Abstract：
:Skin-derived dendritic cells (DCs) play a crucial role in the maintenance of immune homeostasis due to their role in antigen trafficking from the skin to the draining lymph nodes (dLNs). To quantify the spatiotemporal regulation of skin-derived DCs in vivo, we generated knock-in mice expressing the photoconvertible fluorescent protein KikGR. By exposing the skin or dLN of these mice to violet light, we were able to label and track the migration and turnover of endogenous skin-derived DCs. Langerhans cells and CD103(+)DCs, including Langerin(+)CD103(+)dermal DCs (DDCs), remained in the dLN for 4-4.5 days after migration from the skin, while CD103(-)DDCs persisted for only two days. Application of a skin irritant (chemical stress) induced a transient >10-fold increase in CD103(-)DDC migration from the skin to the dLN. Tape stripping (mechanical injury) induced a long-lasting four-fold increase in CD103(-)DDC migration to the dLN and accelerated the trafficking of exogenous protein antigens by these cells. Both stresses increased the turnover of CD103(-)DDCs within the dLN, causing these cells to die within one day of arrival. Therefore, CD103(-)DDCs act as sentinels against skin invasion that respond with increased cellular migration and antigen trafficking from the skin to the dLNs.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Tomura M,Hata A,Matsuoka S,Shand FH,Nakanishi Y,Ikebuchi R,Ueha S,Tsutsui H,Inaba K,Matsushima K,Miyawaki A,Kabashima K,Watanabe T,Kanagawa Odoi
10.1038/srep06030subject
Has Abstractpub_date
2014-08-12 00:00:00pages
6030issn
2045-2322pii
srep06030journal_volume
4pub_type
杂志文章abstract：:Heterostructures based on two-dimensional (2D) materials have sparked wide interests in both fundamental physics and applied devices. Recently, Dirac/Weyl semimetals are emerging as capable functional materials for optoelectronic devices. However, thus far the interfacial coupling of an all-semimetal 2D heterostructur...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-29717-8
更新日期：2018-08-27 00:00:00
abstract：:Hepatocellular carcinoma is a common type of malignancy with a poor prognosis. Identification and utilisation of markers for monitoring and diagnosis are urgently needed. Alpha-fetoprotein (AFP) and Protein Induced by Vitamin K Absence or Antagonist-II (PIVKA-II) have been proved to be efficient biomarkers for hepatit...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-70241-5
更新日期：2020-08-11 00:00:00
abstract：:By moving the alkoxy group on the spacer from position 5 to position 4 to add another protocol for the algorithm for intermolecular and intramolecular hydrogen bonding interactions, highly regioselectivity of noncovalent synthesis of the hydrazide-based cyclic hexamers was achieved: one out of thirteen possible isomer...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep01059
更新日期：2013-01-01 00:00:00
abstract：:Gait speed in laboratory settings (in-laboratory gait speed) is one of the important indicators associated with the decline in functional abilities in older adulthood. Recently, it has become possible to measure gait speed during daily living (daily gait speed) using accelerometers. However, the relationship between t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-39695-0
更新日期：2019-03-05 00:00:00
abstract：:Selective filtration of gas, water, and liquid or gaseous oil is essential to prevent possible environmental pollution and machine/facility malfunction in oil-based industries. Novel materials and structures able to selectively and efficiently filter liquid and vapor in various types of solutions are therefore in cont...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep14321
更新日期：2015-09-23 00:00:00
abstract：:The South American Monsoon System (SAMS) is generally considered to be highly sensitive to Northern Hemisphere (NH) temperature variations on multi-centennial timescales. The direct influence of solar forcing on moisture convergence in global monsoon systems on the other hand, while well explored in modeling studies, ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep24762
更新日期：2016-04-21 00:00:00
abstract：:This study described the results of environmental enterovirus surveillance conducted in Shandong Province of China in 2013. Altogether 39 sewage samples were collected and 873 enterovirus isolates (including 334 polioviruses) belonging to 22 serotypes were obtained. Echovirus (E) -7, coxsackievirus (CV) -B5, E-11, E-6...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep31474
更新日期：2016-08-11 00:00:00
