Abstract:
:The original motivation of the article is to give a systematic investigation on the protocol of combining computer simulation and accurate synthesis of serial peptide protected gold clusters for potent tumor targeting therapy. Glutathione peroxidase-1 (GPx-1) is a crucial antioxidant selenoenzyme that regulates cellular redox level, thus becomes a potential target in cancer treatment. We firstly utilize molecular dynamic (MD) simulation to rationally design and screen serial peptide-Au cluster compounds with special peptide sequences and precise gold atoms, which can recognize and bind specific domain of GPx-1 with high affinity. The theoretical simulations were further verified by the following peptide-Au clusters synthesis and GPx-1 activity suppression studies in buffer and cells, respectively. Further cytological experiments corroborated that peptide-Au clusters are promising nanoparticles inducing tumor cells apoptosis by suppressing GPx-1 activity and increasing higher cellular reactive oxygen species level to initiate tumor cell apoptosis through intrinsic mitochondrial pathway.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Liu M,Gao L,Zhao L,He J,Yuan Q,Zhang P,Zhao Y,Gao Xdoi
10.1038/s41598-017-00278-6subject
Has Abstractpub_date
2017-03-09 00:00:00pages
131issue
1issn
2045-2322pii
10.1038/s41598-017-00278-6journal_volume
7pub_type
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