis. Berberine (BBR) is known for its therapeutic effect on obesity, hyperglycaemia and dyslipidaemia; however, its effect on NAFLD has yet to be thoroughly explored. Db/db mice and methioni...

journal_title：Scientific reports

authors： Zhang Z,Li B,Meng X,Yao S,Jin L,Yang J,Wang J,Zhang H,Zhang Z,Cai D,Zhang Y,Ning G

更新日期：2016-02-09 00:00:00

abstract：:Propagation of oscillatory spike firing activity at specific frequencies plays an important role in distributed cortical networks. However, there is limited evidence for how such frequency-specific signals are induced or how the signal spectra of the propagating signals are modulated during across-layer (radial) and i...

journal_title：Scientific reports

authors： Toda H,Kawasaki K,Sato S,Horie M,Nakahara K,Bepari AK,Sawahata H,Suzuki T,Okado H,Takebayashi H,Hasegawa I

更新日期：2018-05-16 00:00:00