abstract：:Over the last 5-10 years, optical coherence tomography (OCT) and atomic force microscopy (AFM) have been individually applied to monitor the morphological and mechanical properties of various single-species biofilms respectively. This investigation looked to combine OCT and AFM as a multi-scale approach to understand ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-23798-1
更新日期：2018-04-09 00:00:00
abstract：:Acetylcholine binding proteins (AChBPs) are unique spatial homologs of the ligand-binding domains of nicotinic acetylcholine receptors (nAChRs), and they reproduce some pharmacological properties of nAChRs. X-ray crystal structures of AСhBP in complex with α-conotoxins provide important insights into the interactions ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep22349
更新日期：2016-03-01 00:00:00
abstract：:Species of Pomacea, commonly known as apple snails, are native to South America, and have become widely distributed agricultural and environmental pests in southern China since their introduction in the 1980s. However, only since 2010 have researchers recognized that at least two species, P. canaliculata and P. macula...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-19000-7
更新日期：2018-01-19 00:00:00
abstract：:The present study investigated when emotion modulates working memory from the perspective of neural activation. Using fMRI, we measured brain activity during the encoding and retrieval phases of a reading span test (RST) that used emotional contexts. The emotional RST required participants to read sentences that elici...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep01375
更新日期：2013-01-01 00:00:00
abstract：:Many species can successfully colonize new areas despite their propagules having low genetic variation. We assessed whether the decreased genetic diversity could result in temporal fluctuations of genetic parameters of the new populations of an invasive species, western flower thrips, Frankliniella occidentalis, using...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep11877
更新日期：2015-07-03 00:00:00
abstract：:Programmed death-ligand 1 (PD-L1) acts as an immune checkpoint inhibitor in various cancers. PD-L1 is known to be more frequently expressed in EBV (+) gastric cancer (GC). However, the mechanisms underlying the regulation of PD-L1 expression in EBV (+) GC remain unclear. We investigated the basal and inducible PD-L1 e...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-18132-0
更新日期：2017-12-19 00:00:00
abstract：:Graphene grown directly on germanium is a possible route for the integration of graphene into nanoelectronic devices as well as it is of great interest for materials science. The morphology of the interface between graphene and germanium influences the electronic properties and has not already been completely elucidat...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-48998-1
更新日期：2019-08-29 00:00:00
abstract：:We report measurements of the thermal conductance of a structure made from commercial Acrylonitrile Butadiene Styrene (ABS) modules, known as LEGO® blocks, in the temperature range from 70 mK to 1.8 K. A power law for the sample's thermal conductivity κ = (8.7 ± 0.3) × 10-5 T 1.75±0.02 WK-1 m-1 was determined. We conc...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-55616-7
更新日期：2019-12-23 00:00:00
abstract：:After HSP70 binds to the J domain of the substrate and co-chaperone protein, ATP is hydrolyzed to ADP, and the nucleotide exchange factors (NEFs) promote the release of ADP. Under physiological conditions, the nucleotide exchange step is the rate-limiting step, which is accelerated by NEFs. In this study, the promoter...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-74381-6
更新日期：2020-10-14 00:00:00
abstract：:In the field of correlative microscopy, light and electron microscopy form a powerful combination for morphological analyses in zoology. Due to sample thickness limitations, these imaging techniques often require sectioning to investigate small animals and thereby suffer from various artefacts. A recently introduced n...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-60977-5
更新日期：2020-03-03 00:00:00
abstract：:Small bowel capsule endoscopy (SBCE) and balloon-assisted endoscopy (BAE) have revolutionized the diagnosis and treatment of small bowel bleeding (SBB), allowing access to the small bowel and identification of specific bleeding lesions. However, some patients experience rebleeding after small bowel investigation, and ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-24868-0
更新日期：2018-04-23 00:00:00
abstract：:Quaternized polyacrylic polymer has many applications in water treatment because of its ion exchange effects, but its further industrial applications are largely restricted because of its poor mechanical strength. In this work, a magnetic anion exchange resin with a polyacrylic matrix (MAP) was prepared by incorporati...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-62153-1
更新日期：2020-03-23 00:00:00
abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-018-22369-8
更新日期：2018-03-06 00:00:00
abstract：:Solid stress is a biomechanical abnormality of the tumor microenvironment that plays a crucial role in tumor progression. When it is applied to cancer cells, solid stress hinders their proliferation rate and promotes cancer cell invasion and metastatic potential. However, the underlying mechanisms of how it is implica...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-37425-6
更新日期：2019-01-30 00:00:00
abstract：:The aim of this paper is to investigate the effect that bone marrow mesenchymal stem cells (BMMSCs) - endothelial progenitor cells (EPCs), BMMSCs and EPCs sheets have on repairing maxillary alveolar defects in ovariectomized (OVX) rats. In this study, after identification using multi-lineage differentiation and flow c...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-16404-3
更新日期：2017-11-29 00:00:00
abstract：:The family Brassicaceae includes plants that are non-host for arbuscular mycorrhizal fungi (AMF) such as the model plant Arabidopsis thaliana (arabidopsis) and the economically important crop plant Brassica napus (rapeseed). It is well known that Trichoderma species have the ability to colonize the rhizosphere of Bras...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-48269-z
更新日期：2019-08-12 00:00:00
abstract：:Climatic characteristics of Hengduan Mountains region were diverse, and Eothenomys miletus was a native species throughout this region. To investigate adaptive strategies of E. miletus to environmental factors in different locations in this region, five locations were selected, including Deqin (DQ), Xianggelila (XGLL)...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-51493-2
更新日期：2019-10-17 00:00:00
abstract：:Some insect galls are formed on sumac plants by certain aphid species and have been used for medicinal and chemical purposes as they are rich in tannins. The most prominent species among gall aphids in China is Schlechtendalia chinensis, which formed horn-shaped galls on the winged rachis of Rhus chinensis. S. chinens...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-06806-8
更新日期：2017-07-25 00:00:00
abstract：:The study was aimed at assessing the diagnostic performance of 68Ga-PSMA-617 PET/CT in the detection of prostate cancer (PCa) in patients with a prostate-specific antigen (PSA) level of 4-20 ng/ml and to compare its efficacy with that of multiparametric MRI (mpMRI). We analyzed the data of 67 consecutive patients with...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-67385-9
更新日期：2020-07-03 00:00:00
abstract：:A multi-angle light scattering (MALS) system, combined with chromatographic separation, directly measures the absolute molar mass, size and concentration of the eluate species. The measurement of these crucial properties in solution is essential in basic macromolecular characterization and all research and production ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-09051-1
更新日期：2017-08-30 00:00:00
abstract：:During dental erosion, tooth minerals are dissolved, leading to a softening of the surface and consequently to irreversible surface loss. Components from human saliva form a pellicle on the tooth surface, providing some protection against erosion. To assess the effect of different components and compositions of saliva...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep34760
更新日期：2016-10-05 00:00:00
abstract：:Biomarkers for the progression of lung function in COPD are currently scarce. Plasma fetuin-B (FETUB) was identified by iTRAQ-based proteomics and was verified by ELISA in another group. Information regarding acute exacerbation (AE) was collected in a one-year follow-up programme. FETUB concentrations (1652 ± 427 ng/m...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep30045
更新日期：2016-07-22 00:00:00
abstract：:Respiratory syncytial virus (RSV) is a major cause of diseases of the respiratory tract in young children and babies, being mainly associated with bronchiolitis. RSV infection occurs primarily in pulmonary epithelial cells and, once infection is established, an immune response is triggered and neutrophils are recruite...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-32576-y
更新日期：2018-09-21 00:00:00
